RU2352337C2 - Ингибиторы гистондеацетилазы для лечения офтальмологических неоваскулярных нарушений и заболеваний - Google Patents

Ингибиторы гистондеацетилазы для лечения офтальмологических неоваскулярных нарушений и заболеваний Download PDF

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Publication number
RU2352337C2
RU2352337C2 RU2005118107/14A RU2005118107A RU2352337C2 RU 2352337 C2 RU2352337 C2 RU 2352337C2 RU 2005118107/14 A RU2005118107/14 A RU 2005118107/14A RU 2005118107 A RU2005118107 A RU 2005118107A RU 2352337 C2 RU2352337 C2 RU 2352337C2
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Russia
Prior art keywords
vegf
inhibitors
saha
neovascular
angiogenesis
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RU2005118107/14A
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English (en)
Russian (ru)
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RU2005118107A (ru
Inventor
Питер Г. КЛИМКО (US)
Питер Г. КЛИМКО
Дэвид П. БИНГАМЭН (US)
Дэвид П. БИНГАМЭН
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Алькон, Инк.
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Publication of RU2005118107A publication Critical patent/RU2005118107A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2005118107/14A 2002-11-12 2003-10-30 Ингибиторы гистондеацетилазы для лечения офтальмологических неоваскулярных нарушений и заболеваний RU2352337C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42557402P 2002-11-12 2002-11-12
US60/425,574 2002-11-12

Publications (2)

Publication Number Publication Date
RU2005118107A RU2005118107A (ru) 2006-01-20
RU2352337C2 true RU2352337C2 (ru) 2009-04-20

Family

ID=32313018

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005118107/14A RU2352337C2 (ru) 2002-11-12 2003-10-30 Ингибиторы гистондеацетилазы для лечения офтальмологических неоваскулярных нарушений и заболеваний

Country Status (12)

Country Link
US (3) US20060074100A1 (https=)
EP (1) EP1560583A4 (https=)
JP (1) JP2006512318A (https=)
KR (1) KR20050086526A (https=)
CN (1) CN1711087A (https=)
AU (1) AU2003287349B2 (https=)
BR (1) BR0316206A (https=)
CA (1) CA2504460A1 (https=)
MX (1) MXPA05004485A (https=)
RU (1) RU2352337C2 (https=)
WO (1) WO2004043352A2 (https=)
ZA (1) ZA200503237B (https=)

Cited By (1)

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RU2769320C1 (ru) * 2020-12-28 2022-03-30 Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) Способ получения производных N-гидроксибутанамида

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CA2518318A1 (en) 2003-03-17 2004-09-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
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EA200800321A1 (ru) * 2005-07-14 2008-06-30 Такеда Сан Диего, Инк. Ингибиторы гистондеацетилазы
AU2006272497B2 (en) * 2005-07-27 2012-07-19 University Of Florida Research Foundation, Inc. Small compounds that correct protein misfolding and uses thereof
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CN101239929B (zh) * 2007-02-09 2013-04-17 中国科学院上海药物研究所 曲古抑菌素a衍生物及其制备方法和用途
JP2008266321A (ja) * 2007-03-28 2008-11-06 Santen Pharmaceut Co Ltd フェニレンジアミン誘導体を有効成分とする眼圧下降剤
KR102341446B1 (ko) * 2016-09-29 2021-12-21 네이처와이즈 바이오테크 & 메디칼스 코포레이션 안구 질병을 치료하는 방법
WO2019089573A1 (en) * 2017-10-30 2019-05-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Treatment of ocular conditions utilizing a histone/protein deacetylase inhibitor
KR102236356B1 (ko) 2017-11-24 2021-04-05 주식회사 종근당 루푸스의 예방 또는 치료를 위한 조성물
KR20190099952A (ko) * 2018-02-20 2019-08-28 주식회사 종근당 포도막염의 예방 또는 치료를 위한 조성물
WO2019246509A1 (en) * 2018-06-22 2019-12-26 Mohan Rajiv R Methods and compositions for promoting wound healing with decreased scar formation after glaucoma filtration surgery
WO2020102599A1 (en) * 2018-11-14 2020-05-22 Vanderbilt University Treating intraocular retinoblastoma with inhibitors of histone modification

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2769320C1 (ru) * 2020-12-28 2022-03-30 Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) Способ получения производных N-гидроксибутанамида

Also Published As

Publication number Publication date
AU2003287349B2 (en) 2009-04-23
MXPA05004485A (es) 2005-11-23
KR20050086526A (ko) 2005-08-30
EP1560583A4 (en) 2010-09-22
AU2003287349A1 (en) 2004-06-03
EP1560583A2 (en) 2005-08-10
US20040092558A1 (en) 2004-05-13
US20100048608A1 (en) 2010-02-25
WO2004043352A3 (en) 2004-07-15
JP2006512318A (ja) 2006-04-13
BR0316206A (pt) 2005-09-27
CA2504460A1 (en) 2004-05-27
WO2004043352A8 (en) 2005-06-30
US20060074100A1 (en) 2006-04-06
CN1711087A (zh) 2005-12-21
ZA200503237B (en) 2006-06-28
RU2005118107A (ru) 2006-01-20
WO2004043352A2 (en) 2004-05-27

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Effective date: 20111031