RU2322438C2 - Азаспиросоединения для лечения болей - Google Patents

Азаспиросоединения для лечения болей Download PDF

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Publication number
RU2322438C2
RU2322438C2 RU2004129769/04A RU2004129769A RU2322438C2 RU 2322438 C2 RU2322438 C2 RU 2322438C2 RU 2004129769/04 A RU2004129769/04 A RU 2004129769/04A RU 2004129769 A RU2004129769 A RU 2004129769A RU 2322438 C2 RU2322438 C2 RU 2322438C2
Authority
RU
Russia
Prior art keywords
azaspiro
group
thion
ring
compounds
Prior art date
Application number
RU2004129769/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2004129769A (ru
Inventor
Клаус МЕЗЕ (DE)
Клаус МЕЗЕ
Норма ЗЕЛЬВЕ (DE)
Норма Зельве
Дирк ШМИДТ (DE)
Дирк Шмидт
Original Assignee
Шварц Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шварц Фарма Аг filed Critical Шварц Фарма Аг
Publication of RU2004129769A publication Critical patent/RU2004129769A/ru
Application granted granted Critical
Publication of RU2322438C2 publication Critical patent/RU2322438C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
RU2004129769/04A 2002-03-07 2003-02-27 Азаспиросоединения для лечения болей RU2322438C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10210190A DE10210190A1 (de) 2002-03-07 2002-03-07 Aza-Spiroverbindungen
DE10210190.6 2002-03-07

Publications (2)

Publication Number Publication Date
RU2004129769A RU2004129769A (ru) 2005-07-10
RU2322438C2 true RU2322438C2 (ru) 2008-04-20

Family

ID=27771112

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004129769/04A RU2322438C2 (ru) 2002-03-07 2003-02-27 Азаспиросоединения для лечения болей

Country Status (19)

Country Link
US (1) US20050288351A1 (enExample)
EP (2) EP1520854A3 (enExample)
JP (1) JP2005526745A (enExample)
KR (1) KR20040091638A (enExample)
CN (1) CN1324011C (enExample)
AT (1) ATE298745T1 (enExample)
AU (1) AU2003215603A1 (enExample)
BR (1) BR0307922A (enExample)
CA (1) CA2477124A1 (enExample)
DE (2) DE10210190A1 (enExample)
ES (1) ES2242944T3 (enExample)
MX (1) MXPA04008669A (enExample)
NO (1) NO20044239L (enExample)
PL (1) PL372431A1 (enExample)
PT (1) PT1485352E (enExample)
RU (1) RU2322438C2 (enExample)
UA (1) UA78987C2 (enExample)
WO (1) WO2003074486A1 (enExample)
ZA (1) ZA200406245B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201607923A (zh) * 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
CN107216335B (zh) * 2017-06-29 2019-04-30 上海药明康德新药开发有限公司 一种叔丁基1-(羟甲基)-3-氧杂-9-氮杂螺[5.5]十一烷-9-甲酸基酯制法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB967718A (en) * 1960-07-19 1964-08-26 Geschickter Fund Med Res N-substituted azaspiranes
GB1164503A (en) * 1966-02-01 1969-09-17 Mead Johnson & Co Azaspiroalkanediones, process for preparing the same and Pharmaceutical Compositions comprising the same
RU95114363A (ru) * 1992-11-09 1997-03-20 Дзе Бутс Компани ПЛС. (GB) Производные азаспиросоединений, способ их получения, фармацевтическая композиция, средства для лечения ожирения, средства для лечения аффективных расстройств
EP0977758A1 (en) * 1997-04-25 2000-02-09 MERCK SHARP & DOHME LTD. Spiro-azacyclic derivatives and their use as therapeutic agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2866734A (en) * 1956-12-05 1958-12-30 Us Vitamin Corp 3-pyridylethyl 2, 4-oxazolidinediones and process
US3629276A (en) * 1969-07-16 1971-12-21 Abbott Lab 2-amino-5-spiro-substituted-oxazo compounds
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
GB8916447D0 (en) * 1989-07-19 1989-09-06 Ici Plc Composition,process and use
US5132451A (en) * 1989-08-25 1992-07-21 Warner-Lambert Company Process for cyclic amino acid anticonvulsant compounds
US5319135A (en) * 1989-08-25 1994-06-07 Warner-Lambert Company Process for cyclic amino acid anticonvulsant compounds
US5925672A (en) * 1996-12-06 1999-07-20 Neurosciences Research Foundation, Inc. Methods of treating mental diseases, inflammation and pain
DE19732928C2 (de) * 1997-07-31 2000-05-18 Gruenenthal Gmbh Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel
US5948807A (en) * 1997-09-03 1999-09-07 Regents Of The University Of Minnesota Spiroindanamines and Spiroindanimides
DE19751062A1 (de) * 1997-11-18 1999-07-08 Univ Ludwigs Albert An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels
JP2002516312A (ja) * 1998-05-26 2002-06-04 ワーナー−ランバート・カンパニー カルシウムチャンネルのα２δサブユニットに対する親和性を有する立体配座的に制約されたアミノ酸化合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB967718A (en) * 1960-07-19 1964-08-26 Geschickter Fund Med Res N-substituted azaspiranes
GB1164503A (en) * 1966-02-01 1969-09-17 Mead Johnson & Co Azaspiroalkanediones, process for preparing the same and Pharmaceutical Compositions comprising the same
RU95114363A (ru) * 1992-11-09 1997-03-20 Дзе Бутс Компани ПЛС. (GB) Производные азаспиросоединений, способ их получения, фармацевтическая композиция, средства для лечения ожирения, средства для лечения аффективных расстройств
EP0977758A1 (en) * 1997-04-25 2000-02-09 MERCK SHARP & DOHME LTD. Spiro-azacyclic derivatives and their use as therapeutic agents

Also Published As

Publication number Publication date
MXPA04008669A (es) 2004-12-06
EP1520854A3 (de) 2007-02-21
CN1324011C (zh) 2007-07-04
KR20040091638A (ko) 2004-10-28
CN1639122A (zh) 2005-07-13
DE50300710D1 (de) 2005-08-04
DE10210190A1 (de) 2003-09-25
BR0307922A (pt) 2004-12-21
CA2477124A1 (en) 2003-09-12
EP1520854A2 (de) 2005-04-06
EP1485352A1 (de) 2004-12-15
WO2003074486A1 (de) 2003-09-12
UA78987C2 (en) 2007-05-10
HK1080468A1 (zh) 2006-04-28
RU2004129769A (ru) 2005-07-10
ATE298745T1 (de) 2005-07-15
PT1485352E (pt) 2005-10-31
US20050288351A1 (en) 2005-12-29
ES2242944T3 (es) 2005-11-16
JP2005526745A (ja) 2005-09-08
NO20044239L (no) 2004-12-01
ZA200406245B (en) 2005-06-13
PL372431A1 (en) 2005-07-25
AU2003215603A1 (en) 2003-09-16
EP1485352B1 (de) 2005-06-29
AU2003215603A2 (en) 2003-09-16

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Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20090228