CA2477124A1 - Azaspiro compounds for the treatment of pain - Google Patents

Azaspiro compounds for the treatment of pain Download PDF

Info

Publication number
CA2477124A1
CA2477124A1 CA002477124A CA2477124A CA2477124A1 CA 2477124 A1 CA2477124 A1 CA 2477124A1 CA 002477124 A CA002477124 A CA 002477124A CA 2477124 A CA2477124 A CA 2477124A CA 2477124 A1 CA2477124 A1 CA 2477124A1
Authority
CA
Canada
Prior art keywords
azaspiro
ring
hydrogen
alkyl
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002477124A
Other languages
English (en)
French (fr)
Inventor
Claus Meese
Norma Selve
Dirk Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Pharma GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2477124A1 publication Critical patent/CA2477124A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
CA002477124A 2002-03-07 2003-02-27 Azaspiro compounds for the treatment of pain Abandoned CA2477124A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10210190A DE10210190A1 (de) 2002-03-07 2002-03-07 Aza-Spiroverbindungen
DE10210190.6 2002-03-07
PCT/EP2003/001986 WO2003074486A1 (de) 2002-03-07 2003-02-27 Aza-spiroverbindungen zur behandlug von schmerzen

Publications (1)

Publication Number Publication Date
CA2477124A1 true CA2477124A1 (en) 2003-09-12

Family

ID=27771112

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002477124A Abandoned CA2477124A1 (en) 2002-03-07 2003-02-27 Azaspiro compounds for the treatment of pain

Country Status (19)

Country Link
US (1) US20050288351A1 (enExample)
EP (2) EP1520854A3 (enExample)
JP (1) JP2005526745A (enExample)
KR (1) KR20040091638A (enExample)
CN (1) CN1324011C (enExample)
AT (1) ATE298745T1 (enExample)
AU (1) AU2003215603A1 (enExample)
BR (1) BR0307922A (enExample)
CA (1) CA2477124A1 (enExample)
DE (2) DE10210190A1 (enExample)
ES (1) ES2242944T3 (enExample)
MX (1) MXPA04008669A (enExample)
NO (1) NO20044239L (enExample)
PL (1) PL372431A1 (enExample)
PT (1) PT1485352E (enExample)
RU (1) RU2322438C2 (enExample)
UA (1) UA78987C2 (enExample)
WO (1) WO2003074486A1 (enExample)
ZA (1) ZA200406245B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201607923A (zh) * 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
CN107216335B (zh) * 2017-06-29 2019-04-30 上海药明康德新药开发有限公司 一种叔丁基1-(羟甲基)-3-氧杂-9-氮杂螺[5.5]十一烷-9-甲酸基酯制法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2866734A (en) * 1956-12-05 1958-12-30 Us Vitamin Corp 3-pyridylethyl 2, 4-oxazolidinediones and process
US3150143A (en) * 1960-07-19 1964-09-22 Geschicketer Fund For Medical Therapeutically active nu-substituted azaspiranes
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
US3629276A (en) * 1969-07-16 1971-12-21 Abbott Lab 2-amino-5-spiro-substituted-oxazo compounds
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
GB8916447D0 (en) * 1989-07-19 1989-09-06 Ici Plc Composition,process and use
US5319135A (en) * 1989-08-25 1994-06-07 Warner-Lambert Company Process for cyclic amino acid anticonvulsant compounds
US5132451A (en) * 1989-08-25 1992-07-21 Warner-Lambert Company Process for cyclic amino acid anticonvulsant compounds
RU95114363A (ru) * 1992-11-09 1997-03-20 Дзе Бутс Компани ПЛС. (GB) Производные азаспиросоединений, способ их получения, фармацевтическая композиция, средства для лечения ожирения, средства для лечения аффективных расстройств
US5925672A (en) * 1996-12-06 1999-07-20 Neurosciences Research Foundation, Inc. Methods of treating mental diseases, inflammation and pain
GB9708484D0 (en) * 1997-04-25 1997-06-18 Merck Sharp & Dohme Therapeutic agents
DE19732928C2 (de) * 1997-07-31 2000-05-18 Gruenenthal Gmbh Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel
US5948807A (en) * 1997-09-03 1999-09-07 Regents Of The University Of Minnesota Spiroindanamines and Spiroindanimides
DE19751062A1 (de) * 1997-11-18 1999-07-08 Univ Ludwigs Albert An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels
JP2002516312A (ja) * 1998-05-26 2002-06-04 ワーナー−ランバート・カンパニー カルシウムチャンネルのα２δサブユニットに対する親和性を有する立体配座的に制約されたアミノ酸化合物

Also Published As

Publication number Publication date
DE10210190A1 (de) 2003-09-25
CN1639122A (zh) 2005-07-13
ZA200406245B (en) 2005-06-13
RU2004129769A (ru) 2005-07-10
EP1520854A2 (de) 2005-04-06
MXPA04008669A (es) 2004-12-06
PT1485352E (pt) 2005-10-31
UA78987C2 (en) 2007-05-10
AU2003215603A1 (en) 2003-09-16
CN1324011C (zh) 2007-07-04
HK1080468A1 (zh) 2006-04-28
EP1520854A3 (de) 2007-02-21
WO2003074486A1 (de) 2003-09-12
ATE298745T1 (de) 2005-07-15
NO20044239L (no) 2004-12-01
EP1485352A1 (de) 2004-12-15
AU2003215603A2 (en) 2003-09-16
JP2005526745A (ja) 2005-09-08
KR20040091638A (ko) 2004-10-28
PL372431A1 (en) 2005-07-25
BR0307922A (pt) 2004-12-21
RU2322438C2 (ru) 2008-04-20
US20050288351A1 (en) 2005-12-29
DE50300710D1 (de) 2005-08-04
ES2242944T3 (es) 2005-11-16
EP1485352B1 (de) 2005-06-29

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued