RU2351651C2 - Выделенный рекомбинантный вирус гриппа и способы его получения - Google Patents
Выделенный рекомбинантный вирус гриппа и способы его получения Download PDFInfo
- Publication number
- RU2351651C2 RU2351651C2 RU2005136233/13A RU2005136233A RU2351651C2 RU 2351651 C2 RU2351651 C2 RU 2351651C2 RU 2005136233/13 A RU2005136233/13 A RU 2005136233/13A RU 2005136233 A RU2005136233 A RU 2005136233A RU 2351651 C2 RU2351651 C2 RU 2351651C2
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- Russia
- Prior art keywords
- membrane protein
- vector
- influenza virus
- operably linked
- promoter operably
- Prior art date
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- 241000712461 unidentified influenza virus Species 0.000 title claims abstract 31
- 238000000034 method Methods 0.000 title claims abstract 15
- 238000004519 manufacturing process Methods 0.000 title claims 4
- 239000013598 vector Substances 0.000 claims abstract 40
- 108010052285 Membrane Proteins Proteins 0.000 claims abstract 38
- 102000018697 Membrane Proteins Human genes 0.000 claims abstract 31
- 108090000623 proteins and genes Proteins 0.000 claims abstract 10
- 241000700605 Viruses Species 0.000 claims 20
- 108020004414 DNA Proteins 0.000 claims 17
- 239000002299 complementary DNA Substances 0.000 claims 17
- 230000035772 mutation Effects 0.000 claims 17
- 101150112842 NB gene Proteins 0.000 claims 13
- 230000005030 transcription termination Effects 0.000 claims 13
- 108020004705 Codon Proteins 0.000 claims 12
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 12
- 230000000977 initiatory effect Effects 0.000 claims 12
- 229930182817 methionine Natural products 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 6
- 238000012217 deletion Methods 0.000 claims 6
- 230000037430 deletion Effects 0.000 claims 6
- 238000003780 insertion Methods 0.000 claims 6
- 230000037431 insertion Effects 0.000 claims 6
- 206010022000 influenza Diseases 0.000 claims 5
- 230000035897 transcription Effects 0.000 claims 5
- 238000013518 transcription Methods 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 3
- 108010064513 influenza virus polymerase basic protein 1 Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108700029658 influenza virus NS Proteins 0.000 claims 2
- 108700015453 influenza virus PB2 Proteins 0.000 claims 2
- 238000013519 translation Methods 0.000 claims 2
- 108091028026 C-DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 101150080862 NA gene Proteins 0.000 claims 1
- 108091081024 Start codon Proteins 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108010019701 influenza virus M-protein Proteins 0.000 claims 1
- 108700010900 influenza virus proteins Proteins 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C07K14/08—RNA viruses
- C07K14/11—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
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- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16311—Influenzavirus C, i.e. influenza C virus
- C12N2760/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
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- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46477603P | 2003-04-23 | 2003-04-23 | |
| US60/464,776 | 2003-04-23 | ||
| US46532803P | 2003-04-24 | 2003-04-24 | |
| US60/465,328 | 2003-04-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005136233A RU2005136233A (ru) | 2006-06-10 |
| RU2351651C2 true RU2351651C2 (ru) | 2009-04-10 |
Family
ID=33313498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005136233/13A RU2351651C2 (ru) | 2003-04-23 | 2004-04-20 | Выделенный рекомбинантный вирус гриппа и способы его получения |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7588769B2 (https=) |
| EP (1) | EP1618191A2 (https=) |
| JP (3) | JP2007525175A (https=) |
| KR (1) | KR100869011B1 (https=) |
| CN (1) | CN1809633B (https=) |
| AU (1) | AU2004232992A1 (https=) |
| CA (1) | CA2522081C (https=) |
| MX (1) | MXPA05011250A (https=) |
| NZ (1) | NZ542935A (https=) |
| RU (1) | RU2351651C2 (https=) |
| WO (1) | WO2004094466A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1052949B (en) | 2000-04-14 | 2011-04-29 | Wisconsin Alumni Research Foundation | Viruses comprising mutated ion channel protein |
| NZ542935A (en) * | 2003-04-23 | 2008-08-29 | Wisconsin Alumni Res Found | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| AU2004249133B2 (en) * | 2003-05-28 | 2009-05-28 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines and gene therapy |
| RU2420577C2 (ru) * | 2004-11-11 | 2011-06-10 | Эбботт Байолоджикалз Б.В. | Условно дефектная частица вируса гриппа и способы ее получения (варианты) |
| AU2005303817B8 (en) * | 2004-11-11 | 2010-09-30 | Abbott Biologicals B.V. | Defective influenza virus particles |
| CN101103103A (zh) | 2004-11-19 | 2008-01-09 | 威斯康星旧生研究基金会 | 具有串联转录单位的重组流感病毒载体 |
| WO2007126810A2 (en) | 2006-03-31 | 2007-11-08 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| RU2009105099A (ru) | 2006-07-14 | 2010-08-27 | Санофи Пастер Байолоджикс Ко. (Us) | Конструирование рекомбинантных вирусных вакцин путем прямой транспозон-опосредованной инсерции чужеродных иммунологических детерминант в белки векторного вируса |
| KR20090096414A (ko) | 2006-09-29 | 2009-09-10 | 사노피 파스테르 바이오로직스 씨오 | 재조합 리노바이러스 벡터 |
| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| US8883995B2 (en) * | 2009-03-06 | 2014-11-11 | Icahn School Of Medicine At Mount Sinai | Live attenuated influenza virus vaccines comprising microRNA response elements |
| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| WO2011136421A1 (ko) * | 2010-04-30 | 2011-11-03 | 주식회사 바이오트라이온 | 신규한 프라이머 및 이를 이용한 재조합 독감 바이러스 제조방법 |
| EP2723855B1 (en) * | 2011-06-24 | 2018-08-08 | Flugen, Inc. | Influenza virus mutants and uses therefor |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| US9950057B2 (en) | 2013-07-15 | 2018-04-24 | Wisconsin Alumni Research Foundation (Warf) | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| AU2015345579B2 (en) * | 2014-11-13 | 2019-02-21 | Versitech Limited | Live attenuated vaccines for influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| WO2017040203A1 (en) * | 2015-08-28 | 2017-03-09 | Yoshihiro Kawaoka | Generation of infectious influenza viruses from virus-like particles |
| CA3014435C (en) | 2016-02-19 | 2023-04-18 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza b virus replication for vaccine development |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| US11241492B2 (en) | 2019-01-23 | 2022-02-08 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to genes in influenza viruses |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN116134137A (zh) | 2020-07-21 | 2023-05-16 | 复尔健有限公司 | 流感病毒骨架 |
| CN114381439B (zh) * | 2022-01-27 | 2023-12-15 | 浙江迪福润丝生物科技有限公司 | 一种同义突变结合删除突变的流感病毒的致弱方法及致弱流感病毒株和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2008351C1 (ru) * | 1991-06-27 | 1994-02-28 | Научно-исследовательский институт экспериментальной медицины РАМН | Штамм вируса гриппа в/14/28, р для получения живой интраназальной гриппозной вакцины для детей |
| RU2033424C1 (ru) * | 1991-03-19 | 1995-04-20 | Научно-исследовательский институт гриппа РАМН | Штамм вируса гриппа а (нзn2) для получения живой гриппозной интраназальной вакцины для взрослых и детей |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219515A (en) * | 1987-02-10 | 1989-09-27 | Wellcome Found | Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope |
| JPS6479273A (en) * | 1987-09-21 | 1989-03-24 | Nippon Ester Co Ltd | Resin composition for powder coating |
| US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
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| EP1035209A1 (en) | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stable recombinant influenza viruses free of helper viruses |
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| NZ542935A (en) | 2003-04-23 | 2008-08-29 | Wisconsin Alumni Res Found | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| WO2007126810A2 (en) | 2006-03-31 | 2007-11-08 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP5438065B2 (ja) | 2014-03-12 |
| NZ542935A (en) | 2008-08-29 |
| JP2007525175A (ja) | 2007-09-06 |
| CA2522081A1 (en) | 2004-11-04 |
| AU2004232992A1 (en) | 2004-11-04 |
| KR100869011B1 (ko) | 2008-11-17 |
| JP2014039551A (ja) | 2014-03-06 |
| JP2011177192A (ja) | 2011-09-15 |
| WO2004094466A2 (en) | 2004-11-04 |
| CN1809633A (zh) | 2006-07-26 |
| US20040219170A1 (en) | 2004-11-04 |
| CN1809633B (zh) | 2011-01-19 |
| WO2004094466A3 (en) | 2005-03-31 |
| CA2522081C (en) | 2013-01-29 |
| KR20060006055A (ko) | 2006-01-18 |
| US20100247572A1 (en) | 2010-09-30 |
| MXPA05011250A (es) | 2006-03-30 |
| EP1618191A2 (en) | 2006-01-25 |
| RU2005136233A (ru) | 2006-06-10 |
| US7588769B2 (en) | 2009-09-15 |
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