RU2374242C2 - Производные тиазола в качестве антагонистов а2в - Google Patents
Производные тиазола в качестве антагонистов а2в Download PDFInfo
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- RU2374242C2 RU2374242C2 RU2006130002/04A RU2006130002A RU2374242C2 RU 2374242 C2 RU2374242 C2 RU 2374242C2 RU 2006130002/04 A RU2006130002/04 A RU 2006130002/04A RU 2006130002 A RU2006130002 A RU 2006130002A RU 2374242 C2 RU2374242 C2 RU 2374242C2
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- RU
- Russia
- Prior art keywords
- alkyl
- formula
- alkoxy
- group
- optionally substituted
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0401336.3A GB0401336D0 (en) | 2004-01-21 | 2004-01-21 | Organic compounds |
| GB0401336.3 | 2004-01-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006130002A RU2006130002A (ru) | 2008-02-27 |
| RU2374242C2 true RU2374242C2 (ru) | 2009-11-27 |
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|---|---|---|---|
| RU2006130002/04A RU2374242C2 (ru) | 2004-01-21 | 2005-01-20 | Производные тиазола в качестве антагонистов а2в |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090233938A1 (enExample) |
| EP (1) | EP1709036B1 (enExample) |
| JP (1) | JP2007518767A (enExample) |
| KR (1) | KR20060129276A (enExample) |
| CN (1) | CN1910178B (enExample) |
| AT (1) | ATE388147T1 (enExample) |
| AU (1) | AU2005206290B2 (enExample) |
| BR (1) | BRPI0506927A (enExample) |
| CA (1) | CA2553010A1 (enExample) |
| DE (1) | DE602005005161T2 (enExample) |
| ES (1) | ES2300985T3 (enExample) |
| GB (1) | GB0401336D0 (enExample) |
| PL (1) | PL1709036T3 (enExample) |
| PT (1) | PT1709036E (enExample) |
| RU (1) | RU2374242C2 (enExample) |
| WO (1) | WO2005070926A1 (enExample) |
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| ES2270715B1 (es) | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| ES2632940T3 (es) * | 2005-09-13 | 2017-09-18 | Janssen Pharmaceutica Nv | Derivados de tiazol sustituidos con 2-anilin-4-arilo |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| WO2007109547A2 (en) * | 2006-03-17 | 2007-09-27 | Cv Therapeutics, Inc. | Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists |
| DE602007009221D1 (de) | 2006-05-18 | 2010-10-28 | Hoffmann La Roche | Thiazolopyramidin/pyridinharnstoffderivate als antagonisten am adenosin-a2b-rezeptor |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| JP2011500625A (ja) | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリ置換された１，２，４−トリアゾール |
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| JP5486591B2 (ja) | 2008-05-09 | 2014-05-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アセチルコリン受容体モジュレーターとしての三置換ピラゾール |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| ES2580702B1 (es) | 2015-02-25 | 2017-06-08 | Palobiofarma, S.L. | Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina |
| CN109293652B (zh) * | 2017-07-24 | 2021-10-22 | 四川科伦博泰生物医药股份有限公司 | 一种取代的噻唑衍生物及其用途 |
| CN109651358B (zh) * | 2017-10-11 | 2023-04-07 | 上海迪诺医药科技有限公司 | 4-氨基吡啶衍生物、其药物组合物、制备方法及应用 |
| CN112955441B (zh) | 2018-10-24 | 2024-06-18 | 里德埃克斯普洛股份公司 | 官能化氨基三嗪 |
| JP7625524B2 (ja) | 2019-01-11 | 2025-02-03 | オメロス コーポレーション | がんを処置するための方法および組成物 |
| AU2023208887A1 (en) * | 2022-01-19 | 2024-06-13 | Leadxpro Ag | Functionalized aminothiazoles |
| GB2615307A (en) * | 2022-01-28 | 2023-08-09 | Adorx Therapeutics Ltd | Antagonist compounds |
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| JP2000281685A (ja) * | 1999-01-28 | 2000-10-10 | Takeda Chem Ind Ltd | チアゾロピリミジン化合物、その製造法および用途 |
| WO2001030778A1 (en) * | 1999-10-27 | 2001-05-03 | Novartis Ag | Thiazole and imidazo [4,5-b] pyridine compounds and their pharmaceutical use |
| JP2002302445A (ja) * | 2001-02-02 | 2002-10-18 | Takeda Chem Ind Ltd | Ｊｎｋ阻害剤 |
| GB0123589D0 (en) * | 2001-10-01 | 2001-11-21 | Syngenta Participations Ag | Organic compounds |
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2004
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2005
- 2005-01-20 BR BRPI0506927-0A patent/BRPI0506927A/pt not_active IP Right Cessation
- 2005-01-20 CA CA002553010A patent/CA2553010A1/en not_active Abandoned
- 2005-01-20 RU RU2006130002/04A patent/RU2374242C2/ru not_active IP Right Cessation
- 2005-01-20 KR KR1020067014629A patent/KR20060129276A/ko not_active Ceased
- 2005-01-20 PL PL05706936T patent/PL1709036T3/pl unknown
- 2005-01-20 PT PT05706936T patent/PT1709036E/pt unknown
- 2005-01-20 WO PCT/EP2005/000542 patent/WO2005070926A1/en not_active Ceased
- 2005-01-20 US US10/585,614 patent/US20090233938A1/en not_active Abandoned
- 2005-01-20 ES ES05706936T patent/ES2300985T3/es not_active Expired - Lifetime
- 2005-01-20 AU AU2005206290A patent/AU2005206290B2/en not_active Ceased
- 2005-01-20 DE DE602005005161T patent/DE602005005161T2/de not_active Expired - Lifetime
- 2005-01-20 CN CN2005800026886A patent/CN1910178B/zh not_active Expired - Fee Related
- 2005-01-20 AT AT05706936T patent/ATE388147T1/de not_active IP Right Cessation
- 2005-01-20 EP EP05706936A patent/EP1709036B1/en not_active Expired - Lifetime
- 2005-01-20 JP JP2006550041A patent/JP2007518767A/ja active Pending
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| RU2059637C1 (ru) * | 1991-06-05 | 1996-05-10 | Елф Санофи | Гетероциклические производные замещенных 2-ациламино-5-тиазолов, способы их получения, производное замещенного 2-аминотиазола, производные 2-амино-4-фенилтиазола |
| WO1999064418A1 (en) * | 1998-06-05 | 1999-12-16 | Novartis Ag | Aryl pyridinyl thiazoles |
| WO2002042298A1 (en) * | 2000-11-21 | 2002-05-30 | Novartis Ag | Aminothiazoles and their use as adenosine receptor antagonists |
| WO2003039451A2 (en) * | 2001-11-08 | 2003-05-15 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole pyridazinones as adenosine antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| PL1709036T3 (pl) | 2008-08-29 |
| PT1709036E (pt) | 2008-05-28 |
| AU2005206290A1 (en) | 2005-08-04 |
| CA2553010A1 (en) | 2005-08-04 |
| CN1910178B (zh) | 2010-06-02 |
| ATE388147T1 (de) | 2008-03-15 |
| DE602005005161T2 (de) | 2009-03-19 |
| WO2005070926A1 (en) | 2005-08-04 |
| DE602005005161D1 (de) | 2008-04-17 |
| US20090233938A1 (en) | 2009-09-17 |
| EP1709036A1 (en) | 2006-10-11 |
| AU2005206290B2 (en) | 2008-12-04 |
| JP2007518767A (ja) | 2007-07-12 |
| RU2006130002A (ru) | 2008-02-27 |
| KR20060129276A (ko) | 2006-12-15 |
| ES2300985T3 (es) | 2008-06-16 |
| GB0401336D0 (en) | 2004-02-25 |
| BRPI0506927A (pt) | 2007-06-05 |
| CN1910178A (zh) | 2007-02-07 |
| EP1709036B1 (en) | 2008-03-05 |
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