RU2367439C2 - Способы и композиции для лечения вич-инфекции - Google Patents

Способы и композиции для лечения вич-инфекции Download PDF

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Publication number
RU2367439C2
RU2367439C2 RU2006137555/14A RU2006137555A RU2367439C2 RU 2367439 C2 RU2367439 C2 RU 2367439C2 RU 2006137555/14 A RU2006137555/14 A RU 2006137555/14A RU 2006137555 A RU2006137555 A RU 2006137555A RU 2367439 C2 RU2367439 C2 RU 2367439C2
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RU
Russia
Prior art keywords
hiv
aids
inhibitor
hiv infection
compound
Prior art date
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RU2006137555/14A
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English (en)
Russian (ru)
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RU2006137555A (ru
Inventor
Пин-Фанг ЛИН (US)
Пин-Фанг Лин
Беата НОВИЦКА-СЕНЗ (US)
Беата НОВИЦКА-СЕНЗ
Грегори ЯМАНАКА (US)
Грегори Яманака
Original Assignee
Бристол-Маерс Сквибб Компани
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34961940&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2367439(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of RU2006137555A publication Critical patent/RU2006137555A/ru
Application granted granted Critical
Publication of RU2367439C2 publication Critical patent/RU2367439C2/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2006137555/14A 2004-03-24 2005-03-01 Способы и композиции для лечения вич-инфекции RU2367439C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55576704P 2004-03-24 2004-03-24
US60/555,767 2004-03-24

Publications (2)

Publication Number Publication Date
RU2006137555A RU2006137555A (ru) 2008-04-27
RU2367439C2 true RU2367439C2 (ru) 2009-09-20

Family

ID=34961940

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2006137555/14A RU2367439C2 (ru) 2004-03-24 2005-03-01 Способы и композиции для лечения вич-инфекции

Country Status (30)

Country Link
US (1) US7776863B2 (enExample)
EP (1) EP1732604B1 (enExample)
JP (1) JP4847441B2 (enExample)
KR (1) KR101158140B1 (enExample)
CN (1) CN1956720B (enExample)
AR (1) AR048333A1 (enExample)
AT (1) ATE474602T1 (enExample)
AU (1) AU2005235116B2 (enExample)
BR (1) BRPI0509140A (enExample)
CA (1) CA2561146C (enExample)
CY (1) CY1111613T1 (enExample)
DE (1) DE602005022420D1 (enExample)
DK (1) DK1732604T3 (enExample)
ES (1) ES2347801T3 (enExample)
GE (1) GEP20104925B (enExample)
HR (1) HRP20100434T1 (enExample)
IL (1) IL178141A (enExample)
IN (1) IN2012DN06436A (enExample)
MY (1) MY144318A (enExample)
NO (1) NO337116B1 (enExample)
NZ (1) NZ549778A (enExample)
PE (1) PE20060148A1 (enExample)
PL (1) PL1732604T3 (enExample)
PT (1) PT1732604E (enExample)
RU (1) RU2367439C2 (enExample)
SI (1) SI1732604T1 (enExample)
TW (1) TWI347184B (enExample)
UA (1) UA88463C2 (enExample)
WO (1) WO2005102392A2 (enExample)
ZA (1) ZA200607959B (enExample)

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US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
EP1942108B1 (en) 2005-10-28 2013-09-04 Ono Pharmaceutical Co., Ltd. Compound containing basic group and use thereof
DK1961744T3 (da) 2005-11-18 2013-07-15 Ono Pharmaceutical Co Forbindelse indeholdende basiske grupper samt anvendelse deraf
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US7501419B2 (en) * 2006-04-25 2009-03-10 Bristol-Myers Squibb Company 4-Squarylpiperazine derivatives as antiviral agents
US7504399B2 (en) 2006-06-08 2009-03-17 Bristol-Meyers Squibb Company Piperazine enamines as antiviral agents
US7572810B2 (en) * 2006-06-08 2009-08-11 Bristol-Myers Squibb Company Alkene piperidine derivatives as antiviral agents
WO2009158396A1 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Diketopiperidine derivatives as hiv attachment inhibitors
US7960406B2 (en) 2008-06-25 2011-06-14 Bristol-Myers Squibb Company Diketo substituted pyrrolo[2,3-c] pyridines
US20110295365A1 (en) * 2010-05-28 2011-12-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-viral compositions and methods for administration
US8450361B2 (en) 2010-08-06 2013-05-28 Bristol-Myers Squibb Company Substituted indole and azaindole oxoacetyl piperazinamide derivatives
US8912195B2 (en) 2010-12-02 2014-12-16 Bristol-Myers Squibb Company Alkyl amides as HIV attachment inhibitors
EP2670751B1 (en) 2011-01-31 2015-04-22 Bristol-Myers Squibb Company Methods of making hiv attachment inhibitor prodrug compound and intermediates
US8685982B2 (en) 2011-04-12 2014-04-01 Bristol-Myers Squibb Company Thioamide, amidoxime and amidrazone derivatives as HIV attachment inhibitors
WO2013033061A1 (en) 2011-08-29 2013-03-07 Bristol-Myers Squibb Company Fused bicyclic diamine derivatives as hiv attachment inhibitors
US8664213B2 (en) 2011-08-29 2014-03-04 Bristol-Myers Squibb Company Spiro bicyclic diamine derivatives as HIV attachment inhibitors
US9193725B2 (en) 2012-03-14 2015-11-24 Bristol-Meyers Squibb Company Cyclic hydrazine derivatives as HIV attachment inhibitors
ES2616492T3 (es) 2012-08-09 2017-06-13 VIIV Healthcare UK (No.5) Limited Derivados de piperidina amida como inhibidores de la fijación del VIH
EP2895472B1 (en) 2012-08-09 2016-11-23 VIIV Healthcare UK (No.5) Limited Tricyclic alkene derivatives as HIV attachment inhibitors
JP6533514B2 (ja) * 2013-03-27 2019-06-19 ビーブ・ヘルスケア・ユーケイ・（ナンバー５）・リミテッドＶｉｉＶ Ｈｅａｌｔｈｃａｒｅ ＵＫ （Ｎｏ．５） Ｌｉｍｉｔｅｄ Ｈｉｖ結合阻害剤としての２−ケトアミド誘導体
EP3313412A4 (en) 2015-06-23 2019-01-16 CytoDyn Inc. INHIBITION OF CCL5 LIGAND BINDING AT CCR5 RECEPTOR AND CHANGING CCR5 / CCL5 AXIS SIGNALING IN INFUSION, CANCER, AUTOIMMUNE AND OTHER DISORDERS
US20250237642A1 (en) * 2022-03-08 2025-07-24 Emory University Predictive model for variants associated with drug resistance and theranostic applications thereof
US12425371B2 (en) * 2022-09-16 2025-09-23 Cisco Technology, Inc. System and method for providing SCHC-based edge firewalling

Citations (1)

* Cited by examiner, † Cited by third party
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RU2192870C1 (ru) * 2001-07-02 2002-11-20 Закрытое акционерное общество "Агрофарм ПитерСиб" Антивирусная композиция, способ получения ее активной компоненты и способ лечения вич-инфицированных больных этой композицией

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AU762404B2 (en) * 1998-03-02 2003-06-26 Panacos Pharmaceuticals, Inc. Acylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US6476034B2 (en) * 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20030207910A1 (en) * 2001-02-02 2003-11-06 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
RU2284315C2 (ru) * 2001-12-12 2006-09-27 Бристол-Маерс Сквибб Компани Ингибиторы вич-интегразы и содержащие их фармацевтические композиции
CA2467718C (en) * 2001-12-21 2011-04-26 Anormed Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
RU2192870C1 (ru) * 2001-07-02 2002-11-20 Закрытое акционерное общество "Агрофарм ПитерСиб" Антивирусная композиция, способ получения ее активной компоненты и способ лечения вич-инфицированных больных этой композицией

Non-Patent Citations (1)

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PRINCEN К et al. The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level //. AIDS Res Hum Retroviruses. 2003 Dec;19(12):1135-9. реферат, он-лайн [Найдено в Интернет на www.pubmed.com 12.11.2008], PMID: 14709250 [PubMed - indexed for MEDLINE. JACOBSON JM et al. Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542 // Antimicrob Agents Chemother. 2004 Feb; 48(2):423-9. он-лайн [найдено в Интернет на (http://aac.asm.org/cgi/content/rull/48/2/423?view=long&pmid=14742190) 14.11.2008. LI F et al. PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing // Proc Nati Acad Sci USA. 2003, № 11; 100(23):13555-60. Epub 2003 Oct 22. реферат, он-лайн [Найдено в Интернет на www.pubmed.com 12.11.2008], PMID: 14573704 [PubMed - indexed for MEDLINE]. TURPIN JA. The next generation of HIV/AIDS drugs: novel and developmental antiHIV *

Also Published As

Publication number Publication date
ES2347801T3 (es) 2010-11-04
HRP20100434T1 (hr) 2010-09-30
NZ549778A (en) 2010-09-30
IL178141A0 (en) 2006-12-31
NO20064547L (no) 2006-10-06
DE602005022420D1 (de) 2010-09-02
IL178141A (en) 2010-11-30
KR20070011322A (ko) 2007-01-24
WO2005102392A3 (en) 2006-07-20
NO337116B1 (no) 2016-01-25
PT1732604E (pt) 2010-09-24
HK1096540A1 (en) 2007-06-01
PE20060148A1 (es) 2006-03-04
CY1111613T1 (el) 2015-10-07
WO2005102392A2 (en) 2005-11-03
AU2005235116B2 (en) 2011-03-31
ATE474602T1 (de) 2010-08-15
GEP20104925B (en) 2010-03-25
EP1732604B1 (en) 2010-07-21
CN1956720B (zh) 2010-12-15
JP2007530540A (ja) 2007-11-01
US7776863B2 (en) 2010-08-17
JP4847441B2 (ja) 2011-12-28
PL1732604T3 (pl) 2010-12-31
CA2561146C (en) 2013-12-24
CA2561146A1 (en) 2005-11-03
MY144318A (en) 2011-08-29
US20050215545A1 (en) 2005-09-29
RU2006137555A (ru) 2008-04-27
EP1732604A2 (en) 2006-12-20
DK1732604T3 (da) 2010-11-15
ZA200607959B (en) 2008-06-25
SI1732604T1 (sl) 2010-10-29
CN1956720A (zh) 2007-05-02
TWI347184B (en) 2011-08-21
IN2012DN06436A (enExample) 2015-10-09
BRPI0509140A (pt) 2007-09-04
AU2005235116A1 (en) 2005-11-03
KR101158140B1 (ko) 2012-06-19
AR048333A1 (es) 2006-04-19
TW200538117A (en) 2005-12-01
UA88463C2 (ru) 2009-10-26

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PC41 Official registration of the transfer of exclusive right

Effective date: 20181022

TK4A Correction to the publication in the bulletin (patent)

Free format text: CORRECTION TO CHAPTER -PC4A- IN JOURNAL 30-2018 FOR INID CODE(S) D N