RU2319702C2 - Негигроскопическая кристаллическая малеатная соль 5-[(z)-(5-фтор-2-оксо-1,2-дигидро-3h-индол-3-илиден)метил]-n-[(2s)-2-гидрокси-3-морфолин-4-илпропил]-2,4-диметил-1h-пиррол-3-карбоксамида, фармацевтическая композиция и способ лечения рака - Google Patents

Негигроскопическая кристаллическая малеатная соль 5-[(z)-(5-фтор-2-оксо-1,2-дигидро-3h-индол-3-илиден)метил]-n-[(2s)-2-гидрокси-3-морфолин-4-илпропил]-2,4-диметил-1h-пиррол-3-карбоксамида, фармацевтическая композиция и способ лечения рака Download PDF

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Publication number
RU2319702C2
RU2319702C2 RU2006110541/04A RU2006110541A RU2319702C2 RU 2319702 C2 RU2319702 C2 RU 2319702C2 RU 2006110541/04 A RU2006110541/04 A RU 2006110541/04A RU 2006110541 A RU2006110541 A RU 2006110541A RU 2319702 C2 RU2319702 C2 RU 2319702C2
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RU
Russia
Prior art keywords
fluoro
methyl
hydroxy
ylpropyl
ylidene
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RU2006110541/04A
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English (en)
Russian (ru)
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RU2006110541A (ru
Inventor
Андрей БЛАСКО (US)
Андрей БЛАСКО
Цинву ЦЗИНЬ (US)
Цинву ЦЗИНЬ
Цюнь ЛУ (US)
Цюнь ЛУ
Майкл Энтони МОРЕЙДЖИС (US)
Майкл Энтони МОРЕЙДЖИС
Донг СОНГ (US)
Донг СОНГ
Бренда Сью ВОНДЕРВЕЛЛ (US)
Бренда Сью ВОНДЕРВЕЛЛ
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Фармация Энд Апджон Компани Ллс
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2006110541/04A 2003-10-02 2004-09-20 Негигроскопическая кристаллическая малеатная соль 5-[(z)-(5-фтор-2-оксо-1,2-дигидро-3h-индол-3-илиден)метил]-n-[(2s)-2-гидрокси-3-морфолин-4-илпропил]-2,4-диметил-1h-пиррол-3-карбоксамида, фармацевтическая композиция и способ лечения рака RU2319702C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50810403P 2003-10-02 2003-10-02
US60/508,104 2003-10-02

Publications (2)

Publication Number Publication Date
RU2006110541A RU2006110541A (ru) 2006-08-27
RU2319702C2 true RU2319702C2 (ru) 2008-03-20

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RU2006110541/04A RU2319702C2 (ru) 2003-10-02 2004-09-20 Негигроскопическая кристаллическая малеатная соль 5-[(z)-(5-фтор-2-оксо-1,2-дигидро-3h-индол-3-илиден)метил]-n-[(2s)-2-гидрокси-3-морфолин-4-илпропил]-2,4-диметил-1h-пиррол-3-карбоксамида, фармацевтическая композиция и способ лечения рака

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US (1) US7247627B2 (enExample)
EP (1) EP1670785B1 (enExample)
JP (1) JP4933259B2 (enExample)
KR (2) KR20060058728A (enExample)
CN (1) CN100432072C (enExample)
AR (1) AR047762A1 (enExample)
AT (1) ATE473223T1 (enExample)
AU (1) AU2004277464B2 (enExample)
BR (1) BRPI0415022A (enExample)
CA (1) CA2540639C (enExample)
CY (1) CY1110771T1 (enExample)
DE (1) DE602004028028D1 (enExample)
DK (1) DK1670785T3 (enExample)
ES (1) ES2348623T3 (enExample)
IL (1) IL174414A (enExample)
MX (1) MXPA06003661A (enExample)
NO (1) NO20061246L (enExample)
NZ (1) NZ546001A (enExample)
PL (1) PL1670785T3 (enExample)
PT (1) PT1670785E (enExample)
RU (1) RU2319702C2 (enExample)
SI (1) SI1670785T1 (enExample)
TW (1) TW200524921A (enExample)
WO (1) WO2005033098A1 (enExample)
ZA (1) ZA200602691B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050182122A1 (en) * 2003-11-20 2005-08-18 Bello Carlo L. Method of treating abnormal cell growth using indolinone compounds
CA2602316A1 (en) * 2005-03-23 2006-09-28 Pfizer Products Inc. Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer
CN101267824A (zh) * 2005-09-20 2008-09-17 辉瑞产品公司 使用酪氨酸激酶抑制剂的治疗剂型和方法
TWI384986B (zh) * 2007-01-17 2013-02-11 Lg Life Sciences Ltd 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
KR101428833B1 (ko) * 2007-04-04 2014-08-08 오츠카 가가쿠 가부시키가이샤 티탄산칼륨, 그의 제조 방법, 마찰재 및 수지 조성물
KR101129088B1 (ko) * 2008-09-17 2012-03-23 노파르티스 아게 N-[6-(시스-2,6-디메틸모르폴린-4-일)피리딘-3-일]-2-메틸-4'-(트리플루오로메톡시)[1,1'-비페닐]-3-카르복스아미드의 염
RU2430361C1 (ru) * 2010-07-05 2011-09-27 Государственное образовательное учреждение высшего профессионального образования "Красноярский государственный медицинский университет им. В.Ф. Войно-Ясенецкого Министерства здравоохранения и социального развития Российской Федерации" Способ прогнозирования риска развития диабетической ретинопатии при сахарном диабете типа 2 у якутов
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
US9851313B2 (en) * 2015-03-03 2017-12-26 Panalytical B.V. Quantitative X-ray analysis—ratio correction

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1575936A3 (ru) * 1986-04-10 1990-06-30 Е.И.Дюпон Де Немур Энд Ко.(Фирма) Способ получени 3,3-дизамещенных индолин-2-ионов или их солей
WO2001060814A2 (en) * 2000-02-15 2001-08-23 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
WO2002066463A1 (en) * 2001-02-15 2002-08-29 Pharmacia & Upjohn Company 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors
WO2003070725A2 (en) * 2002-02-15 2003-08-28 Pharmacia & Upjohn Company Process for preparing indolinone derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534522A (en) * 1995-06-07 1996-07-09 Warner-Lambert Company (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
DE19622489A1 (de) * 1996-06-05 1997-12-11 Hoechst Ag Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters
SI1419151T1 (sl) 2001-08-15 2014-04-30 Pharmacia & Upjohn Company Llc Kristali, ki vključujejo sol jabolčne kisline N-(2-(dietilamino)etil)-5-((5-fluoro-1,2-dihidro-2-okso-3H-indol-3- iliden)metil)-2,4-dimetil-1H-pirol-3-karboksamida, postopki za njihovo pripravo in sestavki le-teh
YU67702A (sh) 2001-09-28 2004-12-31 Pfizer Products Inc. Postupak za dobijanje alkansulfonil piridina
TWI259081B (en) * 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
PY0323128A (es) * 2002-09-10 2012-12-03 Pharmacia Italia Spa Formulacion sólida que comprende un compuesto de indolina, útil en el tratamiento de trastornos relacionados con proteina de quinasas

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1575936A3 (ru) * 1986-04-10 1990-06-30 Е.И.Дюпон Де Немур Энд Ко.(Фирма) Способ получени 3,3-дизамещенных индолин-2-ионов или их солей
WO2001060814A2 (en) * 2000-02-15 2001-08-23 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
WO2002066463A1 (en) * 2001-02-15 2002-08-29 Pharmacia & Upjohn Company 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors
WO2003070725A2 (en) * 2002-02-15 2003-08-28 Pharmacia & Upjohn Company Process for preparing indolinone derivatives

Also Published As

Publication number Publication date
SI1670785T1 (sl) 2010-10-29
JP4933259B2 (ja) 2012-05-16
HK1093068A1 (zh) 2007-02-23
WO2005033098A9 (en) 2006-05-26
NO20061246L (no) 2006-03-29
CN100432072C (zh) 2008-11-12
RU2006110541A (ru) 2006-08-27
KR20080007520A (ko) 2008-01-21
US7247627B2 (en) 2007-07-24
WO2005033098A8 (en) 2006-04-20
MXPA06003661A (es) 2006-06-05
ZA200602691B (en) 2007-06-27
IL174414A0 (en) 2008-02-09
US20050118255A1 (en) 2005-06-02
CN1863796A (zh) 2006-11-15
CA2540639A1 (en) 2005-04-14
DK1670785T3 (da) 2010-10-18
IL174414A (en) 2011-12-29
ATE473223T1 (de) 2010-07-15
WO2005033098A1 (en) 2005-04-14
ES2348623T3 (es) 2010-12-09
PL1670785T3 (pl) 2010-12-31
PT1670785E (pt) 2010-09-16
EP1670785A1 (en) 2006-06-21
AU2004277464B2 (en) 2010-07-08
NZ546001A (en) 2009-09-25
CY1110771T1 (el) 2015-06-10
JP2007507482A (ja) 2007-03-29
BRPI0415022A (pt) 2006-11-28
KR20060058728A (ko) 2006-05-30
CA2540639C (en) 2010-08-31
DE602004028028D1 (de) 2010-08-19
AU2004277464A1 (en) 2005-04-14
AR047762A1 (es) 2006-02-22
TW200524921A (en) 2005-08-01
EP1670785B1 (en) 2010-07-07

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Effective date: 20110921