RU2250903C2 - Новые биспидиновые соединения, полезные при лечении сердечных аритмий - Google Patents

Новые биспидиновые соединения, полезные при лечении сердечных аритмий Download PDF

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Publication number
RU2250903C2
RU2250903C2 RU2001132563/04A RU2001132563A RU2250903C2 RU 2250903 C2 RU2250903 C2 RU 2250903C2 RU 2001132563/04 A RU2001132563/04 A RU 2001132563/04A RU 2001132563 A RU2001132563 A RU 2001132563A RU 2250903 C2 RU2250903 C2 RU 2250903C2
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RU
Russia
Prior art keywords
alkyl
formula
compound
diazabicyclo
group
Prior art date
Application number
RU2001132563/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2001132563A (ru
Inventor
Кристер АЛЬСТЕРМАРК (SE)
Кристер АЛЬСТЕРМАРК
Кьелль АНДЕРССОН (SE)
Кьелль АНДЕРССОН
Анника БЬЁРЕ (SE)
Анника БЬЁРЕ
Магнус БЬЁРСНЕ (SE)
Магнус БЬЁРСНЕ
АЛЬСТЕРМАРК Ева-Лотте ЛИНДСТЕДТ (SE)
АЛЬСТЕРМАРК Ева-Лотте ЛИНДСТЕДТ
Йёран НИЛЬССОН (SE)
Йёран НИЛЬССОН
Магнус ПОЛЛА (SE)
Магнус Полла
Ерт СТРАНДЛУНД (SE)
Ерт СТРАНДЛУНД
Ильва ЭРТЕНГРЕН (SE)
Ильва ЭРТЕНГРЕН
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of RU2001132563A publication Critical patent/RU2001132563A/ru
Application granted granted Critical
Publication of RU2250903C2 publication Critical patent/RU2250903C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
RU2001132563/04A 1999-06-16 2000-06-15 Новые биспидиновые соединения, полезные при лечении сердечных аритмий RU2250903C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9902268-3 1999-06-16
SE9902268A SE9902268D0 (sv) 1999-06-16 1999-06-16 Pharmaceutically active compounds

Publications (2)

Publication Number Publication Date
RU2001132563A RU2001132563A (ru) 2003-09-10
RU2250903C2 true RU2250903C2 (ru) 2005-04-27

Family

ID=20416100

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001132563/04A RU2250903C2 (ru) 1999-06-16 2000-06-15 Новые биспидиновые соединения, полезные при лечении сердечных аритмий

Country Status (24)

Country Link
EP (1) EP1192157A1 (sv)
JP (1) JP2003502329A (sv)
KR (1) KR20020010713A (sv)
CN (1) CN1144805C (sv)
AR (1) AR024577A1 (sv)
AU (1) AU761576B2 (sv)
BR (1) BR0011660A (sv)
CA (1) CA2375841A1 (sv)
CZ (1) CZ20014495A3 (sv)
EE (1) EE200100675A (sv)
HK (1) HK1045520A1 (sv)
HU (1) HUP0203959A3 (sv)
IL (1) IL146754A0 (sv)
IS (1) IS6201A (sv)
MX (1) MXPA01012919A (sv)
NO (1) NO20016117L (sv)
NZ (1) NZ516013A (sv)
PL (1) PL354032A1 (sv)
RU (1) RU2250903C2 (sv)
SE (1) SE9902268D0 (sv)
SK (1) SK18272001A3 (sv)
TR (1) TR200103663T2 (sv)
WO (1) WO2000077000A1 (sv)
ZA (1) ZA200109796B (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030302A1 (es) * 2000-07-07 2003-08-20 Astrazeneca Ab Compuestos de bispidina, formulacion farmaceutica, uso para la fabricacion de medicamentos, proceso para la preparacion de estos compuestos y compuestos intermediarios
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
TWI499418B (zh) * 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl 異喹啉－１（２ｈ）－酮衍生物
KR101953407B1 (ko) * 2011-07-08 2019-02-28 바이엘 인텔렉쳐 프로퍼티 게엠베하 2-아미노-5-시아노-n,3-디메틸벤즈아미드의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT88381B (pt) * 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) * 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
PL354032A1 (en) 2003-12-15
ZA200109796B (en) 2003-02-28
CN1370167A (zh) 2002-09-18
CN1144805C (zh) 2004-04-07
WO2000077000A1 (en) 2000-12-21
AR024577A1 (es) 2002-10-16
NO20016117D0 (no) 2001-12-14
NO20016117L (no) 2002-02-15
EE200100675A (et) 2003-02-17
NZ516013A (en) 2003-06-30
IS6201A (is) 2001-12-14
SK18272001A3 (sk) 2002-12-03
MXPA01012919A (es) 2002-07-30
SE9902268D0 (sv) 1999-06-16
CA2375841A1 (en) 2000-12-21
CZ20014495A3 (cs) 2002-05-15
EP1192157A1 (en) 2002-04-03
HK1045520A1 (zh) 2002-11-29
AU761576B2 (en) 2003-06-05
WO2000077000A9 (en) 2003-06-19
KR20020010713A (ko) 2002-02-04
TR200103663T2 (tr) 2002-05-21
BR0011660A (pt) 2002-03-26
HUP0203959A2 (hu) 2003-03-28
IL146754A0 (en) 2002-07-25
AU6032400A (en) 2001-01-02
JP2003502329A (ja) 2003-01-21
HUP0203959A3 (en) 2003-04-28

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Legal Events

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20060616