CA2522081C - Recombinant influenza viruses holding a mutation in a transmembrane protein gene - Google Patents
Recombinant influenza viruses holding a mutation in a transmembrane protein gene Download PDFInfo
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- CA2522081C CA2522081C CA2522081A CA2522081A CA2522081C CA 2522081 C CA2522081 C CA 2522081C CA 2522081 A CA2522081 A CA 2522081A CA 2522081 A CA2522081 A CA 2522081A CA 2522081 C CA2522081 C CA 2522081C
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- virus
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- membrane protein
- influenza virus
- protein gene
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16311—Influenzavirus C, i.e. influenza C virus
- C12N2760/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46477603P | 2003-04-23 | 2003-04-23 | |
| US60/464,776 | 2003-04-23 | ||
| US46532803P | 2003-04-24 | 2003-04-24 | |
| US60/465,328 | 2003-04-24 | ||
| PCT/US2004/012050 WO2004094466A2 (en) | 2003-04-23 | 2004-04-20 | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2522081A1 CA2522081A1 (en) | 2004-11-04 |
| CA2522081C true CA2522081C (en) | 2013-01-29 |
Family
ID=33313498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2522081A Expired - Fee Related CA2522081C (en) | 2003-04-23 | 2004-04-20 | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7588769B2 (https=) |
| EP (1) | EP1618191A2 (https=) |
| JP (3) | JP2007525175A (https=) |
| KR (1) | KR100869011B1 (https=) |
| CN (1) | CN1809633B (https=) |
| AU (1) | AU2004232992A1 (https=) |
| CA (1) | CA2522081C (https=) |
| MX (1) | MXPA05011250A (https=) |
| NZ (1) | NZ542935A (https=) |
| RU (1) | RU2351651C2 (https=) |
| WO (1) | WO2004094466A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1052949B (en) | 2000-04-14 | 2011-04-29 | Wisconsin Alumni Research Foundation | Viruses comprising mutated ion channel protein |
| NZ542935A (en) * | 2003-04-23 | 2008-08-29 | Wisconsin Alumni Res Found | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| AU2004249133B2 (en) * | 2003-05-28 | 2009-05-28 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines and gene therapy |
| RU2420577C2 (ru) * | 2004-11-11 | 2011-06-10 | Эбботт Байолоджикалз Б.В. | Условно дефектная частица вируса гриппа и способы ее получения (варианты) |
| AU2005303817B8 (en) * | 2004-11-11 | 2010-09-30 | Abbott Biologicals B.V. | Defective influenza virus particles |
| CN101103103A (zh) | 2004-11-19 | 2008-01-09 | 威斯康星旧生研究基金会 | 具有串联转录单位的重组流感病毒载体 |
| WO2007126810A2 (en) | 2006-03-31 | 2007-11-08 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| RU2009105099A (ru) | 2006-07-14 | 2010-08-27 | Санофи Пастер Байолоджикс Ко. (Us) | Конструирование рекомбинантных вирусных вакцин путем прямой транспозон-опосредованной инсерции чужеродных иммунологических детерминант в белки векторного вируса |
| KR20090096414A (ko) | 2006-09-29 | 2009-09-10 | 사노피 파스테르 바이오로직스 씨오 | 재조합 리노바이러스 벡터 |
| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| US8883995B2 (en) * | 2009-03-06 | 2014-11-11 | Icahn School Of Medicine At Mount Sinai | Live attenuated influenza virus vaccines comprising microRNA response elements |
| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| WO2011136421A1 (ko) * | 2010-04-30 | 2011-11-03 | 주식회사 바이오트라이온 | 신규한 프라이머 및 이를 이용한 재조합 독감 바이러스 제조방법 |
| EP2723855B1 (en) * | 2011-06-24 | 2018-08-08 | Flugen, Inc. | Influenza virus mutants and uses therefor |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| US9950057B2 (en) | 2013-07-15 | 2018-04-24 | Wisconsin Alumni Research Foundation (Warf) | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| AU2015345579B2 (en) * | 2014-11-13 | 2019-02-21 | Versitech Limited | Live attenuated vaccines for influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| WO2017040203A1 (en) * | 2015-08-28 | 2017-03-09 | Yoshihiro Kawaoka | Generation of infectious influenza viruses from virus-like particles |
| CA3014435C (en) | 2016-02-19 | 2023-04-18 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza b virus replication for vaccine development |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| US11241492B2 (en) | 2019-01-23 | 2022-02-08 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to genes in influenza viruses |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN116134137A (zh) | 2020-07-21 | 2023-05-16 | 复尔健有限公司 | 流感病毒骨架 |
| CN114381439B (zh) * | 2022-01-27 | 2023-12-15 | 浙江迪福润丝生物科技有限公司 | 一种同义突变结合删除突变的流感病毒的致弱方法及致弱流感病毒株和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219515A (en) * | 1987-02-10 | 1989-09-27 | Wellcome Found | Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope |
| JPS6479273A (en) * | 1987-09-21 | 1989-03-24 | Nippon Ester Co Ltd | Resin composition for powder coating |
| US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| RU2033424C1 (ru) * | 1991-03-19 | 1995-04-20 | Научно-исследовательский институт гриппа РАМН | Штамм вируса гриппа а (нзn2) для получения живой гриппозной интраназальной вакцины для взрослых и детей |
| RU2008351C1 (ru) * | 1991-06-27 | 1994-02-28 | Научно-исследовательский институт экспериментальной медицины РАМН | Штамм вируса гриппа в/14/28, р для получения живой интраназальной гриппозной вакцины для детей |
| US5919676A (en) | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| US5994526A (en) | 1996-06-21 | 1999-11-30 | Plant Genetic Systems | Gene expression in plants |
| ES2255181T3 (es) * | 1997-08-05 | 2006-06-16 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Antigeno inmunoprotector contra la gripe y su uso en vacunacion. |
| EP1035209A1 (en) | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stable recombinant influenza viruses free of helper viruses |
| US6686168B1 (en) * | 1999-11-04 | 2004-02-03 | Zymogenetics, Inc. | Cell surface display of proteins by recombinant host cells |
| HK1052949B (en) * | 2000-04-14 | 2011-04-29 | Wisconsin Alumni Research Foundation | Viruses comprising mutated ion channel protein |
| CN1338307A (zh) * | 2000-08-10 | 2002-03-06 | 清华大学 | 一种流感病毒表位疫苗及其制备方法 |
| NZ542935A (en) | 2003-04-23 | 2008-08-29 | Wisconsin Alumni Res Found | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| WO2007126810A2 (en) | 2006-03-31 | 2007-11-08 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
-
2004
- 2004-04-20 NZ NZ542935A patent/NZ542935A/en not_active IP Right Cessation
- 2004-04-20 CA CA2522081A patent/CA2522081C/en not_active Expired - Fee Related
- 2004-04-20 WO PCT/US2004/012050 patent/WO2004094466A2/en not_active Ceased
- 2004-04-20 EP EP04750333A patent/EP1618191A2/en not_active Withdrawn
- 2004-04-20 AU AU2004232992A patent/AU2004232992A1/en not_active Abandoned
- 2004-04-20 CN CN200480017037XA patent/CN1809633B/zh not_active Expired - Fee Related
- 2004-04-20 RU RU2005136233/13A patent/RU2351651C2/ru not_active IP Right Cessation
- 2004-04-20 JP JP2006513125A patent/JP2007525175A/ja not_active Withdrawn
- 2004-04-20 US US10/827,995 patent/US7588769B2/en not_active Expired - Fee Related
- 2004-04-20 KR KR1020057020077A patent/KR100869011B1/ko not_active Expired - Fee Related
- 2004-04-20 MX MXPA05011250A patent/MXPA05011250A/es not_active Application Discontinuation
-
2009
- 2009-05-18 US US12/467,492 patent/US20100247572A1/en not_active Abandoned
-
2011
- 2011-05-18 JP JP2011111048A patent/JP5438065B2/ja not_active Expired - Fee Related
-
2013
- 2013-09-25 JP JP2013198377A patent/JP2014039551A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP5438065B2 (ja) | 2014-03-12 |
| NZ542935A (en) | 2008-08-29 |
| JP2007525175A (ja) | 2007-09-06 |
| CA2522081A1 (en) | 2004-11-04 |
| AU2004232992A1 (en) | 2004-11-04 |
| KR100869011B1 (ko) | 2008-11-17 |
| JP2014039551A (ja) | 2014-03-06 |
| JP2011177192A (ja) | 2011-09-15 |
| WO2004094466A2 (en) | 2004-11-04 |
| CN1809633A (zh) | 2006-07-26 |
| RU2351651C2 (ru) | 2009-04-10 |
| US20040219170A1 (en) | 2004-11-04 |
| CN1809633B (zh) | 2011-01-19 |
| WO2004094466A3 (en) | 2005-03-31 |
| KR20060006055A (ko) | 2006-01-18 |
| US20100247572A1 (en) | 2010-09-30 |
| MXPA05011250A (es) | 2006-03-30 |
| EP1618191A2 (en) | 2006-01-25 |
| RU2005136233A (ru) | 2006-06-10 |
| US7588769B2 (en) | 2009-09-15 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200831 |