RU2351651C2 - Выделенный рекомбинантный вирус гриппа и способы его получения - Google Patents
Выделенный рекомбинантный вирус гриппа и способы его получения Download PDFInfo
- Publication number
- RU2351651C2 RU2351651C2 RU2005136233/13A RU2005136233A RU2351651C2 RU 2351651 C2 RU2351651 C2 RU 2351651C2 RU 2005136233/13 A RU2005136233/13 A RU 2005136233/13A RU 2005136233 A RU2005136233 A RU 2005136233A RU 2351651 C2 RU2351651 C2 RU 2351651C2
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- Prior art keywords
- membrane protein
- vector
- influenza virus
- operably linked
- promoter operably
- Prior art date
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- 241000712461 unidentified influenza virus Species 0.000 title claims abstract 31
- 238000000034 method Methods 0.000 title claims abstract 15
- 238000004519 manufacturing process Methods 0.000 title claims 4
- 239000013598 vector Substances 0.000 claims abstract 40
- 108010052285 Membrane Proteins Proteins 0.000 claims abstract 38
- 102000018697 Membrane Proteins Human genes 0.000 claims abstract 31
- 108090000623 proteins and genes Proteins 0.000 claims abstract 10
- 241000700605 Viruses Species 0.000 claims 20
- 108020004414 DNA Proteins 0.000 claims 17
- 239000002299 complementary DNA Substances 0.000 claims 17
- 230000035772 mutation Effects 0.000 claims 17
- 101150112842 NB gene Proteins 0.000 claims 13
- 230000005030 transcription termination Effects 0.000 claims 13
- 108020004705 Codon Proteins 0.000 claims 12
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 12
- 230000000977 initiatory effect Effects 0.000 claims 12
- 229930182817 methionine Natural products 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 6
- 238000012217 deletion Methods 0.000 claims 6
- 230000037430 deletion Effects 0.000 claims 6
- 238000003780 insertion Methods 0.000 claims 6
- 230000037431 insertion Effects 0.000 claims 6
- 206010022000 influenza Diseases 0.000 claims 5
- 230000035897 transcription Effects 0.000 claims 5
- 238000013518 transcription Methods 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 3
- 108010064513 influenza virus polymerase basic protein 1 Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108700029658 influenza virus NS Proteins 0.000 claims 2
- 108700015453 influenza virus PB2 Proteins 0.000 claims 2
- 238000013519 translation Methods 0.000 claims 2
- 108091028026 C-DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 101150080862 NA gene Proteins 0.000 claims 1
- 108091081024 Start codon Proteins 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108010019701 influenza virus M-protein Proteins 0.000 claims 1
- 108700010900 influenza virus proteins Proteins 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07K14/08—RNA viruses
- C07K14/11—Orthomyxoviridae, e.g. influenza virus
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A—HUMAN NECESSITIES
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- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16311—Influenzavirus C, i.e. influenza C virus
- C12N2760/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
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- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Wood Science & Technology (AREA)
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- Immunology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46477603P | 2003-04-23 | 2003-04-23 | |
| US60/464,776 | 2003-04-23 | ||
| US46532803P | 2003-04-24 | 2003-04-24 | |
| US60/465,328 | 2003-04-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005136233A RU2005136233A (ru) | 2006-06-10 |
| RU2351651C2 true RU2351651C2 (ru) | 2009-04-10 |
Family
ID=33313498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005136233/13A RU2351651C2 (ru) | 2003-04-23 | 2004-04-20 | Выделенный рекомбинантный вирус гриппа и способы его получения |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7588769B2 (https=) |
| EP (1) | EP1618191A2 (https=) |
| JP (3) | JP2007525175A (https=) |
| KR (1) | KR100869011B1 (https=) |
| CN (1) | CN1809633B (https=) |
| AU (1) | AU2004232992A1 (https=) |
| CA (1) | CA2522081C (https=) |
| MX (1) | MXPA05011250A (https=) |
| NZ (1) | NZ542935A (https=) |
| RU (1) | RU2351651C2 (https=) |
| WO (1) | WO2004094466A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4927290B2 (ja) | 2000-04-14 | 2012-05-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 変異イオンチャンネルタンパク質を含んで成るウイルス |
| AU2004232992A1 (en) | 2003-04-23 | 2004-11-04 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| CA2525953C (en) * | 2003-05-28 | 2023-10-10 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines and gene therapy |
| EP1812564A2 (en) * | 2004-11-11 | 2007-08-01 | Solvay Pharmaceuticals B.V. | Defective influenza virus particles |
| CN101056976A (zh) * | 2004-11-11 | 2007-10-17 | 索尔瓦药物有限公司 | 有缺陷的流感病毒颗粒 |
| EA200701097A1 (ru) | 2004-11-19 | 2007-10-26 | Висконсин Эламни Рисёч Фаундэйшн | Рекомбинантные векторы вируса гриппа с тандемными транскрипционными единицами |
| CA2647985C (en) | 2006-03-31 | 2014-12-30 | Warf-Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| AU2007297801A1 (en) | 2006-07-14 | 2008-03-27 | Sanofi Pasteur Biologics Co. | Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins |
| EP2069483A4 (en) * | 2006-09-29 | 2010-10-27 | Sanofi Pasteur Biologics Co | RECOMBINANT RHINOVIRAL VECTORS |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| US8883995B2 (en) * | 2009-03-06 | 2014-11-11 | Icahn School Of Medicine At Mount Sinai | Live attenuated influenza virus vaccines comprising microRNA response elements |
| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| WO2011136421A1 (ko) * | 2010-04-30 | 2011-11-03 | 주식회사 바이오트라이온 | 신규한 프라이머 및 이를 이용한 재조합 독감 바이러스 제조방법 |
| KR102080061B1 (ko) * | 2011-06-24 | 2020-02-21 | 플루젠, 인코퍼레이티드 | 인플루엔자 바이러스 돌연변이체들 및 그들의 용도들 |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| CN107208071B (zh) * | 2014-11-13 | 2021-11-30 | 港大科桥有限公司 | 用于流感病毒的减弱活疫苗 |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| US9890363B2 (en) | 2015-07-06 | 2018-02-13 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US10494613B2 (en) * | 2015-08-28 | 2019-12-03 | Wisconsin Alumni Research Foundation (Warf) | Generation of infectious influenza viruses from virus-like particles |
| US11197925B2 (en) | 2016-02-19 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Influenza B virus replication for vaccine development |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| EP3914295A2 (en) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| EP4185601A4 (en) | 2020-07-21 | 2024-10-30 | Flugen, Inc. | SKELETON OF THE INFLUENZA VIRUS |
| CN114381439B (zh) * | 2022-01-27 | 2023-12-15 | 浙江迪福润丝生物科技有限公司 | 一种同义突变结合删除突变的流感病毒的致弱方法及致弱流感病毒株和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2008351C1 (ru) * | 1991-06-27 | 1994-02-28 | Научно-исследовательский институт экспериментальной медицины РАМН | Штамм вируса гриппа в/14/28, р для получения живой интраназальной гриппозной вакцины для детей |
| RU2033424C1 (ru) * | 1991-03-19 | 1995-04-20 | Научно-исследовательский институт гриппа РАМН | Штамм вируса гриппа а (нзn2) для получения живой гриппозной интраназальной вакцины для взрослых и детей |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219515A (en) * | 1987-02-10 | 1989-09-27 | Wellcome Found | Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope |
| JPS6479273A (en) * | 1987-09-21 | 1989-03-24 | Nippon Ester Co Ltd | Resin composition for powder coating |
| US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| US5919676A (en) | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| US5994526A (en) | 1996-06-21 | 1999-11-30 | Plant Genetic Systems | Gene expression in plants |
| CA2297786C (en) * | 1997-08-05 | 2011-06-14 | Vlaams Interuniversitair Instituut Voor Biotechnologie | New immunoprotective influenza antigen and its use in vaccination |
| EP1035209A1 (en) | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stable recombinant influenza viruses free of helper viruses |
| US6686168B1 (en) * | 1999-11-04 | 2004-02-03 | Zymogenetics, Inc. | Cell surface display of proteins by recombinant host cells |
| JP4927290B2 (ja) * | 2000-04-14 | 2012-05-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 変異イオンチャンネルタンパク質を含んで成るウイルス |
| CN1338307A (zh) * | 2000-08-10 | 2002-03-06 | 清华大学 | 一种流感病毒表位疫苗及其制备方法 |
| AU2004232992A1 (en) | 2003-04-23 | 2004-11-04 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| CA2647985C (en) | 2006-03-31 | 2014-12-30 | Warf-Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
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2004
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- 2004-04-20 EP EP04750333A patent/EP1618191A2/en not_active Withdrawn
- 2004-04-20 KR KR1020057020077A patent/KR100869011B1/ko not_active Expired - Fee Related
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| RU2033424C1 (ru) * | 1991-03-19 | 1995-04-20 | Научно-исследовательский институт гриппа РАМН | Штамм вируса гриппа а (нзn2) для получения живой гриппозной интраназальной вакцины для взрослых и детей |
| RU2008351C1 (ru) * | 1991-06-27 | 1994-02-28 | Научно-исследовательский институт экспериментальной медицины РАМН | Штамм вируса гриппа в/14/28, р для получения живой интраназальной гриппозной вакцины для детей |
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Also Published As
| Publication number | Publication date |
|---|---|
| US7588769B2 (en) | 2009-09-15 |
| NZ542935A (en) | 2008-08-29 |
| CA2522081C (en) | 2013-01-29 |
| JP5438065B2 (ja) | 2014-03-12 |
| WO2004094466A3 (en) | 2005-03-31 |
| CA2522081A1 (en) | 2004-11-04 |
| MXPA05011250A (es) | 2006-03-30 |
| JP2014039551A (ja) | 2014-03-06 |
| CN1809633A (zh) | 2006-07-26 |
| EP1618191A2 (en) | 2006-01-25 |
| KR20060006055A (ko) | 2006-01-18 |
| RU2005136233A (ru) | 2006-06-10 |
| US20100247572A1 (en) | 2010-09-30 |
| AU2004232992A1 (en) | 2004-11-04 |
| JP2011177192A (ja) | 2011-09-15 |
| JP2007525175A (ja) | 2007-09-06 |
| KR100869011B1 (ko) | 2008-11-17 |
| WO2004094466A2 (en) | 2004-11-04 |
| US20040219170A1 (en) | 2004-11-04 |
| CN1809633B (zh) | 2011-01-19 |
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