CN1809633B - 跨膜蛋白基因中含有突变的重组流感病毒 - Google Patents
跨膜蛋白基因中含有突变的重组流感病毒 Download PDFInfo
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- CN1809633B CN1809633B CN200480017037XA CN200480017037A CN1809633B CN 1809633 B CN1809633 B CN 1809633B CN 200480017037X A CN200480017037X A CN 200480017037XA CN 200480017037 A CN200480017037 A CN 200480017037A CN 1809633 B CN1809633 B CN 1809633B
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- A61P31/12—Antivirals
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- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16311—Influenzavirus C, i.e. influenza C virus
- C12N2760/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
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- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46477603P | 2003-04-23 | 2003-04-23 | |
| US60/464,776 | 2003-04-23 | ||
| US46532803P | 2003-04-24 | 2003-04-24 | |
| US60/465,328 | 2003-04-24 | ||
| PCT/US2004/012050 WO2004094466A2 (en) | 2003-04-23 | 2004-04-20 | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1809633A CN1809633A (zh) | 2006-07-26 |
| CN1809633B true CN1809633B (zh) | 2011-01-19 |
Family
ID=33313498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200480017037XA Expired - Fee Related CN1809633B (zh) | 2003-04-23 | 2004-04-20 | 跨膜蛋白基因中含有突变的重组流感病毒 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7588769B2 (https=) |
| EP (1) | EP1618191A2 (https=) |
| JP (3) | JP2007525175A (https=) |
| KR (1) | KR100869011B1 (https=) |
| CN (1) | CN1809633B (https=) |
| AU (1) | AU2004232992A1 (https=) |
| CA (1) | CA2522081C (https=) |
| MX (1) | MXPA05011250A (https=) |
| NZ (1) | NZ542935A (https=) |
| RU (1) | RU2351651C2 (https=) |
| WO (1) | WO2004094466A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4927290B2 (ja) | 2000-04-14 | 2012-05-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 変異イオンチャンネルタンパク質を含んで成るウイルス |
| AU2004232992A1 (en) | 2003-04-23 | 2004-11-04 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| CA2525953C (en) * | 2003-05-28 | 2023-10-10 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines and gene therapy |
| EP1812564A2 (en) * | 2004-11-11 | 2007-08-01 | Solvay Pharmaceuticals B.V. | Defective influenza virus particles |
| CN101056976A (zh) * | 2004-11-11 | 2007-10-17 | 索尔瓦药物有限公司 | 有缺陷的流感病毒颗粒 |
| EA200701097A1 (ru) | 2004-11-19 | 2007-10-26 | Висконсин Эламни Рисёч Фаундэйшн | Рекомбинантные векторы вируса гриппа с тандемными транскрипционными единицами |
| CA2647985C (en) | 2006-03-31 | 2014-12-30 | Warf-Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| AU2007297801A1 (en) | 2006-07-14 | 2008-03-27 | Sanofi Pasteur Biologics Co. | Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins |
| EP2069483A4 (en) * | 2006-09-29 | 2010-10-27 | Sanofi Pasteur Biologics Co | RECOMBINANT RHINOVIRAL VECTORS |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| US8883995B2 (en) * | 2009-03-06 | 2014-11-11 | Icahn School Of Medicine At Mount Sinai | Live attenuated influenza virus vaccines comprising microRNA response elements |
| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| WO2011136421A1 (ko) * | 2010-04-30 | 2011-11-03 | 주식회사 바이오트라이온 | 신규한 프라이머 및 이를 이용한 재조합 독감 바이러스 제조방법 |
| KR102080061B1 (ko) * | 2011-06-24 | 2020-02-21 | 플루젠, 인코퍼레이티드 | 인플루엔자 바이러스 돌연변이체들 및 그들의 용도들 |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型pb2遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| CN107208071B (zh) * | 2014-11-13 | 2021-11-30 | 港大科桥有限公司 | 用于流感病毒的减弱活疫苗 |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| US9890363B2 (en) | 2015-07-06 | 2018-02-13 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US10494613B2 (en) * | 2015-08-28 | 2019-12-03 | Wisconsin Alumni Research Foundation (Warf) | Generation of infectious influenza viruses from virus-like particles |
| US11197925B2 (en) | 2016-02-19 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Influenza B virus replication for vaccine development |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン(ha)タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| EP3914295A2 (en) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたnaを有する組換えインフルエンザウイルス |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| EP4185601A4 (en) | 2020-07-21 | 2024-10-30 | Flugen, Inc. | SKELETON OF THE INFLUENZA VIRUS |
| CN114381439B (zh) * | 2022-01-27 | 2023-12-15 | 浙江迪福润丝生物科技有限公司 | 一种同义突变结合删除突变的流感病毒的致弱方法及致弱流感病毒株和应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1338307A (zh) * | 2000-08-10 | 2002-03-06 | 清华大学 | 一种流感病毒表位疫苗及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219515A (en) * | 1987-02-10 | 1989-09-27 | Wellcome Found | Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope |
| JPS6479273A (en) * | 1987-09-21 | 1989-03-24 | Nippon Ester Co Ltd | Resin composition for powder coating |
| US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| RU2033424C1 (ru) * | 1991-03-19 | 1995-04-20 | Научно-исследовательский институт гриппа РАМН | Штамм вируса гриппа а (нзn2) для получения живой гриппозной интраназальной вакцины для взрослых и детей |
| RU2008351C1 (ru) * | 1991-06-27 | 1994-02-28 | Научно-исследовательский институт экспериментальной медицины РАМН | Штамм вируса гриппа в/14/28, р для получения живой интраназальной гриппозной вакцины для детей |
| US5919676A (en) | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| US5994526A (en) | 1996-06-21 | 1999-11-30 | Plant Genetic Systems | Gene expression in plants |
| CA2297786C (en) * | 1997-08-05 | 2011-06-14 | Vlaams Interuniversitair Instituut Voor Biotechnologie | New immunoprotective influenza antigen and its use in vaccination |
| EP1035209A1 (en) | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stable recombinant influenza viruses free of helper viruses |
| US6686168B1 (en) * | 1999-11-04 | 2004-02-03 | Zymogenetics, Inc. | Cell surface display of proteins by recombinant host cells |
| JP4927290B2 (ja) * | 2000-04-14 | 2012-05-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 変異イオンチャンネルタンパク質を含んで成るウイルス |
| AU2004232992A1 (en) | 2003-04-23 | 2004-11-04 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| CA2647985C (en) | 2006-03-31 | 2014-12-30 | Warf-Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
-
2004
- 2004-04-20 AU AU2004232992A patent/AU2004232992A1/en not_active Abandoned
- 2004-04-20 CA CA2522081A patent/CA2522081C/en not_active Expired - Fee Related
- 2004-04-20 WO PCT/US2004/012050 patent/WO2004094466A2/en not_active Ceased
- 2004-04-20 RU RU2005136233/13A patent/RU2351651C2/ru not_active IP Right Cessation
- 2004-04-20 NZ NZ542935A patent/NZ542935A/en not_active IP Right Cessation
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- 2004-04-20 CN CN200480017037XA patent/CN1809633B/zh not_active Expired - Fee Related
- 2004-04-20 EP EP04750333A patent/EP1618191A2/en not_active Withdrawn
- 2004-04-20 KR KR1020057020077A patent/KR100869011B1/ko not_active Expired - Fee Related
- 2004-04-20 JP JP2006513125A patent/JP2007525175A/ja not_active Withdrawn
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2009
- 2009-05-18 US US12/467,492 patent/US20100247572A1/en not_active Abandoned
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2011
- 2011-05-18 JP JP2011111048A patent/JP5438065B2/ja not_active Expired - Fee Related
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2013
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1338307A (zh) * | 2000-08-10 | 2002-03-06 | 清华大学 | 一种流感病毒表位疫苗及其制备方法 |
Non-Patent Citations (4)
| Title |
|---|
| 刘秀梵 |
| 刘红旗 |
| 刘红旗;刘秀梵;张如宽.A型流感病毒蛋白研究进展.动物医学进展23 2.2002,23(2),6-9. * |
| 张如宽.A型流感病毒蛋白研究进展.动物医学进展23 2.2002,23(2),6-9. |
Also Published As
| Publication number | Publication date |
|---|---|
| US7588769B2 (en) | 2009-09-15 |
| NZ542935A (en) | 2008-08-29 |
| CA2522081C (en) | 2013-01-29 |
| JP5438065B2 (ja) | 2014-03-12 |
| WO2004094466A3 (en) | 2005-03-31 |
| CA2522081A1 (en) | 2004-11-04 |
| MXPA05011250A (es) | 2006-03-30 |
| JP2014039551A (ja) | 2014-03-06 |
| CN1809633A (zh) | 2006-07-26 |
| EP1618191A2 (en) | 2006-01-25 |
| KR20060006055A (ko) | 2006-01-18 |
| RU2005136233A (ru) | 2006-06-10 |
| US20100247572A1 (en) | 2010-09-30 |
| AU2004232992A1 (en) | 2004-11-04 |
| JP2011177192A (ja) | 2011-09-15 |
| JP2007525175A (ja) | 2007-09-06 |
| KR100869011B1 (ko) | 2008-11-17 |
| WO2004094466A2 (en) | 2004-11-04 |
| RU2351651C2 (ru) | 2009-04-10 |
| US20040219170A1 (en) | 2004-11-04 |
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