NO20061246L - Salter og polymorfe former av en pyrrol-substituert indolinonforbindelse - Google Patents

Salter og polymorfe former av en pyrrol-substituert indolinonforbindelse

Info

Publication number
NO20061246L
NO20061246L NO20061246A NO20061246A NO20061246L NO 20061246 L NO20061246 L NO 20061246L NO 20061246 A NO20061246 A NO 20061246A NO 20061246 A NO20061246 A NO 20061246A NO 20061246 L NO20061246 L NO 20061246L
Authority
NO
Norway
Prior art keywords
salts
pyrrole
polymorphic forms
indolinone compound
substituted indolinone
Prior art date
Application number
NO20061246A
Other languages
English (en)
Inventor
Andrei Blasko
Qingwu Jin
Qun Lu
Michael Anthony Mauragis
Dian Song
Brenda Sue Vonderwell
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of NO20061246L publication Critical patent/NO20061246L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Oppfinnelsen angår ikke-hygroskopiske salter av 5-[(Z)-(5-fluor-2-okso-1,2-dihydro-3H-indol-3-yliden)metyl]-N-[(2S)-2-hydroksy-3-morfolin-4-ylpropyl]-2,4-dimetyl-1 H-pyrrol-3-karboksamid, så som maleatsalter og krystallinske polymorfer av disse salter. Oppfinnelsen angår videre farmasøytiske preparater av 5-[(Z)-(5-fIuor-2-okso-1,2-dihydro-3H-indol-3-yliden)metyl]-N-[(2S)-2-hydroksy-3-morfolin-4-ylpropyl]-2,4-dimety1-1H-pyrrol-3-karboksamidsalter og metoder for behandling av lidelser så som kreft ved anvendelse av slike preparater.
NO20061246A 2003-10-02 2006-03-17 Salter og polymorfe former av en pyrrol-substituert indolinonforbindelse NO20061246L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50810403P 2003-10-02 2003-10-02
PCT/IB2004/003070 WO2005033098A1 (en) 2003-10-02 2004-09-20 Salts and polymorphs of a pyrrole-substituted indolinone compound

Publications (1)

Publication Number Publication Date
NO20061246L true NO20061246L (no) 2006-03-29

Family

ID=34421700

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061246A NO20061246L (no) 2003-10-02 2006-03-17 Salter og polymorfe former av en pyrrol-substituert indolinonforbindelse

Country Status (26)

Country Link
US (1) US7247627B2 (no)
EP (1) EP1670785B1 (no)
JP (1) JP4933259B2 (no)
KR (2) KR20080007520A (no)
CN (1) CN100432072C (no)
AR (1) AR047762A1 (no)
AT (1) ATE473223T1 (no)
AU (1) AU2004277464B2 (no)
BR (1) BRPI0415022A (no)
CA (1) CA2540639C (no)
CY (1) CY1110771T1 (no)
DE (1) DE602004028028D1 (no)
DK (1) DK1670785T3 (no)
ES (1) ES2348623T3 (no)
HK (1) HK1093068A1 (no)
IL (1) IL174414A (no)
MX (1) MXPA06003661A (no)
NO (1) NO20061246L (no)
NZ (1) NZ546001A (no)
PL (1) PL1670785T3 (no)
PT (1) PT1670785E (no)
RU (1) RU2319702C2 (no)
SI (1) SI1670785T1 (no)
TW (1) TW200524921A (no)
WO (1) WO2005033098A1 (no)
ZA (1) ZA200602691B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050182122A1 (en) * 2003-11-20 2005-08-18 Bello Carlo L. Method of treating abnormal cell growth using indolinone compounds
CA2602316A1 (en) * 2005-03-23 2006-09-28 Pfizer Products Inc. Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer
CA2622870A1 (en) * 2005-09-20 2007-03-29 Pfizer Products Inc. Dosage forms and methods of treatment using a tyrosine kinase inhibitor
CL2008000070A1 (es) * 2007-01-17 2008-07-25 Lg Life Sciences Ltd Monosal del acido maleico (3-[({1-[(2-amino-9h-purin-9-il)metil]ciclopropil}oxi)metil]-8,8-dimetil-3,7-dioxo-2,4,6-trioxa-3 lambda 5-fosfanon-1-il-pivalato; composicion farmaceutica que comprende a dicha monosal; y uso para el tratamiento del virus h
CN101631747B (zh) * 2007-04-04 2012-09-19 大塚化学株式会社 钛酸钾及其制造方法、以及摩擦材料和树脂组合物
US8063043B2 (en) * 2008-09-17 2011-11-22 Novartis Ag Salts of N-[6-cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4′-(trifluoromethoxy)[1,1′-biphenyl]-3-carboxamide
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
US9851313B2 (en) * 2015-03-03 2017-12-26 Panalytical B.V. Quantitative X-ray analysis—ratio correction

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534522A (en) * 1995-06-07 1996-07-09 Warner-Lambert Company (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
DE19622489A1 (de) * 1996-06-05 1997-12-11 Hoechst Ag Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters
SK287142B6 (sk) * 2000-02-15 2010-01-07 Sugen, Inc. Inhibítory proteínkináz na báze pyrolom substituovaného 2-indolinónu, farmaceutický prípravok s ich obsahom a ich použitie
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
EP3168218B1 (en) * 2001-08-15 2018-11-14 Pharmacia & Upjohn Company LLC A crystal comprising an l-malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide for use as a medicament
YU67702A (sh) 2001-09-28 2004-12-31 Pfizer Products Inc. Postupak za dobijanje alkansulfonil piridina
TWI259081B (en) * 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
CA2475455A1 (en) * 2002-02-15 2003-08-28 Pharmacia & Upjohn Company Process for preparing indolinone derivatives
HN2003000272A (es) * 2002-09-10 2008-07-29 Pharmacia Italia Spa Formulaciones que comprenden un compuesto de indolinona

Also Published As

Publication number Publication date
HK1093068A1 (en) 2007-02-23
DE602004028028D1 (de) 2010-08-19
PT1670785E (pt) 2010-09-16
AU2004277464B2 (en) 2010-07-08
AU2004277464A1 (en) 2005-04-14
BRPI0415022A (pt) 2006-11-28
WO2005033098A1 (en) 2005-04-14
DK1670785T3 (da) 2010-10-18
EP1670785B1 (en) 2010-07-07
TW200524921A (en) 2005-08-01
SI1670785T1 (sl) 2010-10-29
CA2540639C (en) 2010-08-31
WO2005033098A8 (en) 2006-04-20
KR20060058728A (ko) 2006-05-30
CN1863796A (zh) 2006-11-15
CY1110771T1 (el) 2015-06-10
KR20080007520A (ko) 2008-01-21
RU2006110541A (ru) 2006-08-27
NZ546001A (en) 2009-09-25
EP1670785A1 (en) 2006-06-21
ES2348623T3 (es) 2010-12-09
RU2319702C2 (ru) 2008-03-20
MXPA06003661A (es) 2006-06-05
AR047762A1 (es) 2006-02-22
JP2007507482A (ja) 2007-03-29
IL174414A0 (en) 2008-02-09
ZA200602691B (en) 2007-06-27
PL1670785T3 (pl) 2010-12-31
JP4933259B2 (ja) 2012-05-16
ATE473223T1 (de) 2010-07-15
IL174414A (en) 2011-12-29
US7247627B2 (en) 2007-07-24
US20050118255A1 (en) 2005-06-02
CA2540639A1 (en) 2005-04-14
WO2005033098A9 (en) 2006-05-26
CN100432072C (zh) 2008-11-12

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