CA2540639C - Salts and polymorphs of a pyrrole-substituted indolinone compound - Google Patents
Salts and polymorphs of a pyrrole-substituted indolinone compound Download PDFInfo
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- CA2540639C CA2540639C CA2540639A CA2540639A CA2540639C CA 2540639 C CA2540639 C CA 2540639C CA 2540639 A CA2540639 A CA 2540639A CA 2540639 A CA2540639 A CA 2540639A CA 2540639 C CA2540639 C CA 2540639C
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- Prior art keywords
- salt
- pyrrole
- fluoro
- methyl
- ylpropyl
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
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| US60/508,104 | 2003-10-02 | ||
| PCT/IB2004/003070 WO2005033098A1 (en) | 2003-10-02 | 2004-09-20 | Salts and polymorphs of a pyrrole-substituted indolinone compound |
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| CA2540639A1 CA2540639A1 (en) | 2005-04-14 |
| CA2540639C true CA2540639C (en) | 2010-08-31 |
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| US20050182122A1 (en) * | 2003-11-20 | 2005-08-18 | Bello Carlo L. | Method of treating abnormal cell growth using indolinone compounds |
| CA2602316A1 (en) * | 2005-03-23 | 2006-09-28 | Pfizer Products Inc. | Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer |
| CN101267824A (zh) * | 2005-09-20 | 2008-09-17 | 辉瑞产品公司 | 使用酪氨酸激酶抑制剂的治疗剂型和方法 |
| TWI384986B (zh) * | 2007-01-17 | 2013-02-11 | Lg Life Sciences Ltd | 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物 |
| KR101428833B1 (ko) * | 2007-04-04 | 2014-08-08 | 오츠카 가가쿠 가부시키가이샤 | 티탄산칼륨, 그의 제조 방법, 마찰재 및 수지 조성물 |
| KR101129088B1 (ko) * | 2008-09-17 | 2012-03-23 | 노파르티스 아게 | Ｎ-［6-(시스-2,6-디메틸모르폴린-4-일)피리딘-3-일］-2-메틸-4'-(트리플루오로메톡시)［1,1'-비페닐］-3-카르복스아미드의 염 |
| RU2430361C1 (ru) * | 2010-07-05 | 2011-09-27 | Государственное образовательное учреждение высшего профессионального образования "Красноярский государственный медицинский университет им. В.Ф. Войно-Ясенецкого Министерства здравоохранения и социального развития Российской Федерации" | Способ прогнозирования риска развития диабетической ретинопатии при сахарном диабете типа 2 у якутов |
| WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
| US9851313B2 (en) * | 2015-03-03 | 2017-12-26 | Panalytical B.V. | Quantitative X-ray analysis—ratio correction |
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|---|---|---|---|---|
| SU1575936A3 (ru) * | 1986-04-10 | 1990-06-30 | Е.И.Дюпон Де Немур Энд Ко.(Фирма) | Способ получени 3,3-дизамещенных индолин-2-ионов или их солей |
| US5534522A (en) * | 1995-06-07 | 1996-07-09 | Warner-Lambert Company | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
| DE19622489A1 (de) * | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
| HRP20020751B1 (hr) | 2000-02-15 | 2011-01-31 | Sugen | Pirolom supstituirani 2-indolinoni kao inhibitori protein kinaze |
| AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| SI1419151T1 (sl) | 2001-08-15 | 2014-04-30 | Pharmacia & Upjohn Company Llc | Kristali, ki vključujejo sol jabolčne kisline N-(2-(dietilamino)etil)-5-((5-fluoro-1,2-dihidro-2-okso-3H-indol-3- iliden)metil)-2,4-dimetil-1H-pirol-3-karboksamida, postopki za njihovo pripravo in sestavki le-teh |
| YU67702A (sh) | 2001-09-28 | 2004-12-31 | Pfizer Products Inc. | Postupak za dobijanje alkansulfonil piridina |
| TWI259081B (en) * | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| JP2005528344A (ja) | 2002-02-15 | 2005-09-22 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | インドリノン誘導体の製造法 |
| PY0323128A (es) * | 2002-09-10 | 2012-12-03 | Pharmacia Italia Spa | Formulacion sólida que comprende un compuesto de indolina, útil en el tratamiento de trastornos relacionados con proteina de quinasas |
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2004
- 2004-09-20 MX MXPA06003661A patent/MXPA06003661A/es active IP Right Grant
- 2004-09-20 PT PT04769435T patent/PT1670785E/pt unknown
- 2004-09-20 CA CA2540639A patent/CA2540639C/en not_active Expired - Fee Related
- 2004-09-20 CN CNB2004800287364A patent/CN100432072C/zh not_active Expired - Fee Related
- 2004-09-20 ES ES04769435T patent/ES2348623T3/es not_active Expired - Lifetime
- 2004-09-20 AT AT04769435T patent/ATE473223T1/de active
- 2004-09-20 NZ NZ546001A patent/NZ546001A/en unknown
- 2004-09-20 JP JP2006530728A patent/JP4933259B2/ja not_active Expired - Fee Related
- 2004-09-20 SI SI200431486T patent/SI1670785T1/sl unknown
- 2004-09-20 DK DK04769435.1T patent/DK1670785T3/da active
- 2004-09-20 KR KR1020067006363A patent/KR20060058728A/ko not_active Ceased
- 2004-09-20 EP EP04769435A patent/EP1670785B1/en not_active Expired - Lifetime
- 2004-09-20 RU RU2006110541/04A patent/RU2319702C2/ru not_active IP Right Cessation
- 2004-09-20 WO PCT/IB2004/003070 patent/WO2005033098A1/en not_active Ceased
- 2004-09-20 DE DE602004028028T patent/DE602004028028D1/de not_active Expired - Lifetime
- 2004-09-20 BR BRPI0415022-8A patent/BRPI0415022A/pt not_active IP Right Cessation
- 2004-09-20 AU AU2004277464A patent/AU2004277464B2/en not_active Ceased
- 2004-09-20 PL PL04769435T patent/PL1670785T3/pl unknown
- 2004-09-20 KR KR1020087000428A patent/KR20080007520A/ko not_active Ceased
- 2004-09-30 US US10/956,420 patent/US7247627B2/en not_active Expired - Fee Related
- 2004-10-01 TW TW093129924A patent/TW200524921A/zh unknown
- 2004-10-01 AR ARP040103580A patent/AR047762A1/es not_active Application Discontinuation
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2006
- 2006-03-17 NO NO20061246A patent/NO20061246L/no not_active Application Discontinuation
- 2006-03-20 IL IL174414A patent/IL174414A/en not_active IP Right Cessation
- 2006-03-31 ZA ZA200602691A patent/ZA200602691B/en unknown
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2010
- 2010-09-03 CY CY20101100810T patent/CY1110771T1/el unknown
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