RU2080872C1 - Фармацевтическая композиция, обладающая ранозаживляющим действием, и способ ее получения - Google Patents

Фармацевтическая композиция, обладающая ранозаживляющим действием, и способ ее получения Download PDF

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Publication number
RU2080872C1
RU2080872C1 SU925052705A SU5052705A RU2080872C1 RU 2080872 C1 RU2080872 C1 RU 2080872C1 SU 925052705 A SU925052705 A SU 925052705A SU 5052705 A SU5052705 A SU 5052705A RU 2080872 C1 RU2080872 C1 RU 2080872C1
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RU
Russia
Prior art keywords
peptide
fgf
composition
wound
chitosan
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SU925052705A
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English (en)
Russian (ru)
Inventor
Нис Берхольд
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Мерк Патент Гмбх
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/225Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028Polypeptides; Proteins; Degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/13Burn treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
SU925052705A 1991-09-26 1992-09-25 Фармацевтическая композиция, обладающая ранозаживляющим действием, и способ ее получения RU2080872C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4132005A DE4132005A1 (de) 1991-09-26 1991-09-26 Kombination enthaltend wachstumsfaktoren und polyelektrolyte
DEP4132005.0 1991-09-26

Publications (1)

Publication Number Publication Date
RU2080872C1 true RU2080872C1 (ru) 1997-06-10

Family

ID=6441511

Family Applications (1)

Application Number Title Priority Date Filing Date
SU925052705A RU2080872C1 (ru) 1991-09-26 1992-09-25 Фармацевтическая композиция, обладающая ранозаживляющим действием, и способ ее получения

Country Status (16)

Country Link
US (2) US5885960A (enExample)
EP (1) EP0534310A1 (enExample)
JP (1) JPH05213766A (enExample)
KR (1) KR930005633A (enExample)
AU (1) AU2525092A (enExample)
CA (1) CA2079042A1 (enExample)
CZ (1) CZ281452B6 (enExample)
DE (1) DE4132005A1 (enExample)
HU (1) HUT64479A (enExample)
MX (1) MX9205438A (enExample)
NO (1) NO923746L (enExample)
PL (1) PL296034A2 (enExample)
RU (1) RU2080872C1 (enExample)
SK (1) SK265692A3 (enExample)
TW (1) TW273512B (enExample)
ZA (1) ZA927398B (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2138295C1 (ru) * 1999-02-04 1999-09-27 Гаврилюк Борис Карпович Покрытие для ран
RU2140264C1 (ru) * 1998-09-24 1999-10-27 Тихоокеанский институт биоорганической химии Дальневосточного отделения РАН Средство для наружного применения "полимед"
RU2153352C1 (ru) * 1999-08-09 2000-07-27 Гончар Александр Михайлович Фармацевтическая композиция, обладающая ранозаживляющим и противовоспалительным действием
RU2189248C2 (ru) * 1996-04-18 2002-09-20 Акцо Нобель Н.В. Аутоантиген и структурно родственные ему белки для применения при иммунотерапии аутоиммунных заболеваний
RU2233290C2 (ru) * 1998-07-23 2004-07-27 Акцо Нобель Н.В. Новые пептиды для применения в иммунотерапии аутоиммунных заболеваний
RU2256440C2 (ru) * 1999-08-27 2005-07-20 Лтс Ломанн Терапи-Зюстеме Аг Фармацевтический препарат
RU2314796C2 (ru) * 2001-11-21 2008-01-20 Безенс Интернэшнл Бельжик Тонкоизмельченный пленкообразующий порошок, содержащие его композиции, способы его получения и применения
RU2366408C1 (ru) * 2008-07-21 2009-09-10 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) Гелевая композиция, обладающая ранозаживляющим, противоожоговым, противовоспалительным, гепатопротекторным, противодиабетическим и противоопухолевым действием

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221840B1 (en) * 1991-02-14 2001-04-24 The General Hospital Corporation Intestinal trefoil proteins
DE4132005A1 (de) * 1991-09-26 1993-04-01 Merck Patent Gmbh Kombination enthaltend wachstumsfaktoren und polyelektrolyte
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
MY137157A (en) 1999-10-22 2008-12-31 Matsushita Electric Industrial Co Ltd Cathode ray tube and image display apparatus using the same
DE10022656B4 (de) * 2000-04-28 2006-07-06 Infineon Technologies Ag Verfahren zum Entfernen von Strukturen
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
TW527722B (en) * 2002-03-20 2003-04-11 Macronix Int Co Ltd Non-volatile memory device and fabrication method thereof
BR0317888A (pt) * 2002-12-31 2005-12-06 Altus Pharmaceuticals Inc Cristais do hormÈnio do crescimento humano e processos para preparação dos mesmos
BR0317896A (pt) * 2002-12-31 2005-12-06 Altus Pharmaceuticals Inc Complexos de cristais de proteìna e polìmeros iÈnicos
US20090023629A1 (en) * 2005-12-23 2009-01-22 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
EP3574909A1 (en) * 2008-01-30 2019-12-04 Imbed Biosciences, Inc. Methods and compositions for wound healing
BRPI0801422B8 (pt) 2008-03-26 2021-05-25 Fund Sao Francisco Xavier composição e método para inibição da severidade das aderências pós-cirúrgicas
EP2533772B1 (en) * 2010-02-10 2021-09-08 Imbed Biosciences, Inc. Methods and compositions for wound healing
EP2558115B1 (en) 2010-04-16 2019-07-31 The Salk Institute for Biological Studies Methods for treating metabolic disorders using fgf
WO2015061331A1 (en) 2013-10-21 2015-04-30 Salk Institute For Biological Studies Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use
CN105828833A (zh) 2013-10-21 2016-08-03 萨克生物研究学院 突变的成纤维细胞生长因子(fgf)1及使用方法
EP3368059A4 (en) 2015-10-30 2019-03-27 Salk Institute for Biological Studies TREATMENT OF STEROID-INDUCED HYPERGLYCEMIA WITH FIBROBLAST GROWTH FACTOR (FGF) -1 ANALOGUE
WO2018023021A1 (en) 2016-07-29 2018-02-01 Imbed Biosciences Inc. Methods and compositions for wound healing
US11542309B2 (en) 2019-07-31 2023-01-03 Salk Institute For Biological Studies Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose
RU2734819C1 (ru) * 2019-12-12 2020-10-23 Общество с ограниченной ответственностью "ИНТЭКОС" (ООО "ИНТЭКОС") Композиция для лечения ран и ожогов (варианты)

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US4783412A (en) * 1983-07-05 1988-11-08 Chiron Corporation Hybrid DNA synthesis of epidermal growth factor
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
JPS61253065A (ja) * 1985-05-02 1986-11-10 片倉チツカリン株式会社 キトサン誘導体およびコラ−ゲンの複合材の医用材料およびその製造法
WO1987001728A1 (en) * 1985-09-12 1987-03-26 Biotechnology Research Partners, Ltd. Recombinant fibroblast growth factors
NZ226171A (en) * 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
DE4132005A1 (de) * 1991-09-26 1993-04-01 Merck Patent Gmbh Kombination enthaltend wachstumsfaktoren und polyelektrolyte

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ЕПВ N 0312208, кл. A 61 K 37/02, 1989. *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2189248C2 (ru) * 1996-04-18 2002-09-20 Акцо Нобель Н.В. Аутоантиген и структурно родственные ему белки для применения при иммунотерапии аутоиммунных заболеваний
RU2233290C2 (ru) * 1998-07-23 2004-07-27 Акцо Нобель Н.В. Новые пептиды для применения в иммунотерапии аутоиммунных заболеваний
RU2140264C1 (ru) * 1998-09-24 1999-10-27 Тихоокеанский институт биоорганической химии Дальневосточного отделения РАН Средство для наружного применения "полимед"
RU2138295C1 (ru) * 1999-02-04 1999-09-27 Гаврилюк Борис Карпович Покрытие для ран
RU2153352C1 (ru) * 1999-08-09 2000-07-27 Гончар Александр Михайлович Фармацевтическая композиция, обладающая ранозаживляющим и противовоспалительным действием
RU2256440C2 (ru) * 1999-08-27 2005-07-20 Лтс Ломанн Терапи-Зюстеме Аг Фармацевтический препарат
RU2314796C2 (ru) * 2001-11-21 2008-01-20 Безенс Интернэшнл Бельжик Тонкоизмельченный пленкообразующий порошок, содержащие его композиции, способы его получения и применения
RU2366408C1 (ru) * 2008-07-21 2009-09-10 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) Гелевая композиция, обладающая ранозаживляющим, противоожоговым, противовоспалительным, гепатопротекторным, противодиабетическим и противоопухолевым действием

Also Published As

Publication number Publication date
CA2079042A1 (en) 1993-03-27
JPH05213766A (ja) 1993-08-24
KR930005633A (ko) 1993-04-20
AU2525092A (en) 1993-04-01
ZA927398B (en) 1993-04-02
MX9205438A (es) 1993-03-01
NO923746L (no) 1993-03-29
US5885960A (en) 1999-03-23
NO923746D0 (no) 1992-09-25
CZ265692A3 (en) 1993-04-14
HU9203079D0 (en) 1992-12-28
DE4132005A1 (de) 1993-04-01
TW273512B (enExample) 1996-04-01
CZ281452B6 (cs) 1996-10-16
SK265692A3 (en) 1994-06-08
EP0534310A1 (de) 1993-03-31
US6147053A (en) 2000-11-14
PL296034A2 (en) 1993-07-12
HUT64479A (en) 1994-01-28

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