RU2307667C2 - Фторсилоксановые матриксные системы доставки лекарств с регулируемой диффузией и способ ее получения - Google Patents

Фторсилоксановые матриксные системы доставки лекарств с регулируемой диффузией и способ ее получения Download PDF

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Publication number
RU2307667C2
RU2307667C2 RU2005100840/04A RU2005100840A RU2307667C2 RU 2307667 C2 RU2307667 C2 RU 2307667C2 RU 2005100840/04 A RU2005100840/04 A RU 2005100840/04A RU 2005100840 A RU2005100840 A RU 2005100840A RU 2307667 C2 RU2307667 C2 RU 2307667C2
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Russia
Prior art keywords
methacrylate
agents
drug delivery
pharmaceutically active
active agent
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Application number
RU2005100840/04A
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English (en)
Russian (ru)
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RU2005100840A (ru
Inventor
Джозеф С. САЛАМОН (US)
Джозеф С. САЛАМОН
Джей Ф. КАНЗЛЕР (US)
Джей Ф. КАНЗЛЕР
Дэниел М. Мл. ЭММОН (US)
Дэниел М. Мл. ЭММОН
Original Assignee
БОШ энд ЛОМБ ИНКОРПОРЕЙТИД
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Publication of RU2005100840A publication Critical patent/RU2005100840A/ru
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Publication of RU2307667C2 publication Critical patent/RU2307667C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/24—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen halogen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/14—Polysiloxanes containing silicon bound to oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/70—Siloxanes defined by use of the MDTQ nomenclature

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2005100840/04A 2002-06-19 2003-06-16 Фторсилоксановые матриксные системы доставки лекарств с регулируемой диффузией и способ ее получения RU2307667C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/175,716 US20040043067A1 (en) 2002-06-19 2002-06-19 Fluorosiloxane matrix controlled diffusion drug delivery systems
US10/175,716 2002-06-19

Publications (2)

Publication Number Publication Date
RU2005100840A RU2005100840A (ru) 2005-07-10
RU2307667C2 true RU2307667C2 (ru) 2007-10-10

Family

ID=29999052

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005100840/04A RU2307667C2 (ru) 2002-06-19 2003-06-16 Фторсилоксановые матриксные системы доставки лекарств с регулируемой диффузией и способ ее получения

Country Status (17)

Country Link
US (1) US20040043067A1 (https=)
EP (1) EP1515705B1 (https=)
JP (1) JP2005530842A (https=)
CN (1) CN1662227A (https=)
AU (1) AU2003238247A1 (https=)
BR (1) BR0311963A (https=)
CA (1) CA2489987A1 (https=)
CZ (1) CZ200537A3 (https=)
DE (1) DE60306379T2 (https=)
ES (1) ES2261947T3 (https=)
MX (1) MXPA04012897A (https=)
PL (1) PL375000A1 (https=)
RU (1) RU2307667C2 (https=)
TW (1) TW200404569A (https=)
UA (1) UA80433C2 (https=)
WO (1) WO2004000288A1 (https=)
ZA (1) ZA200409979B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1765454T3 (en) 2004-07-02 2016-05-02 Mati Therapeutics Inc Device for submission of treatment medium to eye
US7544371B2 (en) * 2005-12-20 2009-06-09 Bausch + Lomb Incorporated Drug delivery systems
US20070148244A1 (en) * 2005-12-22 2007-06-28 Kunzler Jay F Drug delivery systems
US20070218104A1 (en) * 2006-03-15 2007-09-20 Bausch & Lomb Incorporation Rate controlled release of a pharmaceutical agent in a biodegradable device
US20070218103A1 (en) * 2006-03-15 2007-09-20 Bausch & Lomb Incorporated Rate controlled release of a pharmaceutical agent in a biodegradable device
EP2004172B1 (en) 2006-03-31 2019-03-13 Mati Therapeutics Inc. Drug delivery structures and compositions for nasolacrimal system
US7579021B2 (en) * 2006-09-27 2009-08-25 Bausch & Lomb Incorporated Drug delivery systems based on degradable cationic siloxanyl macromonomers
UY30883A1 (es) * 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
NZ583858A (en) 2007-09-07 2012-08-31 Quadra Logic Tech Inc Lacrimal implant detection with detection device
CA2701186C (en) * 2007-10-05 2017-09-19 Evonik Canada Inc. Oligofluorinated cross-linked polymers and uses thereof
AU2010206610A1 (en) * 2009-01-23 2011-08-11 Qlt Inc. Sustained released delivery of one or more agents
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
ES2727203T3 (es) 2011-08-29 2019-10-14 Mati Therapeutics Inc Administración por liberación sostenida de agentes activos para tratar glaucoma e hipertensión ocular

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5321108A (en) * 1993-02-12 1994-06-14 Bausch & Lomb Incorporated Fluorosilicone hydrogels
WO1997020851A1 (en) * 1995-12-07 1997-06-12 Bausch & Lomb Incorporated Monomeric units useful for reducing the modulus of low water polymeric silicone compositions
RU2093147C1 (ru) * 1988-08-30 1997-10-20 Пфайзер Инк. Изделия для пролонгированного выделения одного или нескольких фармацевтически активных веществ
US5908906A (en) * 1995-12-07 1999-06-01 Bausch & Lomb Incorporated Monomeric units useful for reducing the modulus of silicone hydrogels
RU2272617C2 (ru) * 2000-01-27 2006-03-27 Ардана Биосайенс Лимитед Фармацевтический имплантат, способ его получения (варианты) и способ регулируемого высвобождения лекарства

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US4327725A (en) * 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
CA1295941C (en) * 1985-08-16 1992-02-18 Rajan Bawa Sustained-release formulation comprising a hydrophobic polymer system
US4882377A (en) * 1988-09-21 1989-11-21 Dow Corning Corporation Low-viscosity pressure-adherent silicone elastomer compositions
US5463010A (en) * 1993-11-12 1995-10-31 Surface Engineering Technologies, Division Of Innerdyne, Inc. Hydrocyclosiloxane membrane prepared by plasma polymerization process
US6322815B1 (en) * 1994-07-22 2001-11-27 W. Mark Saltzman Multipart drug delivery system
US6296873B1 (en) * 1997-01-23 2001-10-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Zero-order sustained release delivery system for carbamazephine derivatives
ATE279461T1 (de) * 1997-04-03 2004-10-15 Guilford Pharm Inc Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung
US5908996A (en) * 1997-10-24 1999-06-01 Timewarp Technologies Ltd Device for controlling a musical performance
US6312728B1 (en) * 1998-07-07 2001-11-06 Cascade Development, Inc. Sustained release pharmaceutical preparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2093147C1 (ru) * 1988-08-30 1997-10-20 Пфайзер Инк. Изделия для пролонгированного выделения одного или нескольких фармацевтически активных веществ
US5321108A (en) * 1993-02-12 1994-06-14 Bausch & Lomb Incorporated Fluorosilicone hydrogels
WO1997020851A1 (en) * 1995-12-07 1997-06-12 Bausch & Lomb Incorporated Monomeric units useful for reducing the modulus of low water polymeric silicone compositions
US5908906A (en) * 1995-12-07 1999-06-01 Bausch & Lomb Incorporated Monomeric units useful for reducing the modulus of silicone hydrogels
RU2272617C2 (ru) * 2000-01-27 2006-03-27 Ардана Биосайенс Лимитед Фармацевтический имплантат, способ его получения (варианты) и способ регулируемого высвобождения лекарства

Also Published As

Publication number Publication date
JP2005530842A (ja) 2005-10-13
RU2005100840A (ru) 2005-07-10
PL375000A1 (en) 2005-11-14
ZA200409979B (en) 2006-07-26
UA80433C2 (en) 2007-09-25
US20040043067A1 (en) 2004-03-04
DE60306379T2 (de) 2007-06-14
MXPA04012897A (es) 2005-03-31
CZ200537A3 (cs) 2006-04-12
HK1070826A1 (en) 2005-06-30
ES2261947T3 (es) 2006-11-16
DE60306379D1 (de) 2006-08-03
EP1515705B1 (en) 2006-06-21
WO2004000288A1 (en) 2003-12-31
TW200404569A (en) 2004-04-01
BR0311963A (pt) 2005-03-29
EP1515705A1 (en) 2005-03-23
AU2003238247A1 (en) 2004-01-06
CA2489987A1 (en) 2003-12-31
CN1662227A (zh) 2005-08-31

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Effective date: 20100617