RU2018126184A3 - - Google Patents

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Publication number
RU2018126184A3
RU2018126184A3 RU2018126184A RU2018126184A RU2018126184A3 RU 2018126184 A3 RU2018126184 A3 RU 2018126184A3 RU 2018126184 A RU2018126184 A RU 2018126184A RU 2018126184 A RU2018126184 A RU 2018126184A RU 2018126184 A3 RU2018126184 A3 RU 2018126184A3
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RU
Russia
Application number
RU2018126184A
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Russian (ru)
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RU2018126184A (ru
RU2808424C2 (ru
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Publication of RU2018126184A publication Critical patent/RU2018126184A/ru
Publication of RU2018126184A3 publication Critical patent/RU2018126184A3/ru
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Publication of RU2808424C2 publication Critical patent/RU2808424C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • C07C63/06—Benzoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ink Jet (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2018126184A 2013-01-31 2014-01-29 Пиридонамиды в качестве модуляторов натриевых каналов RU2808424C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361759059P 2013-01-31 2013-01-31
US61/759,059 2013-01-31

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2015136795A Division RU2662223C2 (ru) 2013-01-31 2014-01-29 Пиридонамиды в качестве модуляторов натриевых каналов

Publications (3)

Publication Number Publication Date
RU2018126184A RU2018126184A (ru) 2019-03-12
RU2018126184A3 true RU2018126184A3 (cg-RX-API-DMAC10.html) 2021-07-26
RU2808424C2 RU2808424C2 (ru) 2023-11-28

Family

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Also Published As

Publication number Publication date
RS56015B1 (sr) 2017-09-29
US9051270B2 (en) 2015-06-09
JP6741704B2 (ja) 2020-08-19
RU2015136795A (ru) 2017-03-10
SI3239134T1 (sl) 2021-03-31
PL3239134T3 (pl) 2021-06-14
AP2015008633A0 (en) 2015-07-31
CN105026373A (zh) 2015-11-04
SI2953931T1 (sl) 2017-08-31
JP2021001232A (ja) 2021-01-07
AU2018214105A1 (en) 2018-08-30
MX2015009602A (es) 2015-11-25
EP3239134A1 (en) 2017-11-01
CY1119163T1 (el) 2018-02-14
JP2016506963A (ja) 2016-03-07
CN108164457B (zh) 2021-07-09
BR112015018289A2 (pt) 2017-07-18
IL269964A (en) 2019-11-28
SMT202100030T1 (it) 2021-03-15
PL2953931T3 (pl) 2017-09-29
US11673864B2 (en) 2023-06-13
SG11201505953TA (en) 2015-08-28
LT2953931T (lt) 2017-07-25
JP6389194B2 (ja) 2018-09-12
TWI714967B (zh) 2021-01-01
HK1244269A1 (en) 2018-08-03
EP2953931A1 (en) 2015-12-16
US20150246028A1 (en) 2015-09-03
AU2014212509A1 (en) 2015-08-06
HRP20170787T1 (hr) 2017-08-11
PE20191495A1 (es) 2019-10-21
KR20210029848A (ko) 2021-03-16
EP3865475A1 (en) 2021-08-18
AU2014212509B2 (en) 2018-05-10
IL269964B2 (en) 2026-01-01
EP2953931B1 (en) 2017-03-01
US20180016235A1 (en) 2018-01-18
IL240195A0 (en) 2015-09-24
EP3239134B1 (en) 2020-12-23
MX2021003687A (es) 2023-01-25
TWI655187B (zh) 2019-04-01
JP2019089861A (ja) 2019-06-13
AR094667A1 (es) 2015-08-19
RU2018126184A (ru) 2019-03-12
PT3239134T (pt) 2021-01-28
US20140213616A1 (en) 2014-07-31
WO2014120808A8 (en) 2015-09-11
CN108164457A (zh) 2018-06-15
US10087143B2 (en) 2018-10-02
US9758483B2 (en) 2017-09-12
PT2953931T (pt) 2017-06-14
SG10201706206PA (en) 2017-08-30
AU2018214105B9 (en) 2020-04-23
GEP20217286B (en) 2021-08-25
KR102295748B1 (ko) 2021-09-01
MX383688B (es) 2025-03-14
HRP20210349T1 (hr) 2021-04-16
GEAP202014909A (en) 2020-07-10
US10738009B2 (en) 2020-08-11
GEAP201414909A (cg-RX-API-DMAC10.html) 2020-07-10
US20210047271A1 (en) 2021-02-18
CA2898866C (en) 2023-03-07
HK1217693A1 (en) 2017-01-20
KR102227592B1 (ko) 2021-03-15
DK2953931T3 (en) 2017-06-06
JP2018104453A (ja) 2018-07-05
HUE033370T2 (en) 2017-11-28
ES2626555T3 (es) 2017-07-25
TW201943701A (zh) 2019-11-16
TW201443019A (zh) 2014-11-16
CN105026373B (zh) 2018-03-30
PH12015501661B1 (en) 2020-10-16
HUE053448T2 (hu) 2021-06-28
UA120589C2 (uk) 2020-01-10
RU2662223C2 (ru) 2018-07-25
US20170037009A1 (en) 2017-02-09
CL2015002147A1 (es) 2016-06-03
LT3239134T (lt) 2021-02-25
US9393235B2 (en) 2016-07-19
PH12015501661A1 (en) 2015-10-19
UY35288A (es) 2014-08-29
IL269964B1 (en) 2025-09-01
AU2020204425A1 (en) 2020-07-23
IL240195B (en) 2019-10-31
GEAP202113922A (en) 2021-02-25
US20190248745A1 (en) 2019-08-15
WO2014120808A9 (en) 2015-05-14
SMT201700256T1 (it) 2017-09-07
KR20150112031A (ko) 2015-10-06
NZ710270A (en) 2020-09-25
CA2898866A1 (en) 2014-08-07
AU2018214105B2 (en) 2020-04-02
ES2857687T3 (es) 2021-09-29
GEP20207177B (en) 2020-11-10
PE20151781A1 (es) 2015-12-02
DK3239134T3 (da) 2021-02-22
WO2014120808A1 (en) 2014-08-07
NZ750187A (en) 2020-09-25
RS61503B1 (sr) 2021-03-31

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