RU2116072C1 - Диметилбензофураны и диметилбензопираны, их применение в качестве 5-нт3-антагонистов, способы их получения и фармацевтическая композиция - Google Patents

Диметилбензофураны и диметилбензопираны, их применение в качестве 5-нт3-антагонистов, способы их получения и фармацевтическая композиция Download PDF

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RU2116072C1
RU2116072C1 RU95113434A RU95113434A RU2116072C1 RU 2116072 C1 RU2116072 C1 RU 2116072C1 RU 95113434 A RU95113434 A RU 95113434A RU 95113434 A RU95113434 A RU 95113434A RU 2116072 C1 RU2116072 C1 RU 2116072C1
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formula
group
methoxy
amino
compound
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RU95113434A
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Russian (ru)
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RU95113434A (ru
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Поль Ван Даель Жорж-Анри
Рене Мари Андре Босман Жан-Поль
Джоунс Каролус Ван Лаерован Уилли
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Жансен Фармасетика Н.В.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Dental Preparations (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU95113434A 1992-11-20 1993-11-15 Диметилбензофураны и диметилбензопираны, их применение в качестве 5-нт3-антагонистов, способы их получения и фармацевтическая композиция RU2116072C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97901392A 1992-11-20 1992-11-20
US979013 1992-11-20
US979,013 1992-11-20

Publications (2)

Publication Number Publication Date
RU95113434A RU95113434A (ru) 1997-03-10
RU2116072C1 true RU2116072C1 (ru) 1998-07-27

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RU95113434A RU2116072C1 (ru) 1992-11-20 1993-11-15 Диметилбензофураны и диметилбензопираны, их применение в качестве 5-нт3-антагонистов, способы их получения и фармацевтическая композиция

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Country Link
US (2) US5674868A (cg-RX-API-DMAC7.html)
EP (1) EP0669919B1 (cg-RX-API-DMAC7.html)
JP (1) JP2830952B2 (cg-RX-API-DMAC7.html)
KR (1) KR0166661B1 (cg-RX-API-DMAC7.html)
AT (1) ATE176232T1 (cg-RX-API-DMAC7.html)
AU (1) AU680640B2 (cg-RX-API-DMAC7.html)
BG (1) BG62489B1 (cg-RX-API-DMAC7.html)
BR (1) BR9307477A (cg-RX-API-DMAC7.html)
CA (1) CA2149044C (cg-RX-API-DMAC7.html)
CZ (1) CZ287262B6 (cg-RX-API-DMAC7.html)
DE (1) DE69323322T2 (cg-RX-API-DMAC7.html)
DK (1) DK0669919T3 (cg-RX-API-DMAC7.html)
ES (1) ES2129615T3 (cg-RX-API-DMAC7.html)
FI (1) FI952458A0 (cg-RX-API-DMAC7.html)
GR (1) GR3029831T3 (cg-RX-API-DMAC7.html)
HU (2) HUT72740A (cg-RX-API-DMAC7.html)
IL (3) IL119273A0 (cg-RX-API-DMAC7.html)
LV (1) LV10956B (cg-RX-API-DMAC7.html)
MX (1) MX9307257A (cg-RX-API-DMAC7.html)
NO (2) NO307690B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ257854A (cg-RX-API-DMAC7.html)
OA (1) OA10158A (cg-RX-API-DMAC7.html)
PL (1) PL176051B1 (cg-RX-API-DMAC7.html)
RO (1) RO115160B1 (cg-RX-API-DMAC7.html)
RU (1) RU2116072C1 (cg-RX-API-DMAC7.html)
SG (1) SG47488A1 (cg-RX-API-DMAC7.html)
SK (1) SK282378B6 (cg-RX-API-DMAC7.html)
TW (1) TW294595B (cg-RX-API-DMAC7.html)
UA (1) UA49792C2 (cg-RX-API-DMAC7.html)
WO (1) WO1994012494A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA938676B (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
EP0975327B1 (en) 1997-04-18 2003-07-02 Janssen Pharmaceutica N.V. Use of 5ht3 antagonists for promoting intestinal lavage
WO1999002496A1 (en) * 1997-07-11 1999-01-21 Janssen Pharmaceutica N.V. (+)-norcisapride useful for 5-ht3 and 5-ht4 mediated disorders
US6239122B1 (en) * 2000-01-05 2001-05-29 Joy Ann Steele Method of treatment of nausea, vomiting, and other disorders using estrogens
WO2004111014A1 (en) * 2003-06-06 2004-12-23 Vertex Pharmaceuticals Incorporated Pyrimidine derivatives as modulators of atp-binding cassette transporters
SG150533A1 (en) 2003-11-20 2009-03-30 Janssen Pharmaceutica Nv 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2- quinoxalinones as poly(adp-ribose) polymerase inhibitors
EA011211B1 (ru) 2003-11-20 2009-02-27 Янссен Фармацевтика Н. В. 7-фенилалкилзамещённые 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза)полимеразы
AU2005259190B2 (en) 2004-06-30 2011-05-12 Janssen Pharmaceutica N.V. Quinazolinedione derivatives as PARP inhibitors
EA014955B1 (ru) 2004-06-30 2011-04-29 Янссен Фармацевтика Н. В. Производные фталазина в качестве ингибиторов parp
CN1980899B (zh) * 2004-06-30 2013-07-24 詹森药业有限公司 作为parp抑制剂的喹唑啉酮衍生物
JP5545955B2 (ja) 2007-03-08 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体
ES2448870T3 (es) 2007-10-26 2014-03-17 Janssen Pharmaceutica, N.V. Derivados de quinolina como inhibidores de PARP
AU2009228943B2 (en) 2008-03-27 2013-04-04 Janssen Pharmaceutica Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
ES2367760T3 (es) 2008-03-27 2011-11-08 Janssen Pharmaceutica, N.V. Derivados de quinazolinona como inhibidores de la polimerización de la tubulina.

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0397365A1 (en) * 1989-05-09 1990-11-14 Pfizer Inc. Arylthiazolylimidazoles as 5HT3 Antagonists

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CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
ZW12187A1 (en) * 1986-07-03 1989-02-01 Janssen Pharmaceutica Nv 4-(aroylamino)piperidinebutanamide derivatives
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0397365A1 (en) * 1989-05-09 1990-11-14 Pfizer Inc. Arylthiazolylimidazoles as 5HT3 Antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EP, 0445862, A1, C 07D 405/12, 1991 . *

Also Published As

Publication number Publication date
CA2149044A1 (en) 1994-06-09
CA2149044C (en) 2007-04-03
LV10956A (lv) 1995-12-20
DE69323322T2 (de) 1999-09-09
NO308530B1 (no) 2000-09-25
RO115160B1 (ro) 1999-11-30
NO951980L (no) 1995-05-19
FI952458L (fi) 1995-05-19
HU9501476D0 (en) 1995-07-28
NO307690B1 (no) 2000-05-15
BG62489B1 (bg) 1999-12-30
US5863923A (en) 1999-01-26
TW294595B (cg-RX-API-DMAC7.html) 1997-01-01
OA10158A (en) 1996-12-18
FI952458A7 (fi) 1995-05-19
US5674868A (en) 1997-10-07
JP2830952B2 (ja) 1998-12-02
EP0669919A1 (en) 1995-09-06
AU5465994A (en) 1994-06-22
IL107654A0 (en) 1994-02-27
ATE176232T1 (de) 1999-02-15
NO995762D0 (no) 1999-11-24
SK282378B6 (sk) 2002-01-07
ES2129615T3 (es) 1999-06-16
SK67595A3 (en) 1995-11-08
EP0669919B1 (en) 1999-01-27
IL119273A (en) 2000-07-16
LV10956B (en) 1996-10-20
FI952458A0 (fi) 1995-05-19
RU95113434A (ru) 1997-03-10
AU680640B2 (en) 1997-08-07
BG99593A (en) 1995-12-29
CZ125895A3 (en) 1995-10-18
NO951980D0 (no) 1995-05-19
NO995762L (no) 1995-05-19
ZA938676B (en) 1995-05-19
SG47488A1 (en) 1998-04-17
KR0166661B1 (ko) 1999-01-15
IL119273A0 (en) 1996-12-05
IL107654A (en) 1998-01-04
UA49792C2 (uk) 2002-10-15
PL176051B1 (pl) 1999-03-31
NZ257854A (en) 1997-04-24
CZ287262B6 (en) 2000-10-11
HU211546A9 (en) 1995-12-28
GR3029831T3 (en) 1999-06-30
WO1994012494A1 (en) 1994-06-09
DE69323322D1 (de) 1999-03-11
MX9307257A (es) 1994-05-31
DK0669919T3 (da) 1999-09-13
JPH08505840A (ja) 1996-06-25
BR9307477A (pt) 1999-06-29
PL309045A1 (en) 1995-09-18
HUT72740A (en) 1996-05-28

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Effective date: 20041116