CN101947264A - Chinese and western compound suppository for treating dog endometritis and preparation method thereof - Google Patents
Chinese and western compound suppository for treating dog endometritis and preparation method thereof Download PDFInfo
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- CN101947264A CN101947264A CN2010102983358A CN201010298335A CN101947264A CN 101947264 A CN101947264 A CN 101947264A CN 2010102983358 A CN2010102983358 A CN 2010102983358A CN 201010298335 A CN201010298335 A CN 201010298335A CN 101947264 A CN101947264 A CN 101947264A
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Abstract
The invention discloses Chinese and western compound suppository for treating dog endometritis and a preparation method thereof. The Chinese and western compound suppository is prepared from the following components in part by weight: 10 to 30 parts of clindamycin, 20 to 30 parts of motherwort extract, 10 to 30 parts of Chinese angelica extract, 5 to 10 parts of Szechuan lovage rhizome extract, 10 to 15 parts of peach seed extract, 10 to 15 parts of liquorice root extract, and 50 to 55 parts of water-glycerol-gelatin serving as matrix. The preparation method comprises the following steps of: mixing five kinds of Chinese medicament extract powder and the clindamycin uniformly; and heating the matrix of the suppository over a water bath of 40 to 50 DEG C for melting, adding the medicament mixture into the matrix, mixing the mixture uniformly, and performing membrane irrigation, cooling and solidification, membrane release and packing on the mixture. The suppository for treating the dog endometritis has the advantages of convenient administration, safety, no residue, good antibacterial and anti-inflammatory effects, capabilities of promoting uterine cavity purification and recovering uterus function and the like.
Description
Technical field
The invention belongs to technical field of animal remedy preparation, be specifically related to a kind of Chinese and Western compound suppository that is used for the treatment of dog endometritis and preparation method thereof.
Background technology
The endometritis of dog is the inflammation of Uterine mucosa, often can be diffused into tela submucosa or flesh layer, and the endometritis of dog is the one of the main reasons that causes the dog infertility.Normally when oestrus, breeding, childbirth, difficult labour practise midwifery, owing to the intrusions of streptococcus, staphylococcus or escherichia coli etc. causes infection.Clinically, the difference according to the morbidity course of disease is divided into acute endometritis and chronic endometritis.The endometritis of dog brings the dog aquaculture development and has a strong impact on, and the pet fan is caused very big economic loss and moral injury.At present, wash the uterus to the treatment of dog endometritis is many with antibiotic, adopt this method operation more loaded down with trivial details, in addition, use antibiotic continually, some antibacterial can present in various degree drug resistance to medicine, in a single day drug resistance produces, and the therapeutical effect of DO can obviously descend, and also can cause antibiotic consumption increasing, can be residual in the body of dog, so unhealthful.
Summary of the invention
The object of the invention is to provide a kind of Chinese and Western compound suppository that is used for the treatment of dog endometritis, when solving the treatment dog endometritis administration loaded down with trivial details, the problem of weak curative effect.
In order to realize the object of the invention, technical program of the present invention lies in providing a kind of Chinese and Western compound suppository that is used for the treatment of dog endometritis, this Chinese and Western compound suppository is made by following parts by weight of component: clindamycin 10-30 part, Herba Leonuri extract 20-30 part, Radix Angelicae Sinensis extract 10-30 part, Rhizoma Chuanxiong extract 5-10 part, Semen Persicae extract 10-15 part, Radix Glycyrrhizae extract 10-15 part, water-gelatin-glycerol 50-55 part.
Be preferably: clindamycin 15-25 part, Herba Leonuri extract 20-25 part, Radix Angelicae Sinensis extract 15-25 part, Rhizoma Chuanxiong extract 5-8 part, Semen Persicae extract 10-15 part, Radix Glycyrrhizae extract 10-15 part, water-gelatin-glycerol 50-55 part.
Described suppository base is water-glycerol-gelatin.
Technical program of the present invention also lies in adopting a kind of preparation method that is used for the treatment of the Chinese and Western compound suppository of dog endometritis, may further comprise the steps:
1) model is cleaned, is dried, with purified cotton be stained with the lubricant vegetable oil a little, coat model inside, be inverted, unnecessary lubricant is flowed out,
2) with Herba Leonuri extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Semen Persicae extract and Radix Glycyrrhizae extract and clindamycin mixing;
3) water-glycerol-gelatin is put in the 40-50 ℃ of water-bath heating and is made fusing, add step 2 again) in medicinal mixture, stir, the impouring model is degree to overflowing die orifice, cooling, wait solidify fully after, scrape off unnecessary bolt piece, open model suppository released, packing.
Chinese medicinal components of the present invention is a Herba Leonuri, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Semen Persicae.Placenta retention is controlled in the wherein Herba Leonuri effects such as silt, regulating menstruation of invigorating blood circulation, dispel, and abdominalgia with blood stasis has excitation to the uterus; Semen Persicae has blood stasis removing and clots absorbing, the effect of treatment swelling and pain due to blood stasis; Radix Angelicae Sinensis has to enrich blood invigorates blood circulation, and changes the silt tissue regeneration promoting; Radix Glycyrrhizae has the effect of detoxifcation, coordinating the actions of various ingredients in a prescription.Therefore, the present invention not only has antiinflammation, and has good repair function for injured human body.
Product of the present invention places uterus place, and stronger adhesion is arranged, but the long period attach to the my son in utero on the film, slowly release prolongs action time.Directly stimulate the uterus sensor, its vasodilation and blood circulation are quickened, promote glandular secretion and uterine smooth muscle to shrink, help getting rid of the rheuminess thing, purify the uterus, medicine is fully absorbed, thereby play a role faster and better.
Adopt Chinese and Western of the present invention compound suppository to treat one 2 years old female rich U.S. dog:
Female rich U.S. dog was divided 3 days puerperiums in one 2 years old, and body temperature is up to 39.5 ℃, and spirit is tired, inappetence, and vomiting sometimes, the back of a bow is exerted duty, and visible vagina flows a large amount of pus sample secretions, and stench is endometritis after diagnosing.Adopt Chinese and Western of the present invention compound suppository treatment endometritis, at first select for use ampicillin to carry out intramuscular injection with anti-inflammation, venous transfusion is with the adjustment electrolyte balance that keeps the skin wet, cervix uteri is opened a business, wash with normal saline, promptly put into this suppository to depths in utero, 1 time every other day, 2/time.Oneself recovery of this dog body temperature of back of one week of medication is normal, and spirit takes a turn for the better, and can take food, and vaginal secretions gradually is reduced to nothing.
Beneficial effect of the present invention: adopt the inventive method treatment dog endometritis, have convenient drug administration, safety, noresidue, anti-inflammation is effective, can promote cavity of uterus to purify and recover advantages such as uterus function.
The specific embodiment
Embodiment 1
A, the Chinese and Western compound suppository that is used for the treatment of dog endometritis are prepared from by the component of following parts by weight:
In weight portion, take by weighing 25 parts of clindamycins respectively, 25 parts of Herba Leonuri extracts, 20 parts of Radix Angelicae Sinensis extracts, 10 parts of Rhizoma Chuanxiong extracts, 10 parts in Semen Persicae extract, 10 parts of Radix Glycyrrhizae extracts, 50 parts of water-glycerol-gelatin.
B, preparation method are as follows:
1) model is cleaned, is dried, with purified cotton be stained with vegetable oil a little, coat model inside, be inverted, unnecessary lubricant is flowed out,
2) with Herba Leonuri extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Semen Persicae extract and Radix Glycyrrhizae extract and clindamycin mixing;
3) water-glycerol-gelatin is put in the 40-50 ℃ of water-bath heating and is made fusing, add step 2 again) in medicinal mixture, stir, the impouring model is degree to overflowing die orifice, cooling, wait solidify fully after, scrape off unnecessary bolt piece, open model suppository released, packing.
Embodiment 2
A, the Chinese and Western compound suppository that is used for the treatment of dog endometritis are prepared from by the component of following parts by weight:
In weight portion, take by weighing 10 parts of clindamycins respectively, 20 parts of Herba Leonuri extracts, 10 parts of Radix Angelicae Sinensis extracts, 8 parts of Rhizoma Chuanxiong extracts, 12 parts in Semen Persicae extract, 15 parts of Radix Glycyrrhizae extracts, 55 parts of water-glycerol-gelatin.
Manufacture method is with embodiment 1.
Embodiment 3
A, the Chinese and Western compound suppository that is used for the treatment of dog endometritis are prepared from by the component of following parts by weight:
In weight portion, take by weighing 30 parts of clindamycins respectively, 30 parts of Herba Leonuri extracts, 30 parts of Radix Angelicae Sinensis extracts, 5 parts of Rhizoma Chuanxiong extracts, 15 parts in Semen Persicae extract, 10 parts of Radix Glycyrrhizae extracts, 50 parts of water-glycerol-gelatin.
Manufacture method is with embodiment 1.
Claims (4)
1. Chinese and Western compound suppository that is used for the treatment of dog endometritis, it is characterized in that: the component by following parts by weight is prepared from: clindamycin 10-30 part, Herba Leonuri extract 20-30 part, Radix Angelicae Sinensis extract 10-30 part, Rhizoma Chuanxiong extract 5-10 part, Semen Persicae extract 10-15 part, Radix Glycyrrhizae extract 10-15 part, suppository base is water-glycerol-gelatin 50-55 part.
2. the Chinese and Western compound suppository that is used for the treatment of dog endometritis according to claim 1, it is characterized in that: specifically be prepared from: clindamycin 15-25 part by following compositions in portion by weight, Herba Leonuri extract 20-25 part, Radix Angelicae Sinensis extract 15-25 part, Rhizoma Chuanxiong extract 5-8 part, Semen Persicae extract 10-15 part, Radix Glycyrrhizae extract 10-15 part, suppository base is water-glycerol-gelatin 50-55 part.
3. according to each described Chinese and Western compound suppository that is used for the treatment of dog endometritis in claim 1 or 2, it is characterized in that: described suppository base is water-glycerol-gelatin.
4. one kind as each described preparation method that is used for the treatment of the Chinese and Western compound suppository of dog endometritis in claims 1 or 2, and it is characterized in that: described preparation method may further comprise the steps:
1) takes by weighing Herba Leonuri extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Semen Persicae extract and Radix Glycyrrhizae extract and clindamycin mixing;
2) suppository base is placed 40-50 ℃ of water-bath heat fused, add the medicinal mixture in the step 1) again, mixing, filling film, cooled and solidified, demoulding, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102983358A CN101947264A (en) | 2010-09-30 | 2010-09-30 | Chinese and western compound suppository for treating dog endometritis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102983358A CN101947264A (en) | 2010-09-30 | 2010-09-30 | Chinese and western compound suppository for treating dog endometritis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101947264A true CN101947264A (en) | 2011-01-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102983358A Pending CN101947264A (en) | 2010-09-30 | 2010-09-30 | Chinese and western compound suppository for treating dog endometritis and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103181958A (en) * | 2013-03-21 | 2013-07-03 | 河北科技师范学院 | Chinese herbal medicine perfusate for treating endometritis of cow and preparation method thereof |
| RU2535092C1 (en) * | 2013-05-14 | 2014-12-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Государственный аграрный университет Северного Зауралья" (ФГБОУ ВПО ГАУ Северного Зауралья) | Method of therapy of endometritis of cats and dogs |
-
2010
- 2010-09-30 CN CN2010102983358A patent/CN101947264A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103181958A (en) * | 2013-03-21 | 2013-07-03 | 河北科技师范学院 | Chinese herbal medicine perfusate for treating endometritis of cow and preparation method thereof |
| RU2535092C1 (en) * | 2013-05-14 | 2014-12-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Государственный аграрный университет Северного Зауралья" (ФГБОУ ВПО ГАУ Северного Зауралья) | Method of therapy of endometritis of cats and dogs |
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Open date: 20110119 |