HK1043725B - 阿齊霉素的乙醇化物，製備方法以及醫藥組合物 - Google Patents

阿齊霉素的乙醇化物，製備方法以及醫藥組合物

Info

Publication number
HK1043725B
HK1043725B HK02102775.5A HK02102775A HK1043725B HK 1043725 B HK1043725 B HK 1043725B HK 02102775 A HK02102775 A HK 02102775A HK 1043725 B HK1043725 B HK 1043725B
Authority
HK
Hong Kong
Prior art keywords
ethanolate
azithromycin
manufacture
pharmaceutical compositions
pharmaceutical
Prior art date
Application number
HK02102775.5A
Other languages
English (en)
Other versions
HK1043725A1 (en
Inventor
Singer Claude
Aronhime Judith
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22332273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1043725(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of HK1043725A1 publication Critical patent/HK1043725A1/xx
Publication of HK1043725B publication Critical patent/HK1043725B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HK02102775.5A 1998-11-30 2002-04-12 阿齊霉素的乙醇化物，製備方法以及醫藥組合物 HK1043725B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11029898P 1998-11-30 1998-11-30
PCT/US1999/028368 WO2000032203A1 (en) 1998-11-30 1999-11-30 Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
HK1043725A1 HK1043725A1 (en) 2002-09-27
HK1043725B true HK1043725B (zh) 2005-05-06

Family

ID=22332273

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02102775.5A HK1043725B (zh) 1998-11-30 2002-04-12 阿齊霉素的乙醇化物，製備方法以及醫藥組合物

Country Status (26)

Country Link
US (1) US6365574B2 (zh)
EP (2) EP1484062A1 (zh)
JP (1) JP2002531409A (zh)
KR (1) KR100603226B1 (zh)
CN (2) CN100339384C (zh)
AP (1) AP1709A (zh)
AT (1) ATE279200T1 (zh)
AU (1) AU768219B2 (zh)
BG (1) BG105547A (zh)
CA (1) CA2352562A1 (zh)
CZ (1) CZ20011886A3 (zh)
DE (1) DE69921192T2 (zh)
DK (1) DK1152765T3 (zh)
ES (1) ES2229804T3 (zh)
HK (1) HK1043725B (zh)
HU (1) HUP0104241A3 (zh)
IL (1) IL143376A0 (zh)
LV (1) LV12735B (zh)
NZ (1) NZ512496A (zh)
PL (1) PL197894B1 (zh)
PT (1) PT1152765E (zh)
RO (1) RO121408B1 (zh)
RU (1) RU2240124C2 (zh)
SI (1) SI20639A (zh)
WO (1) WO2000032203A1 (zh)
ZA (1) ZA200104312B (zh)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
JP2002531409A (ja) * 1998-11-30 2002-09-24 テバ ファーマシューティカル インダストリーズ リミティド アジスロマイシンのエタノール付加物、その製造方法、及びその医薬製剤
CN100341886C (zh) * 2000-11-27 2007-10-10 桑多斯股份公司 大环内酯类化合物的溶剂化物
HU229488B1 (hu) * 2000-11-27 2014-01-28 Sandoz Ag Eljárás makrolid hidrátok elõállítására
KR100431431B1 (ko) * 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
US6861413B2 (en) * 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
JP2004530703A (ja) * 2001-05-22 2004-10-07 ファイザー・プロダクツ・インク 結晶形アジスロマイシン
SI1390377T1 (sl) * 2001-05-22 2006-06-30 Pfizer Prod Inc Nova kristalna oblika azitromicina
DE60232005D1 (de) * 2001-10-18 2009-05-28 Teva Pharma Stabilisierte azithromycin-zusammensetzungen
US20080149521A9 (en) * 2001-10-18 2008-06-26 Michael Pesachovich Methods of stabilizing azithromycin
EP1541134A3 (en) * 2001-10-18 2007-06-06 Teva Pharmaceutical Industries Limited Stabilized azithromycin compositions
PL371125A1 (en) * 2001-12-21 2005-06-13 Pfizer Products Inc. Methods for wet granulating azithromycin
EP1455758A1 (en) * 2001-12-21 2004-09-15 Pfizer Products Inc. Directly compressible formulations of azithromycin
NZ534234A (en) * 2002-02-01 2007-05-31 Pfizer Prod Inc Dry granulated formulations of non-dihydrate form of azithromycin
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
US20050101547A1 (en) * 2003-11-06 2005-05-12 Sadatrezaei Mohsen Stabilized azithromycin composition
BRPI0416534A (pt) * 2003-12-04 2007-01-09 Pfizer Prod Inc composições multiparticuladas com estabilidade melhorada
ATE399536T1 (de) * 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
RU2006119453A (ru) * 2003-12-04 2007-12-20 Пфайзер Продактс Инк. (Us) Получение посредством основанных на применении жидкостей способов лекарственные формы азитромицина с большим количеством частиц
US7943585B2 (en) 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
JP2008524318A (ja) * 2004-12-21 2008-07-10 ファイザー・プロダクツ・インク 安定なアジスロマイシン非二水和物の経口用懸濁液剤
US20060198895A1 (en) * 2005-03-07 2006-09-07 Kotliar Eleonora M Azithromycin powder for oral suspension compositions
US9433516B2 (en) * 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
MX2011009548A (es) 2009-03-13 2011-12-14 Da Volterra Composiciones y metodos para la eliminacion de bacterias gram-negativas.
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN103983730B (zh) * 2014-06-11 2015-09-30 北京市药品检验所 阿奇霉素或其制剂中的杂质检查方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
CN1093370A (zh) * 1993-12-10 1994-10-12 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
CN1161971A (zh) * 1997-01-03 1997-10-15 石家庄制药集团有限公司 一种阿齐霉素结晶及其制备方法
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
JP2002531409A (ja) * 1998-11-30 2002-09-24 テバ ファーマシューティカル インダストリーズ リミティド アジスロマイシンのエタノール付加物、その製造方法、及びその医薬製剤
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
JP2004530703A (ja) * 2001-05-22 2004-10-07 ファイザー・プロダクツ・インク 結晶形アジスロマイシン

Also Published As

Publication number Publication date
CZ20011886A3 (cs) 2001-10-17
HUP0104241A2 (hu) 2002-03-28
EP1152765A4 (en) 2002-07-17
AU3106500A (en) 2000-06-19
RO121408B1 (ro) 2007-05-30
DE69921192D1 (de) 2004-11-18
DK1152765T3 (da) 2005-01-31
EP1152765A1 (en) 2001-11-14
BG105547A (en) 2001-12-31
PL347971A1 (en) 2002-05-06
ATE279200T1 (de) 2004-10-15
IL143376A0 (en) 2002-04-21
ZA200104312B (en) 2001-11-28
AP1709A (en) 2007-02-27
HUP0104241A3 (en) 2003-12-29
NZ512496A (en) 2003-02-28
HK1043725A1 (en) 2002-09-27
US20020007049A1 (en) 2002-01-17
CN1273142C (zh) 2006-09-06
JP2002531409A (ja) 2002-09-24
CN100339384C (zh) 2007-09-26
KR20010099806A (ko) 2001-11-09
SI20639A (sl) 2002-02-28
AU768219B2 (en) 2003-12-04
US6365574B2 (en) 2002-04-02
WO2000032203A1 (en) 2000-06-08
CA2352562A1 (en) 2000-06-08
KR100603226B1 (ko) 2006-08-28
LV12735A (en) 2001-10-20
AP2001002183A0 (en) 2001-06-30
EP1484062A1 (en) 2004-12-08
ES2229804T3 (es) 2005-04-16
EP1152765B1 (en) 2004-10-13
LV12735B (en) 2002-03-20
PL197894B1 (pl) 2008-05-30
DE69921192T2 (de) 2006-02-16
CN1737008A (zh) 2006-02-22
CN1334735A (zh) 2002-02-06
PT1152765E (pt) 2004-12-31
RU2240124C2 (ru) 2004-11-20

Similar Documents

Publication Publication Date Title
PL347971A1 (en) Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
HUP0102084A3 (en) Quinoline derivatives, process for producing them and pharmaceutical compositions containing them
HUP9900120A3 (en) Benzosulfone derivatives, process for producing them and pharmaceutical compositions containing them
HUP0103224A3 (en) Quinoline derivatives, process for producing them and pharmaceutical compositions containing them
HUP0102851A3 (en) Antiparasitic artemisinin derivatives (endoperoxides), process for their preparation and pharmaceutical compositions containing them
HUP0204252A3 (en) Process for preparing clarithromycin polymorphs and pharmaceutical compositions containing them
HUP0103913A3 (en) Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same
HUP0104762A3 (en) Pharmaceutical moxifloxacin compositions and process for their preparation
PL341549A1 (en) Novel-beta-carbolinic compounds, method of obtaining them and pharmacological compositions containing such compounds
PL349448A1 (en) Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process
HUP0100488A3 (en) Thienopyrimidines, process for their preparation and pharmaceutical compositions containing them
HUP0102215A3 (en) Benzoylpyridazines, pharmaceutical compositions containing the same and process for their preparation
HUP0102622A3 (en) Biphenyl derivatives, process for producing them and pharmaceutical compositions containing them
HU9800781D0 (en) Propanolamine derivatives, process for producing them, pharmaceutical compositions containing them and their use
HK1039122A1 (zh) 取代的6-苄基-4-氧代嘧啶，其製備方法以及含該化合物的藥物組合物
SG118060A1 (en) Process for preparation of pyrazoloÄ4,3-dÜpyrimidin-7-ones and intermediates thereof
EG22344A (en) Process for preparing of novel pharmaceutical composition
HUP0102042A3 (en) New pentasaccharides, their methods of production and pharmaceutical compositions comprising same
HUP0101234A3 (en) Betha-carboline derivatives, process for their preparation and pharmaceutical compositions thereof
HUP0101256A3 (en) Pharmaceutical composition having antitumor activity and process for the preparation thereof
HUP0104202A3 (en) Thiazole-derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0100019A3 (en) Novel polymorphic forms of cipamfylline, process for their preparation and pharmaceutical compositions thereof
HUP9904564A3 (en) Substituted aminomethyl-cycloheptenes, process for producing them, their use, and pharmaceutical compositions containing them
IL139243A0 (en) Ethanolate of zafirlukast, process for manufacture and pharmaceutical compositions thereof
HUP0103992A3 (en) Pregnane glucuronides, process for their production and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20081130