MX2017008274A - Proceso para aumentar la estabilidad de una composicion que comprende acidos grasos omega-6 poliinsaturados. - Google Patents

Proceso para aumentar la estabilidad de una composicion que comprende acidos grasos omega-6 poliinsaturados.

Info

Publication number
MX2017008274A
MX2017008274A MX2017008274A MX2017008274A MX2017008274A MX 2017008274 A MX2017008274 A MX 2017008274A MX 2017008274 A MX2017008274 A MX 2017008274A MX 2017008274 A MX2017008274 A MX 2017008274A MX 2017008274 A MX2017008274 A MX 2017008274A
Authority
MX
Mexico
Prior art keywords
composition
polyunsaturated omega
lysine
compositions
stability
Prior art date
Application number
MX2017008274A
Other languages
English (en)
Inventor
Schwarm Michael
Knaup Günter
Latinovic Milan
Original Assignee
Evonik Degussa Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52344990&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017008274(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evonik Degussa Gmbh filed Critical Evonik Degussa Gmbh
Publication of MX2017008274A publication Critical patent/MX2017008274A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B5/00—Preserving by using additives, e.g. anti-oxidants
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B5/00—Preserving by using additives, e.g. anti-oxidants
    • C11B5/0021—Preserving by using additives, e.g. anti-oxidants containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B5/00—Preserving by using additives, e.g. anti-oxidants
    • C11B5/0085—Substances of natural origin of unknown constitution, f.i. plant extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/18—Lipids
    • A23V2250/186—Fatty acids
    • A23V2250/1882—Polyunsaturated fatty acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Botany (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Proceso para aumentar la estabilidad de una composición que comprende ácidos grasos omega-6 poliinsaturados La presente invención se refiere a procesos para aumentar la estabilidad de composiciones que comprenden ácidos grasos omega-6 poliinsaturados contra la oxidación. Los procesos comprenden las siguientes etapas: (i) proporcionar una composición de partida que comprende al menos un componente ácido graso omega-6 poliinsaturado; (ii) proporcionar una composición de lisina; (iii) mezclar soluciones acuosas, acuoso-alcohólicas o alcohólicas de composición de partida y composición de lisina, y someter posteriormente la mezcla resultante a condiciones de secado por pulverización, formando así una composición de producto sólido que comprende al menos una sal de un catión derivado de lisina con un anión derivado a partir de un ácido graso omega-6 poliinsaturado; la composición del producto que presenta un contenido de disolvente SC seleccionado entre los siguientes: SC <5 % en peso, SC <3 % en peso, SC <1 % en peso, SC <0.5 % en peso. Las composiciones obtenibles mediante tales procesos de secado por pulverización y el uso de tales composiciones para la fabricación de productos alimenticios, nutricionales y farmacéuticos están comprendidos además por la presente invención.
MX2017008274A 2014-12-23 2015-12-17 Proceso para aumentar la estabilidad de una composicion que comprende acidos grasos omega-6 poliinsaturados. MX2017008274A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14199976 2014-12-23
PCT/EP2015/080293 WO2016102316A1 (en) 2014-12-23 2015-12-17 Process for increasing the stability of a composition comprising polyunsaturated omega-6 fatty acids

Publications (1)

Publication Number Publication Date
MX2017008274A true MX2017008274A (es) 2017-10-02

Family

ID=52344990

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017008274A MX2017008274A (es) 2014-12-23 2015-12-17 Proceso para aumentar la estabilidad de una composicion que comprende acidos grasos omega-6 poliinsaturados.

Country Status (25)

Country Link
US (1) US20170367394A1 (es)
EP (1) EP3236783B1 (es)
JP (1) JP6714000B2 (es)
KR (1) KR20170094789A (es)
CN (1) CN107105693B (es)
AU (1) AU2015371457B2 (es)
BR (1) BR112017013445B1 (es)
CA (1) CA2969157C (es)
CL (1) CL2017001613A1 (es)
CO (1) CO2017005849A2 (es)
DK (1) DK3236783T3 (es)
ES (1) ES2776393T3 (es)
IL (1) IL252482B (es)
MX (1) MX2017008274A (es)
MY (1) MY190506A (es)
NZ (1) NZ732380A (es)
PE (1) PE20171082A1 (es)
PH (1) PH12017501144A1 (es)
PL (1) PL3236783T3 (es)
RU (1) RU2706072C2 (es)
SA (1) SA517381762B1 (es)
SG (1) SG11201704399RA (es)
TW (1) TWI693893B (es)
WO (1) WO2016102316A1 (es)
ZA (1) ZA201704821B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3072658C (en) * 2017-08-15 2023-01-24 Evonik Operations Gmbh Tablets with high active ingredient content of omega-3 fatty acid amino acid salts
WO2019093708A1 (ko) * 2017-11-08 2019-05-16 김승수 악취 억제형 불포화오일 및 아르기닌 함유 조성물의 제조 방법
WO2021023848A1 (en) 2019-08-08 2021-02-11 Evonik Operations Gmbh Method of preparing a solid dosage form and a lubricant
EP3804699A1 (en) 2019-10-10 2021-04-14 Evonik Operations GmbH Method of preparing a solid dosage form and a binder
WO2021023857A1 (en) 2019-08-08 2021-02-11 Evonik Operations Gmbh Solubility enhancement of poorly soluble actives
WO2021023850A1 (en) 2019-08-08 2021-02-11 Evonik Operations Gmbh Method of preparing a solid dosage form and a binder
JP2022543283A (ja) 2019-08-08 2022-10-11 エボニック オペレーションズ ゲーエムベーハー 多価不飽和脂肪酸塩を製造するための下流処理
CA3168635A1 (en) * 2020-01-30 2021-08-05 Silicycle Inc. Process for preparing a solid form of basic amino acid salts of polyunsaturated fatty acids
WO2021197969A1 (en) 2020-04-01 2021-10-07 Evonik Operations Gmbh Preparation for use as vasorelaxant
US20230149336A1 (en) 2020-04-01 2023-05-18 Evonik Operations Gmbh Preparation for use as antioxidant
CN111635306B (zh) * 2020-06-12 2022-09-27 上海海益环保科技有限公司 一种芥酸复合稳定剂及制备稳定芥酸的方法

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Publication number Priority date Publication date Assignee Title
IT1264987B1 (it) * 1993-12-14 1996-10-17 Prospa Bv Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono
AU2003284617A1 (en) * 2002-11-22 2004-06-18 Nippon Suisan Kaisha, Ltd. Composition containing organic substance having double bond with improved oxidation stability
WO2004112777A1 (ja) * 2003-06-20 2004-12-29 Mochida Pharmaceutical Co., Ltd. 下肢静脈瘤予防・治療用組成物
JP2008528774A (ja) * 2005-02-02 2008-07-31 ディーエスエム アイピー アセッツ ビー．ブイ． 粉末組成物
US20140199313A1 (en) * 2005-03-02 2014-07-17 Metanomics Gmbh Process for the Production of Fine Chemicals
WO2008017962A2 (en) * 2006-06-05 2008-02-14 Ocean Nutrition Canada Ltd. Microcapsules with improved shells
US20080026109A1 (en) * 2006-06-29 2008-01-31 Martek Biosciences Corporation Sweetened Oil Compositions and Methods of Making
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JP5829607B2 (ja) * 2010-06-30 2015-12-09 持田製薬株式会社 ω３脂肪酸の配合製剤

Also Published As

Publication number Publication date
WO2016102316A1 (en) 2016-06-30
MY190506A (en) 2022-04-26
PE20171082A1 (es) 2017-08-03
CA2969157C (en) 2024-05-28
SA517381762B1 (ar) 2020-10-27
JP6714000B2 (ja) 2020-06-24
PL3236783T3 (pl) 2020-06-15
RU2017125963A3 (es) 2019-06-18
EP3236783A1 (en) 2017-11-01
DK3236783T3 (da) 2020-04-27
SG11201704399RA (en) 2017-07-28
JP2018501790A (ja) 2018-01-25
CO2017005849A2 (es) 2017-09-20
RU2017125963A (ru) 2019-01-24
AU2015371457A1 (en) 2017-06-22
BR112017013445B1 (pt) 2021-11-23
NZ732380A (en) 2024-03-22
ZA201704821B (en) 2019-06-26
TWI693893B (zh) 2020-05-21
CN107105693B (zh) 2021-04-02
US20170367394A1 (en) 2017-12-28
KR20170094789A (ko) 2017-08-21
RU2706072C2 (ru) 2019-11-13
BR112017013445A2 (pt) 2018-06-26
CA2969157A1 (en) 2016-06-30
CL2017001613A1 (es) 2018-01-12
CN107105693A (zh) 2017-08-29
AU2015371457B2 (en) 2020-04-23
TW201639463A (zh) 2016-11-16
IL252482B (en) 2021-08-31
IL252482A0 (en) 2017-07-31
PH12017501144A1 (en) 2018-03-05
ES2776393T3 (es) 2020-07-30
EP3236783B1 (en) 2020-02-05

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