CN1809633B - 跨膜蛋白基因中含有突变的重组流感病毒 - Google Patents

跨膜蛋白基因中含有突变的重组流感病毒 Download PDF

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CN1809633B
CN1809633B CN200480017037XA CN200480017037A CN1809633B CN 1809633 B CN1809633 B CN 1809633B CN 200480017037X A CN200480017037X A CN 200480017037XA CN 200480017037 A CN200480017037 A CN 200480017037A CN 1809633 B CN1809633 B CN 1809633B
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CN1809633A (zh
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河冈义裕
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Wisconsin Alumni Research Foundation
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CN200480017037XA 2003-04-23 2004-04-20 跨膜蛋白基因中含有突变的重组流感病毒 Expired - Fee Related CN1809633B (zh)

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US46477603P 2003-04-23 2003-04-23
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US46532803P 2003-04-24 2003-04-24
US60/465,328 2003-04-24
PCT/US2004/012050 WO2004094466A2 (en) 2003-04-23 2004-04-20 Recombinant influenza viruses holding a mutation in a transmembrane protein gene

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EP (1) EP1618191A2 (https=)
JP (3) JP2007525175A (https=)
KR (1) KR100869011B1 (https=)
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AU (1) AU2004232992A1 (https=)
CA (1) CA2522081C (https=)
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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1052949B (en) 2000-04-14 2011-04-29 Wisconsin Alumni Research Foundation Viruses comprising mutated ion channel protein
NZ542935A (en) * 2003-04-23 2008-08-29 Wisconsin Alumni Res Found Recombinant influenza viruses holding a mutation in a transmembrane protein gene
AU2004249133B2 (en) * 2003-05-28 2009-05-28 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines and gene therapy
RU2420577C2 (ru) * 2004-11-11 2011-06-10 Эбботт Байолоджикалз Б.В. Условно дефектная частица вируса гриппа и способы ее получения (варианты)
AU2005303817B8 (en) * 2004-11-11 2010-09-30 Abbott Biologicals B.V. Defective influenza virus particles
CN101103103A (zh) 2004-11-19 2008-01-09 威斯康星旧生研究基金会 具有串联转录单位的重组流感病毒载体
WO2007126810A2 (en) 2006-03-31 2007-11-08 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
RU2009105099A (ru) 2006-07-14 2010-08-27 Санофи Пастер Байолоджикс Ко. (Us) Конструирование рекомбинантных вирусных вакцин путем прямой транспозон-опосредованной инсерции чужеродных иммунологических детерминант в белки векторного вируса
KR20090096414A (ko) 2006-09-29 2009-09-10 사노피 파스테르 바이오로직스 씨오 재조합 리노바이러스 벡터
WO2008156778A2 (en) 2007-06-18 2008-12-24 Tokiko Watanabe Influenza m2 protein mutant viruses as live influenza attenuated vaccines
US8883995B2 (en) * 2009-03-06 2014-11-11 Icahn School Of Medicine At Mount Sinai Live attenuated influenza virus vaccines comprising microRNA response elements
EP2493912B1 (en) 2009-10-26 2020-07-29 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
WO2011136421A1 (ko) * 2010-04-30 2011-11-03 주식회사 바이오트라이온 신규한 프라이머 및 이를 이용한 재조합 독감 바이러스 제조방법
EP2723855B1 (en) * 2011-06-24 2018-08-08 Flugen, Inc. Influenza virus mutants and uses therefor
ES2655051T3 (es) 2011-08-26 2018-02-16 Wisconsin Alumni Research Foundation Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas
US9950057B2 (en) 2013-07-15 2018-04-24 Wisconsin Alumni Research Foundation (Warf) High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
AU2015345579B2 (en) * 2014-11-13 2019-02-21 Versitech Limited Live attenuated vaccines for influenza viruses
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
WO2017040203A1 (en) * 2015-08-28 2017-03-09 Yoshihiro Kawaoka Generation of infectious influenza viruses from virus-like particles
CA3014435C (en) 2016-02-19 2023-04-18 Wisconsin Alumni Research Foundation (Warf) Improved influenza b virus replication for vaccine development
WO2019084310A1 (en) 2017-10-25 2019-05-02 Yoshihiro Kawaoka HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION
US12343390B2 (en) 2018-08-07 2025-07-01 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
US11241492B2 (en) 2019-01-23 2022-02-08 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to genes in influenza viruses
WO2020163804A1 (en) 2019-02-08 2020-08-13 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
WO2021150874A1 (en) 2020-01-24 2021-07-29 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized na
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
CN116134137A (zh) 2020-07-21 2023-05-16 复尔健有限公司 流感病毒骨架
CN114381439B (zh) * 2022-01-27 2023-12-15 浙江迪福润丝生物科技有限公司 一种同义突变结合删除突变的流感病毒的致弱方法及致弱流感病毒株和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1338307A (zh) * 2000-08-10 2002-03-06 清华大学 一种流感病毒表位疫苗及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219515A (en) * 1987-02-10 1989-09-27 Wellcome Found Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope
JPS6479273A (en) * 1987-09-21 1989-03-24 Nippon Ester Co Ltd Resin composition for powder coating
US5840520A (en) 1989-08-28 1998-11-24 Aviron Recombinant negative strand RNA virus expression systems
RU2033424C1 (ru) * 1991-03-19 1995-04-20 Научно-исследовательский институт гриппа РАМН Штамм вируса гриппа а (нзn2) для получения живой гриппозной интраназальной вакцины для взрослых и детей
RU2008351C1 (ru) * 1991-06-27 1994-02-28 Научно-исследовательский институт экспериментальной медицины РАМН Штамм вируса гриппа в/14/28, р для получения живой интраназальной гриппозной вакцины для детей
US5919676A (en) 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
US5994526A (en) 1996-06-21 1999-11-30 Plant Genetic Systems Gene expression in plants
ES2255181T3 (es) * 1997-08-05 2006-06-16 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Antigeno inmunoprotector contra la gripe y su uso en vacunacion.
EP1035209A1 (en) 1999-03-06 2000-09-13 ARTEMIS Pharmaceuticals GmbH Stable recombinant influenza viruses free of helper viruses
US6686168B1 (en) * 1999-11-04 2004-02-03 Zymogenetics, Inc. Cell surface display of proteins by recombinant host cells
HK1052949B (en) * 2000-04-14 2011-04-29 Wisconsin Alumni Research Foundation Viruses comprising mutated ion channel protein
NZ542935A (en) 2003-04-23 2008-08-29 Wisconsin Alumni Res Found Recombinant influenza viruses holding a mutation in a transmembrane protein gene
WO2007126810A2 (en) 2006-03-31 2007-11-08 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1338307A (zh) * 2000-08-10 2002-03-06 清华大学 一种流感病毒表位疫苗及其制备方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
刘秀梵
刘红旗
刘红旗;刘秀梵;张如宽.A型流感病毒蛋白研究进展.动物医学进展23 2.2002,23(2),6-9. *
张如宽.A型流感病毒蛋白研究进展.动物医学进展23 2.2002,23(2),6-9.

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AU2004232992A1 (en) 2004-11-04
KR100869011B1 (ko) 2008-11-17
JP2014039551A (ja) 2014-03-06
JP2011177192A (ja) 2011-09-15
WO2004094466A2 (en) 2004-11-04
CN1809633A (zh) 2006-07-26
RU2351651C2 (ru) 2009-04-10
US20040219170A1 (en) 2004-11-04
WO2004094466A3 (en) 2005-03-31
CA2522081C (en) 2013-01-29
KR20060006055A (ko) 2006-01-18
US20100247572A1 (en) 2010-09-30
MXPA05011250A (es) 2006-03-30
EP1618191A2 (en) 2006-01-25
RU2005136233A (ru) 2006-06-10
US7588769B2 (en) 2009-09-15

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