CN1142936C - 具有磷酸二酯酶-v抑制作用的稠合噻吩并嘧啶及其制备方法和用途 - Google Patents

具有磷酸二酯酶-v抑制作用的稠合噻吩并嘧啶及其制备方法和用途 Download PDF

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Publication number
CN1142936C
CN1142936C CNB998054569A CN99805456A CN1142936C CN 1142936 C CN1142936 C CN 1142936C CN B998054569 A CNB998054569 A CN B998054569A CN 99805456 A CN99805456 A CN 99805456A CN 1142936 C CN1142936 C CN 1142936C
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CN
China
Prior art keywords
acid
formula
compound
pyrimidin
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB998054569A
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English (en)
Chinese (zh)
Other versions
CN1298406A (zh
Inventor
��R��Լ��˹
R·约纳斯
P·舍林
��³��ɭ˹��˾
F·－W·克鲁克森
M·克里斯塔德勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CN1298406A publication Critical patent/CN1298406A/zh
Application granted granted Critical
Publication of CN1142936C publication Critical patent/CN1142936C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB998054569A 1998-04-29 1999-04-23 具有磷酸二酯酶-v抑制作用的稠合噻吩并嘧啶及其制备方法和用途 Expired - Fee Related CN1142936C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19819023.9 1998-04-29
DE19819023A DE19819023A1 (de) 1998-04-29 1998-04-29 Thienopyrimidine

Publications (2)

Publication Number Publication Date
CN1298406A CN1298406A (zh) 2001-06-06
CN1142936C true CN1142936C (zh) 2004-03-24

Family

ID=7866082

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998054569A Expired - Fee Related CN1142936C (zh) 1998-04-29 1999-04-23 具有磷酸二酯酶-v抑制作用的稠合噻吩并嘧啶及其制备方法和用途

Country Status (26)

Country Link
US (1) US6495557B1 (enExample)
EP (1) EP1084125B1 (enExample)
JP (1) JP4242561B2 (enExample)
KR (1) KR20010042628A (enExample)
CN (1) CN1142936C (enExample)
AR (1) AR016233A1 (enExample)
AT (1) ATE314374T1 (enExample)
AU (1) AU743230B2 (enExample)
BR (1) BR9910032A (enExample)
CA (1) CA2328280C (enExample)
CO (1) CO5011050A1 (enExample)
CZ (1) CZ291109B6 (enExample)
DE (2) DE19819023A1 (enExample)
ES (1) ES2255754T3 (enExample)
HU (1) HUP0101832A3 (enExample)
ID (1) ID27049A (enExample)
MY (1) MY121864A (enExample)
NO (1) NO20005434L (enExample)
PL (1) PL343637A1 (enExample)
RU (1) RU2224760C2 (enExample)
SK (1) SK15972000A3 (enExample)
TR (1) TR200003144T2 (enExample)
TW (1) TWI232220B (enExample)
UA (1) UA66856C2 (enExample)
WO (1) WO1999055708A1 (enExample)
ZA (1) ZA200006994B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19928146A1 (de) 1999-06-19 2000-12-21 Merck Patent Gmbh Thienopyrimidine
DE19943815A1 (de) * 1999-09-14 2001-03-15 Merck Patent Gmbh Verwendung von Thienopyrimidinen
DE19944604A1 (de) * 1999-09-17 2001-03-22 Merck Patent Gmbh Aminderivate
AU2001228454A1 (en) * 2000-01-13 2001-07-24 Merck Patent G.M.B.H Pharmaceutical preparations containing 2-pyrrolidone as the dissolving intermediary
DE10001021A1 (de) * 2000-01-13 2001-07-19 Merck Patent Gmbh Pharmazeutische Zubereitung
DE10010612A1 (de) * 2000-03-03 2001-09-27 Merck Patent Gmbh Verwendung von PDE V-Inhibitoren
DE10017947A1 (de) * 2000-04-11 2001-10-25 Merck Patent Gmbh Verfahren zur Herstellung benzo-annelierter Heterocyclen
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
CZ20031722A3 (cs) * 2000-12-19 2003-09-17 Merck Patent Gmbh Farmaceutický prostředek obsahující deriváty thienopyrimidinu a antitrombotika, vápníkové antagonisty, prostaglandiny nebo deriváty prostaglandinu
DE10064994A1 (de) * 2000-12-23 2002-07-04 Merck Patent Gmbh Sulfamidothienopyrimidine
SK10762003A3 (sk) * 2001-01-31 2004-01-08 Merck Patent Gmbh Farmaceutický prostriedok obsahujúci parazolo-[4,3-d]pyrimidíny a nitráty alebo tienopyrimidíny a nitráty
DE10107261B4 (de) * 2001-02-16 2005-03-10 Merck Patent Gmbh Pharmazeutische Zusammensetzung
DE10148883A1 (de) * 2001-10-04 2003-04-10 Merck Patent Gmbh Pyrimidinderivate
WO2003035653A1 (en) * 2001-10-26 2003-05-01 Nippon Soda Co.,Ltd. Pyridothienopyrimidine compound and salt thereof
EP1799653B1 (en) * 2004-08-20 2013-03-20 Bayer Intellectual Property GmbH Condensed thienopyrimidine derivatives for the treatment of cancer
ES2259891B1 (es) * 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
ES2259892B1 (es) * 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
EA016037B1 (ru) 2005-04-19 2012-01-30 Никомед Гмбх Рофлумиласт для лечения лёгочной гипертензии

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2657760B2 (ja) * 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
PH31122A (en) * 1993-03-31 1998-02-23 Eisai Co Ltd Nitrogen-containing fused-heterocycle compounds.
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
ATE163647T1 (de) 1993-08-26 1998-03-15 Ono Pharmaceutical Co 4-aminopyrimidin derivate
US5869486A (en) 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19632423A1 (de) 1996-08-12 1998-02-19 Merck Patent Gmbh Thienopyrimidine
DE19644228A1 (de) 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
DE19752952A1 (de) * 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine

Also Published As

Publication number Publication date
DE59912986D1 (de) 2006-02-02
SK15972000A3 (sk) 2001-05-10
AU3709899A (en) 1999-11-16
RU2224760C2 (ru) 2004-02-27
NO20005434D0 (no) 2000-10-27
CN1298406A (zh) 2001-06-06
WO1999055708A1 (de) 1999-11-04
PL343637A1 (en) 2001-08-27
AU743230B2 (en) 2002-01-24
EP1084125B1 (de) 2005-12-28
CZ291109B6 (cs) 2002-12-11
HUP0101832A3 (en) 2002-11-28
UA66856C2 (uk) 2004-06-15
ZA200006994B (en) 2002-05-28
CO5011050A1 (es) 2001-02-28
NO20005434L (no) 2000-10-27
EP1084125A1 (de) 2001-03-21
CZ20003976A3 (cs) 2001-02-14
DE19819023A1 (de) 1999-11-04
KR20010042628A (ko) 2001-05-25
US6495557B1 (en) 2002-12-17
CA2328280A1 (en) 1999-11-04
MY121864A (en) 2006-02-28
ATE314374T1 (de) 2006-01-15
HK1037628A1 (en) 2002-02-15
BR9910032A (pt) 2001-10-16
AR016233A1 (es) 2001-06-20
TR200003144T2 (tr) 2001-03-21
ES2255754T3 (es) 2006-07-01
TWI232220B (en) 2005-05-11
HUP0101832A2 (hu) 2001-11-28
ID27049A (id) 2001-02-22
JP4242561B2 (ja) 2009-03-25
CA2328280C (en) 2009-09-29
JP2002513026A (ja) 2002-05-08

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