CN1324011C - 用于治疗疼痛的氮杂－螺环化合物 - Google Patents

用于治疗疼痛的氮杂－螺环化合物 Download PDF

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Publication number
CN1324011C
CN1324011C CNB038054388A CN03805438A CN1324011C CN 1324011 C CN1324011 C CN 1324011C CN B038054388 A CNB038054388 A CN B038054388A CN 03805438 A CN03805438 A CN 03805438A CN 1324011 C CN1324011 C CN 1324011C
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CN
China
Prior art keywords
azaspiro
pain
ring
group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB038054388A
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English (en)
Chinese (zh)
Other versions
CN1639122A (zh
Inventor
C·梅泽
N·塞尔夫
D·施密德特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Pharma GmbH
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Schwarz Pharma AG
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Publication date
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Publication of CN1639122A publication Critical patent/CN1639122A/zh
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Publication of CN1324011C publication Critical patent/CN1324011C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
CNB038054388A 2002-03-07 2003-02-27 用于治疗疼痛的氮杂－螺环化合物 Expired - Fee Related CN1324011C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10210190A DE10210190A1 (de) 2002-03-07 2002-03-07 Aza-Spiroverbindungen
DE10210190.6 2002-03-07

Publications (2)

Publication Number Publication Date
CN1639122A CN1639122A (zh) 2005-07-13
CN1324011C true CN1324011C (zh) 2007-07-04

Family

ID=27771112

Family Applications (1)

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CNB038054388A Expired - Fee Related CN1324011C (zh) 2002-03-07 2003-02-27 用于治疗疼痛的氮杂－螺环化合物

Country Status (19)

Country Link
US (1) US20050288351A1 (enExample)
EP (2) EP1520854A3 (enExample)
JP (1) JP2005526745A (enExample)
KR (1) KR20040091638A (enExample)
CN (1) CN1324011C (enExample)
AT (1) ATE298745T1 (enExample)
AU (1) AU2003215603A1 (enExample)
BR (1) BR0307922A (enExample)
CA (1) CA2477124A1 (enExample)
DE (2) DE10210190A1 (enExample)
ES (1) ES2242944T3 (enExample)
MX (1) MXPA04008669A (enExample)
NO (1) NO20044239L (enExample)
PL (1) PL372431A1 (enExample)
PT (1) PT1485352E (enExample)
RU (1) RU2322438C2 (enExample)
UA (1) UA78987C2 (enExample)
WO (1) WO2003074486A1 (enExample)
ZA (1) ZA200406245B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201607923A (zh) * 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
CN107216335B (zh) * 2017-06-29 2019-04-30 上海药明康德新药开发有限公司 一种叔丁基1-(羟甲基)-3-氧杂-9-氮杂螺[5.5]十一烷-9-甲酸基酯制法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB967718A (en) * 1960-07-19 1964-08-26 Geschickter Fund Med Res N-substituted azaspiranes
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
WO1999025683A1 (de) * 1997-11-18 1999-05-27 KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITäT FREIBURG An 4-stellung substituierte 2-pyrrolidinon-derivate zur verringerung des extrazellulären glutamat-spiegels
US6316638B1 (en) * 1998-05-26 2001-11-13 Warner-Lambert Company Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2866734A (en) * 1956-12-05 1958-12-30 Us Vitamin Corp 3-pyridylethyl 2, 4-oxazolidinediones and process
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
US3629276A (en) * 1969-07-16 1971-12-21 Abbott Lab 2-amino-5-spiro-substituted-oxazo compounds
GB8916447D0 (en) * 1989-07-19 1989-09-06 Ici Plc Composition,process and use
US5132451A (en) * 1989-08-25 1992-07-21 Warner-Lambert Company Process for cyclic amino acid anticonvulsant compounds
US5319135A (en) * 1989-08-25 1994-06-07 Warner-Lambert Company Process for cyclic amino acid anticonvulsant compounds
RU95114363A (ru) * 1992-11-09 1997-03-20 Дзе Бутс Компани ПЛС. (GB) Производные азаспиросоединений, способ их получения, фармацевтическая композиция, средства для лечения ожирения, средства для лечения аффективных расстройств
US5925672A (en) * 1996-12-06 1999-07-20 Neurosciences Research Foundation, Inc. Methods of treating mental diseases, inflammation and pain
GB9708484D0 (en) * 1997-04-25 1997-06-18 Merck Sharp & Dohme Therapeutic agents
DE19732928C2 (de) * 1997-07-31 2000-05-18 Gruenenthal Gmbh Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel
US5948807A (en) * 1997-09-03 1999-09-07 Regents Of The University Of Minnesota Spiroindanamines and Spiroindanimides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB967718A (en) * 1960-07-19 1964-08-26 Geschickter Fund Med Res N-substituted azaspiranes
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
WO1999025683A1 (de) * 1997-11-18 1999-05-27 KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITäT FREIBURG An 4-stellung substituierte 2-pyrrolidinon-derivate zur verringerung des extrazellulären glutamat-spiegels
US6316638B1 (en) * 1998-05-26 2001-11-13 Warner-Lambert Company Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel

Also Published As

Publication number Publication date
MXPA04008669A (es) 2004-12-06
EP1520854A3 (de) 2007-02-21
KR20040091638A (ko) 2004-10-28
CN1639122A (zh) 2005-07-13
DE50300710D1 (de) 2005-08-04
DE10210190A1 (de) 2003-09-25
BR0307922A (pt) 2004-12-21
CA2477124A1 (en) 2003-09-12
EP1520854A2 (de) 2005-04-06
EP1485352A1 (de) 2004-12-15
WO2003074486A1 (de) 2003-09-12
UA78987C2 (en) 2007-05-10
HK1080468A1 (zh) 2006-04-28
RU2004129769A (ru) 2005-07-10
ATE298745T1 (de) 2005-07-15
PT1485352E (pt) 2005-10-31
US20050288351A1 (en) 2005-12-29
ES2242944T3 (es) 2005-11-16
JP2005526745A (ja) 2005-09-08
NO20044239L (no) 2004-12-01
ZA200406245B (en) 2005-06-13
PL372431A1 (en) 2005-07-25
AU2003215603A1 (en) 2003-09-16
RU2322438C2 (ru) 2008-04-20
EP1485352B1 (de) 2005-06-29
AU2003215603A2 (en) 2003-09-16

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