RU2376299C2 - Пиррольные соединения в качестве ингибиторов erk протеинкиназ, их синтез и промежуточные соединения - Google Patents

Пиррольные соединения в качестве ингибиторов erk протеинкиназ, их синтез и промежуточные соединения Download PDF

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RU2376299C2
RU2376299C2 RU2006144445/04A RU2006144445A RU2376299C2 RU 2376299 C2 RU2376299 C2 RU 2376299C2 RU 2006144445/04 A RU2006144445/04 A RU 2006144445/04A RU 2006144445 A RU2006144445 A RU 2006144445A RU 2376299 C2 RU2376299 C2 RU 2376299C2
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compound
compounds
group
aliphatic group
formula
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RU2006144445/04A
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RU2006144445A (ru
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Габриэль МАРТИНЕС-БОТЕЛЛА (US)
Габриэль МАРТИНЕС-БОТЕЛЛА
Майкл Р. ХЭЙЛ (US)
Майкл Р. ХЭЙЛ
Франсуа МАЛЬТЕ (US)
Франсуа Мальте
Цин ТАНГ (US)
Цин ТАНГ
Джудит СТРАУБ (US)
Джудит СТРАУБ
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Вертекс Фармасьютикалз, Инкорпорейтед
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    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Transplantation (AREA)
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  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2006144445/04A 2004-05-14 2005-05-13 Пиррольные соединения в качестве ингибиторов erk протеинкиназ, их синтез и промежуточные соединения RU2376299C2 (ru)

Applications Claiming Priority (2)

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US57130904P 2004-05-14 2004-05-14
US60/571,309 2004-05-14

Publications (2)

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RU2006144445A RU2006144445A (ru) 2008-06-20
RU2376299C2 true RU2376299C2 (ru) 2009-12-20

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US (6) US7354939B2 (enExample)
EP (5) EP3608315B1 (enExample)
JP (1) JP5132305B2 (enExample)
CN (1) CN1976919A (enExample)
AR (2) AR051735A1 (enExample)
AU (1) AU2005245885B2 (enExample)
BR (1) BRPI0511111A (enExample)
CA (1) CA2566461C (enExample)
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NZ (1) NZ551582A (enExample)
PL (1) PL3305776T3 (enExample)
PT (1) PT3305776T (enExample)
RU (1) RU2376299C2 (enExample)
SI (1) SI3305776T1 (enExample)
TW (1) TW200607803A (enExample)
UA (1) UA84930C2 (enExample)
WO (1) WO2005113541A1 (enExample)
ZA (1) ZA200609975B (enExample)

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WO2012172093A1 (en) 2011-06-17 2012-12-20 Merz Pharma Gmbh & Co. Kgaa Dihydroindolizine derivate as metabotropic glutamate receptor modulators
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EP3082422A4 (en) * 2013-12-20 2017-07-05 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of mek type i and erk inhibitors
ES2986019T3 (es) * 2013-12-20 2024-11-08 Biomed Valley Discoveries Inc Tratamientos contra el cáncer que usan combinaciones de inhibidores de ERK y MEK de tipo 2
WO2015095842A2 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers
WO2015095835A1 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Methods of modulating radioiodine uptake for the treatment of radioiodine-refractory cancers
WO2015095807A1 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of egfr and erk inhibitors
WO2015095831A1 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of mtor and erk inhibitors
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CA3240745A1 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Cancer treatment using combinations of erk and raf inhibitors
ES2918375T3 (es) 2013-12-20 2022-07-15 Biomed Valley Discoveries Inc Tratamientos contra el cáncer usando combinaciones de inhibidores de la ruta de PI3K/Akt y ERK
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CA3168216C (en) * 2015-01-30 2025-11-18 Biomed Valley Discoveries, Inc. CRYSTALIN MALONATE C21H22Cl2N4O2
WO2016187028A1 (en) * 2015-05-15 2016-11-24 Celgene Avilomics Research, Inc. Heteroaryl compounds, synthesis thereof, and intermediates thereto
US10479791B2 (en) * 2015-06-03 2019-11-19 Changzhou Jiekai Pharmatech Co. Ltd Heterocyclic compounds as ERK inhibitors
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EP3170822A1 (en) 2015-11-18 2017-05-24 AGV Discovery Azaindole derivatives and their use as erk kinase inhibitors
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GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound
EP3694518A1 (en) * 2017-10-12 2020-08-19 Novartis AG Combinations of mdm2 inhibitors with inhibitors of erk for treating cancers
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WO2020223177A1 (en) * 2019-04-29 2020-11-05 The Board Of Trustees Of The University Of Illinois Mek inhibitors for corneal scarring and neovascularization
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TW202400572A (zh) * 2022-03-24 2024-01-01 美商生物醫學谷探索公司 Erk的吡咯抑制劑之氘化類似物、其合成及其中間物

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ZA200609975B (en) 2008-02-27
PT3305776T (pt) 2019-12-17
CN1976919A (zh) 2007-06-06
EP1753738B1 (en) 2014-07-09
EP2799434A1 (en) 2014-11-05
ES2513965T3 (es) 2014-10-27
WO2005113541A1 (en) 2005-12-01
IL179207A0 (en) 2007-03-08
PL3305776T3 (pl) 2020-03-31
DK3305776T3 (da) 2019-12-09
AR051735A1 (es) 2007-02-07
HK1247910A1 (en) 2018-10-05
USRE47318E1 (en) 2019-03-26
NZ551582A (en) 2011-01-28
LT3305776T (lt) 2020-01-10
BRPI0511111A (pt) 2007-11-27
UA84930C2 (ru) 2008-12-10
HUE047130T2 (hu) 2020-04-28
MXPA06013209A (es) 2007-01-16
RU2006144445A (ru) 2008-06-20
EP1753738A1 (en) 2007-02-21
EP3608315B1 (en) 2021-08-11
AU2005245885A1 (en) 2005-12-01
EP3305776B1 (en) 2019-09-25
CA2566461C (en) 2012-07-10
CY1122336T1 (el) 2021-01-27
US7354939B2 (en) 2008-04-08
ES2897422T3 (es) 2022-03-01
JP5132305B2 (ja) 2013-01-30
NO20065727L (no) 2006-12-12
CA2566461A1 (en) 2005-12-01
HK1203505A1 (en) 2015-10-30
US20230183276A1 (en) 2023-06-15
TW200607803A (en) 2006-03-01
JP2007537295A (ja) 2007-12-20
USRE49500E1 (en) 2023-04-25
AU2005245885B2 (en) 2011-01-20
ES2651439T3 (es) 2018-01-26
SI3305776T1 (sl) 2020-01-31
EP2799434B1 (en) 2017-08-02
EP3608315A1 (en) 2020-02-12
US20060106069A1 (en) 2006-05-18
USRE48266E1 (en) 2020-10-20
AR106755A2 (es) 2018-02-14
ES2751761T3 (es) 2020-04-01
EP3305776A1 (en) 2018-04-11
EP3943489A1 (en) 2022-01-26
USRE46097E1 (en) 2016-08-09

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