BR0307922A - Compostos de aza-espiro para tratamento de dores, composição farmacêutica compreendendo os mesmos e uso dos mesmos para produção de um medicamento - Google Patents
Compostos de aza-espiro para tratamento de dores, composição farmacêutica compreendendo os mesmos e uso dos mesmos para produção de um medicamentoInfo
- Publication number
- BR0307922A BR0307922A BR0307922-8A BR0307922A BR0307922A BR 0307922 A BR0307922 A BR 0307922A BR 0307922 A BR0307922 A BR 0307922A BR 0307922 A BR0307922 A BR 0307922A
- Authority
- BR
- Brazil
- Prior art keywords
- amino
- amido
- sulfonyl
- cooh
- cho
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 9
- 125000003368 amide group Chemical group 0.000 abstract 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 6
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 6
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 6
- 150000008627 azaspiro compounds Chemical class 0.000 abstract 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000000464 thioxo group Chemical group S=* 0.000 abstract 2
- JAWPQJDOQPSNIQ-UHFFFAOYSA-N 2-Azaspiro[4.5]decan-3-one Chemical compound C1NC(=O)CC21CCCCC2 JAWPQJDOQPSNIQ-UHFFFAOYSA-N 0.000 abstract 1
- RBRHMJWQHKXACY-UHFFFAOYSA-N 2-azaspiro[4.6]undecane-3-thione Chemical compound C1NC(=S)CC21CCCCCC2 RBRHMJWQHKXACY-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000007912 intraperitoneal administration Methods 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10210190A DE10210190A1 (de) | 2002-03-07 | 2002-03-07 | Aza-Spiroverbindungen |
| PCT/EP2003/001986 WO2003074486A1 (de) | 2002-03-07 | 2003-02-27 | Aza-spiroverbindungen zur behandlug von schmerzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0307922A true BR0307922A (pt) | 2004-12-21 |
Family
ID=27771112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0307922-8A BR0307922A (pt) | 2002-03-07 | 2003-02-27 | Compostos de aza-espiro para tratamento de dores, composição farmacêutica compreendendo os mesmos e uso dos mesmos para produção de um medicamento |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20050288351A1 (enExample) |
| EP (2) | EP1520854A3 (enExample) |
| JP (1) | JP2005526745A (enExample) |
| KR (1) | KR20040091638A (enExample) |
| CN (1) | CN1324011C (enExample) |
| AT (1) | ATE298745T1 (enExample) |
| AU (1) | AU2003215603A1 (enExample) |
| BR (1) | BR0307922A (enExample) |
| CA (1) | CA2477124A1 (enExample) |
| DE (2) | DE10210190A1 (enExample) |
| ES (1) | ES2242944T3 (enExample) |
| MX (1) | MXPA04008669A (enExample) |
| NO (1) | NO20044239L (enExample) |
| PL (1) | PL372431A1 (enExample) |
| PT (1) | PT1485352E (enExample) |
| RU (1) | RU2322438C2 (enExample) |
| UA (1) | UA78987C2 (enExample) |
| WO (1) | WO2003074486A1 (enExample) |
| ZA (1) | ZA200406245B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201607923A (zh) * | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| CN107216335B (zh) * | 2017-06-29 | 2019-04-30 | 上海药明康德新药开发有限公司 | 一种叔丁基1-(羟甲基)-3-氧杂-9-氮杂螺[5.5]十一烷-9-甲酸基酯制法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2866734A (en) * | 1956-12-05 | 1958-12-30 | Us Vitamin Corp | 3-pyridylethyl 2, 4-oxazolidinediones and process |
| US3150143A (en) * | 1960-07-19 | 1964-09-22 | Geschicketer Fund For Medical | Therapeutically active nu-substituted azaspiranes |
| US3398151A (en) * | 1966-02-01 | 1968-08-20 | Mead Johnson & Co | Azaspirodecanediones and azaspiroundecanediones |
| US3629276A (en) * | 1969-07-16 | 1971-12-21 | Abbott Lab | 2-amino-5-spiro-substituted-oxazo compounds |
| US4430335A (en) * | 1983-02-09 | 1984-02-07 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 1-azaspiro[4,5]decanes and their analgesic compositions |
| GB8916447D0 (en) * | 1989-07-19 | 1989-09-06 | Ici Plc | Composition,process and use |
| US5132451A (en) * | 1989-08-25 | 1992-07-21 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
| US5319135A (en) * | 1989-08-25 | 1994-06-07 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
| RU95114363A (ru) * | 1992-11-09 | 1997-03-20 | Дзе Бутс Компани ПЛС. (GB) | Производные азаспиросоединений, способ их получения, фармацевтическая композиция, средства для лечения ожирения, средства для лечения аффективных расстройств |
| US5925672A (en) * | 1996-12-06 | 1999-07-20 | Neurosciences Research Foundation, Inc. | Methods of treating mental diseases, inflammation and pain |
| GB9708484D0 (en) * | 1997-04-25 | 1997-06-18 | Merck Sharp & Dohme | Therapeutic agents |
| DE19732928C2 (de) * | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
| US5948807A (en) * | 1997-09-03 | 1999-09-07 | Regents Of The University Of Minnesota | Spiroindanamines and Spiroindanimides |
| DE19751062A1 (de) * | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
| JP2002516312A (ja) * | 1998-05-26 | 2002-06-04 | ワーナー−ランバート・カンパニー | カルシウムチャンネルのα２δサブユニットに対する親和性を有する立体配座的に制約されたアミノ酸化合物 |
-
2002
- 2002-03-07 DE DE10210190A patent/DE10210190A1/de not_active Ceased
-
2003
- 2003-02-27 AT AT03743342T patent/ATE298745T1/de not_active IP Right Cessation
- 2003-02-27 EP EP04029311A patent/EP1520854A3/de not_active Withdrawn
- 2003-02-27 KR KR10-2004-7012680A patent/KR20040091638A/ko not_active Ceased
- 2003-02-27 MX MXPA04008669A patent/MXPA04008669A/es not_active Application Discontinuation
- 2003-02-27 CN CNB038054388A patent/CN1324011C/zh not_active Expired - Fee Related
- 2003-02-27 UA UA20041008091A patent/UA78987C2/uk unknown
- 2003-02-27 EP EP03743342A patent/EP1485352B1/de not_active Expired - Lifetime
- 2003-02-27 CA CA002477124A patent/CA2477124A1/en not_active Abandoned
- 2003-02-27 AU AU2003215603A patent/AU2003215603A1/en not_active Abandoned
- 2003-02-27 RU RU2004129769/04A patent/RU2322438C2/ru not_active IP Right Cessation
- 2003-02-27 BR BR0307922-8A patent/BR0307922A/pt not_active IP Right Cessation
- 2003-02-27 JP JP2003572956A patent/JP2005526745A/ja active Pending
- 2003-02-27 DE DE50300710T patent/DE50300710D1/de not_active Expired - Fee Related
- 2003-02-27 ES ES03743342T patent/ES2242944T3/es not_active Expired - Lifetime
- 2003-02-27 WO PCT/EP2003/001986 patent/WO2003074486A1/de not_active Ceased
- 2003-02-27 PT PT03743342T patent/PT1485352E/pt unknown
- 2003-02-27 PL PL03372431A patent/PL372431A1/xx not_active Application Discontinuation
-
2004
- 2004-08-05 ZA ZA200406245A patent/ZA200406245B/xx unknown
- 2004-09-07 US US10/936,134 patent/US20050288351A1/en not_active Abandoned
- 2004-10-06 NO NO20044239A patent/NO20044239L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04008669A (es) | 2004-12-06 |
| EP1520854A3 (de) | 2007-02-21 |
| CN1324011C (zh) | 2007-07-04 |
| KR20040091638A (ko) | 2004-10-28 |
| CN1639122A (zh) | 2005-07-13 |
| DE50300710D1 (de) | 2005-08-04 |
| DE10210190A1 (de) | 2003-09-25 |
| CA2477124A1 (en) | 2003-09-12 |
| EP1520854A2 (de) | 2005-04-06 |
| EP1485352A1 (de) | 2004-12-15 |
| WO2003074486A1 (de) | 2003-09-12 |
| UA78987C2 (en) | 2007-05-10 |
| HK1080468A1 (zh) | 2006-04-28 |
| RU2004129769A (ru) | 2005-07-10 |
| ATE298745T1 (de) | 2005-07-15 |
| PT1485352E (pt) | 2005-10-31 |
| US20050288351A1 (en) | 2005-12-29 |
| ES2242944T3 (es) | 2005-11-16 |
| JP2005526745A (ja) | 2005-09-08 |
| NO20044239L (no) | 2004-12-01 |
| ZA200406245B (en) | 2005-06-13 |
| PL372431A1 (en) | 2005-07-25 |
| AU2003215603A1 (en) | 2003-09-16 |
| RU2322438C2 (ru) | 2008-04-20 |
| EP1485352B1 (de) | 2005-06-29 |
| AU2003215603A2 (en) | 2003-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011. |