RU2224760C2 - Конденсированные тиенопиримидины с ингибирующим фосфодиэстеразу V действием, способ их получения и фармацевтическая композиция - Google Patents

Конденсированные тиенопиримидины с ингибирующим фосфодиэстеразу V действием, способ их получения и фармацевтическая композиция Download PDF

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Publication number
RU2224760C2
RU2224760C2 RU2000129659/04A RU2000129659A RU2224760C2 RU 2224760 C2 RU2224760 C2 RU 2224760C2 RU 2000129659/04 A RU2000129659/04 A RU 2000129659/04A RU 2000129659 A RU2000129659 A RU 2000129659A RU 2224760 C2 RU2224760 C2 RU 2224760C2
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RU
Russia
Prior art keywords
formula
pyrimidin
acid
compound
chloro
Prior art date
Application number
RU2000129659/04A
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English (en)
Russian (ru)
Other versions
RU2000129659A (ru
Inventor
Рохус ЙОНАС (DE)
Рохус ЙОНАС
Пьер ШЕЛЛИНГ (DE)
Пьер ШЕЛЛИНГ
Франц-Вернер КЛУКСЕН (DE)
Франц-Вернер КЛУКСЕН
Мари КРИСТАДЛЕР (DE)
Мария Кристадлер
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of RU2000129659A publication Critical patent/RU2000129659A/ru
Application granted granted Critical
Publication of RU2224760C2 publication Critical patent/RU2224760C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2000129659/04A 1998-04-29 1999-04-23 Конденсированные тиенопиримидины с ингибирующим фосфодиэстеразу V действием, способ их получения и фармацевтическая композиция RU2224760C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19819023A DE19819023A1 (de) 1998-04-29 1998-04-29 Thienopyrimidine
DE19819023.9 1998-04-29

Publications (2)

Publication Number Publication Date
RU2000129659A RU2000129659A (ru) 2003-01-27
RU2224760C2 true RU2224760C2 (ru) 2004-02-27

Family

ID=7866082

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2000129659/04A RU2224760C2 (ru) 1998-04-29 1999-04-23 Конденсированные тиенопиримидины с ингибирующим фосфодиэстеразу V действием, способ их получения и фармацевтическая композиция

Country Status (26)

Country Link
US (1) US6495557B1 (enExample)
EP (1) EP1084125B1 (enExample)
JP (1) JP4242561B2 (enExample)
KR (1) KR20010042628A (enExample)
CN (1) CN1142936C (enExample)
AR (1) AR016233A1 (enExample)
AT (1) ATE314374T1 (enExample)
AU (1) AU743230B2 (enExample)
BR (1) BR9910032A (enExample)
CA (1) CA2328280C (enExample)
CO (1) CO5011050A1 (enExample)
CZ (1) CZ291109B6 (enExample)
DE (2) DE19819023A1 (enExample)
ES (1) ES2255754T3 (enExample)
HU (1) HUP0101832A3 (enExample)
ID (1) ID27049A (enExample)
MY (1) MY121864A (enExample)
NO (1) NO20005434L (enExample)
PL (1) PL343637A1 (enExample)
RU (1) RU2224760C2 (enExample)
SK (1) SK15972000A3 (enExample)
TR (1) TR200003144T2 (enExample)
TW (1) TWI232220B (enExample)
UA (1) UA66856C2 (enExample)
WO (1) WO1999055708A1 (enExample)
ZA (1) ZA200006994B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19928146A1 (de) * 1999-06-19 2000-12-21 Merck Patent Gmbh Thienopyrimidine
DE19943815A1 (de) * 1999-09-14 2001-03-15 Merck Patent Gmbh Verwendung von Thienopyrimidinen
DE19944604A1 (de) * 1999-09-17 2001-03-22 Merck Patent Gmbh Aminderivate
DE10001021A1 (de) * 2000-01-13 2001-07-19 Merck Patent Gmbh Pharmazeutische Zubereitung
WO2001051089A1 (de) * 2000-01-13 2001-07-19 Merck Patent Gmbh Pharmazeutische zubereitungen enthaltend 2-pyrrolidon als lösungsvermittler
DE10010612A1 (de) * 2000-03-03 2001-09-27 Merck Patent Gmbh Verwendung von PDE V-Inhibitoren
DE10017947A1 (de) * 2000-04-11 2001-10-25 Merck Patent Gmbh Verfahren zur Herstellung benzo-annelierter Heterocyclen
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
CA2431147A1 (en) * 2000-12-19 2002-06-27 Merck Patent Gesellschaft Mit Beschraenkter Haftung Pharmaceutical formulation comprising thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives (2)
DE10064994A1 (de) * 2000-12-23 2002-07-04 Merck Patent Gmbh Sulfamidothienopyrimidine
CZ20032339A3 (cs) * 2001-01-31 2004-09-15 Merck Patent Gmbh Farmaceutický prostředek obsahující parazolo [4,3-d]pyrimidiny a nitráty nebo thienopyrimidiny a nitráty
DE10107261B4 (de) * 2001-02-16 2005-03-10 Merck Patent Gmbh Pharmazeutische Zusammensetzung
DE10148883A1 (de) 2001-10-04 2003-04-10 Merck Patent Gmbh Pyrimidinderivate
WO2003035653A1 (en) * 2001-10-26 2003-05-01 Nippon Soda Co.,Ltd. Pyridothienopyrimidine compound and salt thereof
US8207172B2 (en) * 2004-08-20 2012-06-26 Bayer Intellectual Property Gmbh Pyrimidinothienoindazoles useful for the treatment of hyperproliferative disorders
ES2259892B1 (es) * 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
ES2259891B1 (es) * 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
CA2604295C (en) 2005-04-19 2014-10-07 Nycomed Gmbh Roflumilast for the treatment of pulmonary hypertension

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022855A1 (en) * 1993-03-31 1994-10-13 Eisai Co., Ltd. Nitrogen-containing fused-heterocycle compounds
WO1994028902A1 (en) * 1993-06-09 1994-12-22 Pfizer Limited Pyrazolopyrimidinones for the treatment of impotence
WO1998006722A1 (de) * 1996-08-12 1998-02-19 Merck Patent Gmbh Thienopyrimidine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2657760B2 (ja) 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
ES2114662T3 (es) * 1993-08-26 1998-06-01 Ono Pharmaceutical Co Derivados de la 4-aminopirimidina.
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19644228A1 (de) * 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
DE19752952A1 (de) * 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022855A1 (en) * 1993-03-31 1994-10-13 Eisai Co., Ltd. Nitrogen-containing fused-heterocycle compounds
WO1994028902A1 (en) * 1993-06-09 1994-12-22 Pfizer Limited Pyrazolopyrimidinones for the treatment of impotence
WO1998006722A1 (de) * 1996-08-12 1998-02-19 Merck Patent Gmbh Thienopyrimidine

Also Published As

Publication number Publication date
EP1084125B1 (de) 2005-12-28
ATE314374T1 (de) 2006-01-15
AU3709899A (en) 1999-11-16
ID27049A (id) 2001-02-22
WO1999055708A1 (de) 1999-11-04
US6495557B1 (en) 2002-12-17
ZA200006994B (en) 2002-05-28
JP4242561B2 (ja) 2009-03-25
HK1037628A1 (en) 2002-02-15
CZ20003976A3 (cs) 2001-02-14
KR20010042628A (ko) 2001-05-25
HUP0101832A3 (en) 2002-11-28
EP1084125A1 (de) 2001-03-21
HUP0101832A2 (hu) 2001-11-28
DE59912986D1 (de) 2006-02-02
TWI232220B (en) 2005-05-11
UA66856C2 (uk) 2004-06-15
PL343637A1 (en) 2001-08-27
CA2328280C (en) 2009-09-29
MY121864A (en) 2006-02-28
ES2255754T3 (es) 2006-07-01
NO20005434D0 (no) 2000-10-27
AU743230B2 (en) 2002-01-24
CZ291109B6 (cs) 2002-12-11
DE19819023A1 (de) 1999-11-04
CO5011050A1 (es) 2001-02-28
SK15972000A3 (sk) 2001-05-10
CN1298406A (zh) 2001-06-06
CA2328280A1 (en) 1999-11-04
TR200003144T2 (tr) 2001-03-21
BR9910032A (pt) 2001-10-16
CN1142936C (zh) 2004-03-24
JP2002513026A (ja) 2002-05-08
AR016233A1 (es) 2001-06-20
NO20005434L (no) 2000-10-27

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20060424