RU2407736C2 - Пери-замещенные арилсульфонамидные бициклические соединения, предназначенные для лечения окклюзионного заболевания артерий - Google Patents
Пери-замещенные арилсульфонамидные бициклические соединения, предназначенные для лечения окклюзионного заболевания артерий Download PDFInfo
- Publication number
- RU2407736C2 RU2407736C2 RU2007115520/04A RU2007115520A RU2407736C2 RU 2407736 C2 RU2407736 C2 RU 2407736C2 RU 2007115520/04 A RU2007115520/04 A RU 2007115520/04A RU 2007115520 A RU2007115520 A RU 2007115520A RU 2407736 C2 RU2407736 C2 RU 2407736C2
- Authority
- RU
- Russia
- Prior art keywords
- compound
- mmol
- substituted
- halogen
- aryl
- Prior art date
Links
- ORFNTSLTIIPWKB-UHFFFAOYSA-N C[n]1c2cccc(-c(cc3)ccc3NS(c([s]3)cc(Cl)c3Cl)(=O)=O)c2c(Cc2cc(cccc3)c3cc2)c1 Chemical compound C[n]1c2cccc(-c(cc3)ccc3NS(c([s]3)cc(Cl)c3Cl)(=O)=O)c2c(Cc2cc(cccc3)c3cc2)c1 ORFNTSLTIIPWKB-UHFFFAOYSA-N 0.000 description 1
- NTZWPVMTUYKSLC-UHFFFAOYSA-N C[n]1c2cccc(-c3cc(NS(c([s]4)cc(Cl)c4Cl)(=O)=O)n[nH]3)c2c(Cc2cc(cccc3)c3cc2)c1 Chemical compound C[n]1c2cccc(-c3cc(NS(c([s]4)cc(Cl)c4Cl)(=O)=O)n[nH]3)c2c(Cc2cc(cccc3)c3cc2)c1 NTZWPVMTUYKSLC-UHFFFAOYSA-N 0.000 description 1
- XZMMSGGIVXOCOH-UHFFFAOYSA-N C[n]1c2cccc(-c3cccc(NS(c([s]4)cc(Cl)c4Cl)(=O)=O)c3)c2c(Cc2cc(cccc3)c3cc2)c1 Chemical compound C[n]1c2cccc(-c3cccc(NS(c([s]4)cc(Cl)c4Cl)(=O)=O)c3)c2c(Cc2cc(cccc3)c3cc2)c1 XZMMSGGIVXOCOH-UHFFFAOYSA-N 0.000 description 1
- XNQOCIOBXBZTDB-UHFFFAOYSA-N C[n]1c2cccc(C3=NCCC=C(NS(c([s]4)cc(Cl)c4Cl)(=O)=O)O3)c2c(Cc2cc(cccc3)c3cc2)c1 Chemical compound C[n]1c2cccc(C3=NCCC=C(NS(c([s]4)cc(Cl)c4Cl)(=O)=O)O3)c2c(Cc2cc(cccc3)c3cc2)c1 XNQOCIOBXBZTDB-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61820204P | 2004-10-12 | 2004-10-12 | |
| US60/618,202 | 2004-10-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007115520A RU2007115520A (ru) | 2008-10-27 |
| RU2407736C2 true RU2407736C2 (ru) | 2010-12-27 |
Family
ID=35677621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007115520/04A RU2407736C2 (ru) | 2004-10-12 | 2005-10-11 | Пери-замещенные арилсульфонамидные бициклические соединения, предназначенные для лечения окклюзионного заболевания артерий |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20060142348A1 (enExample) |
| EP (1) | EP1812426B1 (enExample) |
| JP (1) | JP2008515980A (enExample) |
| KR (1) | KR20070085340A (enExample) |
| CN (1) | CN101076529A (enExample) |
| AT (1) | ATE512144T1 (enExample) |
| AU (1) | AU2005295902A1 (enExample) |
| BR (1) | BRPI0517417A (enExample) |
| CA (1) | CA2583710A1 (enExample) |
| IL (1) | IL182489A0 (enExample) |
| MX (1) | MX2007004526A (enExample) |
| NO (1) | NO20072269L (enExample) |
| NZ (1) | NZ554493A (enExample) |
| RU (1) | RU2407736C2 (enExample) |
| SG (1) | SG156637A1 (enExample) |
| WO (1) | WO2006044405A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| PH12012502411A1 (en) | 2005-05-10 | 2019-07-17 | Intermune Inc | Method of modulating stress-activated protein kinase system |
| US20090163586A1 (en) | 2007-12-20 | 2009-06-25 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy 205 |
| US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| FR2938538B1 (fr) * | 2008-11-17 | 2011-08-05 | Univ Nice Sophia Antipolis | Procede de preparation d'acides et d'esters boroniques en presence de magnesium metallique |
| EP2414344A1 (en) | 2009-03-31 | 2012-02-08 | ArQule, Inc. | Substituted indolo-pyridinone compounds |
| JP5841361B2 (ja) * | 2011-06-29 | 2016-01-13 | 壽製薬株式会社 | 三環性化合物及びそれを含有する医薬組成物 |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| WO2015048553A1 (en) * | 2013-09-27 | 2015-04-02 | Allergan, Inc. | Compounds and methods for skin repair |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| GB201810092D0 (en) | 2018-06-20 | 2018-08-08 | Ctxt Pty Ltd | Compounds |
| GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
| AU2020296361A1 (en) | 2019-06-18 | 2022-01-06 | Ctxt Pty Ltd | Benzisoxazole sulfonamide derivatives |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981533A (en) * | 1995-04-03 | 1999-11-09 | Novartis Ag | Pyrazole derivatives and processes for the preparation thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA984040B (en) * | 1997-05-15 | 1998-11-20 | Ono Pharmaceutical Co | Benzenesulfonamide compounds |
| AU1047601A (en) * | 1999-11-30 | 2001-06-12 | Pfizer Products Inc. | 2,4-diaminopyrimidine compounds useful as immunosuppressants |
| RU2315746C2 (ru) * | 2001-08-09 | 2008-01-27 | Оно Фармасьютикал Ко., Лтд. | Производные карбоновых кислот и фармацевтическое средство, содержащее их в качестве активного ингредиента |
| EP1600440A1 (en) * | 2003-03-06 | 2005-11-30 | Ono Pharmaceutical Co., Ltd. | Indole derivative compounds and drugs containing the compounds as the active ingredient |
| CA2528626A1 (en) * | 2003-07-09 | 2005-01-20 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| US7504509B2 (en) * | 2003-12-19 | 2009-03-17 | Plexxikon, Inc. | Compounds and methods for development of Ret modulators |
-
2005
- 2005-10-11 EP EP05812269A patent/EP1812426B1/en not_active Expired - Lifetime
- 2005-10-11 CN CNA200580042679XA patent/CN101076529A/zh active Pending
- 2005-10-11 AU AU2005295902A patent/AU2005295902A1/en not_active Abandoned
- 2005-10-11 WO PCT/US2005/036558 patent/WO2006044405A1/en not_active Ceased
- 2005-10-11 RU RU2007115520/04A patent/RU2407736C2/ru not_active IP Right Cessation
- 2005-10-11 SG SG200906805-7A patent/SG156637A1/en unknown
- 2005-10-11 US US11/247,456 patent/US20060142348A1/en not_active Abandoned
- 2005-10-11 BR BRPI0517417-1A patent/BRPI0517417A/pt not_active IP Right Cessation
- 2005-10-11 JP JP2007536818A patent/JP2008515980A/ja active Pending
- 2005-10-11 CA CA002583710A patent/CA2583710A1/en not_active Abandoned
- 2005-10-11 MX MX2007004526A patent/MX2007004526A/es unknown
- 2005-10-11 NZ NZ554493A patent/NZ554493A/en not_active IP Right Cessation
- 2005-10-11 AT AT05812269T patent/ATE512144T1/de not_active IP Right Cessation
- 2005-10-11 KR KR1020077010839A patent/KR20070085340A/ko not_active Ceased
-
2007
- 2007-04-11 IL IL182489A patent/IL182489A0/en unknown
- 2007-05-02 NO NO20072269A patent/NO20072269L/no not_active Application Discontinuation
-
2008
- 2008-11-03 US US12/264,053 patent/US20090075985A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981533A (en) * | 1995-04-03 | 1999-11-09 | Novartis Ag | Pyrazole derivatives and processes for the preparation thereof |
Non-Patent Citations (1)
| Title |
|---|
| Karpeiskii et al, BIOORGANISCHESKAYA KHIMIYA, vol.13, no.8, 1987, pages 1059-1065. * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1812426B1 (en) | 2011-06-08 |
| NO20072269L (no) | 2007-07-06 |
| EP1812426A1 (en) | 2007-08-01 |
| US20060142348A1 (en) | 2006-06-29 |
| IL182489A0 (en) | 2007-09-20 |
| JP2008515980A (ja) | 2008-05-15 |
| WO2006044405A1 (en) | 2006-04-27 |
| ATE512144T1 (de) | 2011-06-15 |
| CA2583710A1 (en) | 2006-04-27 |
| RU2007115520A (ru) | 2008-10-27 |
| NZ554493A (en) | 2009-09-25 |
| CN101076529A (zh) | 2007-11-21 |
| US20090075985A1 (en) | 2009-03-19 |
| MX2007004526A (es) | 2007-09-21 |
| BRPI0517417A (pt) | 2008-10-07 |
| HK1110580A1 (en) | 2008-07-18 |
| AU2005295902A1 (en) | 2006-04-27 |
| SG156637A1 (en) | 2009-11-26 |
| KR20070085340A (ko) | 2007-08-27 |
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