RU2227033C2 - Тауролидин и/или таурултам при лечении инфекционной язвенной болезни или инфекционного гастрита - Google Patents
Тауролидин и/или таурултам при лечении инфекционной язвенной болезни или инфекционного гастритаInfo
- Publication number
- RU2227033C2 RU2227033C2 RU2001107149/15A RU2001107149A RU2227033C2 RU 2227033 C2 RU2227033 C2 RU 2227033C2 RU 2001107149/15 A RU2001107149/15 A RU 2001107149/15A RU 2001107149 A RU2001107149 A RU 2001107149A RU 2227033 C2 RU2227033 C2 RU 2227033C2
- Authority
- RU
- Russia
- Prior art keywords
- combination
- taurolidine
- taurultam
- helicobacter
- microorganisms
- Prior art date
Links
- AJKIRUJIDFJUKJ-UHFFFAOYSA-N taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 title claims abstract 10
- 229960004267 taurolidine Drugs 0.000 title claims abstract 10
- RJGYJMFQWGPBGM-UHFFFAOYSA-N 1,2,4-thiadiazinane 1,1-dioxide Chemical compound O=S1(=O)CCNCN1 RJGYJMFQWGPBGM-UHFFFAOYSA-N 0.000 title claims abstract 8
- 229950007343 taurultam Drugs 0.000 title claims abstract 8
- 208000015181 infectious disease Diseases 0.000 title claims 6
- 230000002458 infectious effect Effects 0.000 title 2
- 208000007882 Gastritis Diseases 0.000 title 1
- 208000025865 Ulcer Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 claims abstract 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 6
- 244000005700 microbiome Species 0.000 claims abstract 6
- 241000589989 Helicobacter Species 0.000 claims abstract 5
- 241000590002 Helicobacter pylori Species 0.000 claims abstract 5
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract 5
- 229940037467 helicobacter pylori Drugs 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 210000002784 stomach Anatomy 0.000 claims abstract 4
- 102100021904 Potassium-transporting ATPase alpha chain 1 Human genes 0.000 claims abstract 2
- 108010083204 Proton Pumps Proteins 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims abstract 2
- 239000003112 inhibitor Substances 0.000 claims abstract 2
- 239000004599 antimicrobial Substances 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229940126409 proton pump inhibitor Drugs 0.000 claims 2
- 239000000612 proton pump inhibitor Substances 0.000 claims 2
- 229960004157 rabeprazole Drugs 0.000 claims 2
- YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 claims 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims 1
- 229940069428 antacid Drugs 0.000 claims 1
- 239000003159 antacid agent Substances 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 210000004211 gastric acid Anatomy 0.000 claims 1
- 210000001156 gastric mucosa Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 229960000381 omeprazole Drugs 0.000 claims 1
- 239000011253 protective coating Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 abstract 2
- 101710112752 Cytotoxin Proteins 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 239000002619 cytotoxin Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 230000007918 pathogenicity Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15445198A | 1998-09-16 | 1998-09-16 | |
| US09/154,451 | 1998-09-16 | ||
| US09/316,115 | 1999-05-20 | ||
| US09/316,115 US6117868A (en) | 1998-09-16 | 1999-05-20 | Treatment of gastrointestinal ulcers or gastritis caused by microbial infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001107149A RU2001107149A (ru) | 2003-04-20 |
| RU2227033C2 true RU2227033C2 (ru) | 2004-04-20 |
Family
ID=26851461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001107149/15A RU2227033C2 (ru) | 1998-09-16 | 1999-09-13 | Тауролидин и/или таурултам при лечении инфекционной язвенной болезни или инфекционного гастрита |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6117868A (enExample) |
| EP (1) | EP1112074B1 (enExample) |
| JP (1) | JP4981208B2 (enExample) |
| CA (1) | CA2344308C (enExample) |
| DE (1) | DE69916629T2 (enExample) |
| ES (1) | ES2219061T3 (enExample) |
| RU (1) | RU2227033C2 (enExample) |
| WO (1) | WO2000015232A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010114425A2 (ru) | 2009-03-30 | 2010-10-07 | Dikovskiy Aleksander Vladimirovich | Фармацевтическая композиция ингибитора протонной помпы и пребиотика для лечения язвенных поражений желудка и 12- перстной кишки |
| RU2576511C2 (ru) * | 2010-02-24 | 2016-03-10 | Эмисфире Текнолоджис, Инк. | Пероральная терапия недостаточности витамина в12 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050124608A1 (en) * | 2001-04-03 | 2005-06-09 | Redmond H. P. | Treatment of cancers |
| US8304390B2 (en) * | 1997-07-31 | 2012-11-06 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method of treatment for preventing or reducing tumor growth in the liver of patient |
| US7345039B2 (en) * | 1999-06-04 | 2008-03-18 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer |
| US8030301B2 (en) * | 1999-06-04 | 2011-10-04 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of cancers with methylol-containing compounds and at least one electrolyte |
| US7892530B2 (en) * | 1999-06-04 | 2011-02-22 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of tumor metastases and cancer |
| JP2001122777A (ja) * | 1999-10-27 | 2001-05-08 | Nagase & Co Ltd | 抗潰瘍剤 |
| CN100519525C (zh) * | 1999-12-06 | 2009-07-29 | 葛兰素集团有限公司 | 芳香砜类及其医疗用途 |
| JP2003515558A (ja) * | 1999-12-06 | 2003-05-07 | ロード アイランド ホスピタル, ア ライフスパン パートナー | 腫瘍を治療するためのメチロール含有化合物の使用 |
| FR2803206A1 (fr) * | 1999-12-30 | 2001-07-06 | Aventis Pharma Sa | Composition comprenant des acides nucleiques, preparation et utilisation |
| US6365198B1 (en) * | 2001-01-28 | 2002-04-02 | Gulf Pharmaceutical Industries | Pharmaceutical preparation for the treatment of gastrointestinal ulcers and hemorrhoids |
| US6753328B2 (en) | 2001-10-01 | 2004-06-22 | Rhode Island Hospital | Methods of inhibiting metastases |
| FI20021819A0 (fi) * | 2002-10-14 | 2002-10-14 | Pekka Untamo Heino | Valmiste alkoholin metabolian tehostamiseksi |
| RU2265437C2 (ru) * | 2003-07-02 | 2005-12-10 | Суханов Александр Владимирович | Способ лечения заболеваний желудка и двенадцатиперстной кишки, вызванных helicobacter pylori |
| JP2007537200A (ja) * | 2004-05-14 | 2007-12-20 | ハンス−ディートリヒ・ポラシェグ | タウロリジン製剤及び投与:細菌マイクロフィルム形成に対する治療処置及び抗菌保護 |
| ES2372429T3 (es) * | 2006-12-20 | 2012-01-19 | Kyowa Chemical Industry Co., Ltd. | Antiácido. |
| EP2601947A1 (en) * | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Fixed-dose combination for treatment of helicobacter pylori associated diseases |
| PL2861573T3 (pl) | 2012-06-18 | 2018-02-28 | Geistlich Pharma Ag | Pochodne oksatiazyny jako środki przeciwbakteryjne i przeciwnowotworowe |
| KR20180105115A (ko) * | 2015-10-07 | 2018-09-27 | 코르메딕스, 인코포레이티드 | 타우로리딘의 피부-침투성 제제 |
| CN117159461A (zh) * | 2023-07-26 | 2023-12-05 | 合肥远志医药科技开发有限公司 | 一种铝碳酸镁混悬液及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5077281A (en) * | 1985-09-20 | 1991-12-31 | Reinmueller Johannes | Novel use of taurolin |
| RU2025128C1 (ru) * | 1989-01-19 | 1994-12-30 | ШМИДТ Альфред | Средство для лечения воспалительных заболеваний пищевода и воспалительных и язвенных заболеваний желудочно-кишечного тракта |
| WO1996024375A1 (en) * | 1995-02-06 | 1996-08-15 | Astra Aktiebolag | New oral pharmaceutical dosage form |
| WO1997036599A1 (en) * | 1996-03-29 | 1997-10-09 | Marcin Krotkiewski | Pharmaceutical preparation for the treatment of gastritis, reflux oesophagitis, duodenitis, dyspepsia and ulcer disease |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1124285A (en) * | 1964-10-06 | 1968-08-21 | Geistlich Soehne Ag | Novel perhydro-1,2,4-thiadiazine dioxides-(1,1), their preparation and compositionscontaining them |
| US5256684A (en) * | 1985-06-13 | 1993-10-26 | The Procter & Gamble Company | Methods and compositions for the treatment of gastrointestinal disorders |
| US5210083A (en) * | 1986-07-17 | 1993-05-11 | Ed. Geistlich Sohne A.G. Fur Chemische Industrie | Pharmaceutical compositions |
| GB8617482D0 (en) * | 1986-07-17 | 1986-08-28 | Geistlich Soehne Ag | Pharmaceutical composition |
| GB9005856D0 (en) * | 1990-03-15 | 1990-05-09 | Geistlich Soehne Ag | Compositions |
| IL105155A (en) * | 1992-04-24 | 1999-05-09 | Astra Ab | Combination of a substance with gastric acid secretion inhibiting effect and an acid degradable antibiotic |
| JPH09121890A (ja) * | 1995-10-30 | 1997-05-13 | Mitsubishi Kagaku B C L:Kk | ヘリコバクター属細菌の検出方法 |
| JPH1017471A (ja) * | 1996-07-04 | 1998-01-20 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物系併用医薬 |
| JP3677376B2 (ja) * | 1996-08-13 | 2005-07-27 | 武田薬品工業株式会社 | 医薬 |
| US5972933A (en) * | 1998-01-08 | 1999-10-26 | Ed. Geistlich Sohne Ag Fur Chemische Industrie | Method of treating microbial infections |
-
1999
- 1999-05-20 US US09/316,115 patent/US6117868A/en not_active Expired - Lifetime
- 1999-09-13 RU RU2001107149/15A patent/RU2227033C2/ru not_active IP Right Cessation
- 1999-09-13 DE DE69916629T patent/DE69916629T2/de not_active Expired - Lifetime
- 1999-09-13 CA CA002344308A patent/CA2344308C/en not_active Expired - Fee Related
- 1999-09-13 JP JP2000569816A patent/JP4981208B2/ja not_active Expired - Fee Related
- 1999-09-13 ES ES99946325T patent/ES2219061T3/es not_active Expired - Lifetime
- 1999-09-13 WO PCT/GB1999/003030 patent/WO2000015232A1/en not_active Ceased
- 1999-09-13 EP EP99946325A patent/EP1112074B1/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5077281A (en) * | 1985-09-20 | 1991-12-31 | Reinmueller Johannes | Novel use of taurolin |
| RU2025128C1 (ru) * | 1989-01-19 | 1994-12-30 | ШМИДТ Альфред | Средство для лечения воспалительных заболеваний пищевода и воспалительных и язвенных заболеваний желудочно-кишечного тракта |
| WO1996024375A1 (en) * | 1995-02-06 | 1996-08-15 | Astra Aktiebolag | New oral pharmaceutical dosage form |
| WO1997036599A1 (en) * | 1996-03-29 | 1997-10-09 | Marcin Krotkiewski | Pharmaceutical preparation for the treatment of gastritis, reflux oesophagitis, duodenitis, dyspepsia and ulcer disease |
Non-Patent Citations (1)
| Title |
|---|
| Реферат из АБД Medline: Focht J et al. [1996 pathogen incidence and resistance status in peritonitis] Langenbecks Arch Chir. 1997; 382(4 Suppl 1):S1-4. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010114425A2 (ru) | 2009-03-30 | 2010-10-07 | Dikovskiy Aleksander Vladimirovich | Фармацевтическая композиция ингибитора протонной помпы и пребиотика для лечения язвенных поражений желудка и 12- перстной кишки |
| RU2576511C2 (ru) * | 2010-02-24 | 2016-03-10 | Эмисфире Текнолоджис, Инк. | Пероральная терапия недостаточности витамина в12 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69916629T2 (de) | 2004-08-12 |
| CA2344308C (en) | 2008-05-20 |
| WO2000015232A1 (en) | 2000-03-23 |
| US6117868A (en) | 2000-09-12 |
| DE69916629D1 (de) | 2004-05-27 |
| EP1112074B1 (en) | 2004-04-21 |
| ES2219061T3 (es) | 2004-11-16 |
| CA2344308A1 (en) | 2000-03-23 |
| EP1112074A1 (en) | 2001-07-04 |
| JP2002525266A (ja) | 2002-08-13 |
| JP4981208B2 (ja) | 2012-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20100914 |