IN2012DN06436A - - Google Patents
Info
- Publication number
- IN2012DN06436A IN2012DN06436A IN6436DEN2012A IN2012DN06436A IN 2012DN06436 A IN2012DN06436 A IN 2012DN06436A IN 6436DEN2012 A IN6436DEN2012 A IN 6436DEN2012A IN 2012DN06436 A IN2012DN06436 A IN 2012DN06436A
- Authority
- IN
- India
- Prior art keywords
- acceptable salt
- pharmaceutically acceptable
- piperazine
- pharmaceutically
- dioxoethyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
A pharmaceutical composition comprising of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-lH- 1,2,4-triazol-l-yl)-lH-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, or a pharmaceutically acceptable salt thereof along with nucleoside HIV reverse transcriptase inhibitor selected from the group consisting of didanosine, emtricitabine and zalcitabine, including pharmaceutically acceptable salt thereof, used for treatment of AIDS or HIV infection, and a pharmaceutically, acceptable carrier, wherein the EC50 ratio of said piperazine compound to said other agent is 1:1, 1:2.5 or 2.5:1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55576704P | 2004-03-24 | 2004-03-24 | |
PCT/US2005/006277 WO2005102392A2 (en) | 2004-03-24 | 2005-03-01 | Combinations for treating hiv infection |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN06436A true IN2012DN06436A (en) | 2015-10-09 |
Family
ID=34961940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN6436DEN2012 IN2012DN06436A (en) | 2004-03-24 | 2005-03-01 |
Country Status (31)
Country | Link |
---|---|
US (1) | US7776863B2 (en) |
EP (1) | EP1732604B1 (en) |
JP (1) | JP4847441B2 (en) |
KR (1) | KR101158140B1 (en) |
CN (1) | CN1956720B (en) |
AR (1) | AR048333A1 (en) |
AT (1) | ATE474602T1 (en) |
AU (1) | AU2005235116B2 (en) |
BR (1) | BRPI0509140A (en) |
CA (1) | CA2561146C (en) |
CY (1) | CY1111613T1 (en) |
DE (1) | DE602005022420D1 (en) |
DK (1) | DK1732604T3 (en) |
ES (1) | ES2347801T3 (en) |
GE (1) | GEP20104925B (en) |
HK (1) | HK1096540A1 (en) |
HR (1) | HRP20100434T1 (en) |
IL (1) | IL178141A (en) |
IN (1) | IN2012DN06436A (en) |
MY (1) | MY144318A (en) |
NO (1) | NO337116B1 (en) |
NZ (1) | NZ549778A (en) |
PE (1) | PE20060148A1 (en) |
PL (1) | PL1732604T3 (en) |
PT (1) | PT1732604E (en) |
RU (1) | RU2367439C2 (en) |
SI (1) | SI1732604T1 (en) |
TW (1) | TWI347184B (en) |
UA (1) | UA88463C2 (en) |
WO (1) | WO2005102392A2 (en) |
ZA (1) | ZA200607959B (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
US20060100432A1 (en) * | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
US20060100209A1 (en) * | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
EP2657235A1 (en) | 2005-10-28 | 2013-10-30 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
JP5217438B2 (en) | 2005-11-18 | 2013-06-19 | 小野薬品工業株式会社 | COMPOUND CONTAINING BASIC GROUP AND USE THEREOF |
US7851476B2 (en) * | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
US7501419B2 (en) * | 2006-04-25 | 2009-03-10 | Bristol-Myers Squibb Company | 4-Squarylpiperazine derivatives as antiviral agents |
US7572810B2 (en) * | 2006-06-08 | 2009-08-11 | Bristol-Myers Squibb Company | Alkene piperidine derivatives as antiviral agents |
US7504399B2 (en) | 2006-06-08 | 2009-03-17 | Bristol-Meyers Squibb Company | Piperazine enamines as antiviral agents |
JP5433691B2 (en) * | 2008-06-25 | 2014-03-05 | ブリストル−マイヤーズ スクイブ カンパニー | Diketopiperidine derivatives as HIV binding inhibitors |
JP5433690B2 (en) | 2008-06-25 | 2014-03-05 | ブリストル−マイヤーズ スクイブ カンパニー | Diketo-fused azolopiperidine and azolopiperazine as anti-HIV drugs |
US20110293521A1 (en) * | 2010-05-28 | 2011-12-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-viral compositions and methods for administration |
WO2012019003A1 (en) | 2010-08-06 | 2012-02-09 | Bristol-Myers Squibb Company | Substituted indole and azaindole oxoacetyl piperazinamide derivatives |
ES2585396T3 (en) | 2010-12-02 | 2016-10-05 | VIIV Healthcare UK (No.5) Limited | Alkylamides as inhibitors of HIV binding |
KR101848533B1 (en) | 2011-01-31 | 2018-04-12 | 비브 헬스케어 유케이 (넘버4) 리미티드 | Methods of making hiv attachment inhibitor prodrug compound and intermediates |
WO2012142080A1 (en) | 2011-04-12 | 2012-10-18 | Bristol-Myers Squibb Company | Thioamide, amidoxime and amidrazone derivatives as hiv attachment inhibitors |
US8664213B2 (en) | 2011-08-29 | 2014-03-04 | Bristol-Myers Squibb Company | Spiro bicyclic diamine derivatives as HIV attachment inhibitors |
WO2013033061A1 (en) | 2011-08-29 | 2013-03-07 | Bristol-Myers Squibb Company | Fused bicyclic diamine derivatives as hiv attachment inhibitors |
WO2013138436A1 (en) | 2012-03-14 | 2013-09-19 | Bristol-Myers Squibb Company | Cyclolic hydrazine derivatives as hiv attachment inhibitors |
ES2616432T3 (en) | 2012-08-09 | 2017-06-13 | VIIV Healthcare UK (No.5) Limited | Derivatives of tricyclic alkenes as inhibitors of HIV binding |
US9505752B2 (en) | 2012-08-09 | 2016-11-29 | Viiv Healthcare Uk (No. 5) Limited | Piperidine amide derivatives as HIV attachment inhibitors |
JP6533514B2 (en) * | 2013-03-27 | 2019-06-19 | ビーブ・ヘルスケア・ユーケイ・(ナンバー5)・リミテッドViiV Healthcare UK (No.5) Limited | 2-ketoamide derivatives as HIV binding inhibitors |
EP3313412A4 (en) * | 2015-06-23 | 2019-01-16 | CytoDyn Inc. | Inhibition of ccl5 ligand binding to ccr5 receptor and alteration of ccr5/ccl5 axis signaling in inflammation, cancer, autoimmune, and other conditions |
WO2023172635A1 (en) * | 2022-03-08 | 2023-09-14 | Emory University | Predictive model for variants associated with drug resistance and theranostic applications thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1068219T3 (en) * | 1998-03-02 | 2007-04-30 | Univ North Carolina | Acylated betulin and dihydrobetulin derivatives as well as their preparation and use |
US6476034B2 (en) | 2000-02-22 | 2002-11-05 | Bristol-Myers Squibb Company | Antiviral azaindole derivatives |
US20030207910A1 (en) | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
HUP0402675A2 (en) * | 2001-12-12 | 2005-03-29 | Bristol-Myers Squibb Co. | Hydroxylamine-derivatives as hiv integrase inhibitors, pharmaceutical compositions containing them and use thereof |
IL161784A0 (en) * | 2001-12-21 | 2005-11-20 | Anormed Inc | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
-
2005
- 2005-02-24 US US11/064,683 patent/US7776863B2/en active Active
- 2005-03-01 DE DE602005022420T patent/DE602005022420D1/en active Active
- 2005-03-01 PL PL05723932T patent/PL1732604T3/en unknown
- 2005-03-01 AT AT05723932T patent/ATE474602T1/en active
- 2005-03-01 DK DK05723932.9T patent/DK1732604T3/en active
- 2005-03-01 IN IN6436DEN2012 patent/IN2012DN06436A/en unknown
- 2005-03-01 KR KR1020067019595A patent/KR101158140B1/en active IP Right Grant
- 2005-03-01 SI SI200531100T patent/SI1732604T1/en unknown
- 2005-03-01 ES ES05723932T patent/ES2347801T3/en active Active
- 2005-03-01 JP JP2007504971A patent/JP4847441B2/en active Active
- 2005-03-01 UA UAA200611163A patent/UA88463C2/en unknown
- 2005-03-01 RU RU2006137555/14A patent/RU2367439C2/en active
- 2005-03-01 WO PCT/US2005/006277 patent/WO2005102392A2/en active Application Filing
- 2005-03-01 BR BRPI0509140-3A patent/BRPI0509140A/en not_active Application Discontinuation
- 2005-03-01 CN CN2005800160669A patent/CN1956720B/en active Active
- 2005-03-01 PT PT05723932T patent/PT1732604E/en unknown
- 2005-03-01 AU AU2005235116A patent/AU2005235116B2/en active Active
- 2005-03-01 GE GEAP20059667A patent/GEP20104925B/en unknown
- 2005-03-01 CA CA2561146A patent/CA2561146C/en active Active
- 2005-03-01 EP EP05723932A patent/EP1732604B1/en active Active
- 2005-03-01 NZ NZ549778A patent/NZ549778A/en unknown
- 2005-03-17 MY MYPI20051136A patent/MY144318A/en unknown
- 2005-03-18 TW TW094108462A patent/TWI347184B/en active
- 2005-03-23 AR ARP050101159A patent/AR048333A1/en active Pending
- 2005-03-28 PE PE2005000344A patent/PE20060148A1/en not_active Application Discontinuation
-
2006
- 2006-09-17 IL IL178141A patent/IL178141A/en active IP Right Review Request
- 2006-09-22 ZA ZA200607959A patent/ZA200607959B/en unknown
- 2006-10-06 NO NO20064547A patent/NO337116B1/en unknown
-
2007
- 2007-04-20 HK HK07104156.5A patent/HK1096540A1/en unknown
-
2010
- 2010-08-03 HR HR20100434T patent/HRP20100434T1/en unknown
- 2010-10-20 CY CY20101100937T patent/CY1111613T1/en unknown
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