RU2240124C2 - Этанолят азитромицина, процесс получения и содержащие его фармацевтические составы - Google Patents

Этанолят азитромицина, процесс получения и содержащие его фармацевтические составы Download PDF

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RU2240124C2
RU2240124C2 RU2001118035/15A RU2001118035A RU2240124C2 RU 2240124 C2 RU2240124 C2 RU 2240124C2 RU 2001118035/15 A RU2001118035/15 A RU 2001118035/15A RU 2001118035 A RU2001118035 A RU 2001118035A RU 2240124 C2 RU2240124 C2 RU 2240124C2
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Russia
Prior art keywords
azithromycin
ethanolate
ethanol
water
suspension
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RU2001118035/15A
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English (en)
Russian (ru)
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RU2001118035A (ru
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АРОНХИМЕ Джудит (IL)
АРОНХИМЕ Джудит
СИНГЕР Клауди (IL)
СИНГЕР Клауди
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Тева Фармасьютикал Индастриз, Лтд.
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Application filed by Тева Фармасьютикал Индастриз, Лтд. filed Critical Тева Фармасьютикал Индастриз, Лтд.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
RU2001118035/15A 1998-11-30 1999-11-30 Этанолят азитромицина, процесс получения и содержащие его фармацевтические составы RU2240124C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11029898P 1998-11-30 1998-11-30
US60/110298 1998-11-30

Publications (2)

Publication Number Publication Date
RU2001118035A RU2001118035A (ru) 2003-04-20
RU2240124C2 true RU2240124C2 (ru) 2004-11-20

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ID=22332273

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Application Number Title Priority Date Filing Date
RU2001118035/15A RU2240124C2 (ru) 1998-11-30 1999-11-30 Этанолят азитромицина, процесс получения и содержащие его фармацевтические составы

Country Status (26)

Country Link
US (1) US6365574B2 (enExample)
EP (2) EP1484062A1 (enExample)
JP (1) JP2002531409A (enExample)
KR (1) KR100603226B1 (enExample)
CN (2) CN100339384C (enExample)
AP (1) AP1709A (enExample)
AT (1) ATE279200T1 (enExample)
AU (1) AU768219B2 (enExample)
BG (1) BG105547A (enExample)
CA (1) CA2352562A1 (enExample)
CZ (1) CZ20011886A3 (enExample)
DE (1) DE69921192T2 (enExample)
DK (1) DK1152765T3 (enExample)
ES (1) ES2229804T3 (enExample)
HK (1) HK1043725B (enExample)
HU (1) HUP0104241A3 (enExample)
IL (1) IL143376A0 (enExample)
LV (1) LV12735B (enExample)
NZ (1) NZ512496A (enExample)
PL (1) PL197894B1 (enExample)
PT (1) PT1152765E (enExample)
RO (1) RO121408B1 (enExample)
RU (1) RU2240124C2 (enExample)
SI (1) SI20639A (enExample)
WO (1) WO2000032203A1 (enExample)
ZA (1) ZA200104312B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2348644C1 (ru) * 2005-06-08 2009-03-10 Ханми Фарм. Ко., Лтд. Кристаллический моногидрат l-малата азитромицина и содержащая его фармацевтическая композиция

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HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
HK1043725B (en) * 1998-11-30 2005-05-06 Teva Pharmaceutical Industries Ltd. Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
JP2004519430A (ja) * 2000-11-27 2004-07-02 バイオケミ・エセ・ア マクロライドの溶媒和物
CN100341886C (zh) * 2000-11-27 2007-10-10 桑多斯股份公司 大环内酯类化合物的溶剂化物
KR100431431B1 (ko) * 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HUP0400446A2 (hu) * 2001-05-22 2004-09-28 Pfizer Products Inc. Azitromicin kristályformái
US6861413B2 (en) * 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1671978A1 (en) * 2001-05-22 2006-06-21 Pfizer Products Inc. New Cristal Form of Azithromycin
EP1541134A3 (en) * 2001-10-18 2007-06-06 Teva Pharmaceutical Industries Limited Stabilized azithromycin compositions
EP1446010B1 (en) 2001-10-18 2009-04-15 Teva Pharmaceutical Industries Ltd. Stabilized azithromycin compositions
US20080149521A9 (en) * 2001-10-18 2008-06-26 Michael Pesachovich Methods of stabilizing azithromycin
IL161259A0 (en) * 2001-12-21 2004-09-27 Pfizer Prod Inc Methods for wet granulating azithromycin
WO2003053416A1 (en) * 2001-12-21 2003-07-03 Pfizer Products Inc. Directly compressible formulations of azithromycin
PL372394A1 (en) * 2002-02-01 2005-07-25 Pfizer Products Inc. Dry granulated formulations of azithromycin
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
US20050101547A1 (en) * 2003-11-06 2005-05-12 Sadatrezaei Mohsen Stabilized azithromycin composition
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
JP2007513147A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 押し出し機を使用して、好ましくはポロキサマーとグリセリドを含有する多粒子結晶性医薬組成物を製造するための噴霧凝結方法
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
DE602004014805D1 (de) * 2003-12-04 2008-08-14 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
CN1889933A (zh) * 2003-12-04 2007-01-03 辉瑞产品公司 由基于液体的工艺制备的阿奇霉素多颗粒剂型
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
US7943585B2 (en) 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
CA2591744A1 (en) * 2004-12-21 2006-06-29 Pfizer Products Inc. Stable non-dihydrate azithromycin oral suspensions
US20060198895A1 (en) * 2005-03-07 2006-09-07 Kotliar Eleonora M Azithromycin powder for oral suspension compositions
US9433516B2 (en) * 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
JP2012520268A (ja) 2009-03-13 2012-09-06 ダ・ボルテラ グラム陰性細菌の除去のための組成物及び方法
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN103983730B (zh) * 2014-06-11 2015-09-30 北京市药品检验所 阿奇霉素或其制剂中的杂质检查方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989000576A1 (en) * 1987-07-09 1989-01-26 Pfizer Inc. Azithromycin dihydrate

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YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
CN1093370A (zh) 1993-12-10 1994-10-12 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
CN1161971A (zh) * 1997-01-03 1997-10-15 石家庄制药集团有限公司 一种阿齐霉素结晶及其制备方法
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
HK1043725B (en) * 1998-11-30 2005-05-06 Teva Pharmaceutical Industries Ltd. Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
HUP0400446A2 (hu) * 2001-05-22 2004-09-28 Pfizer Products Inc. Azitromicin kristályformái

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1989000576A1 (en) * 1987-07-09 1989-01-26 Pfizer Inc. Azithromycin dihydrate
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2348644C1 (ru) * 2005-06-08 2009-03-10 Ханми Фарм. Ко., Лтд. Кристаллический моногидрат l-малата азитромицина и содержащая его фармацевтическая композиция

Also Published As

Publication number Publication date
HK1043725A1 (en) 2002-09-27
PL197894B1 (pl) 2008-05-30
AP2001002183A0 (en) 2001-06-30
LV12735B (en) 2002-03-20
RO121408B1 (ro) 2007-05-30
HUP0104241A3 (en) 2003-12-29
EP1152765A4 (en) 2002-07-17
KR20010099806A (ko) 2001-11-09
IL143376A0 (en) 2002-04-21
DE69921192T2 (de) 2006-02-16
PL347971A1 (en) 2002-05-06
DK1152765T3 (da) 2005-01-31
EP1152765A1 (en) 2001-11-14
JP2002531409A (ja) 2002-09-24
CN1334735A (zh) 2002-02-06
KR100603226B1 (ko) 2006-08-28
CN1737008A (zh) 2006-02-22
DE69921192D1 (de) 2004-11-18
PT1152765E (pt) 2004-12-31
US6365574B2 (en) 2002-04-02
CA2352562A1 (en) 2000-06-08
AU3106500A (en) 2000-06-19
ATE279200T1 (de) 2004-10-15
BG105547A (en) 2001-12-31
ZA200104312B (en) 2001-11-28
EP1152765B1 (en) 2004-10-13
SI20639A (sl) 2002-02-28
CN1273142C (zh) 2006-09-06
US20020007049A1 (en) 2002-01-17
WO2000032203A1 (en) 2000-06-08
AP1709A (en) 2007-02-27
ES2229804T3 (es) 2005-04-16
LV12735A (en) 2001-10-20
HK1043725B (en) 2005-05-06
EP1484062A1 (en) 2004-12-08
AU768219B2 (en) 2003-12-04
NZ512496A (en) 2003-02-28
CZ20011886A3 (cs) 2001-10-17
CN100339384C (zh) 2007-09-26
HUP0104241A2 (hu) 2002-03-28

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Effective date: 20041201