RU2358972C2 - Производные арилхиназолина, которые способствуют высвобождению паратиреоидного гормона - Google Patents

Производные арилхиназолина, которые способствуют высвобождению паратиреоидного гормона Download PDF

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RU2358972C2
RU2358972C2 RU2005123329/04A RU2005123329A RU2358972C2 RU 2358972 C2 RU2358972 C2 RU 2358972C2 RU 2005123329/04 A RU2005123329/04 A RU 2005123329/04A RU 2005123329 A RU2005123329 A RU 2005123329A RU 2358972 C2 RU2358972 C2 RU 2358972C2
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Russia
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quinazolin
isopropylphenyl
prop
propargyloxy
ylmethyl
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RU2005123329/04A
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RU2005123329A (ru
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Эва АЛЬТМАНН (CH)
Эва АЛЬТМАНН
Рене БЕРЛИ (CH)
Рене БЕРЛИ
Марк ГЕРШПАХЕР (CH)
Марк Гершпахер
Жоанне РЕНО (CH)
Жоанне РЕНО
Свен ВАЙЛЕР (DE)
Свен Вайлер
Лео ВИДЛЕР (CH)
Лео Видлер
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Новартис Аг
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Abstract

Изобретение относится к новым соединениям формулы I
Figure 00000172
где R1, R2, R3 и Y совместно с остатком формулы I представляют собой соединения, выбранные из группы, указанной в формуле изобретения, или к их фармацевтически приемлемым и расщепляемым сложным эфирам, или к их кислотно-аддитивным солям, обладающим свойствами промотора высвобождения паратиреоидного гормона. Соединения могут быть использованы для приготовления лекарственного средства, обладающего свойствами антагониста к чувствительному к кальцию рецептору паращитовидной железы, для лечения заболеваний, опосредованных действием паратиреоидного гормона. 6 н. и 1 з.п. ф-лы.

Description

Текст описания приведен в факсимильном виде.
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Claims (7)

1. Соединение формулы I
Figure 00000172
,
где заместители R1, R2, R3 и Y совместно с остатком формулы I представляют собой соединение, выбранное из группы следующих соединений:
4-(4-Изопропилфенил)-1-(3-метансульфонилбензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-[3-(2-метансульфинилэтокси)бензил]-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-[3-(2-метансульфонилэтокси)бензил]-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-[2-(2-метоксиэтил)-2Н-тетразол-5-илметил]-6-проп-2-инилокси-1Н-хиназолин-2-тион
4-(4-Изопропилфенил)-1-(3-метансульфинилбензил)-6-пронаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-пиридин-2-илметил-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-(4-[1,2,3]триазол-2-ил-бензил)-1Н-хиназолин-2-он
1-(3-Бромпропил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-пиридин-3-илметил-1Н-хиназолин-2-он
1-[2-(2-Гидроксиэтокси)бензил]-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-[3-(2-Гидроксиэтокси)тиофен-2-илметил]-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(3-Хлор-4-гидрокси-5-метоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(2-Этоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(3-Этоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(2-Гидрокси-6-метоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(1Н-Индол-4-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(4-Гидрокси-3-метоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(2-Гидрокси-4-метоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
Метиловый эфир
2-гидрокси-5-[4-(4-изопропилфенил)-2-оксо-6-проп-2-инилокси-2Н-хиназолин-1-илметил]бензойной кислоты
1-(3-Хлор-4-гидроксибензил)-4-(4-изопропилфенил)-6-проп-2-инил-окси-1Н-хиназолин-2-он
1-(2-Хлорбензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(4-Гидрокси-3,5-диметоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(2,5-Диметоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
Амид 4-[4-(4-изопропилфенил)-2-оксо-6-проп-2-инилокси-2Н-хиназолин-1-илметил]-1Н-индол-2-карбоновой кислоты
1-(2-Этилбутил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
{3-[4-(4-Изопропилфенил)-2-оксо-6-проп-2-инилокси-2Н-хиназолин-1-илметил]фенокси}уксусная кислота
1-(2,3-Диметоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(2,3-Дигидробензо[1,4]диоксин-6-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(4-оксо-4Н-хромен-3-илметил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(2-метилбутил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(2,6-Дихлорбензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(2,3-Дихлорбензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-(3-трифторметил-бензил)-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-(4-трифторметил-бензил)-1Н-хиназолин-2-он
1-(3-Этокси-4-гидроксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(3-фенилбутил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(3,4-Диэтоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(3-Фтор-4-метоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
{4-[4-(4-Изопропилфенил)-2-оксо-6-проп-2-инилокси-2Н-хиназолин-1-илметил]фенокси}уксусная кислота
4-(4-Изопропилфенил)-1-(4-метокси-2,3-диметилбензил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(4-Бензилоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(3-Гидрокси-6-метилпиридин-2-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
{2-[4-(4-Изопропилфенил)-2-оксо-6-проп-2-инилокси-2Н-хиназолин-1-илметил]-6-метоксифенокси}уксусная кислота
4-(4-Изопропилфенил)-1-(3-метоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(3,4-диметоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(4-метоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(3,5-диметоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(2,5-диэтоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(4-этокси-2-гидроксибензил)-6-пропаргил-окси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(2,4-диэтоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(2-метоксибензил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(4-этоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(3-изопропоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(2,4-диэтоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(4-Бром-3-метоксибензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(3-гидрокси-4-метоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(2-метоксиметоксибензил)-6-проп-2-инил-окси-1Н-хиназолин-2-он
1-(4-Бром-3-этоксибензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(4-Хлор-4-метоксибензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3-Хлор-4-этоксибензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3-Хлор-4,5-диметоксибензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(4-Хлор-3-метоксибензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3-Фторбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3,4-Дифторбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(4-Хлорбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(4-Фторбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3-Хлорбеизил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3-Бром-4-гидрокси-5-метоксибензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3-Бром-4-гидрокси-5-метоксибензил)-4-(4-изопропилфенил)-6-пропаргилокси-1H-хиназолин-2-он
1-(3-Бромбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3-Бром-4,5-диметоксибензил)-4-(4-изопропилфснил)-6-пропаргилпкси-1Н-хиназолин-2-он
1-(3,4-Дибромбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3,4-Дихлорбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(4-Метилбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3-Метилбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(4-Этилбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(3,4-Диметилбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-Циклопропилметил-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(2-Бромтиазол-5-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(4,5-Дихлортиофен-2-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(5-метилтиофен-2-илметил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-хинолин-2-илметил-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-[2-(2,6,6-триметилциклогекс-1-енил)этил]-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-пропаргилокси-1-(3,3,3-трифторпропил)-1Н-хиназолин-2-он
1-(3,3-Диметилбутил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(2,2-Диметилпент-4-енил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(3,5-Диметил-1-фенил-1Н-пиразол-4-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(5-Бромтиофен-2-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(5-Гидроксиметилфуран-2-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(2-Бутил-5-хлор-1Н-имидазол-4-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(6-метоксипиридин-3-илметил)-6-проп-2-инилокси-1Н-хиназолин-2-он
7-[4-(4-Изопропилфенил)-2-оксо-6-проп-2-инилокси-2Н-хиназолин-1-илметил]-1Н-индол-2-карбонитрил
1-(2,4-Диаминопиримидин-5-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(6-Гидроксиметилпиридин-2-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-(3,5-Ди-трет-бутил-4-гидроксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
трет-Бутиловый эфир
4-[4-(4-изопропилфенил)-2-оксо-6-проп-2-инилокси-2Н-хиназолин-1-илметил]-2,2-диметилоксазолидин-3-карбоновой кислоты
4-(4-Изопропилфенил)-1-(4-метиламино-2-метилсульфанил-пиримидин-5-илметил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-{4-[2-(метилпиридин-2-иламино)этокси]-бензил}-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(2-метилгекс-4-енил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-(4-пиразин-2-илбензил)-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(3-метилсульфанилпропил)-6-проп-2-инилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-тиофен-2-илметил-1Н-хиназолин-2-он
1-Бензил-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-тион
4-(4-Изопропилфенил)-1-(3-метансульфонилбензил)-6-пропаргилокси-1Н-хиназолин-2-тион
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-тиофен-2-илметил-1Н-хиназолин-2-тион
1-Бензил-4-(4-изопропилфенил)-6-метокси-1Н-хиназолин-2-тион
4-(4-Изопропилфенил)-1-[2-(2-метоксиэтокси)пиридин-3-илметил]-6-пропаргилокси-1Н-хиназолин-2-тион
1-Бензо[1,2,5]тиадиазол-5-илметил-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-тион
2-{3-[4-(4-Изопропилфенил)-6-проп-2-инилокси-2-тиоксо-2Н-хиназолин-1-илметил]феиокси}этиловый эфир уксусной кислоты
1-(2,3-Диметоксихиноксалин-6-илметил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин
1-[5-(2-Гидроксиэтокси)тиофеи-2-илметил]-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-тион
1-Изопропил-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-тион
1-Бензил-4-(4-циклопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Циклопропилфенил)-1-(3,3-Диметилбутил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Циклопропилфенил)-1-(3-этокси-4-метоксибензил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Циклопропилфенил)-1-изопропил-6-пропаргилокси-1Н-хиназолин-2-он
1-Бензил-4-(4-циклопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-тион
2-{3-[4-(4-Изопропилфенил)-2-оксо-6-пропаргилокси-2Н-хиназолин-1-илметил]фенокси}масляная кислота
2-{3-[4-(4-Изопропилфенил)-2-оксо-6-пропаргилокси-2Н-хиназолин-1-илметил]фенокси}-2-метилпропионовая кислота
4-(4-Изопропилфенил)-1-[2-(2-метоксиэтокси)пиридин-3-илметил]-6-проп-2-инилокси-1Н-хиназолин-2-он
1-[6-(2-гидроксиэтокси)пиридин-2-илметил]-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-она
1-[6-Хлорпиридин-3-илметил]-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(2-Гидроксипиридин-3-илметил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(5-метоксипиридин-2-илметил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(6-метилпиридин-2-илметил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(2-Хлорпиридин-4-илметил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
1-(2-Хлорпиридин-3-илметил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-{6-[2-(2-метоксиэтокси)этокси]пиридин-2-илметил}-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-[6-(2-метоксиэтокси)пиридин-2-илметил]-6-пропаргилокси-1Н-хиназолин-2-он
5-Аллил-1-бензил-6-гидрокси-4-(4-изопропилфенил)-1Н-хиназолин-2-он
5-Аллил-1-[3-(2-хлорэтокси)-4-метоксибензил]-6-гидрокси-4-(4-изопропилфенил)-1Н-хиназолин-2-он
5-Аллил-6-гидрокси-4-(4-изопропилфенил)-1-тиофен-2-илметил-1Н-хиназолин-2-он
5-Аллил-6-гидрокси-4-(4-изопропилфенил)-1-(3-метилсульфанилбутил)-1Н-хиназолин-2-он
5-Аллил-6-гидрокси-4-(4-изопропилфенил)-1-(1-метил-2-фенилэтил)-1Н-хиназолин-2-он
5-Аллил-6-гидрокси-4-(4-изопропилфенил)-1-пиридин-3-илметил-1Н-хиназолин-2-он
5-Аллил-6-гидрокси-1-(4-гидрокси-3-метоксибензил)-4-(4-изопропилфенил)-1Н-хиназолин-2-он
5-Аллил-6-гидрокси-1-[2-(2-гидроксиэтокси)бензил]-4-(4-изопропилфенил)-1Н-хиназолин-2-он
5-Аллил-6-гидрокси-1-[3-(2-гидроксиэтокси)бензил]-4-(4-изопропилфенил)-1Н-хиназолин-2-он
5-Аллил-1-(3,5-диметоксибензил)-6-гидрокси-4-(4-изопропил-фенил)-1Н-хиназолин-2-он
1-Бензил-6-гидрокси-4-(4-изопропилфенил)-5-пропил-1Н-хиназолин-2-он
6-Гидрокси-1-изобутил-4-(4-изопропилфенил)-5-пропил-1Н-хиназолин-2-он
1-[(3-(3,4-Диметоксифенил)пропил)]-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-1-(3-фенилпропил)-6-пропаргилокси-1Н-хиназолин-2-он
1-[2-(3,5-диметоксифенил)этил]-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-[2-Гидрокси-2-(2,4,6-триметилфенил)этил]-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он
1-[2-(3,5-Дифторфенил)-2-гидроксиэтил]-4-(4-изопропилфенил)-6-проп-2-инилокси-1H-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-[(Е)-2-(2,4,6-триметилфенил)винил]-1Н-хиназолин-2-он
4-(4-Изопропилфенил)-6-проп-2-инилокси-1-((Е)-стирил)-1Н-хиназолин-2-он
1-[(Е)-2-(3-Хлор-4-метоксифенил)винил]-4-(4-изопропилфенил)-6-проп-2-инилокси-1H-хиназолин-2-он
1-[(Е)-2-(3,5-Диметилфенил)винил]-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он;
или его фармацевтически приемлемый и расщепляемый сложный эфир или кислотно-аддитивная соль.
2. 1-(3-Этокси-4-метоксибензил)-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-он или его фармацевтически приемлемая кислотно-аддитивная соль.
3. 1-(4-Бромбензил)-4-(4-изопропилфенил)-6-пропаргилокси-1Н-хиназолин-2-он или его фармацевтически приемлемая кислотно-аддитивная соль.
4. 1-[3-(2-Гидроксиэтокси)бензил]-4-(4-изопропилфенил)-6-проп-2-инилокси-1Н-хиназолин-2-тион или его фармацевтически приемлемая кислотно-аддитивная соль.
5. Соединение по п.1 или его фармацевтически приемлемая кислотно-аддитивная соль для получения фармацевтического препарата, обладающего свойствами промотора высвобождения паратиреоидного гормона.
6. Фармацевтическая композиция, обладающая свойствами промотора высвобождения паратиреоидного гормона, включающая соединение по любому из пп.1-4 в смеси с фармацевтически приемлемым наполнителем, разбавителем или носителем.
7. Применение соединения по любому из пп.1-4 для приготовления лекарственного средства, обладающего антагонизмом к чувствительному к кальцию рецептору паращитовидной железы, для лечения заболеваний, опосредованных действием паратиреоидного гормона.
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