HRP20100434T1 - Postupci liječenja zaraze virusom hiv - Google Patents
Postupci liječenja zaraze virusom hiv Download PDFInfo
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- HRP20100434T1 HRP20100434T1 HR20100434T HRP20100434T HRP20100434T1 HR P20100434 T1 HRP20100434 T1 HR P20100434T1 HR 20100434 T HR20100434 T HR 20100434T HR P20100434 T HRP20100434 T HR P20100434T HR P20100434 T1 HRP20100434 T1 HR P20100434T1
- Authority
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- Croatia
- Prior art keywords
- pharmaceutically acceptable
- solvate
- acceptable salt
- agent
- treatment
- Prior art date
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- 208000031886 HIV Infections Diseases 0.000 title claims abstract 11
- 208000037357 HIV infectious disease Diseases 0.000 title claims abstract 10
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 title claims abstract 10
- 150000003839 salts Chemical class 0.000 claims abstract 17
- 239000012453 solvate Substances 0.000 claims abstract 17
- WHBIGIKBNXZKFE-UHFFFAOYSA-N delavirdine Chemical compound CC(C)NC1=CC=CN=C1N1CCN(C(=O)C=2NC3=CC=C(NS(C)(=O)=O)C=C3C=2)CC1 WHBIGIKBNXZKFE-UHFFFAOYSA-N 0.000 claims abstract 14
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 claims abstract 7
- XPOQHMRABVBWPR-UHFFFAOYSA-N Efavirenz Natural products O1C(=O)NC2=CC=C(Cl)C=C2C1(C(F)(F)F)C#CC1CC1 XPOQHMRABVBWPR-UHFFFAOYSA-N 0.000 claims abstract 7
- XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 claims abstract 7
- 108010032976 Enfuvirtide Proteins 0.000 claims abstract 7
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims abstract 7
- XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 claims abstract 7
- WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 claims abstract 7
- 229960005319 delavirdine Drugs 0.000 claims abstract 7
- 229960002656 didanosine Drugs 0.000 claims abstract 7
- XPOQHMRABVBWPR-ZDUSSCGKSA-N efavirenz Chemical compound C([C@]1(C2=CC(Cl)=CC=C2NC(=O)O1)C(F)(F)F)#CC1CC1 XPOQHMRABVBWPR-ZDUSSCGKSA-N 0.000 claims abstract 7
- 229960003804 efavirenz Drugs 0.000 claims abstract 7
- 229960000366 emtricitabine Drugs 0.000 claims abstract 7
- 229960002062 enfuvirtide Drugs 0.000 claims abstract 7
- PEASPLKKXBYDKL-FXEVSJAOSA-N enfuvirtide Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(C)=O)[C@@H](C)O)[C@@H](C)CC)C1=CN=CN1 PEASPLKKXBYDKL-FXEVSJAOSA-N 0.000 claims abstract 7
- 229960002169 plerixafor Drugs 0.000 claims abstract 7
- YIQPUIGJQJDJOS-UHFFFAOYSA-N plerixafor Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCCNCC1 YIQPUIGJQJDJOS-UHFFFAOYSA-N 0.000 claims abstract 7
- 229960000311 ritonavir Drugs 0.000 claims abstract 7
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims abstract 7
- 229960001852 saquinavir Drugs 0.000 claims abstract 7
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 claims abstract 7
- 229960001203 stavudine Drugs 0.000 claims abstract 7
- 229960004556 tenofovir Drugs 0.000 claims abstract 7
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims abstract 7
- 229960000523 zalcitabine Drugs 0.000 claims abstract 7
- 208000030507 AIDS Diseases 0.000 claims abstract 6
- 239000003814 drug Substances 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 239000003795 chemical substances by application Substances 0.000 claims 10
- GACIOSIZKMLELV-POHAHGRESA-N (z)-4-[(4-fluorophenyl)methyl-methoxyamino]-2-hydroxy-4-oxobut-2-enoic acid Chemical compound OC(=O)C(/O)=C/C(=O)N(OC)CC1=CC=C(F)C=C1 GACIOSIZKMLELV-POHAHGRESA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- QRPZBKAMSFHVRW-UHFFFAOYSA-N 1-(4-benzoylpiperazin-1-yl)-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione Chemical compound C1=2NC=C(C(=O)C(=O)N3CCN(CC3)C(=O)C=3C=CC=CC=3)C=2C(OC)=CN=C1N1C=NC(C)=N1 QRPZBKAMSFHVRW-UHFFFAOYSA-N 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- -1 3-methyl-1H-1,2,4-triazol-1-yl Chemical group 0.000 abstract 1
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Uporaba 1-benzoil-4-[2-[4-metoksi-7-(3-metil-1H-1,2,4-triazol-1-il)-1H pirolo [2,3-c] piridin-3-il]-1,2-dioksoetil]-piperazina, ili njegove farmaceutski prihvatljive soli ili solvata, naznačena time što se radi o uporabi za proizvodnju lijeka za liječenje zaraze virusom HIV kod ljudskog bolesnika, s barem još jednim drugim sredstvom za liječenje AIDS-a ili zaraze virusom HIV, izabranim iz skupine koja obuhvaća zalcitabin, emtricitabin, didanozin, tenofovir, stavudin, efavirenz, delavirdin, ritonavir, sakvinavir, enfuvirtid, AMD-3100 i 3-[(4-fluorobenzil)metoksikarbamoil]-2-hidroksiakrilnu kiselinu, ili njihovu farmaceutski prihvatljivu sol ili solvat. Patent sadrži još 9 patentnih zahtjeva.
Claims (10)
1. Uporaba 1-benzoil-4-[2-[4-metoksi-7-(3-metil-1H-1,2,4-triazol-1-il)-1H pirolo [2,3-c] piridin-3-il]-1,2-dioksoetil]-piperazina, ili njegove farmaceutski prihvatljive soli ili solvata, naznačena time što se radi o uporabi za proizvodnju lijeka za liječenje zaraze virusom HIV kod ljudskog bolesnika, s barem još jednim drugim sredstvom za liječenje AIDS-a ili zaraze virusom HIV, izabranim iz skupine koja obuhvaća zalcitabin, emtricitabin, didanozin, tenofovir, stavudin, efavirenz, delavirdin, ritonavir, sakvinavir, enfuvirtid, AMD-3100 i 3-[(4-fluorobenzil)metoksikarbamoil]-2-hidroksiakrilnu kiselinu, ili njihovu farmaceutski prihvatljivu sol ili solvat.
2. Uporaba 1-benzoil-4-[2-[4-metoksi-7-(3-metil-1H-1,2,4-triazol-1-il)-1H pirolo [2,3-c] piridin-3-il]-1,2-dioksoetil]-piperazina, ili njegove farmaceutski prihvatljive soli ili solvata, naznačena time što se radi o uporabi za proizvodnju lijeka koji se koristi u kombinaciji, ali odvojeno, s barem još jednim drugim sredstvom za liječenje AIDS-a ili zaraze virusom HIV, izabranim iz skupine koja obuhvaća zalcitabin, emtricitabin, didanozin, tenofovir, stavudin, efavirenz, delavirdin, ritonavir, sakvinavir, enfuvirtid, AMD-3100 i 3-[(4-fluorobenzil)metoksikarbamoil]-2-hidroksiakrilnu kiselinu, ili njihovu farmaceutski prihvatljivu sol ili solvat, za liječenje zaraze virusom HIV kod ljudskog bolesnika.
3. 1-benzoil-4-[2-[4-metoksi-7-(3-metil-1H-1,2,4-triazol-1-il)-1H-pirolo[2,3-c]piridin-3-il]-1,2-dioksoetil]-piperazin, ili njegova farmaceutski prihvatljiva sol ili solvat, i barem još jedno drugo sredstvo za liječenje AIDS-a ili zaraze virusom HIV, izabrano iz skupine koja obuhvaća zalcitabin, emtricitabin, didanozin, tenofovir, stavudin, efavirenz, delavirdin, ritonavir, sakvinavir, enfuvirtid, AMD-3100 i 3-[(4-fluorobenzil)metoksikarbamoil]-2-hidroksiakrilnu kiselinu, ili njihovu farmaceutski prihvatljivu sol ili solvat, naznačeni time što su za uporabu u liječenju zaraze virusom HIV kod ljudskog bolesnika.
4. 1-benzoil-4-[2-[4-metoksi-7-(3-metil-1H-1,2,4-triazol-1-il)-1H-pirolo[2,3-c]piridin-3-il]-1,2-dioksoetil]-piperazin, ili njegova farmaceutski prihvatljiva sol ili solvat, za uporabu u kombinaciji, ali odvojeno, s barem još jednim drugim sredstvom za liječenje AIDS-a ili zaraze virusom HIV, izabranim iz skupine koja obuhvaća zalcitabin, emtricitabin, didanozin, tenofovir, stavudin, efavirenz, delavirdin, ritonavir, sakvinavir, enfuvirtid, AMD-3100 i 3-[(4-fluorobenzil)metoksikarbamoil]-2-hidroksiakrilnu kiselinu, ili njihovu farmaceutski prihvatljivu sol ili solvat, naznačeno time što se radi o uporabi za liječenje zaraze virusom HIV kod ljudskog bolesnika.
5. Farmaceutska smjesa, naznačena time što sadrži terapijski učinkovitu količinu 1-benzoil-4-[2-[4-metoksi-7-(3-metil-1H-1,2,4-triazol-1-il)-1H-pirolo[2,3-c]piridin-3-il]-1,2-dioksoetil]-piperazina, ili njegove farmaceutski prihvatljive soli ili solvata, s još barem jednim drugim sredstvom za liječenje AIDS-a ili zaraze virusom HIV, izabranim iz skupine koja obuhvaća zalcitabin, emtricitabin, didanozin, tenofovir, stavudin, efavirenz, delavirdin, ritonavir, sakvinavir, enfuvirtid, AMD-3100 i 3-[(4-fluorobenzil)metoksikarbamoil]-2-hidroksiakrilnu kiselinu, ili njihovu farmaceutski prihvatljivu sol ili solvat, i farmaceutski prihvatljiv nosač.
6. Uporaba prema zahtjevu 1 ili 2, spoj prema zahtjevu 4 ili smjesa prema zahtjevu 3 ili 5, naznačeno time što se sredstvo izabire između zalcitabina, emtricitabina, didanozina, tenofovira i stavudina, ili njihove farmaceutski prihvatljive soli ili solvata.
7. Uporaba prema zahtjevu 1 ili 2, spoj prema zahtjevu 4 ili smjesa prema zahtjevu 3 ili 5, naznačeno time što se sredstvo izabire između efavirenza i delavirdina, ili njihove farmaceutski prihvatljive soli ili solvata.
8. Uporaba prema zahtjevu 1 ili 2, spoj prema zahtjevu 4 ili smjesa prema zahtjevu 3 ili 5, naznačeno time što se sredstvo izabire između ritonavira i sakvinavira, ili njihove farmaceutski prihvatljive soli ili solvata.
9. Uporaba prema zahtjevu 1 ili 2, spoj prema zahtjevu 4 ili smjesa prema zahtjevu 3 ili 5, naznačeno time što se sredstvo izabire između enfuvirtida i AMD-3100, ili njihove farmaceutski prihvatljive soli ili solvata.
10. Uporaba prema zahtjevu 1 ili 2, spoj prema zahtjevu 4 ili smjesa prema zahtjevu 3 ili 5, naznačeno time što se sredstvo izabire između 3-[(4-fluorobenzil)metoksikarbamoil]-2-hidroksiakrilne kiseline, ili njezine farmaceutski prihvatljive soli ili solvata.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55576704P | 2004-03-24 | 2004-03-24 | |
PCT/US2005/006277 WO2005102392A2 (en) | 2004-03-24 | 2005-03-01 | Combinations for treating hiv infection |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20100434T1 true HRP20100434T1 (hr) | 2010-09-30 |
Family
ID=34961940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20100434T HRP20100434T1 (hr) | 2004-03-24 | 2010-08-03 | Postupci liječenja zaraze virusom hiv |
Country Status (31)
Country | Link |
---|---|
US (1) | US7776863B2 (hr) |
EP (1) | EP1732604B1 (hr) |
JP (1) | JP4847441B2 (hr) |
KR (1) | KR101158140B1 (hr) |
CN (1) | CN1956720B (hr) |
AR (1) | AR048333A1 (hr) |
AT (1) | ATE474602T1 (hr) |
AU (1) | AU2005235116B2 (hr) |
BR (1) | BRPI0509140A (hr) |
CA (1) | CA2561146C (hr) |
CY (1) | CY1111613T1 (hr) |
DE (1) | DE602005022420D1 (hr) |
DK (1) | DK1732604T3 (hr) |
ES (1) | ES2347801T3 (hr) |
GE (1) | GEP20104925B (hr) |
HK (1) | HK1096540A1 (hr) |
HR (1) | HRP20100434T1 (hr) |
IL (1) | IL178141A (hr) |
IN (1) | IN2012DN06436A (hr) |
MY (1) | MY144318A (hr) |
NO (1) | NO337116B1 (hr) |
NZ (1) | NZ549778A (hr) |
PE (1) | PE20060148A1 (hr) |
PL (1) | PL1732604T3 (hr) |
PT (1) | PT1732604E (hr) |
RU (1) | RU2367439C2 (hr) |
SI (1) | SI1732604T1 (hr) |
TW (1) | TWI347184B (hr) |
UA (1) | UA88463C2 (hr) |
WO (1) | WO2005102392A2 (hr) |
ZA (1) | ZA200607959B (hr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
US20060100432A1 (en) * | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
US20060100209A1 (en) * | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
PT1942108E (pt) | 2005-10-28 | 2013-10-24 | Ono Pharmaceutical Co | Composto com um grupo básico e a sua utilização |
ES2407115T3 (es) | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
US7851476B2 (en) * | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
US7501419B2 (en) * | 2006-04-25 | 2009-03-10 | Bristol-Myers Squibb Company | 4-Squarylpiperazine derivatives as antiviral agents |
US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
US7504399B2 (en) | 2006-06-08 | 2009-03-17 | Bristol-Meyers Squibb Company | Piperazine enamines as antiviral agents |
US7572810B2 (en) * | 2006-06-08 | 2009-08-11 | Bristol-Myers Squibb Company | Alkene piperidine derivatives as antiviral agents |
US7960406B2 (en) | 2008-06-25 | 2011-06-14 | Bristol-Myers Squibb Company | Diketo substituted pyrrolo[2,3-c] pyridines |
CN102076686B (zh) * | 2008-06-25 | 2013-03-06 | 百时美施贵宝公司 | 作为hiv附着抑制剂的二酮哌啶衍生物 |
US20110290821A1 (en) * | 2010-05-28 | 2011-12-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-viral compositions and methods for administration |
US8450361B2 (en) | 2010-08-06 | 2013-05-28 | Bristol-Myers Squibb Company | Substituted indole and azaindole oxoacetyl piperazinamide derivatives |
ES2585396T3 (es) | 2010-12-02 | 2016-10-05 | VIIV Healthcare UK (No.5) Limited | Alquilamidas como inhibidores de la unión del VIH |
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EP1068219B1 (en) * | 1998-03-02 | 2006-12-20 | The University of North Carolina at Chapel Hill | Acylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
US6476034B2 (en) | 2000-02-22 | 2002-11-05 | Bristol-Myers Squibb Company | Antiviral azaindole derivatives |
US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
US20030207910A1 (en) * | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
CA2469592C (en) * | 2001-12-12 | 2005-08-23 | Bristol-Myers Squibb Company | Hiv integrase inhibitors |
RU2325387C2 (ru) * | 2001-12-21 | 2008-05-27 | Анормед Инк. | Гетероциклические соединения с повышенной эффективностью, связывающиеся с рецептором хемокина |
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