RU2104285C1 - Пептид-гелонин - Google Patents
Пептид-гелонин Download PDFInfo
- Publication number
- RU2104285C1 RU2104285C1 RU93005126A RU93005126A RU2104285C1 RU 2104285 C1 RU2104285 C1 RU 2104285C1 RU 93005126 A RU93005126 A RU 93005126A RU 93005126 A RU93005126 A RU 93005126A RU 2104285 C1 RU2104285 C1 RU 2104285C1
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- Prior art keywords
- gelonin
- sequence
- protein
- amino acid
- peptide
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
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- Plant Pathology (AREA)
- Botany (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US567220 | 1983-12-30 | ||
| US56722090A | 1990-08-14 | 1990-08-14 | |
| PCT/US1991/005766 WO1992003144A1 (en) | 1990-08-14 | 1991-08-14 | Protein structure of the plant toxin gelonin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93005126A RU93005126A (ru) | 1995-02-20 |
| RU2104285C1 true RU2104285C1 (ru) | 1998-02-10 |
Family
ID=24266242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93005126A RU2104285C1 (ru) | 1990-08-14 | 1991-08-14 | Пептид-гелонин |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US5631348A (enFirst) |
| EP (1) | EP0546087B1 (enFirst) |
| JP (1) | JPH06502847A (enFirst) |
| KR (1) | KR100220502B1 (enFirst) |
| CN (1) | CN1055123C (enFirst) |
| AT (1) | ATE150791T1 (enFirst) |
| CA (1) | CA2088068C (enFirst) |
| DE (1) | DE69125381T2 (enFirst) |
| DK (1) | DK0546087T3 (enFirst) |
| ES (1) | ES2100960T3 (enFirst) |
| FI (1) | FI112492B (enFirst) |
| GR (1) | GR3023593T3 (enFirst) |
| HK (1) | HK1006727A1 (enFirst) |
| IE (1) | IE912716A1 (enFirst) |
| IL (1) | IL99079A (enFirst) |
| NO (1) | NO309656B1 (enFirst) |
| NZ (1) | NZ239249A (enFirst) |
| PT (1) | PT98669B (enFirst) |
| RU (1) | RU2104285C1 (enFirst) |
| SA (1) | SA92130322B1 (enFirst) |
| WO (1) | WO1992003144A1 (enFirst) |
| ZA (1) | ZA916171B (enFirst) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE62496B1 (en) * | 1990-04-19 | 1995-02-08 | Res Dev Foundation | Antibody conjugates for treatment of neoplastic disease |
| IE912716A1 (en) | 1990-08-14 | 1992-02-26 | Res Dev Foundation | Protein Structure of the Plant Toxin Gelonin |
| JPH06510431A (ja) * | 1991-09-06 | 1994-11-24 | リサーチ ディベロップメント ファンデーション | ジェロニン・ポリペプチドをコードするｄｎａ配列 |
| US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
| US6146850A (en) * | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
| US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
| US6599505B1 (en) * | 1992-04-10 | 2003-07-29 | Research Development Foundation | Immunotoxins directed against CD33 related surface antigens |
| CA2139571C (en) * | 1992-07-07 | 2006-11-14 | Eleanor N. Fish | Interferon receptor binding peptides |
| ZA200305980B (en) * | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
| CA2454048C (en) * | 2001-07-17 | 2011-05-03 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
| JP2006506964A (ja) * | 2002-06-12 | 2006-03-02 | リサーチ ディベロップメント ファンデーション | 治療剤としての免疫毒素及びその利用 |
| JP2008528633A (ja) * | 2005-02-01 | 2008-07-31 | リサーチ ディベロップメント ファウンデーション | Ｂｌｙｓレセプターを標的化するためのｂｌｙｓ融合タンパク質およびｂ細胞増殖性疾患の処置方法 |
| WO2014127211A1 (en) | 2013-02-15 | 2014-08-21 | Research Development Foundation | Deimmunized gelonin molecules and therapies |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446240A (en) * | 1981-01-30 | 1984-05-01 | Nerenberg Samuel T | Pancreas specific protein systems |
| US4921802A (en) * | 1983-05-05 | 1990-05-01 | Pioneer Hi-Bred International, Inc. | Plant virus cDNA |
| US4888415A (en) * | 1985-03-04 | 1989-12-19 | Dana-Farber Cancer Institute, Inc. | Gelonin immunotoxin |
| US4810648A (en) * | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
| EP0341304A4 (en) | 1987-11-24 | 1991-01-30 | Genetics Institute, Inc. | Improved ricin molecules and ricin toxin conjugates |
| GB8801877D0 (en) * | 1988-01-28 | 1988-02-24 | Erba Carlo Spa | Nucleotide sequence encoding plant ribosome inactivating protein |
| IE62463B1 (en) * | 1988-07-07 | 1995-02-08 | Res Dev Foundation | Immunoconjugates for cancer diagnosis and therapy |
| IE912716A1 (en) | 1990-08-14 | 1992-02-26 | Res Dev Foundation | Protein Structure of the Plant Toxin Gelonin |
-
1991
- 1991-07-31 IE IE271691A patent/IE912716A1/en not_active IP Right Cessation
- 1991-08-02 NZ NZ239249A patent/NZ239249A/xx not_active IP Right Cessation
- 1991-08-05 IL IL9907991A patent/IL99079A/en not_active IP Right Cessation
- 1991-08-06 ZA ZA916171A patent/ZA916171B/xx unknown
- 1991-08-13 PT PT98669A patent/PT98669B/pt not_active IP Right Cessation
- 1991-08-14 WO PCT/US1991/005766 patent/WO1992003144A1/en not_active Ceased
- 1991-08-14 AT AT91917004T patent/ATE150791T1/de not_active IP Right Cessation
- 1991-08-14 DK DK91917004.3T patent/DK0546087T3/da active
- 1991-08-14 CA CA002088068A patent/CA2088068C/en not_active Expired - Lifetime
- 1991-08-14 DE DE69125381T patent/DE69125381T2/de not_active Expired - Lifetime
- 1991-08-14 RU RU93005126A patent/RU2104285C1/ru not_active IP Right Cessation
- 1991-08-14 ES ES91917004T patent/ES2100960T3/es not_active Expired - Lifetime
- 1991-08-14 EP EP91917004A patent/EP0546087B1/en not_active Expired - Lifetime
- 1991-08-14 KR KR1019930700412A patent/KR100220502B1/ko not_active Expired - Fee Related
- 1991-08-14 HK HK98106041A patent/HK1006727A1/en not_active IP Right Cessation
- 1991-08-14 CN CN91105802A patent/CN1055123C/zh not_active Expired - Fee Related
- 1991-08-14 JP JP3515854A patent/JPH06502847A/ja active Pending
-
1992
- 1992-12-30 SA SA92130322A patent/SA92130322B1/ar unknown
-
1993
- 1993-02-08 NO NO930428A patent/NO309656B1/no not_active IP Right Cessation
- 1993-02-12 FI FI930626A patent/FI112492B/fi active
-
1994
- 1994-06-06 US US08/254,662 patent/US5631348A/en not_active Ceased
-
1997
- 1997-05-30 GR GR970401236T patent/GR3023593T3/el unknown
-
1999
- 1999-05-20 US US09/316,071 patent/USRE37462E1/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| Stipne. J.Biol. chem. 1980, 255, 6947-6953. Falaske et al. Biochem.j. 1982, 207, 505-509 Younget et. al. International j. Peptide Profeine Res. 1988, 31, 265-268. Якубке Х.-Д., Ешкайт Х. Аминокислоты. Пептиды. Белки. - М.: Мир, 1985, с.90 и 366. * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20100815 |