RU2342947C1 - Выбрасываемая жидкость, устройство для выбрасывания, картридж для выбрасывания и способ получения капель жидкости - Google Patents
Выбрасываемая жидкость, устройство для выбрасывания, картридж для выбрасывания и способ получения капель жидкости Download PDFInfo
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- B41J29/00—Details of, or accessories for, typewriters or selective printing mechanisms not otherwise provided for
- B41J29/12—Guards, shields or dust excluders
- B41J29/13—Cases or covers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/30—Inkjet printing inks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
- A61M2205/123—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Coating Apparatus (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004-279864 | 2004-09-27 | ||
| JP2004279864 | 2004-09-27 | ||
| JP2005252154A JP4147234B2 (ja) | 2004-09-27 | 2005-08-31 | 吐出用液体、吐出方法、カートリッジ及び吐出装置 |
| JP2005-252154 | 2005-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2342947C1 true RU2342947C1 (ru) | 2009-01-10 |
Family
ID=36119107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007115884/28A RU2342947C1 (ru) | 2004-09-27 | 2005-09-27 | Выбрасываемая жидкость, устройство для выбрасывания, картридж для выбрасывания и способ получения капель жидкости |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8029609B2 (enExample) |
| EP (1) | EP1776135A4 (enExample) |
| JP (1) | JP4147234B2 (enExample) |
| CN (1) | CN101027077B (enExample) |
| RU (1) | RU2342947C1 (enExample) |
| WO (1) | WO2006035977A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4147234B2 (ja) | 2004-09-27 | 2008-09-10 | キヤノン株式会社 | 吐出用液体、吐出方法、カートリッジ及び吐出装置 |
| AU2002310054B2 (en) * | 2001-05-21 | 2007-02-01 | Injet Digital Aerosols Limited | Compositions for protein delivery via the pulmonary route |
| JP4564936B2 (ja) * | 2006-03-27 | 2010-10-20 | キヤノン株式会社 | 吐出用液体、吐出方法、液滴化方法、液体吐出カートリッジ及び吐出装置 |
| JP2006087815A (ja) * | 2004-09-27 | 2006-04-06 | Canon Inc | 噴霧方法および該方法に基づく噴霧装置 |
| JP4147235B2 (ja) * | 2004-09-27 | 2008-09-10 | キヤノン株式会社 | 吐出用液体、吐出方法、液滴化方法、液体吐出カートリッジ及び吐出装置 |
| JP4646669B2 (ja) | 2005-03-30 | 2011-03-09 | キヤノン株式会社 | 吐出用液体、吐出方法、液滴化方法、カートリッジ及び吐出装置 |
| JP4689340B2 (ja) * | 2005-05-02 | 2011-05-25 | キヤノン株式会社 | 吐出用液体医薬組成物 |
| JP2007254421A (ja) * | 2006-03-24 | 2007-10-04 | Canon Inc | 吐出用液体、吐出方法、吐出用カートリッジ、吐出装置及び吐出用液体の液滴化方法 |
| JP4777225B2 (ja) * | 2006-12-04 | 2011-09-21 | キヤノン株式会社 | 吐出用液体及び吐出方法 |
| JP5110898B2 (ja) * | 2007-02-16 | 2012-12-26 | キヤノン株式会社 | 吐出用液体及び吐出方法 |
| AU2008299822A1 (en) * | 2007-06-20 | 2009-03-19 | Northwestern University | Universal matrix |
| USD613331S1 (en) * | 2009-01-27 | 2010-04-06 | Samsung Electronics Co., Ltd. | Toner cartridge for printer |
| US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| JP4784789B2 (ja) | 2009-06-29 | 2011-10-05 | セイコーエプソン株式会社 | 吐出用液体及び生体試料の吐出方法 |
| JP5451556B2 (ja) * | 2009-09-18 | 2014-03-26 | キヤノン株式会社 | 色素化合物 |
| US9545488B2 (en) | 2010-01-12 | 2017-01-17 | Dance Biopharm Inc. | Preservative-free single dose inhaler systems |
| US10525214B2 (en) | 2010-01-12 | 2020-01-07 | Dance Biopharm Inc. | Preservative-free single dose inhaler system |
| US10842951B2 (en) | 2010-01-12 | 2020-11-24 | Aerami Therapeutics, Inc. | Liquid insulin formulations and methods relating thereto |
| US9180261B2 (en) | 2010-01-12 | 2015-11-10 | Dance Biopharm Inc. | Preservative free insulin formulations and systems and methods for aerosolizing |
| US20130269684A1 (en) | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Methods and systems for supplying aerosolization devices with liquid medicaments |
| US8950394B2 (en) | 2010-01-12 | 2015-02-10 | Dance Biopharm Inc. | Preservative-free single dose inhaler systems |
| CA2816114C (en) * | 2010-11-03 | 2019-02-12 | Jan Jezek | Novel composition comprising glucagon |
| US10857313B2 (en) | 2014-07-01 | 2020-12-08 | Aerami Therapeutics, Inc. | Liquid nebulization systems and methods |
| US11273271B2 (en) | 2014-07-01 | 2022-03-15 | Aerami Therapeutics, Inc. | Aerosolization system with flow restrictor and feedback device |
| US10471222B2 (en) | 2014-07-01 | 2019-11-12 | Dance Biopharm Inc. | Aerosolization system with flow restrictor and feedback device |
| AR102869A1 (es) | 2014-12-16 | 2017-03-29 | Lilly Co Eli | Composiciones de insulina de rápida acción |
| CA3011902C (en) | 2015-02-25 | 2023-08-15 | Dance Biopharm, Inc. | Liquid insulin formulations and methods relating thereto |
| US10167399B2 (en) | 2016-01-22 | 2019-01-01 | Canon Kabushiki Kaisha | Ink, ink cartridge, and image recording method |
| US10190010B2 (en) | 2016-01-22 | 2019-01-29 | Canon Kabushiki Kaisha | Ink, ink cartridge, and image recording method |
| JP2017197709A (ja) | 2016-01-22 | 2017-11-02 | キヤノン株式会社 | インク、インクカートリッジ、及び画像記録方法 |
| JP2017128700A (ja) | 2016-01-22 | 2017-07-27 | キヤノン株式会社 | インク、インクカートリッジ、及び画像記録方法 |
| EP3196259A1 (en) | 2016-01-22 | 2017-07-26 | Canon Kabushiki Kaisha | Ink, ink cartridge, and image recording method |
| US12018162B2 (en) | 2018-10-25 | 2024-06-25 | Cabot Corporation | Acrylic polymers for inkjet ink applications |
| DE102018132106B4 (de) | 2018-12-13 | 2024-06-13 | Schott Ag | Wässrige Bedruckungszusammensetzungen und Verfahren zur Herstellung beschichteter Glassubstrate und Glassubstrat |
| EP4380591A4 (en) * | 2021-09-09 | 2025-01-08 | Ramot at Tel-Aviv University Ltd. | Peptide liquid droplets and methods of using the same |
| CN115192554A (zh) * | 2022-08-08 | 2022-10-18 | 浙江仙琚萃泽医药科技有限公司 | 无抛射剂的含肽吸入溶液剂及其制备方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2175866C2 (ru) * | 1994-12-22 | 2001-11-20 | Астра Актиеболаг | Аэрозольные препараты пептидов и белков |
| RU2179037C2 (ru) * | 1991-12-12 | 2002-02-10 | Глэксо Груп Лимитед | Баллон для доставки фармацевтического состава, дозирующий ингалятор |
| WO2002011695A2 (en) * | 2000-08-07 | 2002-02-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| JP2002248171A (ja) * | 2001-01-16 | 2002-09-03 | Hewlett Packard Co <Hp> | エアロゾルの液滴の熱生成 |
| WO2002094342A2 (en) * | 2001-05-21 | 2002-11-28 | Vapotronics, Inc. | Compositions for protein delivery via the pulmonary route |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371523A (en) * | 1980-12-29 | 1983-02-01 | The Regents Of The University Of California | Reducing the aggregation of insulin in solution |
| FI78616C (fi) * | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
| JPH0441421A (ja) * | 1990-06-07 | 1992-02-12 | Taisho Pharmaceut Co Ltd | 肺吸収組成物 |
| US5894841A (en) * | 1993-06-29 | 1999-04-20 | Ponwell Enterprises Limited | Dispenser |
| JP3867931B2 (ja) | 1993-11-08 | 2007-01-17 | 財団法人化学及血清療法研究所 | 液状フィブリノゲン製剤 |
| US5679143A (en) * | 1995-12-06 | 1997-10-21 | Hewlett-Packard Company | Bleed alleviation in ink jet inks using acids containing a basic functional group |
| TWI240627B (en) | 1996-04-26 | 2005-10-01 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| EP0909798B1 (en) * | 1997-03-25 | 2005-11-09 | Seiko Epson Corporation | Inks for ink-jet recording |
| CA2244414A1 (en) * | 1997-08-01 | 1999-02-01 | Canon Kabushiki Kaisha | Reaction site array, preparation process of it, reaction process using it and quantitative determination method of substance in sample solution using it |
| JP3610231B2 (ja) | 1997-08-01 | 2005-01-12 | キヤノン株式会社 | 反応場アレー、反応場アレーの製造方法、反応場アレーを用いた反応方法及び反応場アレーを用いた試料溶液中の物質の定量方法 |
| ZA989744B (en) * | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
| CN100389821C (zh) * | 1999-10-04 | 2008-05-28 | 希龙公司 | 稳定化的含多肽的液体药物组合物 |
| AU783795B2 (en) | 1999-12-30 | 2005-12-08 | Novartis Vaccines And Diagnostics, Inc. | Methods for pulmonary delivery of interleukin-2 |
| US6227367B1 (en) * | 2000-06-09 | 2001-05-08 | Riverwood International Corporation | Fully enclosed carton with diamond corner panels |
| US6907005B1 (en) | 2000-07-24 | 2005-06-14 | Telefonaktiebolaget L M Ericsson (Publ) | Flexible ARQ for packet data transmission |
| JP4147234B2 (ja) * | 2004-09-27 | 2008-09-10 | キヤノン株式会社 | 吐出用液体、吐出方法、カートリッジ及び吐出装置 |
| WO2002013860A1 (en) * | 2000-08-11 | 2002-02-21 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing preparations |
| EP1329224A4 (en) | 2000-09-01 | 2004-04-14 | Chugai Pharmaceutical Co Ltd | PREPARATIONS OF STABILIZED SOLUTIONS OVER A LONG PERIOD OF TIME |
| JP2002148259A (ja) | 2000-11-07 | 2002-05-22 | Rohto Pharmaceut Co Ltd | 被検試料の調製方法 |
| DE50114021D1 (de) * | 2001-01-08 | 2008-07-24 | Csl Behring Gmbh | Stabilisierte Flüssigzubereitung der den Blutgerinnungsfaktor VII aktivierenden Protease oder ihres Proenzyms |
| JP4378069B2 (ja) | 2001-03-29 | 2009-12-02 | キヤノン株式会社 | 細胞スクリーニング基板とその製造方法、それを用いた細胞スクリーニング法および細胞スクリーニング装置 |
| EP1248108B1 (en) * | 2001-03-29 | 2011-08-31 | Canon Kabushiki Kaisha | method of cellular screening and substrates suitable for it |
| US7833701B2 (en) * | 2001-05-11 | 2010-11-16 | Panasonic Corporation | Biomolecule substrate, and test and diagnosis methods and apparatuses using the same |
| JP2003154655A (ja) | 2001-11-22 | 2003-05-27 | Canon Inc | 液体吐出ヘッド |
| JP2003154665A (ja) | 2001-11-22 | 2003-05-27 | Canon Inc | 液体吐出ヘッド |
| DE60234373D1 (de) * | 2001-11-22 | 2009-12-24 | Canon Kk | Flüssigkeitsstrahlkopf |
| US6838975B2 (en) | 2001-12-20 | 2005-01-04 | Xerox Corporation | Retractable pin array identification apparatus and method |
| JP4612788B2 (ja) * | 2002-05-21 | 2011-01-12 | キヤノン株式会社 | 水不溶性色材を含む粒子の分散体及びその製造方法 |
| US20040045546A1 (en) * | 2002-09-05 | 2004-03-11 | Peirce Management, Llc | Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use |
| JP4508703B2 (ja) * | 2003-04-24 | 2010-07-21 | キヤノン株式会社 | インクジェット用インク及びこれを用いたインクジェット記録方法 |
| US7598012B2 (en) * | 2003-05-16 | 2009-10-06 | Canon Kabushiki Kaisha | Coloring compound and recording material using the same |
| JP4731923B2 (ja) * | 2004-02-13 | 2011-07-27 | キヤノン株式会社 | 新規な色素化合物、インク、インクタンク、記録ユニット、記録装置及び記録方法 |
| US7303615B2 (en) * | 2004-02-27 | 2007-12-04 | Canon Kabushiki Kaisha | Colorant material, and water dispersion, ink, ink tank, recording unit, recording apparatus and recording method using the same |
| JP2007254421A (ja) * | 2006-03-24 | 2007-10-04 | Canon Inc | 吐出用液体、吐出方法、吐出用カートリッジ、吐出装置及び吐出用液体の液滴化方法 |
| JP5020542B2 (ja) * | 2006-05-19 | 2012-09-05 | キヤノン株式会社 | 新規色素化合物及び該色素化合物を含有するインク |
-
2005
- 2005-08-31 JP JP2005252154A patent/JP4147234B2/ja not_active Expired - Fee Related
- 2005-09-27 WO PCT/JP2005/018247 patent/WO2006035977A1/en not_active Ceased
- 2005-09-27 CN CN2005800324989A patent/CN101027077B/zh not_active Expired - Fee Related
- 2005-09-27 US US11/570,744 patent/US8029609B2/en not_active Expired - Fee Related
- 2005-09-27 EP EP05788361A patent/EP1776135A4/en not_active Withdrawn
- 2005-09-27 RU RU2007115884/28A patent/RU2342947C1/ru not_active IP Right Cessation
-
2007
- 2007-03-15 US US11/724,299 patent/US7827982B2/en not_active Expired - Fee Related
- 2007-05-09 US US11/746,305 patent/US7605124B2/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2179037C2 (ru) * | 1991-12-12 | 2002-02-10 | Глэксо Груп Лимитед | Баллон для доставки фармацевтического состава, дозирующий ингалятор |
| RU2175866C2 (ru) * | 1994-12-22 | 2001-11-20 | Астра Актиеболаг | Аэрозольные препараты пептидов и белков |
| WO2002011695A2 (en) * | 2000-08-07 | 2002-02-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| JP2002248171A (ja) * | 2001-01-16 | 2002-09-03 | Hewlett Packard Co <Hp> | エアロゾルの液滴の熱生成 |
| WO2002094342A2 (en) * | 2001-05-21 | 2002-11-28 | Vapotronics, Inc. | Compositions for protein delivery via the pulmonary route |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101027077A (zh) | 2007-08-29 |
| US20080029083A1 (en) | 2008-02-07 |
| US7827982B2 (en) | 2010-11-09 |
| US20070222842A1 (en) | 2007-09-27 |
| JP2006117632A (ja) | 2006-05-11 |
| EP1776135A1 (en) | 2007-04-25 |
| US7605124B2 (en) | 2009-10-20 |
| WO2006035977A1 (en) | 2006-04-06 |
| CN101027077B (zh) | 2012-09-19 |
| US20070206081A1 (en) | 2007-09-06 |
| JP4147234B2 (ja) | 2008-09-10 |
| EP1776135A4 (en) | 2012-11-28 |
| US8029609B2 (en) | 2011-10-04 |
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