RU2097047C1 - Препарат человеческого фактора xi свертывания крови и способ его получения - Google Patents
Препарат человеческого фактора xi свертывания крови и способ его получения Download PDFInfo
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- RU2097047C1 RU2097047C1 SU925011788A SU5011788A RU2097047C1 RU 2097047 C1 RU2097047 C1 RU 2097047C1 SU 925011788 A SU925011788 A SU 925011788A SU 5011788 A SU5011788 A SU 5011788A RU 2097047 C1 RU2097047 C1 RU 2097047C1
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- buffer solution
- sodium chloride
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- 238000000034 method Methods 0.000 title claims abstract description 15
- 108010074864 Factor XI Proteins 0.000 title claims description 35
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 238000001914 filtration Methods 0.000 claims abstract description 9
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- 239000011347 resin Substances 0.000 claims abstract description 3
- 229920005989 resin Polymers 0.000 claims abstract description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 28
- 239000011780 sodium chloride Substances 0.000 claims description 14
- 239000007853 buffer solution Substances 0.000 claims description 13
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 12
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 9
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- 239000004472 Lysine Substances 0.000 claims description 6
- 229920002684 Sepharose Polymers 0.000 claims description 6
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 6
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 6
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- 239000004475 Arginine Substances 0.000 claims description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
- 229960005348 antithrombin iii Drugs 0.000 claims description 3
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- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
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- 238000004062 sedimentation Methods 0.000 claims 1
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- 108010093008 Kinins Proteins 0.000 description 1
- 235000019766 L-Lysine Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
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- 239000000706 filtrate Substances 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
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- 239000012264 purified product Substances 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
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- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6443—Coagulation factor XIa (3.4.21.27)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21027—Coagulation factor XIa (3.4.21.27)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9105572 | 1991-05-07 | ||
| FR9105572A FR2676231A1 (fr) | 1991-05-07 | 1991-05-07 | Concentre de facteur xi de la coagulation sanguine a haute activite specifique, approprie a usage therapeutique et son procede de preparation. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2097047C1 true RU2097047C1 (ru) | 1997-11-27 |
Family
ID=9412593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU925011788A RU2097047C1 (ru) | 1991-05-07 | 1992-05-06 | Препарат человеческого фактора xi свертывания крови и способ его получения |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5252217A (enExample) |
| EP (1) | EP0512883B1 (enExample) |
| AT (1) | ATE156360T1 (enExample) |
| AU (1) | AU652043B2 (enExample) |
| BR (1) | BR9201718A (enExample) |
| CA (1) | CA2068069C (enExample) |
| DE (1) | DE69221369T2 (enExample) |
| DK (1) | DK0512883T3 (enExample) |
| EE (1) | EE03017B1 (enExample) |
| ES (1) | ES2107511T3 (enExample) |
| FR (1) | FR2676231A1 (enExample) |
| GR (1) | GR3025134T3 (enExample) |
| IL (1) | IL99567A (enExample) |
| LT (1) | LT3417B (enExample) |
| RU (1) | RU2097047C1 (enExample) |
| UA (1) | UA27733C2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2151604C1 (ru) * | 1999-01-21 | 2000-06-27 | Станкевич Виктор Евгеньевич | Способ приготовления универсальной гемотрансфузионной среды |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030040480A1 (en) * | 2001-07-20 | 2003-02-27 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides |
| JP2004534855A (ja) * | 2001-07-20 | 2004-11-18 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第ｖｉｉ因子ポリペプチドおよび第ｘｉ因子ポリペプチドを含んでなる医薬組成物 |
| US20050181978A1 (en) * | 2003-11-20 | 2005-08-18 | Rasmus Rojkjaer | Therapeutic use of factor XI |
| RU2006115783A (ru) * | 2003-11-20 | 2007-12-27 | Ново Нордиск Хелс Кеа Аг (Ch) | Терапевтическое применение фактора xi |
| WO2006128497A1 (en) * | 2005-06-01 | 2006-12-07 | Novo Nordisk A/S | Pharmaceutical formulation of factor xi |
| US8350013B2 (en) * | 2006-09-08 | 2013-01-08 | Wyeth Llc | Arginine wash in protein purification using affinity chromatography |
| ATE546520T1 (de) * | 2007-01-04 | 2012-03-15 | Crucell Holland Bv | Faktor-xi-reinigung |
| KR101979134B1 (ko) | 2008-10-15 | 2019-05-15 | 아이오니스 파마수티컬즈, 인코포레이티드 | 인자 １１ 발현의 조정 |
| FR2974366B1 (fr) | 2011-04-20 | 2016-06-24 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre de facteur xi |
| FR2974301B1 (fr) | 2011-04-20 | 2013-08-23 | Lab Francais Du Fractionnement | Procede de preparation d'un produit plasmatique deplete en un ou plusieurs facteurs thrombogenes |
| IL212911A0 (en) | 2011-05-16 | 2011-07-31 | Omrix Biopharmaceuticals Ltd | Immunoglobulin reduced in thrombogenic contaminants and preparation thereof |
| DE102012022233A1 (de) | 2012-11-14 | 2014-05-15 | Instraction Gmbh | Verfahren zur Reinigung eines (Blut)plasmaproteins |
| DE102012022234A1 (de) | 2012-11-14 | 2014-05-15 | Instraction Gmbh | Einstufiges Verfahren zur Reinigung von (Blut)Plasmaproteinen wie Albumin aus Gemischen |
| FR3032621A1 (fr) | 2015-02-13 | 2016-08-19 | Lab Francais Du Fractionnement | Colle biologique et son utilisation comme medicament |
| KR101941974B1 (ko) * | 2016-11-18 | 2019-01-24 | 주식회사 녹십자 | 혈장 단백질 정제시 fxi의 제거방법 |
| MY204000A (en) | 2018-05-09 | 2024-07-31 | Ionis Pharmaceuticals Inc | Compounds and methods for reducing fxi expression |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4859340A (en) * | 1976-03-15 | 1989-08-22 | Cuno, Incorporated | Filter sheet |
| US4783262A (en) * | 1987-03-30 | 1988-11-08 | Cuno Incorporated | Separator for cell type filter element |
-
1991
- 1991-05-07 FR FR9105572A patent/FR2676231A1/fr active Granted
- 1991-09-25 IL IL9956791A patent/IL99567A/en not_active IP Right Cessation
-
1992
- 1992-04-23 DK DK92401157.0T patent/DK0512883T3/da active
- 1992-04-23 AT AT92401157T patent/ATE156360T1/de active
- 1992-04-23 ES ES92401157T patent/ES2107511T3/es not_active Expired - Lifetime
- 1992-04-23 EP EP92401157A patent/EP0512883B1/fr not_active Expired - Lifetime
- 1992-04-23 DE DE69221369T patent/DE69221369T2/de not_active Expired - Lifetime
- 1992-04-29 AU AU15263/92A patent/AU652043B2/en not_active Expired
- 1992-05-06 RU SU925011788A patent/RU2097047C1/ru active
- 1992-05-06 CA CA002068069A patent/CA2068069C/en not_active Expired - Lifetime
- 1992-05-07 BR BR929201718A patent/BR9201718A/pt not_active Application Discontinuation
- 1992-05-07 US US07/879,273 patent/US5252217A/en not_active Expired - Lifetime
- 1992-12-29 LT LTIP265A patent/LT3417B/lt not_active IP Right Cessation
-
1993
- 1993-05-21 UA UA93002714A patent/UA27733C2/uk unknown
-
1994
- 1994-05-23 EE EE9400003A patent/EE03017B1/xx not_active IP Right Cessation
-
1997
- 1997-10-22 GR GR970402766T patent/GR3025134T3/el unknown
Non-Patent Citations (1)
| Title |
|---|
| J. Biol. Chem. - 1977, N 252, р.6432 - 6437, 1977. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2151604C1 (ru) * | 1999-01-21 | 2000-06-27 | Станкевич Виктор Евгеньевич | Способ приготовления универсальной гемотрансфузионной среды |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2068069A1 (en) | 1992-11-08 |
| EE03017B1 (et) | 1997-08-15 |
| BR9201718A (pt) | 1992-12-29 |
| FR2676231A1 (fr) | 1992-11-13 |
| AU1526392A (en) | 1992-11-12 |
| DE69221369D1 (de) | 1997-09-11 |
| DE69221369T2 (de) | 1998-03-19 |
| US5252217A (en) | 1993-10-12 |
| AU652043B2 (en) | 1994-08-11 |
| UA27733C2 (uk) | 2000-10-16 |
| CA2068069C (en) | 2005-03-15 |
| DK0512883T3 (da) | 1998-03-16 |
| GR3025134T3 (en) | 1998-02-27 |
| EP0512883B1 (fr) | 1997-08-06 |
| LT3417B (en) | 1995-09-25 |
| IL99567A (en) | 1996-01-19 |
| ATE156360T1 (de) | 1997-08-15 |
| EP0512883A1 (fr) | 1992-11-11 |
| FR2676231B1 (enExample) | 1995-04-21 |
| LTIP265A (en) | 1994-10-25 |
| ES2107511T3 (es) | 1997-12-01 |
| IL99567A0 (en) | 1992-08-18 |
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