DE69921192D1 - Ethanolate des azithromycin, herstllungsverfahren und deren pharmazeutische zusammenstellungen - Google Patents

Ethanolate des azithromycin, herstllungsverfahren und deren pharmazeutische zusammenstellungen

Info

Publication number
DE69921192D1
DE69921192D1 DE1999621192 DE69921192T DE69921192D1 DE 69921192 D1 DE69921192 D1 DE 69921192D1 DE 1999621192 DE1999621192 DE 1999621192 DE 69921192 T DE69921192 T DE 69921192T DE 69921192 D1 DE69921192 D1 DE 69921192D1
Authority
DE
Germany
Prior art keywords
compilations
ethanolate
azithromycin
pharmaceutical
production process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE1999621192
Other languages
English (en)
Other versions
DE69921192T2 (de
Inventor
Claude Singer
Judith Aronhime
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22332273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69921192(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of DE69921192D1 publication Critical patent/DE69921192D1/de
Publication of DE69921192T2 publication Critical patent/DE69921192T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69921192T 1998-11-30 1999-11-30 Ethanolate des azithromycin, herstllungsverfahren und deren pharmazeutische zusammenstellungen Expired - Fee Related DE69921192T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11029898P 1998-11-30 1998-11-30
US110298P 1998-11-30
PCT/US1999/028368 WO2000032203A1 (en) 1998-11-30 1999-11-30 Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
DE69921192D1 true DE69921192D1 (de) 2004-11-18
DE69921192T2 DE69921192T2 (de) 2006-02-16

Family

ID=22332273

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69921192T Expired - Fee Related DE69921192T2 (de) 1998-11-30 1999-11-30 Ethanolate des azithromycin, herstllungsverfahren und deren pharmazeutische zusammenstellungen

Country Status (26)

Country Link
US (1) US6365574B2 (de)
EP (2) EP1484062A1 (de)
JP (1) JP2002531409A (de)
KR (1) KR100603226B1 (de)
CN (2) CN100339384C (de)
AP (1) AP1709A (de)
AT (1) ATE279200T1 (de)
AU (1) AU768219B2 (de)
BG (1) BG105547A (de)
CA (1) CA2352562A1 (de)
CZ (1) CZ20011886A3 (de)
DE (1) DE69921192T2 (de)
DK (1) DK1152765T3 (de)
ES (1) ES2229804T3 (de)
HK (1) HK1043725B (de)
HU (1) HUP0104241A3 (de)
IL (1) IL143376A0 (de)
LV (1) LV12735B (de)
NZ (1) NZ512496A (de)
PL (1) PL197894B1 (de)
PT (1) PT1152765E (de)
RO (1) RO121408B1 (de)
RU (1) RU2240124C2 (de)
SI (1) SI20639A (de)
WO (1) WO2000032203A1 (de)
ZA (1) ZA200104312B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
CZ20011886A3 (cs) * 1998-11-30 2001-10-17 Teva Pharmaceutical Industries Ltd. Etanolát azitromycinu, postup přípravy a jeho farmaceutické preparáty
JP2004519430A (ja) * 2000-11-27 2004-07-02 バイオケミ・エセ・ア マクロライドの溶媒和物
UA76967C2 (uk) * 2000-11-27 2006-10-16 Сандоз Аг Азитроміцин у формі моногідрату, фармацевтична композиція та спосіб його одержання
KR100431431B1 (ko) * 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
EE200300575A (et) 2001-05-22 2004-04-15 Pfizer Products Inc. Asitromütsiini kristalsed vormid
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
SI1390377T1 (sl) * 2001-05-22 2006-06-30 Pfizer Prod Inc Nova kristalna oblika azitromicina
US20080149521A9 (en) * 2001-10-18 2008-06-26 Michael Pesachovich Methods of stabilizing azithromycin
EP1541134A3 (de) * 2001-10-18 2007-06-06 Teva Pharmaceutical Industries Limited Stabilisierte Azithromycin-Zusammensetzungen
HUP0402291A2 (hu) * 2001-10-18 2005-03-29 Teva Pharmaceutical Industries Ltd. Stabilizált azithromycin összetételek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
JP2005513099A (ja) * 2001-12-21 2005-05-12 ファイザー・プロダクツ・インク アジスロマイシンの直接的に圧縮可能な配合品
RU2283651C2 (ru) * 2001-12-21 2006-09-20 Пфайзер Продактс Инк. Способы мокрой грануляции азитромицина
EP1478347A1 (de) * 2002-02-01 2004-11-24 Pfizer Products Inc. Trockene granulierte formulierungen von azithromycin
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
US20050101547A1 (en) * 2003-11-06 2005-05-12 Sadatrezaei Mohsen Stabilized azithromycin composition
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
ATE399536T1 (de) * 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
CA2547239A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
US7943585B2 (en) 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
WO2006067577A2 (en) * 2004-12-21 2006-06-29 Pfizer Products Inc. Stable non-dihydrate azithromycin oral suspensions
US20060198895A1 (en) * 2005-03-07 2006-09-07 Kotliar Eleonora M Azithromycin powder for oral suspension compositions
US9433516B2 (en) * 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
JP2012520268A (ja) 2009-03-13 2012-09-06 ダ・ボルテラ グラム陰性細菌の除去のための組成物及び方法
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN103983730B (zh) * 2014-06-11 2015-09-30 北京市药品检验所 阿奇霉素或其制剂中的杂质检查方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
UA27040C2 (uk) * 1987-07-09 2000-02-28 Пфайзер Інк. Кристалічhий дигідрат азитроміциhу та спосіб одержаhhя кристалічhого дигідрату азитроміциhу
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
CN1093370A (zh) 1993-12-10 1994-10-12 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
CN1161971A (zh) * 1997-01-03 1997-10-15 石家庄制药集团有限公司 一种阿齐霉素结晶及其制备方法
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
CZ20011886A3 (cs) * 1998-11-30 2001-10-17 Teva Pharmaceutical Industries Ltd. Etanolát azitromycinu, postup přípravy a jeho farmaceutické preparáty
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
EE200300575A (et) * 2001-05-22 2004-04-15 Pfizer Products Inc. Asitromütsiini kristalsed vormid

Also Published As

Publication number Publication date
EP1484062A1 (de) 2004-12-08
AP1709A (en) 2007-02-27
PT1152765E (pt) 2004-12-31
RU2240124C2 (ru) 2004-11-20
CA2352562A1 (en) 2000-06-08
JP2002531409A (ja) 2002-09-24
ES2229804T3 (es) 2005-04-16
SI20639A (sl) 2002-02-28
LV12735A (en) 2001-10-20
US6365574B2 (en) 2002-04-02
EP1152765A4 (de) 2002-07-17
LV12735B (en) 2002-03-20
RO121408B1 (ro) 2007-05-30
DK1152765T3 (da) 2005-01-31
HUP0104241A2 (hu) 2002-03-28
NZ512496A (en) 2003-02-28
AP2001002183A0 (en) 2001-06-30
BG105547A (en) 2001-12-31
US20020007049A1 (en) 2002-01-17
PL347971A1 (en) 2002-05-06
CN100339384C (zh) 2007-09-26
CN1737008A (zh) 2006-02-22
AU768219B2 (en) 2003-12-04
AU3106500A (en) 2000-06-19
KR100603226B1 (ko) 2006-08-28
HUP0104241A3 (en) 2003-12-29
ATE279200T1 (de) 2004-10-15
CN1334735A (zh) 2002-02-06
CN1273142C (zh) 2006-09-06
EP1152765B1 (de) 2004-10-13
CZ20011886A3 (cs) 2001-10-17
HK1043725B (zh) 2005-05-06
KR20010099806A (ko) 2001-11-09
ZA200104312B (en) 2001-11-28
IL143376A0 (en) 2002-04-21
PL197894B1 (pl) 2008-05-30
DE69921192T2 (de) 2006-02-16
EP1152765A1 (de) 2001-11-14
HK1043725A1 (en) 2002-09-27
WO2000032203A1 (en) 2000-06-08

Similar Documents

Publication Publication Date Title
DE69921192D1 (de) Ethanolate des azithromycin, herstllungsverfahren und deren pharmazeutische zusammenstellungen
DE69903279D1 (de) Fumagillolderivate und deren herstellngsverfahren
EE200300370A (et) Atsüülitud 6,7,8,9-tetrahüdro-5H-bensotsükloheptenüülamiinid, nende valmistamismeetod, kasutamine ja farmatseutiline preparaat
ATE164843T1 (de) Naphthalinderivate, ihre herstellungsverfahren und zwischenprodukte dafür, und diese enthaltende pharmazeutische zusammensetzungen
DE69910222D1 (de) Flanschlose naht für wegwerfartikel und deren herstellungsverfahren
DE69900366D1 (de) Flammfeste emv-gerechte dichtungsmaterialen und deren herststellungsverfahren
EE200200095A (et) Sulfonüülkarboksamiidi derivaadid, nende kasutamine, ravim ja nende valmistamismeetod
DE60018158T8 (de) Seitenairbagsystem und dessen Herstellungsverfahren
BR9506147A (pt) Novos derivados de eritromicina seu processo de preparação e sua aplicação como medicamentos
DE69808499D1 (de) Widerstand und herstellungsverfahren
DZ1880A1 (fr) Forme posologique d'azithromycine et son procédé de production.
DE59913180D1 (de) Produktebestellungsverfahren und system
DZ3373A1 (fr) Catalyseur et procede de preparation d'hydrocarbures
DE60017012D1 (de) Orginalitätsverschluss und Herstellungverfahren
ATE246270T1 (de) Rhodium-elektrokatalysator und dessen herstellungsverfahren
EE03767B1 (et) Arüülglütsiinamiidi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline preparaat
NO20011409D0 (no) Farmasøytiske midler for behandling av Parkinsonssykdom, ADHD og mikroadenomer
HU9904392D0 (en) New derivatives of erythromycin, process for their production and their use as medicament
TR199801871A3 (tr) Bifenilsulfonilsiyanamidler üretim yöntemi ve ilaç olarak kullanimlari.
FR2774910B1 (fr) Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques
HU9901526D0 (en) Pharmaceutical intermediates and process for producing them
DE69822676D1 (de) Walzanlage und Walzverfahren
FR2791980B1 (fr) Pyrido-thieno-diazepines, leur procede de preparation, et les compositions pharmaceutiques les contenant
BR9710537A (pt) Novos derivados da eritromicina seu processo de preparo e sua aplica-Æo como medicamentos
FR2831169B1 (fr) Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee