RU2016148887A3 - - Google Patents
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- Publication number
- RU2016148887A3 RU2016148887A3 RU2016148887A RU2016148887A RU2016148887A3 RU 2016148887 A3 RU2016148887 A3 RU 2016148887A3 RU 2016148887 A RU2016148887 A RU 2016148887A RU 2016148887 A RU2016148887 A RU 2016148887A RU 2016148887 A3 RU2016148887 A3 RU 2016148887A3
- Authority
- RU
- Russia
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993423P | 2014-05-15 | 2014-05-15 | |
| US61/993,423 | 2014-05-15 | ||
| PCT/US2015/030464 WO2015175594A1 (en) | 2014-05-15 | 2015-05-13 | Pladienolide pyridine compounds and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019124012A Division RU2807278C2 (ru) | 2014-05-15 | 2015-05-13 | Пиридиновые соединения пладиенолида и способы применения |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016148887A RU2016148887A (ru) | 2018-06-18 |
| RU2016148887A3 true RU2016148887A3 (ru) | 2018-12-11 |
| RU2707730C2 RU2707730C2 (ru) | 2019-11-29 |
Family
ID=53284528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016148887A RU2707730C2 (ru) | 2014-05-15 | 2015-05-13 | Пиридиновые соединения пладиенолида и способы применения |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US9481669B2 (ru) |
| EP (2) | EP3143016B1 (ru) |
| JP (1) | JP6067943B1 (ru) |
| KR (2) | KR102146726B1 (ru) |
| CN (1) | CN107074827B (ru) |
| AR (1) | AR100431A1 (ru) |
| AU (1) | AU2015259237B2 (ru) |
| BR (1) | BR112016026638B1 (ru) |
| CA (1) | CA2947754C (ru) |
| CL (1) | CL2016002835A1 (ru) |
| CY (1) | CY1121550T1 (ru) |
| DK (1) | DK3143016T3 (ru) |
| ES (1) | ES2712401T3 (ru) |
| HR (1) | HRP20190432T1 (ru) |
| HU (1) | HUE041838T2 (ru) |
| IL (1) | IL248529B (ru) |
| JO (1) | JO3668B1 (ru) |
| LT (1) | LT3143016T (ru) |
| MA (1) | MA39915B1 (ru) |
| ME (1) | ME03417B (ru) |
| MX (2) | MX2016014997A (ru) |
| MY (1) | MY195081A (ru) |
| PE (1) | PE20170384A1 (ru) |
| PH (1) | PH12016502249A1 (ru) |
| PL (1) | PL3143016T3 (ru) |
| PT (1) | PT3143016T (ru) |
| RS (1) | RS58400B1 (ru) |
| RU (1) | RU2707730C2 (ru) |
| SG (1) | SG11201609693XA (ru) |
| SI (1) | SI3143016T1 (ru) |
| TR (1) | TR201902328T4 (ru) |
| TW (1) | TWI634115B (ru) |
| UA (1) | UA119458C2 (ru) |
| WO (1) | WO2015175594A1 (ru) |
| ZA (1) | ZA201607354B (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10889866B2 (en) | 2015-09-01 | 2021-01-12 | Eisai R&D Management Co., Ltd. | Splice variants associated with neomorphic SF3B1 mutants |
| CN108473479B (zh) * | 2015-11-18 | 2024-05-07 | 卫材研究发展管理有限公司 | 普拉二烯内酯吡啶化合物的固态形式和使用方法 |
| CA3056389A1 (en) | 2017-03-15 | 2018-09-20 | Eisai R&D Management Co., Ltd. | Spliceosome mutations and uses thereof |
| CN111727059A (zh) | 2017-10-31 | 2020-09-29 | 卫材研究发展管理有限公司 | 包含至少一种剪接体调控剂和至少一种选自BCL2抑制剂、BCL2/BCLxL抑制剂和BCLxL抑制剂的抑制剂的组合及其使用方法 |
| WO2019199667A2 (en) * | 2018-04-09 | 2019-10-17 | Keaney Gregg F | Certain pladienolide compounds and methods of use |
| EP3774760A1 (en) * | 2018-04-12 | 2021-02-17 | Eisai R&D Management Co., Ltd. | Pladienolide derivatives as spliceosome targeting agents for treating cancer |
| EP3801523A2 (en) * | 2018-06-01 | 2021-04-14 | Eisai R&D Management Co., Ltd. | Methods of using splicing modulators |
| IL262658A (en) * | 2018-10-28 | 2020-04-30 | Memorial Sloan Kettering Cancer Center | Prevention of age related clonal hematopoiesis and diseases associated therewith |
| EP4240360A1 (en) | 2020-11-04 | 2023-09-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
| EP4361136A1 (en) * | 2021-06-18 | 2024-05-01 | Universidad De Córdoba | Compound for the treatment of glioblastoma |
| CN113876771B (zh) * | 2021-11-12 | 2022-09-23 | 中国医学科学院基础医学研究所 | 一种靶向pabpc1的小分子药物及其在慢性髓系白血病中的应用 |
| WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI312681B (en) * | 2001-02-01 | 2009-08-01 | Novel physiologically active substance | |
| TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| US7576204B2 (en) | 2002-07-31 | 2009-08-18 | Mercian Corporation | Heterocyclic macrolide pharmaceutical agent, a method of producing the same and use of the same |
| MXPA05001104A (es) | 2002-07-31 | 2005-09-08 | Eisai Co Ltd | Nuevas sustancias fisiologicamente activas. |
| WO2004037212A2 (en) | 2002-10-24 | 2004-05-06 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
| AU2003284469B2 (en) | 2002-11-29 | 2008-02-21 | Eisai R&D Management Co., Ltd. | Process for producing macrolide compound |
| JP4441489B2 (ja) | 2003-11-27 | 2010-03-31 | メルシャン株式会社 | マクロライド系化合物の水酸化に関与するｄｎａ |
| ES2345493T3 (es) | 2003-11-28 | 2010-09-24 | Kanagawa Academy Of Science And Technology | Metodo de deteccion de cancer de higado, diagnostico de cancer de higado y remedio para el cancer. |
| US20070199741A1 (en) | 2004-07-02 | 2007-08-30 | Kenji Noumi | Combined Weighing Apparatus |
| ATE538203T1 (de) | 2004-07-20 | 2012-01-15 | Eisai R&D Man Co Ltd | Für an der biosynthese von pladienolid beteiligtes polypeptid codierende dna |
| TW200716744A (en) * | 2005-05-26 | 2007-05-01 | Eisai R&D Man Co Ltd | Genetically modified microorganism and process for production of macrolide compound using the microorganism |
| EP1935893A4 (en) | 2005-10-13 | 2009-07-22 | Eisai R&D Man Co Ltd | TOTAL SYNTHESIS OF PLADIENOLIDE B AND PLADIENOLIDE D |
| JPWO2008111464A1 (ja) * | 2007-03-05 | 2010-06-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スプライシング異常を指標とする抗ガン剤の作用検定方法 |
| US20080312317A1 (en) | 2007-04-12 | 2008-12-18 | Eisai R&D Management Co., Ltd. | 12 membered-ring macrolactam derivatives |
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2015
- 2015-05-13 CN CN201580025344.0A patent/CN107074827B/zh active Active
- 2015-05-13 RS RS20190233A patent/RS58400B1/sr unknown
- 2015-05-13 EP EP15727125.5A patent/EP3143016B1/en active Active
- 2015-05-13 KR KR1020177004442A patent/KR102146726B1/ko active IP Right Grant
- 2015-05-13 ES ES15727125T patent/ES2712401T3/es active Active
- 2015-05-13 EP EP18210019.8A patent/EP3514154B1/en active Active
- 2015-05-13 BR BR112016026638-2A patent/BR112016026638B1/pt active IP Right Grant
- 2015-05-13 LT LTEP15727125.5T patent/LT3143016T/lt unknown
- 2015-05-13 MX MX2016014997A patent/MX2016014997A/es active IP Right Grant
- 2015-05-13 HU HUE15727125A patent/HUE041838T2/hu unknown
- 2015-05-13 SI SI201530641T patent/SI3143016T1/sl unknown
- 2015-05-13 SG SG11201609693XA patent/SG11201609693XA/en unknown
- 2015-05-13 JP JP2016526218A patent/JP6067943B1/ja active Active
- 2015-05-13 KR KR1020167016648A patent/KR101710318B1/ko active IP Right Grant
- 2015-05-13 WO PCT/US2015/030464 patent/WO2015175594A1/en active Application Filing
- 2015-05-13 MX MX2020004476A patent/MX2020004476A/es unknown
- 2015-05-13 TW TW104115293A patent/TWI634115B/zh active
- 2015-05-13 PT PT15727125T patent/PT3143016T/pt unknown
- 2015-05-13 AU AU2015259237A patent/AU2015259237B2/en active Active
- 2015-05-13 TR TR2019/02328T patent/TR201902328T4/tr unknown
- 2015-05-13 AR ARP150101485A patent/AR100431A1/es unknown
- 2015-05-13 DK DK15727125.5T patent/DK3143016T3/en active
- 2015-05-13 MY MYPI2016001944A patent/MY195081A/en unknown
- 2015-05-13 UA UAA201612731A patent/UA119458C2/uk unknown
- 2015-05-13 PL PL15727125T patent/PL3143016T3/pl unknown
- 2015-05-13 JO JOP/2015/0113A patent/JO3668B1/ar active
- 2015-05-13 MA MA39915A patent/MA39915B1/fr unknown
- 2015-05-13 RU RU2016148887A patent/RU2707730C2/ru active
- 2015-05-13 CA CA2947754A patent/CA2947754C/en active Active
- 2015-05-13 ME MEP-2019-81A patent/ME03417B/me unknown
- 2015-05-13 PE PE2016002233A patent/PE20170384A1/es unknown
- 2015-05-13 US US14/710,687 patent/US9481669B2/en active Active
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2016
- 2016-10-25 ZA ZA2016/07354A patent/ZA201607354B/en unknown
- 2016-10-26 IL IL24852916A patent/IL248529B/en active IP Right Grant
- 2016-11-08 CL CL2016002835A patent/CL2016002835A1/es unknown
- 2016-11-11 PH PH12016502249A patent/PH12016502249A1/en unknown
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2019
- 2019-02-22 CY CY20191100228T patent/CY1121550T1/el unknown
- 2019-03-04 HR HRP20190432TT patent/HRP20190432T1/hr unknown