LTIP265A - Blood coagulation factor xi concentrate and process for the preparing same - Google Patents

Blood coagulation factor xi concentrate and process for the preparing same

Info

Publication number
LTIP265A
LTIP265A LTIP265A LTIP265A LTIP265A LT IP265 A LTIP265 A LT IP265A LT IP265 A LTIP265 A LT IP265A LT IP265 A LTIP265 A LT IP265A LT IP265 A LTIP265 A LT IP265A
Authority
LT
Lithuania
Prior art keywords
concentrate
blood coagulation
coagulation factor
preparing same
factor
Prior art date
Application number
LTIP265A
Inventor
Miryana Burnouf
Dominique Dernis
Original Assignee
Aetsrn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aetsrn filed Critical Aetsrn
Publication of LTIP265A publication Critical patent/LTIP265A/en
Publication of LT3417B publication Critical patent/LT3417B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6443—Coagulation factor XIa (3.4.21.27)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21027—Coagulation factor XIa (3.4.21.27)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a human Factor XI concentrate having high specific activity prepared using a process comprising a filtration-adsorption step and a single step of chromatography on cation exchange resin. The concentrate obtained is perfectly suitable for therapeutic use in replacement therapy in cases of Factor XI deficiency.
LTIP265A 1991-05-07 1992-12-29 Blood coagulation factor xi concentrate and process for the preparing same LT3417B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9105572A FR2676231A1 (en) 1991-05-07 1991-05-07 BLOOD COAGULATION FACTOR XI CONCENTRATE WITH HIGH SPECIFIC ACTIVITY, SUITABLE FOR THERAPEUTIC USE AND ITS PREPARATION PROCESS.

Publications (2)

Publication Number Publication Date
LTIP265A true LTIP265A (en) 1994-10-25
LT3417B LT3417B (en) 1995-09-25

Family

ID=9412593

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP265A LT3417B (en) 1991-05-07 1992-12-29 Blood coagulation factor xi concentrate and process for the preparing same

Country Status (16)

Country Link
US (1) US5252217A (en)
EP (1) EP0512883B1 (en)
AT (1) ATE156360T1 (en)
AU (1) AU652043B2 (en)
BR (1) BR9201718A (en)
CA (1) CA2068069C (en)
DE (1) DE69221369T2 (en)
DK (1) DK0512883T3 (en)
EE (1) EE03017B1 (en)
ES (1) ES2107511T3 (en)
FR (1) FR2676231A1 (en)
GR (1) GR3025134T3 (en)
IL (1) IL99567A (en)
LT (1) LT3417B (en)
RU (1) RU2097047C1 (en)
UA (1) UA27733C2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040480A1 (en) * 2001-07-20 2003-02-27 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides
WO2003007983A1 (en) * 2001-07-20 2003-01-30 Novo Nordisk Health Care Ag Pharmaceutical composition comprising factor vii polypeptides and factor xi polypeptides
US20050181978A1 (en) * 2003-11-20 2005-08-18 Rasmus Rojkjaer Therapeutic use of factor XI
CA2540986A1 (en) * 2003-11-20 2005-06-02 Novo Nordisk Health Care Ag Therapeutic use of factor xi
WO2006128497A1 (en) * 2005-06-01 2006-12-07 Novo Nordisk A/S Pharmaceutical formulation of factor xi
WO2008031020A2 (en) * 2006-09-08 2008-03-13 Wyeth Arginine wash in protein purification using affinity chromatography
WO2008081025A1 (en) * 2007-01-04 2008-07-10 Crucell Holland B.V. Purification of factor xi
EP3335715A3 (en) * 2008-10-15 2018-08-08 Ionis Pharmaceuticals, Inc. Modulation of factor 11 expression
FR2974366B1 (en) * 2011-04-20 2016-06-24 Lab Francais Du Fractionnement PROCESS FOR PREPARING A FACTOR XI CONCENTRATE
FR2974301B1 (en) 2011-04-20 2013-08-23 Lab Francais Du Fractionnement PROCESS FOR THE PREPARATION OF A PLASMATIC PRODUCT DEPLETE IN ONE OR MORE THROMBOGENIC FACTORS
IL212911A0 (en) 2011-05-16 2011-07-31 Omrix Biopharmaceuticals Ltd Immunoglobulin reduced in thrombogenic contaminants and preparation thereof
DE102012022234A1 (en) 2012-11-14 2014-05-15 Instraction Gmbh One step process for purifying (blood) plasma proteins, such as albumin from mixtures
DE102012022233A1 (en) 2012-11-14 2014-05-15 Instraction Gmbh Process for purifying a (blood) plasma protein
FR3032621A1 (en) 2015-02-13 2016-08-19 Lab Francais Du Fractionnement BIOLOGICAL GLUE AND ITS USE AS MEDICINE
KR101941974B1 (en) * 2016-11-18 2019-01-24 주식회사 녹십자 Methods for Eliminating Factor XI during Plasma Protein Purification
MX2020011913A (en) 2018-05-09 2021-01-29 Ionis Pharmaceuticals Inc Compounds and methods for reducing fxi expression.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859340A (en) * 1976-03-15 1989-08-22 Cuno, Incorporated Filter sheet
US4783262A (en) * 1987-03-30 1988-11-08 Cuno Incorporated Separator for cell type filter element

Also Published As

Publication number Publication date
US5252217A (en) 1993-10-12
RU2097047C1 (en) 1997-11-27
CA2068069C (en) 2005-03-15
EP0512883B1 (en) 1997-08-06
AU1526392A (en) 1992-11-12
EE03017B1 (en) 1997-08-15
DK0512883T3 (en) 1998-03-16
CA2068069A1 (en) 1992-11-08
ES2107511T3 (en) 1997-12-01
DE69221369T2 (en) 1998-03-19
ATE156360T1 (en) 1997-08-15
FR2676231A1 (en) 1992-11-13
EP0512883A1 (en) 1992-11-11
LT3417B (en) 1995-09-25
UA27733C2 (en) 2000-10-16
GR3025134T3 (en) 1998-02-27
FR2676231B1 (en) 1995-04-21
IL99567A (en) 1996-01-19
DE69221369D1 (en) 1997-09-11
IL99567A0 (en) 1992-08-18
BR9201718A (en) 1992-12-29
AU652043B2 (en) 1994-08-11

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Legal Events

Date Code Title Description
PC9A Transfer of patents

Owner name: THE LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES

Effective date: 20090511

TC9A Change of representative

Representative=s name: ZABOLIENE, REDA, LT

MM9A Lapsed patents

Effective date: 20091229