RU2017125963A - Способ повышения устойчивости композиции, содержащей омега-6 полиненасыщенные жирные кислоты - Google Patents
Способ повышения устойчивости композиции, содержащей омега-6 полиненасыщенные жирные кислоты Download PDFInfo
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- RU2017125963A RU2017125963A RU2017125963A RU2017125963A RU2017125963A RU 2017125963 A RU2017125963 A RU 2017125963A RU 2017125963 A RU2017125963 A RU 2017125963A RU 2017125963 A RU2017125963 A RU 2017125963A RU 2017125963 A RU2017125963 A RU 2017125963A
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- composition
- lysine
- polyunsaturated fatty
- fatty acids
- omega
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- 239000000203 mixture Substances 0.000 title claims 19
- 235000020665 omega-6 fatty acid Nutrition 0.000 title claims 8
- 238000000034 method Methods 0.000 title claims 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 10
- 239000004472 Lysine Substances 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 3
- 150000001450 anions Chemical class 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000003839 salts Chemical group 0.000 claims 2
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 1
- -1 fatty acid esters Chemical class 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B5/00—Preserving by using additives, e.g. anti-oxidants
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B5/00—Preserving by using additives, e.g. anti-oxidants
- C11B5/0021—Preserving by using additives, e.g. anti-oxidants containing oxygen
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
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- Proteomics, Peptides & Aminoacids (AREA)
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Claims (11)
1. Способ повышения устойчивости к окислению композиции, содержащей омега-6 полиненасыщенные жирные кислоты, включающий следующие стадии:
(i) обеспечение исходной композиции, содержащей по меньшей мере один компонент, представляющий собой омега-6 полиненасыщенную жирную кислоту;
(ii) обеспечение композиции на основе лизина;
(iii) смешивание водных, водно-спиртовых или спиртовых растворов исходной композиции и композиции на основе лизина и затем подвергание полученной в результате смеси воздействию условий высушивания распылением с образованием, таким образом, композиции в виде твердого продукта, содержащей по меньшей мере одну соль, образованную катионом, полученным из лизина, и анионом, полученным из омега-6 полиненасыщенной жирной кислоты; при этом композиция в виде продукта характеризуется содержанием растворителя SC, выбранным из следующего: SC < 5 вес. %, SC < 3 вес. %, SC < 1 вес. %, SC < 0,5 вес. %.
2. Способ по п. 1, где композицию на основе лизина на стадии (ii) обеспечивают таким образом, что отношение R = n(ca)/n(lys) количества функциональных групп карбоновой кислоты n(ca) в исходной композиции, обеспеченной на стадии (i), к количеству лизина n(lys) в композиции на основе лизина, обеспеченной на стадии (ii), находится в диапазоне, выбранном из 0,9 < R < 1,1, 0,95 < R < 1,05, 0,98 < R < 1,02.
3. Способ по п. 2, где исходная композиция, обеспеченная на стадии (i), содержит не более x(fe) вес. % сложных эфиров жирных кислот, где x(fe) выбран из 5, 3, 2, 1, 0,3, 0.
4. Способ по п. 3, где исходную композицию на стадии (i) и композицию на основе лизина на стадии (ii) обеспечивают таким образом, что по меньшей мере sp вес. % композиции в виде продукта состоит из одной или более солей, образованных катионами, полученными из лизина, и анионами, полученными из одной или более омега-6 полиненасыщенных жирных кислот и других встречающихся в природе жирных кислот, при этом sp выбран из 90, 95, 97, 98, 99, 100.
5. Композиция, получаемая с помощью способа по любому из пп. 1-4.
6. Применение композиции по п. 5 для изготовления пищевых продуктов, содержащих омега-6 полиненасыщенные жирные кислоты.
7. Применение композиции по п. 5 для изготовления питательных продуктов, содержащих омега-6 полиненасыщенные жирные кислоты.
8. Применение композиции по п. 5 для изготовления фармацевтических продуктов, содержащих омега-6 полиненасыщенные жирные кислоты.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14199976 | 2014-12-23 | ||
| EP14199976.3 | 2014-12-23 | ||
| PCT/EP2015/080293 WO2016102316A1 (en) | 2014-12-23 | 2015-12-17 | Process for increasing the stability of a composition comprising polyunsaturated omega-6 fatty acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017125963A true RU2017125963A (ru) | 2019-01-24 |
| RU2017125963A3 RU2017125963A3 (ru) | 2019-06-18 |
| RU2706072C2 RU2706072C2 (ru) | 2019-11-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017125963A RU2706072C2 (ru) | 2014-12-23 | 2015-12-17 | Способ повышения устойчивости композиции, содержащей омега-6 полиненасыщенные жирные кислоты |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20170367394A1 (ru) |
| EP (1) | EP3236783B1 (ru) |
| JP (1) | JP6714000B2 (ru) |
| KR (1) | KR20170094789A (ru) |
| CN (1) | CN107105693B (ru) |
| AU (1) | AU2015371457B2 (ru) |
| BR (1) | BR112017013445B1 (ru) |
| CA (1) | CA2969157C (ru) |
| CL (1) | CL2017001613A1 (ru) |
| CO (1) | CO2017005849A2 (ru) |
| DK (1) | DK3236783T3 (ru) |
| ES (1) | ES2776393T3 (ru) |
| IL (1) | IL252482B (ru) |
| MX (1) | MX2017008274A (ru) |
| MY (1) | MY190506A (ru) |
| NZ (1) | NZ732380A (ru) |
| PE (1) | PE20171082A1 (ru) |
| PH (1) | PH12017501144A1 (ru) |
| PL (1) | PL3236783T3 (ru) |
| RU (1) | RU2706072C2 (ru) |
| SA (1) | SA517381762B1 (ru) |
| SG (1) | SG11201704399RA (ru) |
| TW (1) | TWI693893B (ru) |
| WO (1) | WO2016102316A1 (ru) |
| ZA (1) | ZA201704821B (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2018317802B2 (en) | 2017-08-15 | 2024-04-04 | Evonik Operations Gmbh | Tablets with high active ingredient content of omega-3 fatty acid amino acid salts |
| WO2019093708A1 (ko) * | 2017-11-08 | 2019-05-16 | 김승수 | 악취 억제형 불포화오일 및 아르기닌 함유 조성물의 제조 방법 |
| BR112022002129A2 (pt) * | 2019-08-08 | 2022-04-19 | Evonik Operations Gmbh | Processo a jusante para a produção de sais de ácidos graxos poli-insaturados |
| WO2021023850A1 (en) | 2019-08-08 | 2021-02-11 | Evonik Operations Gmbh | Method of preparing a solid dosage form and a binder |
| EP3804699A1 (en) | 2019-10-10 | 2021-04-14 | Evonik Operations GmbH | Method of preparing a solid dosage form and a binder |
| US20220287979A1 (en) | 2019-08-08 | 2022-09-15 | Evonik Operations Gmbh | Method of preparing a solid dosage form and a lubricant |
| US20220287345A1 (en) | 2019-08-08 | 2022-09-15 | Evonik Operations Gmbh | Solubility enhancement of poorly soluble actives |
| WO2021151199A1 (en) * | 2020-01-30 | 2021-08-05 | Silicycle Inc. | Process for preparing a solid form of basic amino acid salts of polyunsaturated fatty acids |
| US20230037453A1 (en) | 2020-04-01 | 2023-02-09 | Evonik Operations Gmbh | Preparation for use as vasorelaxant |
| EP4125438A1 (en) | 2020-04-01 | 2023-02-08 | Evonik Operations GmbH | Preparation for use as antioxidant |
| CN111635306B (zh) * | 2020-06-12 | 2022-09-27 | 上海海益环保科技有限公司 | 一种芥酸复合稳定剂及制备稳定芥酸的方法 |
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| IT1264987B1 (it) * | 1993-12-14 | 1996-10-17 | Prospa Bv | Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono |
| CN100352889C (zh) * | 2002-11-22 | 2007-12-05 | 日本水产株式会社 | 高氧化稳定性的含有双键有机物的组合物 |
| JP4870430B2 (ja) * | 2003-06-20 | 2012-02-08 | 持田製薬株式会社 | 下肢静脈瘤予防・治療用組成物 |
| ES2337082T3 (es) * | 2005-02-02 | 2010-04-20 | Dsm Ip Assets B.V. | Composiciones en polvo. |
| EP2573188A2 (en) * | 2005-03-02 | 2013-03-27 | Metanomics GmbH | Process for the production of fine chemicals |
| CN107362154B (zh) * | 2006-06-05 | 2020-10-30 | 帝斯曼营养品股份公司 | 具有改进壳层的微胶囊 |
| EP2037746A4 (en) * | 2006-06-29 | 2010-09-22 | Martek Biosciences Corp | GREATEST OIL COMPOSITIONS AND MANUFACTURING METHOD THEREFOR |
| US8975299B2 (en) * | 2007-11-01 | 2015-03-10 | Enzymotec Ltd. | Lipid mixture for infant nutrition |
| CA2803558C (en) * | 2010-06-30 | 2018-05-29 | Mochida Pharmaceutical Co., Ltd. | .omega.3 fatty acid compound preparation |
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