RU2018131244A - Использование микробных сообществ для лечения человека и животных - Google Patents
Использование микробных сообществ для лечения человека и животных Download PDFInfo
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- 241001465754 Metazoa Species 0.000 title 1
- 230000000813 microbial effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 21
- 241000894006 Bacteria Species 0.000 claims 11
- 241000872832 Roseburia hominis Species 0.000 claims 4
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 4
- 241000702462 Akkermansia muciniphila Species 0.000 claims 3
- 241000301580 Butyricicoccus pullicaecorum Species 0.000 claims 3
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- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 3
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- 241001505572 Anaerostipes caccae Species 0.000 claims 1
- 241000606123 Bacteroides thetaiotaomicron Species 0.000 claims 1
- 241000606215 Bacteroides vulgatus Species 0.000 claims 1
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims 1
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
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- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
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- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
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- 241000394636 Lactobacillus mucosae Species 0.000 claims 1
- 241001394655 Roseburia inulinivorans Species 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
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Claims (18)
1. Композиция, состоящая, по существу, из бактерий, принадлежащих к виду Faecalibacterium prausnitzii, Butyricicoccus pullicaecorum, Roseburia inulinivorans, Roseburia hominis, Akkermansia muciniphila, Lactobacillus plantarum и Anaerostipes caccae.
2. Композиция по п.1, которая используется в целях профилактики или лечения симптомов, ассоциированных с желудочно-кишечным расстройством.
3. Композиция по п.2, где указанным желудочно-кишечным расстройством является нарушение барьерной функции кишечника, диарея, запор, синдром раздраженного кишечника, воспалительное заболевание кишечника, болезнь Крона, язвенный колит, глютеновая болезнь, резервуарный илеит, воспаление слизистой оболочки, инфекция кишечника, дисбактериоз микробиоты кишечника и любая их комбинация.
4. Композиция по пп. 2, 3, где указанное желудочно-кишечное расстройство подвергают профилактике или лечению посредством: а) стимуляции роста и/или активности одной или ограниченного числа полезных бактерий в кишечном тракте, b) ингибирования роста и/или активности одной или ограниченного числа патогенных бактерий в кишечном тракте, c) относительного увеличения уровня связывания непатогенных бактерий со слизистой оболочкой желудочно-кишечной поверхности, d) снижения неконтролируемого поглощения антигенов, противовоспалительных агентов, бактерий или бактериальных продуктов кишечником, e) обеспечения противовоспалительной активности на поверхности кишечника, f) улучшения функционирования кишечного барьера, g) получения бактериальных метаболитов или h) любой комбинации а)-g).
5. Композиция по пп. 1-4, где бактерии, принадлежащие к виду Roseburia hominis, были удалены из указанной композиции.
6. Композиция по пп. 1-5, где бактерии, принадлежащие к виду Escherichia coli, Enterococcus faecium, Lactobacillus mucosae, Bifidobacterium adolescentis, Bifidobacterium longum, Bacteroides thetaiotaomicron и Bacteroides vulgatus, были добавлены в указанную композицию.
7. Композиция по пп. 1-6, которая также содержит один или более пребиотиков.
8. Композиция по пп. 1-7, где указанные бактерии культивируют вместе в ферментере перед введением указанной композиции для профилактики или лечения указанных желудочно-кишечных расстройств.
9. Композиция по п. 8, где указанный ферментер представляет собой динамический имитатор желудочно-кишечного тракта.
10. Композиция по п.1, где указанные бактерии выбраны из списка следующих штаммов: Faecalibacterium prausnitzii LMG P-29362, Faecalibacterium prausnitzii DSMZ 17677, Butyricicoccus pullicaecorum LMG P-29360, Butyricicoccus pullicaecorum LMG24109, Roseburia inulinivorans LMG P-29365, Roseburia inulinivorans DSMZ 16841, Roseburia hominis LMG P-29364, Roseburia hominis DSMZ 16839, Akkermansia muciniphila LMG P-29361, Akkermansia muciniphila DSMZ 22959, Lactobacillus plantarum LMG P-29366, Lactobacillus plantarum ZJ31 6, Anaerostipes caccae LMG P-29359, Anaerostipes caccae DSMZ 14662 или штаммов, последовательности которых по меньшей мере на 97% идентичны последовательностям рРНК 16S по меньшей мере одного из указанных штаммов.
11. Композиция по пп. 1-10, где указанной композицией является фармацевтическая композиция, приготовленная в виде лекарственной формы для ректального введения или в виде лекарственной формы для перорального введения.
12. Композиция по п. 11, где указанная пероральная лекарственная форма представляет собой капсулу, микрокапсулу, таблетку, гранулу, порошок, пастилку, пилюлю, суспензию или сироп.
13. Композиция по п. 12, которая включена в продукты питания, напитки, пищевые добавки или натуральные препараты.
14. Композиция по пп. 1-32, где указанная композиция содержит от 105 до 1011 колониеобразующих единиц бактерий.
15. Реактор, содержащий композицию по любому из пп. 1-10.
16. Реактор, работающий в стандартизированных условиях, репрезентативных для желудочно-кишечного тракта, где указанный реактор имеет следующие параметры: рН в пределах от 1,5 до 8; наличие источников углерода; время удерживания от 10 мин до 200 ч; доступность кислорода в пределах от 0 до 8 г/л; наличие микроэлементов; присутствие/отсутствие антибиотиков; концентрация солей желчных кислот в пределах от 0 до 20 мМ; присутствие тяжелых металлов; наличие факторов, таких как молекулы иммунной системы хозяина.
17. Реактор по п. 16, где параметры, характеризующие стандартизированные условия, включают рН, время удерживания в конкретном реакторе и концентрацию солей желчных кислот по п. 16.
18. Реактор по п. 16 или 17, где композиция из 5-20 бактерий различных видов, а предпочтительно, из 5-15 бактерий различных видов сохраняется в течение периода времени от 3 до 14 дней, что позволяет получить функционально стабильный коллабором.
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