RU2250903C2 - Новые биспидиновые соединения, полезные при лечении сердечных аритмий - Google Patents

Новые биспидиновые соединения, полезные при лечении сердечных аритмий Download PDF

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Publication number
RU2250903C2
RU2250903C2 RU2001132563/04A RU2001132563A RU2250903C2 RU 2250903 C2 RU2250903 C2 RU 2250903C2 RU 2001132563/04 A RU2001132563/04 A RU 2001132563/04A RU 2001132563 A RU2001132563 A RU 2001132563A RU 2250903 C2 RU2250903 C2 RU 2250903C2
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RU
Russia
Prior art keywords
alkyl
formula
compound
diazabicyclo
group
Prior art date
Application number
RU2001132563/04A
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English (en)
Russian (ru)
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RU2001132563A (ru
Inventor
Кристер АЛЬСТЕРМАРК (SE)
Кристер АЛЬСТЕРМАРК
Кьелль АНДЕРССОН (SE)
Кьелль АНДЕРССОН
Анника БЬЁРЕ (SE)
Анника БЬЁРЕ
Магнус БЬЁРСНЕ (SE)
Магнус БЬЁРСНЕ
АЛЬСТЕРМАРК Ева-Лотте ЛИНДСТЕДТ (SE)
АЛЬСТЕРМАРК Ева-Лотте ЛИНДСТЕДТ
Йёран НИЛЬССОН (SE)
Йёран НИЛЬССОН
Магнус ПОЛЛА (SE)
Магнус Полла
Ерт СТРАНДЛУНД (SE)
Ерт СТРАНДЛУНД
Ильва ЭРТЕНГРЕН (SE)
Ильва ЭРТЕНГРЕН
Original Assignee
Астразенека Аб
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Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of RU2001132563A publication Critical patent/RU2001132563A/ru
Application granted granted Critical
Publication of RU2250903C2 publication Critical patent/RU2250903C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
RU2001132563/04A 1999-06-16 2000-06-15 Новые биспидиновые соединения, полезные при лечении сердечных аритмий RU2250903C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9902268A SE9902268D0 (sv) 1999-06-16 1999-06-16 Pharmaceutically active compounds
SE9902268-3 1999-06-16

Publications (2)

Publication Number Publication Date
RU2001132563A RU2001132563A (ru) 2003-09-10
RU2250903C2 true RU2250903C2 (ru) 2005-04-27

Family

ID=20416100

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001132563/04A RU2250903C2 (ru) 1999-06-16 2000-06-15 Новые биспидиновые соединения, полезные при лечении сердечных аритмий

Country Status (24)

Country Link
EP (1) EP1192157A1 (enrdf_load_stackoverflow)
JP (1) JP2003502329A (enrdf_load_stackoverflow)
KR (1) KR20020010713A (enrdf_load_stackoverflow)
CN (1) CN1144805C (enrdf_load_stackoverflow)
AR (1) AR024577A1 (enrdf_load_stackoverflow)
AU (1) AU761576B2 (enrdf_load_stackoverflow)
BR (1) BR0011660A (enrdf_load_stackoverflow)
CA (1) CA2375841A1 (enrdf_load_stackoverflow)
CZ (1) CZ20014495A3 (enrdf_load_stackoverflow)
EE (1) EE200100675A (enrdf_load_stackoverflow)
HK (1) HK1045520A1 (enrdf_load_stackoverflow)
HU (1) HUP0203959A3 (enrdf_load_stackoverflow)
IL (1) IL146754A0 (enrdf_load_stackoverflow)
IS (1) IS6201A (enrdf_load_stackoverflow)
MX (1) MXPA01012919A (enrdf_load_stackoverflow)
NO (1) NO20016117L (enrdf_load_stackoverflow)
NZ (1) NZ516013A (enrdf_load_stackoverflow)
PL (1) PL354032A1 (enrdf_load_stackoverflow)
RU (1) RU2250903C2 (enrdf_load_stackoverflow)
SE (1) SE9902268D0 (enrdf_load_stackoverflow)
SK (1) SK18272001A3 (enrdf_load_stackoverflow)
TR (1) TR200103663T2 (enrdf_load_stackoverflow)
WO (1) WO2000077000A1 (enrdf_load_stackoverflow)
ZA (1) ZA200109796B (enrdf_load_stackoverflow)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030302A1 (es) * 2000-07-07 2003-08-20 Astrazeneca Ab Compuestos de bispidina, formulacion farmaceutica, uso para la fabricacion de medicamentos, proceso para la preparacion de estos compuestos y compuestos intermediarios
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
TWI499418B (zh) * 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl 異喹啉－１（２ｈ）－酮衍生物
KR101953407B1 (ko) * 2011-07-08 2019-02-28 바이엘 인텔렉쳐 프로퍼티 게엠베하 2-아미노-5-시아노-n,3-디메틸벤즈아미드의 제조 방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306871A2 (de) * 1987-09-09 1989-03-15 Kali-Chemie Pharma GmbH 3,7-Diazabicyclo [3,3,1] nonan-Verbindungen sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0308843A2 (de) * 1987-09-24 1989-03-29 BASF Aktiengesellschaft Bispidinderivate als Klasse III-Antiarrhythmika
WO1991007407A1 (en) * 1989-11-22 1991-05-30 Novo Nordisk A/S Imidazoquinoxaline compounds, their preparation and use
SU1107541A1 (ru) * 1982-12-03 1995-10-20 Институт Тонкой Органической Химии Им.А.Л.Мнджояна 10-нитро-1,6,8-триазатрицикло [6,3,1,1] тридекан-2,5-дион
RU2100357C1 (ru) * 1991-10-03 1997-12-27 Пфайзер Инк. Гетероариламины или их фармацевтически приемлемые соли и фармацевтическая композиция на их основе

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1107541A1 (ru) * 1982-12-03 1995-10-20 Институт Тонкой Органической Химии Им.А.Л.Мнджояна 10-нитро-1,6,8-триазатрицикло [6,3,1,1] тридекан-2,5-дион
EP0306871A2 (de) * 1987-09-09 1989-03-15 Kali-Chemie Pharma GmbH 3,7-Diazabicyclo [3,3,1] nonan-Verbindungen sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0308843A2 (de) * 1987-09-24 1989-03-29 BASF Aktiengesellschaft Bispidinderivate als Klasse III-Antiarrhythmika
WO1991007407A1 (en) * 1989-11-22 1991-05-30 Novo Nordisk A/S Imidazoquinoxaline compounds, their preparation and use
RU2100357C1 (ru) * 1991-10-03 1997-12-27 Пфайзер Инк. Гетероариламины или их фармацевтически приемлемые соли и фармацевтическая композиция на их основе

Also Published As

Publication number Publication date
SE9902268D0 (sv) 1999-06-16
PL354032A1 (en) 2003-12-15
JP2003502329A (ja) 2003-01-21
WO2000077000A1 (en) 2000-12-21
CN1370167A (zh) 2002-09-18
TR200103663T2 (tr) 2002-05-21
CN1144805C (zh) 2004-04-07
BR0011660A (pt) 2002-03-26
HK1045520A1 (zh) 2002-11-29
NO20016117L (no) 2002-02-15
WO2000077000A9 (en) 2003-06-19
ZA200109796B (en) 2003-02-28
EE200100675A (et) 2003-02-17
CZ20014495A3 (cs) 2002-05-15
MXPA01012919A (es) 2002-07-30
EP1192157A1 (en) 2002-04-03
IS6201A (is) 2001-12-14
AU6032400A (en) 2001-01-02
HUP0203959A2 (hu) 2003-03-28
SK18272001A3 (sk) 2002-12-03
HUP0203959A3 (en) 2003-04-28
AU761576B2 (en) 2003-06-05
CA2375841A1 (en) 2000-12-21
NO20016117D0 (no) 2001-12-14
IL146754A0 (en) 2002-07-25
KR20020010713A (ko) 2002-02-04
NZ516013A (en) 2003-06-30
AR024577A1 (es) 2002-10-16

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20060616