RU2299889C2 - Конформационно аномальные формы белков тау и специфические антитела к ним - Google Patents

Конформационно аномальные формы белков тау и специфические антитела к ним Download PDF

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RU2299889C2
RU2299889C2 RU2003126594/13A RU2003126594A RU2299889C2 RU 2299889 C2 RU2299889 C2 RU 2299889C2 RU 2003126594/13 A RU2003126594/13 A RU 2003126594/13A RU 2003126594 A RU2003126594 A RU 2003126594A RU 2299889 C2 RU2299889 C2 RU 2299889C2
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tau protein
human tau
antibody
tau
amino acid
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Михаль НОВАК (SK)
Михаль НОВАК
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Аксон Нойрошинс Форшунгс-Унд Энтвиклунгс Гмбх
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Genetics & Genomics (AREA)
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  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2003126594/13A 2001-02-02 2002-01-29 Конформационно аномальные формы белков тау и специфические антитела к ним RU2299889C2 (ru)

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Application Number Priority Date Filing Date Title
AT0017501A AT500379B8 (de) 2001-02-02 2001-02-02 Tau-proteine
ATA175/2001 2001-02-02

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RU2003126594A RU2003126594A (ru) 2005-03-10
RU2299889C2 true RU2299889C2 (ru) 2007-05-27

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US (2) US7446180B2 (https=)
EP (1) EP1355949B1 (https=)
JP (1) JP4163955B2 (https=)
CN (2) CN101307107A (https=)
AT (2) AT500379B8 (https=)
AU (1) AU2002237296A1 (https=)
CA (1) CA2437453C (https=)
DE (1) DE60235746D1 (https=)
DK (1) DK1355949T3 (https=)
ES (1) ES2339427T3 (https=)
RU (1) RU2299889C2 (https=)
WO (1) WO2002062851A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2639537C2 (ru) * 2011-10-07 2017-12-21 Ац Иммуне С.А. Фосфоспецифичные антитела, распознающие тау
US10633436B2 (en) 2015-06-05 2020-04-28 Genentech, Inc. Anti-tau antibodies and methods of use
US10836817B2 (en) 2016-12-07 2020-11-17 Ac Immune Sa Anti-Tau antibodies and methods of use
RU2743152C2 (ru) * 2014-06-27 2021-02-15 Си2Эн ДАЙАГНОСТИКС ЭлЭлСи Гуманизированные анти-тау-антитела
RU2760875C1 (ru) * 2016-07-12 2021-12-01 Х. Лундбекк А/С Антитела, специфичные к гиперфосфорилированному тау-белку, и способы их применения
US11427629B2 (en) 2016-12-07 2022-08-30 Ac Immune Sa Anti-Tau antibodies and methods of use
RU2808829C2 (ru) * 2019-03-18 2023-12-05 Регенерон Фармасьютикалз, Инк. Платформа crispr/cas для исключающего скрининга для выявления генетических уязвимостей, связанных с агрегацией тау-белка

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT500379B8 (de) 2001-02-02 2009-08-15 Axon Neuroscience Tau-proteine
US20060167227A1 (en) * 2002-07-12 2006-07-27 Axon Neuroscience Forschungs-Und Entwicklungs Gmbh Truncated tau proteins
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
HRP20140240T4 (hr) 2005-11-30 2017-02-24 Abbvie Inc. Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba
ES2321996B1 (es) * 2006-01-26 2010-03-05 Consejo Superior Investig. Cientificas Uso de compuestos que se unen al dominio de union a microtubulos de tau en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y su aplicacion en el tratamiento de tauopatias.
US8012936B2 (en) * 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
WO2009143556A1 (en) * 2008-05-30 2009-12-03 The University Of Sydney TREATMENTS FOR EXCITOTOXICITY AND Aß-MEDIATED TOXICITY AND AGE-ASSOCIATED NEURONAL DYSFUNCTION
US8609097B2 (en) * 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
CN106390107B (zh) * 2009-06-10 2019-12-31 纽约大学 病理tau蛋白的免疫靶向
AU2010286501B2 (en) * 2009-08-28 2015-06-11 The Board Of Regents Of The University Of Texas System Antibodies that bind Tau oligomers
US10266585B2 (en) 2009-08-28 2019-04-23 The Board Of Regents Of The Univerity Of Texas System Methods of treating brain injury
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
ITRM20100320A1 (it) * 2010-06-11 2011-12-11 Consiglio Nazionale Ricerche Metodo per la diagnostica e il trattamento delle taupatie
EP3533803B1 (en) 2010-08-14 2021-10-27 AbbVie Inc. Anti-amyloid-beta antibodies
CA2813493C (en) 2010-10-11 2019-07-09 University Of Zurich Human anti-tau antibodies
AU2011315920B2 (en) 2010-10-15 2016-04-28 The Board Of Regents Of The University Of Texas System Antibodies that bind amyloid oligomers
US20120244174A1 (en) 2011-01-31 2012-09-27 Intellect Neurosciences Inc. Treatment of tauopathies
JP6457263B2 (ja) * 2011-05-20 2019-01-23 オリゴメリックス インコーポレイテッド タウプロテアーゼ組成物および使用方法
ME03008B (me) * 2011-09-19 2018-10-20 Axon Neuroscience Se Terapija na osnovu proteina i dijagnoza patologije u којој posreduje tau u alcнajмerovoj bolesti
SG10201708959WA (en) 2012-07-03 2017-11-29 Univ Washington Antibodies to tau
NZ630542A (en) * 2012-08-16 2017-06-30 Ipierian Inc Methods of treating a tauopathy
US9200068B2 (en) * 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
CA2896066C (en) 2012-12-21 2022-07-12 Biogen Ma Inc. Human anti-tau antibodies
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
US10501531B2 (en) 2013-03-13 2019-12-10 Prothena Biosciences Limited Tau immunotherapy
WO2014150877A2 (en) * 2013-03-15 2014-09-25 Ac Immune S.A. Anti-tau antibodies and methods of use
AU2014368696A1 (en) 2013-12-20 2016-06-02 F. Hoffmann-La Roche Ag Humanized anti-Tau(pS422) antibodies and methods of use
JP2017512751A (ja) 2014-02-14 2017-05-25 アイピエリアン，インコーポレイティド タウペプチド、抗タウ抗体、およびそれらの使用方法
AR100978A1 (es) 2014-06-26 2016-11-16 Hoffmann La Roche LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
CN107073297B (zh) 2014-07-08 2021-09-14 纽约大学 Tau显像配体和其在Tau蛋白病的诊断和治疗中的用途
TWI669314B (zh) 2015-02-26 2019-08-21 美國禮來大藥廠 針對ｔａｕ之抗體及其用途
WO2016207245A1 (en) 2015-06-24 2016-12-29 F. Hoffmann-La Roche Ag Humanized anti-tau(ps422) antibodies and methods of use
WO2017005734A1 (en) 2015-07-06 2017-01-12 Ucb Biopharma Sprl Tau-binding antibodies
WO2017027685A2 (en) 2015-08-13 2017-02-16 New York University Antibody-based molecules specific for the truncated asp421 epitope of tau and their uses in the diagnosis and treatment of tauopathy
PT3452507T (pt) 2016-05-02 2022-12-20 Prothena Biosciences Ltd Imunoterapia anti-tau
MY198194A (en) 2016-05-02 2023-08-09 Prothena Biosciences Ltd Antibodies Recognizing Tau
CA3032692A1 (en) 2016-08-09 2018-02-15 Eli Lilly And Company Combination antibody therapy for the treatment of neurodegenerative diseases
KR102784294B1 (ko) 2017-05-02 2025-03-19 프로테나 바이오사이언시즈 리미티드 타우 인식 항체
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
CN107686839B (zh) * 2017-09-25 2020-12-04 安徽朵能生物科技有限公司 微管结合蛋白cript、其治疗性突变体及其应用
CA3107788A1 (en) 2018-07-31 2020-02-06 Eli Lilly And Company Combination of anti-tau antibody and oga inhibitor for treatment of diseases characterized by aberrant tau aggregation
WO2020160156A2 (en) 2019-01-30 2020-08-06 Immutics, Inc. Anti-gal3 antibodies and uses thereof
JP7630834B2 (ja) 2019-03-03 2025-02-18 プロセナ バイオサイエンシーズ リミテッド タウ認識抗体
CN120648640A (zh) 2019-03-18 2025-09-16 瑞泽恩制药公司 用于鉴定tau接种或聚集的基因修饰因子的CRISPR/Cas筛选平台
WO2020201828A1 (en) 2019-04-05 2020-10-08 Tauc3 Biologics Limited Anti-tauc3 antibodies and uses thereof
GB2585252A (en) 2019-07-05 2021-01-06 Gen2 Neuroscience Ltd Tau epitope and binding molecules
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
WO2022144406A1 (en) 2020-12-29 2022-07-07 Neurimmune Ag Human anti-tau antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733734A (en) * 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
JPH06239899A (ja) 1993-02-12 1994-08-30 Teijin Ltd ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法
AT500379B8 (de) 2001-02-02 2009-08-15 Axon Neuroscience Tau-proteine
US20020164657A1 (en) * 2001-02-23 2002-11-07 Sharma Satish K. Assays for assessing A beta-Tau aggregation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Acta virologica, 38, 1994, p.p.173-189, M.Novak. Truncated tau protein as new Marker for Alzheimer's disease. J. of Neuroscience Research, 55, 1999, p.p.713-723, Gregory A.Jicha et al. Sequence Requirements for Formation of Conformational Variants of Tau Similar to Those Found in Alzheimer's Desiese. Neurobiology of Aging, 21. 2000, p.p.719-727, Charles L. Weaver et al. Conformational change as one of the earliest alterations of tau in Alzheimer's disease. *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10066010B2 (en) 2011-10-07 2018-09-04 Ac Immune S.A. Methods of diagnosing diseases caused by or associated with neurofibrillary tangles by phosphospecific antibodies recognising Tau
RU2639537C2 (ru) * 2011-10-07 2017-12-21 Ац Иммуне С.А. Фосфоспецифичные антитела, распознающие тау
RU2743152C2 (ru) * 2014-06-27 2021-02-15 Си2Эн ДАЙАГНОСТИКС ЭлЭлСи Гуманизированные анти-тау-антитела
US11555065B2 (en) 2015-06-05 2023-01-17 Ac Immune Sa Anti-Tau antibodies and methods of use
RU2732122C2 (ru) * 2015-06-05 2020-09-11 Дженентек, Инк. Антитела против тау-белка и способы их применения
US10633436B2 (en) 2015-06-05 2020-04-28 Genentech, Inc. Anti-tau antibodies and methods of use
US12486319B2 (en) 2015-06-05 2025-12-02 Ac Immune Sa Anti-tau antibodies and methods of use
RU2760875C1 (ru) * 2016-07-12 2021-12-01 Х. Лундбекк А/С Антитела, специфичные к гиперфосфорилированному тау-белку, и способы их применения
US10836817B2 (en) 2016-12-07 2020-11-17 Ac Immune Sa Anti-Tau antibodies and methods of use
US11352419B2 (en) 2016-12-07 2022-06-07 Ac Immune Sa Anti-tau antibodies and methods of use
US11427629B2 (en) 2016-12-07 2022-08-30 Ac Immune Sa Anti-Tau antibodies and methods of use
RU2808829C2 (ru) * 2019-03-18 2023-12-05 Регенерон Фармасьютикалз, Инк. Платформа crispr/cas для исключающего скрининга для выявления генетических уязвимостей, связанных с агрегацией тау-белка
RU2819350C2 (ru) * 2019-03-18 2024-05-17 Регенерон Фармасьютикалз, Инк. Скрининговая платформа crispr/cas для идентификации генетических модификаторов засева или агрегации тау-белка
RU2857374C2 (ru) * 2019-03-18 2026-03-02 Регенерон Фармасьютикалз, Инк. Скрининговая платформа crispr/cas для идентификации генетических модификаторов засева или агрегации тау-белка

Also Published As

Publication number Publication date
CN101307107A (zh) 2008-11-19
RU2003126594A (ru) 2005-03-10
CA2437453C (en) 2013-06-11
US20040082763A1 (en) 2004-04-29
AU2002237296A1 (en) 2002-08-19
WO2002062851A8 (en) 2002-09-12
DE60235746D1 (de) 2010-05-06
EP1355949B1 (en) 2010-03-24
JP2004532817A (ja) 2004-10-28
AT500379B1 (de) 2009-07-15
CA2437453A1 (en) 2002-08-15
EP1355949A1 (en) 2003-10-29
CN1492879A (zh) 2004-04-28
US20090123936A1 (en) 2009-05-14
DK1355949T3 (da) 2010-05-25
US7446180B2 (en) 2008-11-04
JP4163955B2 (ja) 2008-10-08
AT500379A2 (de) 2005-12-15
ATE461941T1 (de) 2010-04-15
WO2002062851A1 (en) 2002-08-15
ES2339427T3 (es) 2010-05-20
AT500379A3 (de) 2009-02-15
CN100503638C (zh) 2009-06-24
AT500379B8 (de) 2009-08-15

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