RU2219176C2 - Производные 2-аминопиридинов, фармацевтическая композиция на их основе и способ ее получения - Google Patents

Производные 2-аминопиридинов, фармацевтическая композиция на их основе и способ ее получения Download PDF

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RU2219176C2
RU2219176C2 RU2001111815/04A RU2001111815A RU2219176C2 RU 2219176 C2 RU2219176 C2 RU 2219176C2 RU 2001111815/04 A RU2001111815/04 A RU 2001111815/04A RU 2001111815 A RU2001111815 A RU 2001111815A RU 2219176 C2 RU2219176 C2 RU 2219176C2
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phenyl
pyridyl
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quinolyl
thiazolyl
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Венделин ФРИК (DE)
Венделин Фрик
Райнхард КИРШ (DE)
Райнхард Кирш
Хайнер ГЛОМБИК (DE)
Хайнер Гломбик
Хуберт ХОЙЕР (DE)
Хуберт Хойер
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Авентис Фарма Дойчланд Гмбх
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

Изобретение относится к новым производным 2-аминопиридинов ф-лы (1), где С обозначает незамещенные или замещенные фенил, пиридил, тиенил, тиазолил, хинолил, хиноксалин-2-ил или их бензоаннелированные производные; D - незамещенные или замещенные фенил, пиридил, тиенил, пиримидил, индолил, тиазолил, имидазолил, хинолил, триазолил, оксазолил, изоксазолил или их бензоаннелированные производные при условии, что С и D не имеют одновременно следующие значения: С - фенил и D - фенил, С - фенил и D - пиридил, С - пиридил и D - фенил, С - пиридил и D - пиридил; R1 - R4 - водород, NO2 или NH2. Соединения ф-лы (1) проявляют гиполипидемическую активность и могут быть использованы в медицине для лечения нарушений липидного обмена. 3 с. и 1 з. п. ф-лы, 1 табл.

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Текст описания в факсимильном виде (см. графическую часть) Тк

Claims (4)

1. Производные 2-аминопиридинов формулы I
Figure 00000033
где С - фенил, пиридил, тиенил, тиазолил, хинолил, хиноксалин-2-ил или их бензоаннелированные производные, причем ароматический или гетероароматический остаток может быть замещен -NO2-группой или (C1-C8)-алкилом;
D - фенил, пиридил, тиенил, пиримидил, индолил, тиазолил, имидазолил, хинолил, триазолил, оксазолил, изоксазолил или их бензоаннелированные производные, причем ароматический или гетероароматический остаток может быть одно- или двукратно замещен хлором, СF3, (C1-C8)-алкилом, (C1-C8)-алкоксилом, (C0-C6)-алкилпиридилом или (C0-C6)-алкил-фенилом, причем фенильный остаток может быть замещен галогеном,
при условии, что С и D не имеют одновременно следующие значения:
С = фенил и D = фенил, С = фенил и D = пиридил, С = пиридил и D = фенил, С = пиридил и D = пиридил;
R1, R2, R3 и R4 независимо друг от друга - водород, -NO2 или NH2.
2. Соединения формулы I по п.1, отличающиеся тем, что С - фенил, пиридил, тиенил, тиазолил, хинолил, хиноксалин-2-ил, причем ароматический или гетероароматический остаток может быть замещен (C1-C8)-алкилом; D - фенил, пиридил, тиенил, пиримидил, индолил, тиазолил, имидазолил, хинолил, триазолил, оксазолил, изоксазолил, причем ароматический или гетероароматический остаток может быть одно- или двукратно замещен хлором, (C1-C8)-алкилом, при условии, что С и D не имеют одновременно следующие значения: С = фенил и D = фенил, С = фенил и D = пиридил, С = пиридил и D = фенил, С = пиридил и D = пиридил; R1, R2, R3 и R4 независимо друг от друга - водород, -NO2 или NH2.
3. Фармацевтическая композиция, проявляющая гиполипидемическую активность и содержащая одно или несколько соединений по п.1 или 2.
4. Способ получения фармацевтической композиции с гиполипидемической активностью, отличающийся тем, что одно или несколько соединений формулы I по п.1 или 2 смешивают с фармацевтически приемлемым носителем и эту смесь готовят в виде пригодной для введения формы.
RU2001111815/04A 1998-10-02 1999-09-18 Производные 2-аминопиридинов, фармацевтическая композиция на их основе и способ ее получения RU2219176C2 (ru)

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DE19845402A DE19845402B4 (de) 1998-10-02 1998-10-02 Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19845402.3 1998-10-02

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US7161008B2 (en) * 2002-05-03 2007-01-09 Sanofi - Aventis Deutschland GmbH Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them
DE10219987A1 (de) * 2002-05-03 2004-04-08 Aventis Pharma Deutschland Gmbh Optisch aktive β-Aminoketone, optisch aktive 1,3-Aminoalkohole und Verfahren zu deren Herstellung
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
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EP2575821B1 (en) 2010-05-26 2015-08-12 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
KR20190135545A (ko) 2011-10-28 2019-12-06 루메나 파마수티컬즈, 인코포레이티드 고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제
MX369466B (es) 2011-10-28 2019-11-08 Lumena Pharmaceuticals Inc Inhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas.
MX2015013196A (es) 2013-03-15 2016-04-15 Lumena Pharmaceuticals Inc Inhibidores de reciclaje de acidos biliares para el tratamiento de la enfermedad de reflujo gastroesofagico y esofago de barrett.
JP2016514684A (ja) 2013-03-15 2016-05-23 ルメナ ファーマシューティカルズ エルエルシー 原発性硬化性胆管炎および炎症性腸疾患の処置のための胆汁酸再循環阻害剤
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