RU2018132691A - Бета-казеин и когнитивная функция - Google Patents
Бета-казеин и когнитивная функция Download PDFInfo
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- RU2018132691A RU2018132691A RU2018132691A RU2018132691A RU2018132691A RU 2018132691 A RU2018132691 A RU 2018132691A RU 2018132691 A RU2018132691 A RU 2018132691A RU 2018132691 A RU2018132691 A RU 2018132691A RU 2018132691 A RU2018132691 A RU 2018132691A
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- RU
- Russia
- Prior art keywords
- casein
- beta
- milk
- animal
- cognitive
- Prior art date
Links
- 102000011632 Caseins Human genes 0.000 title claims 28
- 108010076119 Caseins Proteins 0.000 title claims 28
- 235000021247 β-casein Nutrition 0.000 title claims 28
- 230000003920 cognitive function Effects 0.000 title claims 5
- 241001465754 Metazoa Species 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 235000013336 milk Nutrition 0.000 claims 8
- 239000008267 milk Substances 0.000 claims 8
- 210000004080 milk Anatomy 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 238000012360 testing method Methods 0.000 claims 6
- 208000010877 cognitive disease Diseases 0.000 claims 5
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 210000000936 intestine Anatomy 0.000 claims 4
- 230000003557 neuropsychological effect Effects 0.000 claims 4
- 208000028698 Cognitive impairment Diseases 0.000 claims 3
- 230000001149 cognitive effect Effects 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 2
- 235000013351 cheese Nutrition 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 235000013365 dairy product Nutrition 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- 238000010855 neuropsychological testing Methods 0.000 claims 2
- 235000020200 pasteurised milk Nutrition 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000008131 Bone Morphogenetic Protein 7 Human genes 0.000 claims 1
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 1
- 235000014121 butter Nutrition 0.000 claims 1
- 230000019771 cognition Effects 0.000 claims 1
- 235000020186 condensed milk Nutrition 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 235000020603 homogenised milk Nutrition 0.000 claims 1
- 235000015243 ice cream Nutrition 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000006386 memory function Effects 0.000 claims 1
- 230000006996 mental state Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 235000020183 skimmed milk Nutrition 0.000 claims 1
- 235000013618 yogurt Nutrition 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/54—Proteins
- A23V2250/542—Animal Protein
- A23V2250/5424—Dairy protein
- A23V2250/54246—Casein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Mycology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Animal Husbandry (AREA)
- Marine Sciences & Fisheries (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
Claims (13)
1. Способ улучшения когнитивной функции у животного путем приема внутрь композиции, содержащей бета-казеин, или путем обеспечения животного композицией, содержащей бета-казеин, где по меньшей мере 75% по массе бета-казеина представляет собой вариант бета-казеина, который не приводит к образованию БКМ-7 при расщеплении в кишечнике указанного животного.
2. Способ по п. 1, отличающийся тем, что вариант бета-казеина представляет собой бета-казеин А2, бета-казеин A3, бета-казеин D, бета-казеин Е, бета-казеин Н2 или бета-казеин I.
3. Способ по п. 1 или 2, отличающийся тем, что вариант бета-казеина представляет собой бета-казеин А2.
4. Способ по любому из пп. 1-3, отличающийся тем, что бета-казеин содержит по меньшей мере 90% по массе бета-казеина А2.
5. Способ по любому из пл. 1-4, отличающийся таи, что бета-казеин содержит 100% бета-казеина А2.
6. Способ по любому из пп. 1-5, отличающийся тем, что когнитивную функцию оценивают с использованием любого одного или более из Теста слабого когнитивного нарушения (SCIT), Автоматизированного когнитивного теста (ACT), Автоматизированных метрик нейропсихологической оценки (ANAM), Компьютеризированной системы оценки деменции с медикаментозным исследованием когнитивных процессов (COGDRAS-D), Совместного скринингового инструмента для деменции (CSI-D), Компьютеризированного нейропсихологического скрининга умеренного когнитивного нарушения (CANS-MCI), Компьютеризированной оценки умеренного когнитивного нарушения (CAMCI), Компьютеризированного самостоятельного тестирования (CST), Флоридской краткой шкалы памяти (FBMS), Умеренного когнитивного нарушения (МО), Нейропсихологической батареи тестов (NTB), Краткой оценки когнитивных процессов при шизофрении (BACS), Кембриджского обследования ментальных расстройств у пожилых - Пересмотренный (CAMDEX-R), Кембриджской батареи автоматизированных нейропсихологических тестов (CANTAB), Компьютеризированной мультифазной интерактивной двухдисплейной системы (CMINDS), Батареи компьютеризированных нейропсихологических тестов (CNTB), Теста возможностей памяти (МСТ), Батареи нейропсихологической оценки (NAB), Совместного исследования болезни Альцгеймера (ADCS), Батареи исполнительных, лингвистических, пространственных функций и функции памяти (ELSMEM), Мини-определения ментального состояния (MMSE) и Когнитивного теста Гамильтона D (HAM-D).
7. Способ по любому из пп. 1-6, отличающийся тем, что указанная композиция представляет собой молоко или молочный продукт.
8. Способ по п. 7, отличающийся тем, что указанное молоко представляет собой свежее молоко, сухое молоко, жидкое молоко, восстановленное из порошка, обезжиренное молоко, гомогенизированное молоко, концентрированное молоко, сгущенное молоко, пастеризованное молоко или не пастеризованное молоко.
9. Способ по п. 7, отличающийся тем, что указанный молочный продукт представляет собой сливки, йогурт, творог, сыр, масло или мороженое.
10. Способ по любому из пп. 1-9, отличающийся тем, что указанное животное представляет собой человека.
11. Композиция для улучшения когнитивной функции у животного, при этом указанная композиция содержит бета-казеин, при этом по меньшей мере 75% по массе бета-казеина представляет собой вариант бета-казеина, который не приводит к образованию БКМ-7 при расщеплении в кишечнике указанного животного.
12. Применение молока при получении композиции для улучшения когнитивной функции у животного, согласно которому молоко содержит бета-казеин, и при этом по меньшей мере 75% по массе бета-казеина представляет собой вариант бета-казеина, который не приводит к образованию БКМ-7 при расщеплении в кишечнике указанного животного.
13. Способ профилактики или лечения когнитивного нарушения у животного, включающий прием внутрь указанным животным композиции, содержащей бета-казеин, или обеспечение указанного животного композицией, которая содержит бета-казеин, где по меньшей мере 75% по массе бета-казеина представляет собой вариант бета-казеина, который не приводит к образованию БКМ-7 при расщеплении в кишечнике указанного животного.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662315441P | 2016-03-30 | 2016-03-30 | |
| US62/315,441 | 2016-03-30 | ||
| PCT/NZ2017/050035 WO2017171563A1 (en) | 2016-03-30 | 2017-03-29 | Beta-caseins and cognitive function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018132691A true RU2018132691A (ru) | 2020-04-30 |
| RU2018132691A3 RU2018132691A3 (ru) | 2020-06-25 |
| RU2766194C2 RU2766194C2 (ru) | 2022-02-09 |
Family
ID=59964978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018132691A RU2766194C2 (ru) | 2016-03-30 | 2017-03-29 | Бета-казеин и когнитивная функция |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US11504412B2 (ru) |
| EP (1) | EP3436038B1 (ru) |
| JP (1) | JP7394527B2 (ru) |
| KR (1) | KR102471621B1 (ru) |
| CN (1) | CN109069540B (ru) |
| AU (1) | AU2017240635B2 (ru) |
| BR (1) | BR112018068817A2 (ru) |
| CA (1) | CA3017727C (ru) |
| CL (1) | CL2018002688A1 (ru) |
| ES (1) | ES2886647T3 (ru) |
| IL (1) | IL261704B (ru) |
| MX (1) | MX2018011817A (ru) |
| MY (1) | MY193655A (ru) |
| NZ (1) | NZ746167A (ru) |
| PH (1) | PH12018550149A1 (ru) |
| RU (1) | RU2766194C2 (ru) |
| SG (1) | SG11201807574XA (ru) |
| TW (1) | TWI831732B (ru) |
| WO (1) | WO2017171563A1 (ru) |
| ZA (1) | ZA201806247B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3436038B1 (en) | 2016-03-30 | 2021-06-23 | The A2 Milk Company Limited | Beta-caseins and cognitive function |
| NL2019906B1 (en) * | 2017-11-14 | 2019-05-20 | Ausnutria Hyproca B V | Composition comprising a2 b-casein and a vegetable fat mixture |
| CN114586983A (zh) * | 2022-03-07 | 2022-06-07 | 黑龙江飞鹤乳业有限公司 | 一种促神经发育营养组合物及其制备和应用 |
| CN114716531B (zh) * | 2022-05-17 | 2023-11-03 | 中国农业科学院农业质量标准与检测技术研究所 | 一种酪蛋白多肽、多肽抗原、抗体、试纸条及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451368B1 (en) * | 1994-04-11 | 2002-09-17 | New Zealand Dairy Board | Method of selecting non-diabetogenic milk or milk products and milk or milk products so selected |
| DK0871366T3 (da) | 1995-05-16 | 2005-10-10 | A2 Corp Ltd | Födevareprodukt og fremgangsmåde til fremstilling heraf |
| RU2161500C1 (ru) | 1999-07-06 | 2001-01-10 | Институт молекулярной генетики РАН | Гептапептид с адаптогенной и анксиолитической активностью |
| AU9037401A (en) * | 2000-09-08 | 2002-03-22 | New Zealand Dairy Board | Milk containing beta-casein with proline at position 67 does not aggravate neurological disorders |
| US20100166859A1 (en) * | 2006-01-16 | 2010-07-01 | Luppo Edens | Novel nutraceutical compositions and use thereof |
| EP2422629A1 (en) | 2010-08-23 | 2012-02-29 | Abbott Laboratories | Methods for enhancing cognition and/or memory using maltodextrins |
| EP3542813A1 (en) | 2013-05-31 | 2019-09-25 | The A2 Milk Company Limited | Beta-casein a2 and prevention of inflammation of the bowel |
| WO2015005804A1 (en) * | 2013-07-12 | 2015-01-15 | The A2 Milk Company Limited | Beta-casein a2 and reducing or preventing symptoms of lactose intolerance |
| JP6866159B2 (ja) | 2013-08-23 | 2021-04-28 | ズィ・エイツー・ミルク・カンパニー・リミテッド | ベータカゼインａ２および血中グルコースレベル |
| US20170086481A1 (en) * | 2014-06-03 | 2017-03-30 | Abbott Laboratories | Nutritional compositions comprising a lipophilic active ingredient |
| JP6005202B2 (ja) * | 2015-03-19 | 2016-10-12 | アサヒグループホールディングス株式会社 | 脳機能改善用ペプチドの酵素的製造方法 |
| US10702580B2 (en) * | 2015-05-22 | 2020-07-07 | The A2 Milk Company Limited | Beta-casein A2 and antioxidant capacity |
| CN105053217A (zh) * | 2015-09-14 | 2015-11-18 | 海普诺凯营养品有限公司 | 一种婴幼儿配方羊奶粉及其制作方法 |
| US20190000128A1 (en) * | 2015-12-22 | 2019-01-03 | The A2 Milk Company Limited | Infant formula comprising human milk peptides |
| EP3436038B1 (en) | 2016-03-30 | 2021-06-23 | The A2 Milk Company Limited | Beta-caseins and cognitive function |
-
2017
- 2017-03-29 EP EP17775963.6A patent/EP3436038B1/en not_active Revoked
- 2017-03-29 AU AU2017240635A patent/AU2017240635B2/en active Active
- 2017-03-29 CN CN201780017821.8A patent/CN109069540B/zh active Active
- 2017-03-29 WO PCT/NZ2017/050035 patent/WO2017171563A1/en active Application Filing
- 2017-03-29 JP JP2018551398A patent/JP7394527B2/ja active Active
- 2017-03-29 BR BR112018068817A patent/BR112018068817A2/pt unknown
- 2017-03-29 NZ NZ746167A patent/NZ746167A/en unknown
- 2017-03-29 CA CA3017727A patent/CA3017727C/en active Active
- 2017-03-29 RU RU2018132691A patent/RU2766194C2/ru active
- 2017-03-29 SG SG11201807574XA patent/SG11201807574XA/en unknown
- 2017-03-29 ES ES17775963T patent/ES2886647T3/es active Active
- 2017-03-29 KR KR1020187029896A patent/KR102471621B1/ko active IP Right Grant
- 2017-03-29 MX MX2018011817A patent/MX2018011817A/es unknown
- 2017-03-29 US US16/084,853 patent/US11504412B2/en active Active
- 2017-03-29 MY MYPI2018703463A patent/MY193655A/en unknown
- 2017-03-30 TW TW106110702A patent/TWI831732B/zh active
-
2018
- 2018-09-05 PH PH12018550149A patent/PH12018550149A1/en unknown
- 2018-09-12 IL IL261704A patent/IL261704B/en unknown
- 2018-09-17 ZA ZA2018/06247A patent/ZA201806247B/en unknown
- 2018-09-21 CL CL2018002688A patent/CL2018002688A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201737936A (zh) | 2017-11-01 |
| PH12018550149A1 (en) | 2019-03-25 |
| MX2018011817A (es) | 2019-01-24 |
| CA3017727C (en) | 2024-03-12 |
| EP3436038A4 (en) | 2019-11-20 |
| ES2886647T3 (es) | 2021-12-20 |
| NZ746167A (en) | 2023-04-28 |
| CN109069540A (zh) | 2018-12-21 |
| CN109069540B (zh) | 2023-03-28 |
| IL261704A (en) | 2018-10-31 |
| EP3436038A1 (en) | 2019-02-06 |
| TWI831732B (zh) | 2024-02-11 |
| KR102471621B1 (ko) | 2022-11-25 |
| ZA201806247B (en) | 2019-06-26 |
| KR20180129829A (ko) | 2018-12-05 |
| IL261704B (en) | 2022-04-01 |
| CA3017727A1 (en) | 2017-10-05 |
| US20190083567A1 (en) | 2019-03-21 |
| RU2766194C2 (ru) | 2022-02-09 |
| CL2018002688A1 (es) | 2019-01-18 |
| SG11201807574XA (en) | 2018-10-30 |
| MY193655A (en) | 2022-10-23 |
| RU2018132691A3 (ru) | 2020-06-25 |
| EP3436038B1 (en) | 2021-06-23 |
| WO2017171563A1 (en) | 2017-10-05 |
| US11504412B2 (en) | 2022-11-22 |
| JP2019509755A (ja) | 2019-04-11 |
| AU2017240635A1 (en) | 2018-10-04 |
| BR112018068817A2 (pt) | 2019-01-22 |
| JP7394527B2 (ja) | 2023-12-08 |
| AU2017240635B2 (en) | 2023-01-19 |
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