RU2356888C2 - Новые азетидиновые соединения - Google Patents

Новые азетидиновые соединения Download PDF

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RU2356888C2
RU2356888C2 RU2005136535/04A RU2005136535A RU2356888C2 RU 2356888 C2 RU2356888 C2 RU 2356888C2 RU 2005136535/04 A RU2005136535/04 A RU 2005136535/04A RU 2005136535 A RU2005136535 A RU 2005136535A RU 2356888 C2 RU2356888 C2 RU 2356888C2
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Russia
Prior art keywords
fluorophenyl
butyl
formula
compounds
het
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RU2005136535/04A
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English (en)
Russian (ru)
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RU2005136535A (ru
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Андерс ЙОХАНССОН (SE)
Андерс Йоханссон
Иоахим ПЕРССОН (SE)
Иоахим ПЕРССОН
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Альбирео Аб
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Priority claimed from SE0301744A external-priority patent/SE0301744D0/xx
Priority claimed from SE0303493A external-priority patent/SE0303493D0/xx
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Publication of RU2005136535A publication Critical patent/RU2005136535A/ru
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    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
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    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2005136535/04A 2003-06-13 2004-06-09 Новые азетидиновые соединения RU2356888C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0301744-9 2003-06-13
SE0301744A SE0301744D0 (sv) 2003-06-13 2003-06-13 New compounds
SE0303493-1 2003-12-19
SE0303493A SE0303493D0 (sv) 2003-12-19 2003-12-19 New compounds

Publications (2)

Publication Number Publication Date
RU2005136535A RU2005136535A (ru) 2006-07-27
RU2356888C2 true RU2356888C2 (ru) 2009-05-27

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RU2005136535/04A RU2356888C2 (ru) 2003-06-13 2004-06-09 Новые азетидиновые соединения

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US (1) US7402581B2 (enExample)
EP (1) EP1636221B1 (enExample)
JP (1) JP4982886B2 (enExample)
KR (1) KR20060021373A (enExample)
AR (1) AR044662A1 (enExample)
AT (1) ATE439358T1 (enExample)
AU (1) AU2004246983B2 (enExample)
BR (1) BRPI0411285A (enExample)
CA (1) CA2529126C (enExample)
CO (1) CO5640122A2 (enExample)
DE (1) DE602004022546D1 (enExample)
DK (1) DK1636221T3 (enExample)
ES (1) ES2330522T3 (enExample)
IL (1) IL171894A (enExample)
IS (1) IS8228A (enExample)
MX (1) MXPA05013276A (enExample)
MY (1) MY146599A (enExample)
NO (1) NO332109B1 (enExample)
PL (1) PL1636221T3 (enExample)
PT (1) PT1636221E (enExample)
RU (1) RU2356888C2 (enExample)
TW (1) TW200508221A (enExample)
WO (1) WO2004110344A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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SE0403005D0 (sv) * 2004-12-09 2004-12-09 Astrazeneca Ab New use
CN101208327A (zh) * 2005-06-23 2008-06-25 阿斯利康(瑞典)有限公司 作为神经激肽受体拮抗剂用于治疗胃肠疾病的新氮杂环丁烷衍生物
AU2006259891A1 (en) * 2005-06-23 2006-12-28 Albireo Ab New azetidine derivatives as neurokinin receptor antagonists for the treatment of gastrointestinal diseases
AR056087A1 (es) * 2005-09-29 2007-09-19 Astrazeneca Ab Derivados de azetidina como antagonistas de receptores de neuroquina nk
AR057828A1 (es) * 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
WO2007043938A1 (en) * 2005-10-07 2007-04-19 Astrazeneca Ab NOVEL CRYSTALLINE FORM OF 3,5-DIBROMO-N- [ (2S) -2- (-4- FLUOROPHENYL) -4- (3-MORPHOLIN-4-YLAZTIDIN-l-YL) BUTYL] -N METHYLBENZAMIDE, MODIFICATION B
WO2007043939A1 (en) * 2005-10-07 2007-04-19 Astrazeneca Ab Novel crystalline form of 3,5-dibromo-n- [(2s)-2-(-4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl] -n-methylbenzamide, modification a
US8106208B2 (en) * 2006-05-18 2012-01-31 Albireo Ab Benzamide compounds that act as NK receptor antagonists
WO2007136325A1 (en) * 2006-05-18 2007-11-29 Astrazeneca Ab 1- [ (4- [benzoyl (methyl) amino] -3- (phenyl) butyl] azetidine derivatives for the treatment of gastrointestinal disorders 2
WO2007136326A2 (en) * 2006-05-18 2007-11-29 Astrazeneca Ab ) t e text as een esta s e y t s ut o ty to rea as o ows: 1- [ (4- [benzoyl (methyl) amino] -3- (phenyl) butyl] azetidine derivatives for the treatment of gastrointestinal disorders 3
CL2007002097A1 (es) * 2006-07-20 2008-01-18 Smithkline Beecham Corp Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras.
AU2007285371A1 (en) * 2006-08-15 2008-02-21 Actelion Pharmaceuticals Ltd. Azetidine compounds as orexin receptor antagonists
WO2008076042A1 (en) * 2006-12-19 2008-06-26 Astrazeneca Ab Azetidinpiperazine derivatives that are neurokinin (nk) receptor antagonists and their use.
WO2008076041A1 (en) * 2006-12-19 2008-06-26 Albireo Ab Azetidinazabicyclo [3.2.1] octan derivatives that are neurokinin (nk) receptor antagonists and their use.
PL2125711T3 (pl) * 2007-03-08 2014-05-30 Albireo Ab Pochodne kwasy 3-fenylopropionowego oraz ich zastosowanie w leczeniu nieswoistego zapalenia jelit
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