RU2311900C2 - Содержащие действующее вещество пленочные препараты с повышенной химической стойкостью и способы их получения - Google Patents
Содержащие действующее вещество пленочные препараты с повышенной химической стойкостью и способы их получения Download PDFInfo
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- RU2311900C2 RU2311900C2 RU2004136576/15A RU2004136576A RU2311900C2 RU 2311900 C2 RU2311900 C2 RU 2311900C2 RU 2004136576/15 A RU2004136576/15 A RU 2004136576/15A RU 2004136576 A RU2004136576 A RU 2004136576A RU 2311900 C2 RU2311900 C2 RU 2311900C2
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- Prior art keywords
- cellulose
- active substance
- peroxide
- drug
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- 241000167880 Hirundinidae Species 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical class CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
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- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- 229940127292 dihydropyridine calcium channel blocker Drugs 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940116333 ethyl lactate Drugs 0.000 description 1
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- 229940067592 ethyl palmitate Drugs 0.000 description 1
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- 239000000796 flavoring agent Substances 0.000 description 1
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- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
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- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
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- 235000010981 methylcellulose Nutrition 0.000 description 1
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
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- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 238000006864 oxidative decomposition reaction Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
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- ILVGAIQLOCKNQA-UHFFFAOYSA-N propyl 2-hydroxypropanoate Chemical compound CCCOC(=O)C(C)O ILVGAIQLOCKNQA-UHFFFAOYSA-N 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- RNVYQYLELCKWAN-UHFFFAOYSA-N solketal Chemical compound CC1(C)OCC(CO)O1 RNVYQYLELCKWAN-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 125000003375 sulfoxide group Chemical group 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- 125000000101 thioether group Chemical group 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
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- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
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- 239000000230 xanthan gum Substances 0.000 description 1
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- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10224612A DE10224612A1 (de) | 2002-06-04 | 2002-06-04 | Wirkstoffhaltige filmförmige Zubereitungen mit verbesserter chemischer Stabilität, und Verfahren zu deren Herstellung |
| DE10224612.2 | 2002-06-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004136576A RU2004136576A (ru) | 2005-08-27 |
| RU2311900C2 true RU2311900C2 (ru) | 2007-12-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004136576/15A RU2311900C2 (ru) | 2002-06-04 | 2003-05-08 | Содержащие действующее вещество пленочные препараты с повышенной химической стойкостью и способы их получения |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20050226823A1 (enExample) |
| EP (1) | EP1509201B1 (enExample) |
| JP (1) | JP2005528427A (enExample) |
| KR (1) | KR20050010024A (enExample) |
| CN (1) | CN1658833A (enExample) |
| AR (1) | AR039955A1 (enExample) |
| AT (1) | ATE426400T1 (enExample) |
| AU (1) | AU2003236632B2 (enExample) |
| BR (1) | BR0311663A (enExample) |
| CA (1) | CA2487590C (enExample) |
| DE (2) | DE10224612A1 (enExample) |
| ES (1) | ES2324909T3 (enExample) |
| RU (1) | RU2311900C2 (enExample) |
| TW (1) | TWI344373B (enExample) |
| WO (1) | WO2003101421A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2447819C1 (ru) * | 2008-03-18 | 2012-04-20 | Джапан Тобакко Инк. | Адсорбент компонентов основного потока сигаретного дыма и сигаретный фильтр |
| RU2748487C1 (ru) * | 2017-11-21 | 2021-05-26 | Лтс Ломанн Терапи-Системе Аг | Водорастворимые полимерные клеевые слои |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2351315C2 (ru) * | 2003-07-24 | 2009-04-10 | Смитклайн Бичам Корпорейшн | Пленки, растворяющиеся в полости рта |
| DE10361306A1 (de) * | 2003-12-24 | 2005-07-28 | Lts Lohmann Therapie-Systeme Ag | Wundauflage und Wundschnellverband mit einem vasokonstriktorischen Inhaltsstoff, sowie Herstellungsverfahren hierfür |
| AR051397A1 (es) * | 2004-10-21 | 2007-01-10 | Novartis Ag | Composicion farmaceutica |
| DE102005005974A1 (de) * | 2005-02-09 | 2006-08-10 | Basf Ag | Verfahren zur Stabilisierung von Polyvinylpyrrolidonen |
| WO2006135491A2 (en) * | 2005-06-08 | 2006-12-21 | Basf Aktiengesellschaft | Medicament carrier composition and method of forming a film therefrom |
| WO2007034287A2 (en) * | 2005-09-19 | 2007-03-29 | University Of The Witwatersrand, Johannesburg | Oramucosal pharmaceutical dosage form |
| KR100742432B1 (ko) * | 2005-12-27 | 2007-07-24 | 한미약품 주식회사 | 암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법 |
| FR2902655B1 (fr) * | 2006-06-23 | 2008-11-28 | Oreal | Compositon topique a effet froid |
| RU2418574C2 (ru) * | 2007-02-08 | 2011-05-20 | Медтроник Ксомед Инк. | Сольватирующая система и герметик для медицинского применения |
| EA201170287A1 (ru) * | 2008-08-01 | 2011-10-31 | Дзе Медсинз Компани | Фармацевтические композиции и способы их стабилизации |
| ES2699077T3 (es) | 2009-06-12 | 2019-02-07 | Sunovion Pharmaceuticals Inc | Apomorfina sublingual |
| EA031156B1 (ru) | 2010-12-16 | 2018-11-30 | Суновион Фармасьютикалз Инк. | Сублингвальные пленки |
| JP5725940B2 (ja) * | 2011-04-01 | 2015-05-27 | 日東電工株式会社 | ニコチン含有貼付製剤 |
| CN103788552B (zh) * | 2012-10-26 | 2016-12-21 | 厦门加岩高分子材料有限公司 | 聚乙烯醇共混物 |
| SG11201610636VA (en) * | 2014-06-20 | 2017-01-27 | Ctc Bio Inc | Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor |
| WO2016172095A1 (en) | 2015-04-21 | 2016-10-27 | Cynapsus Therapeutics, Inc. | Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa |
| WO2017081725A1 (ja) * | 2015-11-09 | 2017-05-18 | 花王株式会社 | 口腔用組成物 |
| US11648212B2 (en) * | 2016-02-03 | 2023-05-16 | Intelgenx Corp. | Loxapine film oral dosage form |
| WO2019171843A1 (ja) * | 2018-03-05 | 2019-09-12 | パナソニックＩｐマネジメント株式会社 | 化粧料または医療材料 |
| IT201800011125A1 (it) | 2018-12-14 | 2020-06-14 | Dpl Pharma S P A | Composizioni farmaceutiche orali solide comprendenti matrici monolitiche complesse per la somministrazione cronotropica di medicamenti nel tratto gastroenterico |
| CN110339118B (zh) * | 2019-08-19 | 2022-08-16 | 广州明辉化妆品有限公司 | 具有美白保湿功效的美白霜 |
| SE544672C2 (en) | 2020-05-07 | 2022-10-11 | Liw Innovation Ab | New compositions for oral or nasal use |
| IT202000011050A1 (it) | 2020-05-14 | 2021-11-14 | Mogon Pharmaceuticals Sagl | Composizioni orali solide comprendenti matrici monolitiche composite per la somministrazione cronotropica nel tratto gastroenterico di ingredienti attivi |
| IT202000011053A1 (it) | 2020-05-14 | 2021-11-14 | Int Health Science S R L | Composizioni orali solide comprendenti matrici monolitiche composite per la somministrazione cronotropica nel tratto gastroenterico di alimenti, integratori alimentari, nutraceutici, dispositivi medici |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2106136C1 (ru) * | 1991-04-23 | 1998-03-10 | Перио Продактс Лимитед | Пленкообразующая жидкая полимерная композиция, способ внешнего и внутреннего отбеливания зубов, способ лечения гингивита и зубного камня |
| RU2155071C1 (ru) * | 1999-08-10 | 2000-08-27 | Мизина Прасковья Георгиевна | Способ получения лекарственной фитопленки |
| RU2195545C1 (ru) * | 2001-08-14 | 2002-12-27 | Хаминов Николай Иванович | Способ изоляции промытых зон в добывающей и нагнетательной скважинах |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2019275B3 (es) * | 1985-10-09 | 1991-06-16 | Desitin Arzneimittel Gmbh | Metodo para la produccion de una forma de administracion y de dosificacion para farmacos reactivos u otros principios activos. |
| US5032384A (en) * | 1989-01-27 | 1991-07-16 | Block Drug Company, Inc. | Compositions and method for the treatment of disease |
| JP2671248B2 (ja) * | 1991-10-23 | 1997-10-29 | ブロック・ドラッグ・カンパニー・インコーポレイテッド | 薬効または化粧効果成分の浸透性増進方法 |
| AU4327193A (en) * | 1992-07-08 | 1994-01-31 | Dianorm-Gerate G. Maierhofer | Liposomes, method of preparing them and their use in the preparation of drugs |
| DE69724424T2 (de) * | 1996-05-13 | 2004-06-24 | Novartis Consumer Health S.A. | Mundfreisetzungssystem |
| US6375963B1 (en) * | 1999-06-16 | 2002-04-23 | Michael A. Repka | Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof |
| JP5753645B2 (ja) * | 1999-11-29 | 2015-07-22 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 安定性が改善された経皮治療システムおよびそれらの製法 |
| DE10018834A1 (de) * | 2000-04-15 | 2001-10-25 | Lohmann Therapie Syst Lts | Transdermale oder transmucosale Darreichungsformen mit einer nicotinhaltigen Wirkstoffkombination zur Raucherentwöhnung |
| DE10107659B4 (de) * | 2001-02-19 | 2008-03-13 | Lts Lohmann Therapie-Systeme Ag | Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin |
-
2002
- 2002-06-04 DE DE10224612A patent/DE10224612A1/de not_active Withdrawn
-
2003
- 2003-05-08 AT AT03735367T patent/ATE426400T1/de not_active IP Right Cessation
- 2003-05-08 EP EP03735367A patent/EP1509201B1/de not_active Expired - Lifetime
- 2003-05-08 ES ES03735367T patent/ES2324909T3/es not_active Expired - Lifetime
- 2003-05-08 RU RU2004136576/15A patent/RU2311900C2/ru not_active IP Right Cessation
- 2003-05-08 CN CN03812839XA patent/CN1658833A/zh active Pending
- 2003-05-08 CA CA2487590A patent/CA2487590C/en not_active Expired - Fee Related
- 2003-05-08 DE DE50311338T patent/DE50311338D1/de not_active Expired - Lifetime
- 2003-05-08 JP JP2004508779A patent/JP2005528427A/ja active Pending
- 2003-05-08 WO PCT/EP2003/004816 patent/WO2003101421A1/de not_active Ceased
- 2003-05-08 US US10/517,087 patent/US20050226823A1/en not_active Abandoned
- 2003-05-08 AU AU2003236632A patent/AU2003236632B2/en not_active Ceased
- 2003-05-08 KR KR10-2004-7019688A patent/KR20050010024A/ko not_active Ceased
- 2003-05-08 BR BR0311663-8A patent/BR0311663A/pt not_active Application Discontinuation
- 2003-05-26 TW TW092114186A patent/TWI344373B/zh not_active IP Right Cessation
- 2003-06-04 AR ARP030101977A patent/AR039955A1/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2106136C1 (ru) * | 1991-04-23 | 1998-03-10 | Перио Продактс Лимитед | Пленкообразующая жидкая полимерная композиция, способ внешнего и внутреннего отбеливания зубов, способ лечения гингивита и зубного камня |
| RU2155071C1 (ru) * | 1999-08-10 | 2000-08-27 | Мизина Прасковья Георгиевна | Способ получения лекарственной фитопленки |
| RU2195545C1 (ru) * | 2001-08-14 | 2002-12-27 | Хаминов Николай Иванович | Способ изоляции промытых зон в добывающей и нагнетательной скважинах |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2447819C1 (ru) * | 2008-03-18 | 2012-04-20 | Джапан Тобакко Инк. | Адсорбент компонентов основного потока сигаретного дыма и сигаретный фильтр |
| RU2748487C1 (ru) * | 2017-11-21 | 2021-05-26 | Лтс Ломанн Терапи-Системе Аг | Водорастворимые полимерные клеевые слои |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200307566A (en) | 2003-12-16 |
| ATE426400T1 (de) | 2009-04-15 |
| US20050226823A1 (en) | 2005-10-13 |
| AU2003236632B2 (en) | 2008-07-31 |
| AU2003236632A1 (en) | 2003-12-19 |
| WO2003101421A1 (de) | 2003-12-11 |
| AR039955A1 (es) | 2005-03-09 |
| TWI344373B (en) | 2011-07-01 |
| DE10224612A1 (de) | 2003-12-24 |
| BR0311663A (pt) | 2005-06-28 |
| CA2487590A1 (en) | 2003-12-11 |
| ES2324909T3 (es) | 2009-08-19 |
| EP1509201A1 (de) | 2005-03-02 |
| EP1509201B1 (de) | 2009-03-25 |
| JP2005528427A (ja) | 2005-09-22 |
| CA2487590C (en) | 2011-01-11 |
| KR20050010024A (ko) | 2005-01-26 |
| RU2004136576A (ru) | 2005-08-27 |
| DE50311338D1 (de) | 2009-05-07 |
| CN1658833A (zh) | 2005-08-24 |
| WO2003101421A8 (de) | 2005-04-21 |
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