RU2535092C1 - Method of therapy of endometritis of cats and dogs - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: method comprises administering an agent containing gentamicin, gamavit, sodium benzoate, potassium sorbate and propylene glycol. The agent is used in intrauterine mode 2 times a day for 7-10 days at a dose of 5-10 ml to cat and 10-20 ml to dog.

EFFECT: method comprises high therapeutic efficacy in endometritis of cats and dogs.

1 ex

Description

The invention relates to veterinary medicine, in particular for the treatment of endometritis of catarrhal and purulent-catarrhal origin in cats and dogs.

The complex of therapeutic measures for endometritis of animals is aimed at timely removal of exudate from the uterine cavity, restoration of contractile function of the organ and suppression of microflora in it, as well as activation of the body's defenses [1]. For the treatment of endometritis of dogs and cats, a large number of hormonal, chemotherapeutic, and antibiotic agents have been proposed. Conservative therapy includes the use of antibiotics (albipen LA, cefacure, enroflox), prostaglandin (enzaprost F), oxytocin, sulfonamides [2].

The use of antibiotics for the prevention and treatment of endometritis in dogs and cats is advisable and highly effective, but often accompanied by the emergence of antibiotic resistance of microorganisms. In addition, many antibiotics are rapidly inactivated in biological fluids, which makes it difficult to obtain the desired result [3].

Sulfanilamide preparations require the use of high-dose regimen, which makes it difficult to maintain the necessary bacteriostatic concentration.

Perhaps a successful homeopathic treatment (mastometrine, lachesis compositum and mucose compositum). However, these drugs are effective only for catarrhal endometritis in the initial stage and have low therapeutic efficacy in purulent-catarrhal forms.

Known drug for the prevention and treatment of endometritis of cows (RF Patent 2350325, 2007). The drug contains the antibiotic chloramphenicol and antiseptics sodium benzoate and potassium sorbate, dissolved in propylene glycol, has a complex antimicrobial and antifungal effect with intrauterine use at a dose of 50-100 ml for endometritis in cows. The use of the drug helps to increase the effectiveness of prophylaxis of postpartum endometritis by 10% and to reduce the treatment time for catarrhal and purulent-catarrhal endometritis (including those caused by microorganisms in association with Candida fungi) by 2-6 days. However, the use of this drug for endometritis of small domestic animals is not known.

It should be noted that in some cases the course of endometritis can be complicated by pathogenic fungi, in particular of the genus Candida. The use of antimicrobial agents with antifungal activity for intrauterine use in endometritis is limited by the insufficient assortment of dosage forms and effectiveness.

The purpose of the invention is the expansion of the arsenal of highly effective agents for the treatment of endometritis in cats and dogs.

This goal is achieved by using the proposed method for the treatment of endometritis in cats and dogs. The method is based on the use of antibacterial and biologically active agents, as well as preservatives with fungicidal properties.

As an antibacterial drug, we chose the antibiotic gentamicin.

Gentamicins are antibiotics of the aminoglycoside series with a wide spectrum of action, inhibit bacterial protein synthesis, highly active against aerobic gram-negative bacteria. Gentamicins are produced by Micromonospora bacteria, industrial producer Micromonospora purpurea, actively penetrating the bacterial cell membrane, gentamicin binds irreversibly to the A site of the 30S subunit of bacterial ribosomes (tRNA binding site) and thereby inhibits the synthesis of the pathogen protein. Highly active against aerobic gram-negative bacteria: Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Serratia spp., Proteus spp., Pseudomonas aeruginosa, Acinetobacter spp. Also active against aerobic gram-positive cocci: Staphylococcus spp. (including those resistant to penicillins and other antibiotics), some strains of Streptococcus spp.

Gamavit is a complex preparation, the main active ingredients of which are denatured emulsified placenta (PDE) and sodium nucleinate; the preparation is made in liquid form on the basis of a growth medium containing a balanced solution of salts, amino acids and vitamins. Gamavit contains a complex of biologically active substances, thanks to which it optimizes metabolic processes in the body (in particular, protein, vitamin and mineral), normalizes the blood formula, increases the bactericidal activity of blood serum, and has an immunomodulating and general biotonizing effect. It is a biogenic stimulant and adaptogen, reduces postnatal mortality, increases the viability of offspring, increases muscle performance and resistance of animals to increased stress and stress. It is a source of metabolic substrates, contributes to increased growth.

As preservatives with a pronounced fungicidal effect, preservatives used in the food industry were included in the composition of the developed preparation: sodium benzoate (E 211) and potassium sorbate (E 202). They are approved for use as excipients in dosage forms in order to stabilize pharmaceutical preparations [5].

The resulting agent for the treatment of endometritis in cats and dogs contains the antibiotic gentamicin, gamavit, sodium benzoate, potassium sorbate and propylene glycol solvent, characterized in that these components are used in the following ratio of components, wt.%:

gentamicin 10 gamavit 10 sodium benzoate 10 potassium sorbate 10 propylene glycol up to 100

Compared with the analogue preparation, an essential distinguishing feature of the proposed method of the invention is that it contains gentamicin and an additional biologically active compound gamavit as an antibiotic.

The agent is obtained by mixing in the reactor 10 g.% Gentamicin in propylene glycol, gamavit 10 wt.%, Sodium benzoate 10 wt.%, Potassium sorbate 10 wt.% And apply 2 times a day for 7-10 days in the form of intrauterine syringes.

The invention is illustrated by examples.

To justify the therapeutic efficacy of the proposed method for endometritis of dogs and cats, an agent containing the antibiotic gentamicin, gamavit, sodium benzoate, potassium sorbate and solvent propylene glycol was used in the following ratio, wt.%: Gentamicin 10; gamavit 10; sodium benzoate 10: potassium sorbate 10; propylene glycol to 100.

According to the invention, this agent was administered to 50 dogs and 50 cats belonging to individuals of the city of Tyumen.

All animals were diagnosed with uterine inflammation. Bacteriological studies of uterine microflora showed the presence of E. Coli, Staph. Aureus, Str. Pyogenes, Proteus vulgaris, Klebsiella pneumoniae, Enterobacter agglomerans, Erwinia herbicola, Candida albicans. The drug was administered intrauterine 2 times a day for 5 days at a dose of 5-10 ml for cats and 10-20 ml for dogs (depending on the body weight of the animals). The claimed method showed a 100% therapeutic effect. The claimed method for the treatment of endometritis of dogs and cats did not cause signs of toxicosis or other adverse signs in animals.

Information sources

1. Guidelines on obstetrics, gynecology and biotechnology of animal reproduction. Ilyinsky E.V., Nazarov M.V., Troshin A.N., Shevkoplyas V.N. Tutorial. KGAU. Krasnodar, 2002, 381 pp.

2. Karpov V.A. ″ Obstetrics and Gynecology of Small Pets ″, 1999.

3. Navashin S.M., Fomina I.P. Rational antibiotic therapy, 1982.

4. RF patent 2350325, 08.08.2007.

5. European Pharmacopeia 4, 2002, P.407, 1793, 1902.

Claims (1)

A method for the treatment of endometritis of dogs and cats, which consists in administering an agent containing gentamicin, gamavit, sodium benzoate, potassium sorbate and propylene glycol, taken in the following ratio (wt.%):
gentamicin 10 gamavit 10 sodium benzoate 10 potassium sorbate 10 propylene glycol up to 100,
and the drug is used intrauterine 2 times a day for 7-10 days at a dose of 5-10 ml to a cat and 10-20 ml to a dog.