HUP0402291A2 - Stabilizált azithromycin összetételek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Stabilizált azithromycin összetételek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0402291A2
HUP0402291A2 HU0402291A HUP0402291A HUP0402291A2 HU P0402291 A2 HUP0402291 A2 HU P0402291A2 HU 0402291 A HU0402291 A HU 0402291A HU P0402291 A HUP0402291 A HU P0402291A HU P0402291 A2 HUP0402291 A2 HU P0402291A2
Authority
HU
Hungary
Prior art keywords
azithromycin
compositions
preparation
stabilized
stabilized azithromycin
Prior art date
Application number
HU0402291A
Other languages
English (en)
Inventor
Ruth Tenengauzer
Joseph Schwarz
Julia Hrakovsky
Tania Lessen
Lev Khondo
Mathi Mathivanan
Claude Singer
Michael Pesachovich
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of HUP0402291A2 publication Critical patent/HUP0402291A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

Ezúton az azithromycin-összetételek stabilizációs módszereit és azokösszetételeit adják meg. A stabilizált azithromycin-összetételek azazithromycinnek és a stabilizálást célzó, az azithromycin-bomlásgátlását javító, hatékony mennyiségű antioxidánsnak az adottösszetételű keverékét tartalmazzák. Az adott összetétel elérésénekgyakorlatilag előnyös módszere az azithromycinnek és az antioxidánsnakaz egyidejű kicsapása, ill. egyidejű őrlése. A stabilizáltazithromycin- összetételeket tartalmazó gyógyszerkészítményeket,valamint ilyen gyógyszerkészítmények előállítását szintén megadják. Ó
HU0402291A 2001-10-18 2002-10-18 Stabilizált azithromycin összetételek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények HUP0402291A2 (hu)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33634601P 2001-10-18 2001-10-18
US33193101P 2001-11-21 2001-11-21
US34129501P 2001-12-17 2001-12-17
PCT/US2002/033339 WO2003032922A2 (en) 2001-10-18 2002-10-18 Stabilized azithromycin compositions

Publications (1)

Publication Number Publication Date
HUP0402291A2 true HUP0402291A2 (hu) 2005-03-29

Family

ID=27406829

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402291A HUP0402291A2 (hu) 2001-10-18 2002-10-18 Stabilizált azithromycin összetételek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Country Status (13)

Country Link
US (3) US6764997B2 (hu)
EP (1) EP1446010B1 (hu)
AT (1) ATE428403T1 (hu)
AU (1) AU2002335087A1 (hu)
CA (1) CA2463619C (hu)
DE (1) DE60232005D1 (hu)
DK (1) DK1446010T3 (hu)
ES (1) ES2324527T3 (hu)
HK (1) HK1067278A1 (hu)
HU (1) HUP0402291A2 (hu)
IL (1) IL161398A0 (hu)
PT (1) PT1446010E (hu)
WO (1) WO2003032922A2 (hu)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
JP2004530703A (ja) 2001-05-22 2004-10-07 ファイザー・プロダクツ・インク 結晶形アジスロマイシン
US20080149521A9 (en) * 2001-10-18 2008-06-26 Michael Pesachovich Methods of stabilizing azithromycin
EP1455758A1 (en) * 2001-12-21 2004-09-15 Pfizer Products Inc. Directly compressible formulations of azithromycin
WO2003053399A2 (en) * 2001-12-21 2003-07-03 Pfizer Products Inc. Methods for wet granulating azithromycin
BR0307331A (pt) * 2002-02-01 2004-12-07 Pfizer Prod Inc Formulações granuladas a seco de azitromicina
CA2517004A1 (en) * 2003-02-19 2004-09-02 Teva Pharmaceutical Industries Ltd. Methods of stabilizing azithromycin during storage by packaging in a gas impermeable container
US20040266997A1 (en) * 2003-03-25 2004-12-30 Michael Pesachovich Degradation products of azithromycin, and methods for their indentification
CA2521462A1 (en) * 2003-04-17 2004-10-28 Sandoz Ag Derivatives of azithromycin
EP1648472A2 (en) * 2003-07-01 2006-04-26 Ranbaxy Laboratories, Ltd. Stable oral compositions of azithromycin monohydrate
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
JP2007507489A (ja) * 2003-09-30 2007-03-29 ソルベスト リミテッド 水可溶性ナノ粒子封入複合体
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
EP1830860A2 (en) * 2004-12-21 2007-09-12 Pfizer Products Incorporated Stable non-dihydrate azithromycin oral suspensions
US20060198895A1 (en) * 2005-03-07 2006-09-07 Kotliar Eleonora M Azithromycin powder for oral suspension compositions
US8906823B2 (en) * 2007-09-24 2014-12-09 Basf Corporation Pollutant emission control sorbents and methods of manufacture and use
TWI468167B (zh) 2007-11-16 2015-01-11 威佛（國際）股份有限公司 藥學組成物
US8106111B2 (en) 2009-05-15 2012-01-31 Eastman Chemical Company Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions
WO2011015219A1 (en) 2009-08-06 2011-02-10 Shifa Pharmed Industrial Group Co. Process for the purification of azithromycin by separation from its thermal degradation products and/or isomers
RU2512683C2 (ru) * 2012-06-08 2014-04-10 Общество с ограниченной ответственностью "ВИК-здоровье животных" Антибактериальная инъекционная фармацевтическая композиция
EP3615032A4 (en) * 2017-04-28 2020-12-23 Asana BioSciences, LLC FORMULATIONS, PROCEDURES, KITS AND DOSING FORMS FOR TREATMENT OF ATOPIC DERMATITIS AND IMPROVED STABILITY OF AN ACTIVE INGREDIENT
RU2666607C1 (ru) * 2017-05-03 2018-09-11 Общество С Ограниченной Ответственностью "Вик - Здоровье Животных" Способ повышения стабильности инъекционной фармацевтической композиции
US11654124B2 (en) 2019-07-29 2023-05-23 Amneal Pharmaceuticals Llc Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives
US10792262B1 (en) * 2019-07-29 2020-10-06 Saol International Limited Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives
CN111450065B (zh) * 2020-04-22 2022-04-01 南京嘉晨医药科技有限公司 一种阿奇霉素干混悬剂的制备方法

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YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
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US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
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TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
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EP1484062A1 (en) * 1998-11-30 2004-12-08 Teva Pharmaceutical Industries Limited Crystalline azithromycin, process for manufacture and pharmaceutical compositions thereof
US6239113B1 (en) * 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
IT1313610B1 (it) * 1999-08-09 2002-09-09 S I F I Societa Ind Farmaceuti Processo per la preparazione di formulazioni acquose per uso oftalmico

Also Published As

Publication number Publication date
ES2324527T3 (es) 2009-08-10
AU2002335087A1 (en) 2003-04-28
CA2463619A1 (en) 2003-04-24
CA2463619C (en) 2008-05-06
IL161398A0 (en) 2004-09-27
EP1446010A4 (en) 2007-06-13
DK1446010T3 (da) 2009-06-22
PT1446010E (pt) 2009-06-08
HK1067278A1 (en) 2005-04-08
DE60232005D1 (de) 2009-05-28
US20050106239A1 (en) 2005-05-19
US20040192622A1 (en) 2004-09-30
EP1446010B1 (en) 2009-04-15
WO2003032922A2 (en) 2003-04-24
US6764997B2 (en) 2004-07-20
WO2003032922A3 (en) 2003-10-16
US20030176369A1 (en) 2003-09-18
ATE428403T1 (de) 2009-05-15
EP1446010A2 (en) 2004-08-18

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees