RU2017108203A - Слитые белки sirp-альфа с иммуноглобулином - Google Patents
Слитые белки sirp-альфа с иммуноглобулином Download PDFInfo
- Publication number
- RU2017108203A RU2017108203A RU2017108203A RU2017108203A RU2017108203A RU 2017108203 A RU2017108203 A RU 2017108203A RU 2017108203 A RU2017108203 A RU 2017108203A RU 2017108203 A RU2017108203 A RU 2017108203A RU 2017108203 A RU2017108203 A RU 2017108203A
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- Prior art keywords
- immunoglobulin
- fusion protein
- seq
- sirpα
- residues
- Prior art date
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- 108060003951 Immunoglobulin Proteins 0.000 title claims 73
- 102000018358 immunoglobulin Human genes 0.000 title claims 73
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 claims 71
- 102000037865 fusion proteins Human genes 0.000 claims 71
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 34
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 34
- 238000012986 modification Methods 0.000 claims 20
- 230000004048 modification Effects 0.000 claims 20
- 239000000427 antigen Substances 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 8
- 229960005395 cetuximab Drugs 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 102220638759 Phosphomannomutase 2_Q37H_mutation Human genes 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 102220266399 rs1555186817 Human genes 0.000 claims 5
- 102220024927 rs199472833 Human genes 0.000 claims 5
- 102200145334 rs2274084 Human genes 0.000 claims 5
- 210000004881 tumor cell Anatomy 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 210000003743 erythrocyte Anatomy 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
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- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
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- 229950002140 futuximab Drugs 0.000 claims 2
- 229950005646 imgatuzumab Drugs 0.000 claims 2
- 229950008001 matuzumab Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 229960000513 necitumumab Drugs 0.000 claims 2
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- 229960001972 panitumumab Drugs 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
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- 102220486151 Alpha-galactosidase A_M72V_mutation Human genes 0.000 claims 1
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- 102220574677 Lysosomal alpha-mannosidase_V27A_mutation Human genes 0.000 claims 1
- 102220574678 Lysosomal alpha-mannosidase_V27S_mutation Human genes 0.000 claims 1
- 102220574679 Lysosomal alpha-mannosidase_V27T_mutation Human genes 0.000 claims 1
- 102220555086 MORC family CW-type zinc finger protein 1_P35Q_mutation Human genes 0.000 claims 1
- 102220567664 Matrilysin_V92D_mutation Human genes 0.000 claims 1
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Classifications
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462038196P | 2014-08-15 | 2014-08-15 | |
| US62/038,196 | 2014-08-15 | ||
| PCT/EP2015/068798 WO2016024021A1 (en) | 2014-08-15 | 2015-08-14 | Sirp-alpha immunoglobulin fusion proteins |
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| US20250154172A1 (en) | 2023-11-03 | 2025-05-15 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
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| GB9930706D0 (en) | 1999-12-24 | 2000-02-16 | Medical Res Council | Composition for inhibiting macrophage activity |
| US20090191202A1 (en) * | 2005-09-29 | 2009-07-30 | Jamieson Catriona Helen M | Methods for manipulating phagocytosis mediated by CD47 |
| JP2009516513A (ja) | 2005-11-21 | 2009-04-23 | ラボラトワール セローノ ソシエテ アノニム | ハイブリッド抗原結合分子の組成物及び製造方法並びにその使用 |
| AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| US20100239578A1 (en) | 2007-10-11 | 2010-09-23 | University Health Network | Modulation of sirp-alpha - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor |
| EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
| CN102257001A (zh) | 2008-12-19 | 2011-11-23 | 诺瓦提斯公司 | 治疗自体免疫和炎性病症的可溶性多肽 |
| CN102596233A (zh) | 2009-05-15 | 2012-07-18 | 大学健康网络 | 用于以SIRPα-CD47的相互作用为靶标治疗血液癌症的组合物和方法 |
| PT2477648T (pt) | 2009-09-15 | 2022-10-27 | The Board Of Trustees Of The Univ Of The Leland Stanford Junior Univ | Terapia sinérgica anti-cd47 para cancros hematológicos |
| EP3181149A1 (en) | 2010-05-14 | 2017-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Humanized and chimeric monoclonal antibodies to cd47 |
| EP2407487A1 (en) | 2010-07-14 | 2012-01-18 | F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. | Multispecific modular antibody |
| KR101764096B1 (ko) | 2011-11-28 | 2017-08-02 | 메르크 파텐트 게엠베하 | 항-ｐｄ-ｌ1 항체 및 그의 용도 |
| EP3766511A1 (en) | 2012-01-17 | 2021-01-20 | The Board of Trustees of the Leland Stanford Junior University | High affinity sirp-alpha reagents |
| LT2931752T (lt) | 2012-12-17 | 2019-12-10 | Trillium Therapeutics Inc | Ligos cd47+ ląstelių gydymas su sirp alfa-fc junginiais |
| WO2014121093A1 (en) * | 2013-01-31 | 2014-08-07 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
| KR20150130349A (ko) | 2013-03-15 | 2015-11-23 | 메르크 파텐트 게엠베하 | 4가 이중특이적 항체 |
| JP6355032B2 (ja) * | 2014-03-24 | 2018-07-11 | イミューンオンコ バイオファーマシューティカルズ （シャンハイ） カンパニー リミテッド | 新規組換え二機能性融合タンパク質、それらの調製および使用 |
| WO2016022971A1 (en) | 2014-08-08 | 2016-02-11 | The Board Of Trustees Of The Leland Stanford Junior University | Sirp alpha-antibody fusion proteins |
| PT3180363T (pt) | 2014-08-15 | 2019-11-05 | Merck Patent Gmbh | Proteínas de fusão de sirp-alfa e imunoglobulina |
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| JP6764858B2 (ja) | 2020-10-07 |
| PL3180363T3 (pl) | 2020-02-28 |
| CA2956126A1 (en) | 2016-02-18 |
| IL250622B (en) | 2022-12-01 |
| WO2016024021A1 (en) | 2016-02-18 |
| EP3180363B1 (en) | 2019-09-25 |
| IL250622A0 (en) | 2017-04-30 |
| ZA201701810B (en) | 2020-10-28 |
| EP3643727A1 (en) | 2020-04-29 |
| KR20170036796A (ko) | 2017-04-03 |
| US20160177276A1 (en) | 2016-06-23 |
| AU2015303135A1 (en) | 2017-02-23 |
| HUE046661T2 (hu) | 2020-03-30 |
| ES2751915T3 (es) | 2020-04-02 |
| EP3180363B2 (en) | 2022-09-14 |
| CN107108748A (zh) | 2017-08-29 |
| US11021694B2 (en) | 2021-06-01 |
| MX2017001712A (es) | 2017-04-27 |
| HRP20191872T1 (hr) | 2020-02-07 |
| AU2015303135B2 (en) | 2021-05-20 |
| PT3180363T (pt) | 2019-11-05 |
| EP3180363A1 (en) | 2017-06-21 |
| MX377196B (es) | 2025-03-07 |
| RU2017108203A3 (cg-RX-API-DMAC7.html) | 2019-03-13 |
| SI3180363T1 (sl) | 2020-05-29 |
| LT3180363T (lt) | 2019-11-25 |
| BR112017002646A2 (pt) | 2018-02-27 |
| SG11201701189TA (en) | 2017-03-30 |
| ES2751915T5 (es) | 2022-12-23 |
| JP2017525698A (ja) | 2017-09-07 |
| IL250622B2 (en) | 2023-04-01 |
| DK3180363T3 (da) | 2019-11-04 |
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