RU2188868C2 - Способ получения клавулановой кислоты - Google Patents

Способ получения клавулановой кислоты Download PDF

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Publication number
RU2188868C2
RU2188868C2 RU98120408/13A RU98120408A RU2188868C2 RU 2188868 C2 RU2188868 C2 RU 2188868C2 RU 98120408/13 A RU98120408/13 A RU 98120408/13A RU 98120408 A RU98120408 A RU 98120408A RU 2188868 C2 RU2188868 C2 RU 2188868C2
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RU
Russia
Prior art keywords
phosphorus
source
paragraphs
nitrogen
fermentation
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RU98120408/13A
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English (en)
Russian (ru)
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RU98120408A (ru
Inventor
Саса КРАНЬЦ (SI)
Саса Краньц
Артур РАКМАН (SI)
Артур Ракман
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Лек Фармасьютикал энд Кемикал Ко. ДД
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Publication of RU98120408A publication Critical patent/RU98120408A/ru
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Publication of RU2188868C2 publication Critical patent/RU2188868C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU98120408/13A 1996-04-12 1997-04-11 Способ получения клавулановой кислоты RU2188868C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SIP-9600120 1996-04-12
SI9600120A SI9600120A (en) 1996-04-12 1996-04-12 New and improved fermentative procedure for the production of clavulanic acid and its salts

Publications (2)

Publication Number Publication Date
RU98120408A RU98120408A (ru) 2000-10-20
RU2188868C2 true RU2188868C2 (ru) 2002-09-10

Family

ID=20431824

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98120408/13A RU2188868C2 (ru) 1996-04-12 1997-04-11 Способ получения клавулановой кислоты

Country Status (9)

Country Link
EP (1) EP0906446A1 (ja)
JP (1) JP2001503244A (ja)
AU (1) AU2516497A (ja)
CA (1) CA2251596A1 (ja)
PL (1) PL185620B1 (ja)
RU (1) RU2188868C2 (ja)
SI (1) SI9600120A (ja)
WO (1) WO1997039137A1 (ja)
ZA (1) ZA973139B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2101658B1 (es) * 1995-11-23 1998-03-01 Antibioticos Sa Nuevo procedimiento de produccion de acido clavulanico y sus sales.
AR015825A1 (es) * 1997-05-28 2001-05-30 Gist Brocades Bv Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato
US6440708B1 (en) 1998-09-29 2002-08-27 Dsm N.V. Fermentation of clavulanic acid at a controlled level of ammonia
TR200100873T2 (tr) * 1998-09-29 2001-07-23 Dsm N.V. Klavülanik asitin kontrol edilen bir amonyak seviyesinde mayalanması
EP2589663A1 (en) 2011-11-04 2013-05-08 LEK Pharmaceuticals d.d. Process for production of clavulanic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
GB1571888A (en) * 1977-02-04 1980-07-23 Glaxo Lab Ltd Clavulanic acid production
NZ213963A (en) * 1984-10-27 1989-01-06 Antibioticos Sa Production of clavulanic acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LILLEY G. et al, J. Chem. Tech. Biotechnol. 1981, v.31, p.127-134. *

Also Published As

Publication number Publication date
CA2251596A1 (en) 1997-10-23
EP0906446A1 (en) 1999-04-07
AU2516497A (en) 1997-11-07
WO1997039137A1 (en) 1997-10-23
ZA973139B (en) 1998-08-05
JP2001503244A (ja) 2001-03-13
PL329291A1 (en) 1999-03-15
SI9600120A (en) 1997-12-31
PL185620B1 (pl) 2003-06-30

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20050412