RU2219176C2 - Производные 2-аминопиридинов, фармацевтическая композиция на их основе и способ ее получения - Google Patents
Производные 2-аминопиридинов, фармацевтическая композиция на их основе и способ ее получения Download PDFInfo
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- RU2219176C2 RU2219176C2 RU2001111815/04A RU2001111815A RU2219176C2 RU 2219176 C2 RU2219176 C2 RU 2219176C2 RU 2001111815/04 A RU2001111815/04 A RU 2001111815/04A RU 2001111815 A RU2001111815 A RU 2001111815A RU 2219176 C2 RU2219176 C2 RU 2219176C2
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
Изобретение относится к новым производным 2-аминопиридинов ф-лы (1), где С обозначает незамещенные или замещенные фенил, пиридил, тиенил, тиазолил, хинолил, хиноксалин-2-ил или их бензоаннелированные производные; D - незамещенные или замещенные фенил, пиридил, тиенил, пиримидил, индолил, тиазолил, имидазолил, хинолил, триазолил, оксазолил, изоксазолил или их бензоаннелированные производные при условии, что С и D не имеют одновременно следующие значения: С - фенил и D - фенил, С - фенил и D - пиридил, С - пиридил и D - фенил, С - пиридил и D - пиридил; R1 - R4 - водород, NO2 или NH2. Соединения ф-лы (1) проявляют гиполипидемическую активность и могут быть использованы в медицине для лечения нарушений липидного обмена. 3 с. и 1 з. п. ф-лы, 1 табл.
Description
Текст описания в факсимильном виде (см. графическую часть) Тк
Claims (4)
1. Производные 2-аминопиридинов формулы I
где С - фенил, пиридил, тиенил, тиазолил, хинолил, хиноксалин-2-ил или их бензоаннелированные производные, причем ароматический или гетероароматический остаток может быть замещен -NO2-группой или (C1-C8)-алкилом;
D - фенил, пиридил, тиенил, пиримидил, индолил, тиазолил, имидазолил, хинолил, триазолил, оксазолил, изоксазолил или их бензоаннелированные производные, причем ароматический или гетероароматический остаток может быть одно- или двукратно замещен хлором, СF3, (C1-C8)-алкилом, (C1-C8)-алкоксилом, (C0-C6)-алкилпиридилом или (C0-C6)-алкил-фенилом, причем фенильный остаток может быть замещен галогеном,
при условии, что С и D не имеют одновременно следующие значения:
С = фенил и D = фенил, С = фенил и D = пиридил, С = пиридил и D = фенил, С = пиридил и D = пиридил;
R1, R2, R3 и R4 независимо друг от друга - водород, -NO2 или NH2.
2. Соединения формулы I по п.1, отличающиеся тем, что С - фенил, пиридил, тиенил, тиазолил, хинолил, хиноксалин-2-ил, причем ароматический или гетероароматический остаток может быть замещен (C1-C8)-алкилом; D - фенил, пиридил, тиенил, пиримидил, индолил, тиазолил, имидазолил, хинолил, триазолил, оксазолил, изоксазолил, причем ароматический или гетероароматический остаток может быть одно- или двукратно замещен хлором, (C1-C8)-алкилом, при условии, что С и D не имеют одновременно следующие значения: С = фенил и D = фенил, С = фенил и D = пиридил, С = пиридил и D = фенил, С = пиридил и D = пиридил; R1, R2, R3 и R4 независимо друг от друга - водород, -NO2 или NH2.
3. Фармацевтическая композиция, проявляющая гиполипидемическую активность и содержащая одно или несколько соединений по п.1 или 2.
4. Способ получения фармацевтической композиции с гиполипидемической активностью, отличающийся тем, что одно или несколько соединений формулы I по п.1 или 2 смешивают с фармацевтически приемлемым носителем и эту смесь готовят в виде пригодной для введения формы.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19845402A DE19845402B4 (de) | 1998-10-02 | 1998-10-02 | Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
DE19845402.3 | 1998-10-02 |
Publications (2)
Publication Number | Publication Date |
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RU2001111815A RU2001111815A (ru) | 2003-07-20 |
RU2219176C2 true RU2219176C2 (ru) | 2003-12-20 |
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Application Number | Title | Priority Date | Filing Date |
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RU2001111815/04A RU2219176C2 (ru) | 1998-10-02 | 1999-09-18 | Производные 2-аминопиридинов, фармацевтическая композиция на их основе и способ ее получения |
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US (1) | US6303639B1 (ru) |
EP (1) | EP1117661B1 (ru) |
JP (1) | JP2002526539A (ru) |
KR (1) | KR100611030B1 (ru) |
CN (1) | CN1150185C (ru) |
AR (1) | AR021843A1 (ru) |
AT (1) | ATE267825T1 (ru) |
AU (1) | AU760412B2 (ru) |
BR (1) | BR9914266A (ru) |
CA (1) | CA2346083A1 (ru) |
DE (2) | DE19845402B4 (ru) |
DK (1) | DK1117661T3 (ru) |
ES (1) | ES2219065T3 (ru) |
HK (1) | HK1040249B (ru) |
HU (1) | HUP0103893A3 (ru) |
PL (1) | PL347105A1 (ru) |
PT (1) | PT1117661E (ru) |
RU (1) | RU2219176C2 (ru) |
TR (1) | TR200100895T2 (ru) |
WO (1) | WO2000020410A1 (ru) |
ZA (1) | ZA200102589B (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19845406C2 (de) * | 1998-10-02 | 2001-10-18 | Aventis Pharma Gmbh | Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
SK7782003A3 (en) | 2000-12-21 | 2003-12-02 | Aventis Pharma Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
EP1420826A2 (de) * | 2001-08-22 | 2004-05-26 | Aventis Pharma Deutschland GmbH | Kombinationspräparate von arylsubstituierten propanolaminderivaten mit weiteren wirkstoffen und deren verwendung |
US7161008B2 (en) * | 2002-05-03 | 2007-01-09 | Sanofi - Aventis Deutschland GmbH | Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them |
DE10219987A1 (de) * | 2002-05-03 | 2004-04-08 | Aventis Pharma Deutschland Gmbh | Optisch aktive β-Aminoketone, optisch aktive 1,3-Aminoalkohole und Verfahren zu deren Herstellung |
GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
AU2011232347B2 (en) * | 2010-03-24 | 2015-08-06 | Musc Foundation For Research Development | Compositions and methods for the treatment of degenerative diseases |
EP2575821B1 (en) | 2010-05-26 | 2015-08-12 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
KR20190135545A (ko) | 2011-10-28 | 2019-12-06 | 루메나 파마수티컬즈, 인코포레이티드 | 고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제 |
MX369466B (es) | 2011-10-28 | 2019-11-08 | Lumena Pharmaceuticals Inc | Inhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas. |
MX2015013196A (es) | 2013-03-15 | 2016-04-15 | Lumena Pharmaceuticals Inc | Inhibidores de reciclaje de acidos biliares para el tratamiento de la enfermedad de reflujo gastroesofagico y esofago de barrett. |
JP2016514684A (ja) | 2013-03-15 | 2016-05-23 | ルメナ ファーマシューティカルズ エルエルシー | 原発性硬化性胆管炎および炎症性腸疾患の処置のための胆汁酸再循環阻害剤 |
US11238759B1 (en) | 2015-10-29 | 2022-02-01 | Ward-Kraft, Inc. | Single ply wristband with printable coating |
US11232719B1 (en) | 2019-09-04 | 2022-01-25 | Ward-Kraft, Inc. | Single ply wristband with printable coating |
KR20210137046A (ko) | 2019-02-12 | 2021-11-17 | 미룸 파마슈티컬스, 인크. | 담즙정체의 치료 방법 |
USD988404S1 (en) | 2020-02-14 | 2023-06-06 | Rekon, Llc | Wristband label form with single strap wristbands |
USD941917S1 (en) | 2020-02-18 | 2022-01-25 | Ward-Kraft, Inc. | Combination wristband label form with extender |
USD967253S1 (en) | 2020-02-26 | 2022-10-18 | Ward-Kraft, Inc. | Wristband form with extender |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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ATE268758T1 (de) | 1997-04-04 | 2004-06-15 | Aventis Pharma Gmbh | Hypolipidämische propanolaminderivate |
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1998
- 1998-10-02 DE DE19845402A patent/DE19845402B4/de not_active Expired - Fee Related
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1999
- 1999-09-18 DE DE59909609T patent/DE59909609D1/de not_active Expired - Lifetime
- 1999-09-18 HU HU0103893A patent/HUP0103893A3/hu unknown
- 1999-09-18 RU RU2001111815/04A patent/RU2219176C2/ru not_active IP Right Cessation
- 1999-09-18 CN CNB998116351A patent/CN1150185C/zh not_active Expired - Fee Related
- 1999-09-18 WO PCT/EP1999/006932 patent/WO2000020410A1/de not_active Application Discontinuation
- 1999-09-18 BR BR9914266-0A patent/BR9914266A/pt not_active Application Discontinuation
- 1999-09-18 DK DK99948790T patent/DK1117661T3/da active
- 1999-09-18 TR TR2001/00895T patent/TR200100895T2/xx unknown
- 1999-09-18 AT AT99948790T patent/ATE267825T1/de not_active IP Right Cessation
- 1999-09-18 PL PL99347105A patent/PL347105A1/xx not_active Application Discontinuation
- 1999-09-18 JP JP2000574523A patent/JP2002526539A/ja active Pending
- 1999-09-18 PT PT99948790T patent/PT1117661E/pt unknown
- 1999-09-18 CA CA002346083A patent/CA2346083A1/en not_active Abandoned
- 1999-09-18 AU AU61925/99A patent/AU760412B2/en not_active Ceased
- 1999-09-18 EP EP99948790A patent/EP1117661B1/de not_active Expired - Lifetime
- 1999-09-18 KR KR1020017004129A patent/KR100611030B1/ko not_active IP Right Cessation
- 1999-09-18 ES ES99948790T patent/ES2219065T3/es not_active Expired - Lifetime
- 1999-09-29 US US09/407,973 patent/US6303639B1/en not_active Expired - Lifetime
- 1999-09-30 AR ARP990104958A patent/AR021843A1/es unknown
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2001
- 2001-03-29 ZA ZA200102589A patent/ZA200102589B/xx unknown
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- 2002-03-15 HK HK02102007.5A patent/HK1040249B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
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DE59909609D1 (de) | 2004-07-01 |
AU6192599A (en) | 2000-04-26 |
WO2000020410A1 (de) | 2000-04-13 |
CA2346083A1 (en) | 2000-04-13 |
EP1117661B1 (de) | 2004-05-26 |
KR100611030B1 (ko) | 2006-08-10 |
PT1117661E (pt) | 2004-09-30 |
US6303639B1 (en) | 2001-10-16 |
CN1150185C (zh) | 2004-05-19 |
DE19845402A1 (de) | 2000-04-13 |
CN1321154A (zh) | 2001-11-07 |
ATE267825T1 (de) | 2004-06-15 |
HK1040249B (zh) | 2005-04-01 |
AU760412B2 (en) | 2003-05-15 |
BR9914266A (pt) | 2001-11-06 |
DK1117661T3 (da) | 2004-08-30 |
PL347105A1 (en) | 2002-03-25 |
HK1040249A1 (en) | 2002-05-31 |
AR021843A1 (es) | 2002-08-07 |
HUP0103893A3 (en) | 2002-10-28 |
EP1117661A1 (de) | 2001-07-25 |
ES2219065T3 (es) | 2004-11-16 |
HUP0103893A2 (hu) | 2002-05-29 |
TR200100895T2 (tr) | 2001-12-21 |
KR20010103593A (ko) | 2001-11-23 |
JP2002526539A (ja) | 2002-08-20 |
ZA200102589B (en) | 2002-02-27 |
DE19845402B4 (de) | 2005-04-07 |
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