ATE538203T1 - Für an der biosynthese von pladienolid beteiligtes polypeptid codierende dna - Google Patents
Für an der biosynthese von pladienolid beteiligtes polypeptid codierende dnaInfo
- Publication number
- ATE538203T1 ATE538203T1 AT05766205T AT05766205T ATE538203T1 AT E538203 T1 ATE538203 T1 AT E538203T1 AT 05766205 T AT05766205 T AT 05766205T AT 05766205 T AT05766205 T AT 05766205T AT E538203 T1 ATE538203 T1 AT E538203T1
- Authority
- AT
- Austria
- Prior art keywords
- pladienolide
- dna
- biosynthesis
- dna coding
- polypeptide involved
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 2
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004211279 | 2004-07-20 | ||
| PCT/JP2005/013541 WO2006009276A1 (ja) | 2004-07-20 | 2005-07-19 | プラジエノライドの生合成に関与するポリペプチドをコードするｄｎａ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538203T1 true ATE538203T1 (de) | 2012-01-15 |
Family
ID=35785378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05766205T ATE538203T1 (de) | 2004-07-20 | 2005-07-19 | Für an der biosynthese von pladienolid beteiligtes polypeptid codierende dna |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8008049B2 (de) |
| EP (1) | EP1770165B1 (de) |
| JP (1) | JP4599357B2 (de) |
| KR (1) | KR100834488B1 (de) |
| CN (1) | CN1977046A (de) |
| AT (1) | ATE538203T1 (de) |
| AU (1) | AU2005265443B2 (de) |
| CA (1) | CA2574092C (de) |
| IL (1) | IL180167A0 (de) |
| WO (1) | WO2006009276A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2546614A1 (en) * | 2003-11-27 | 2005-06-09 | Mercian Corporation | Dna participating in hydroxylation of macrolide compound |
| US8008049B2 (en) | 2004-07-20 | 2011-08-30 | Eisai R&D Management Co., Ltd. | DNA coding for polypeptide participating in biosynthesis of pladienolide |
| TW200716744A (en) * | 2005-05-26 | 2007-05-01 | Eisai R&D Man Co Ltd | Genetically modified microorganism and process for production of macrolide compound using the microorganism |
| CN102010403A (zh) | 2005-10-13 | 2011-04-13 | 卫材R&D管理有限公司 | 普拉二烯内酯b和普拉二烯内酯d的全合成 |
| WO2009147984A1 (ja) | 2008-06-04 | 2009-12-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハーボキシジエンの生合成に関与するポリペプチドをコードするｄｎａ |
| US8865761B1 (en) | 2012-08-07 | 2014-10-21 | The University Of Notre Dame Du Lac | Regulation of cholesterol homeostasis |
| PH12016502249B1 (en) | 2014-05-15 | 2023-12-13 | Eisai R&D Man Co Ltd | Pladienolide pyridine compounds and methods of use |
| WO2017040526A2 (en) | 2015-09-01 | 2017-03-09 | Eisai R&D Management Co., Ltd. | Splice variants associated with neomorphic sf3b1 mutants |
| BR112018009995B1 (pt) | 2015-11-18 | 2024-04-30 | Eisai R&D Management Co., Ltd | Forma cristalina, composição farmacêutica, e, uso da forma cristalina |
| US20200190593A1 (en) | 2017-03-15 | 2020-06-18 | Eisai R&D Management Co., Ltd. | Spliceosome mutations and uses thereof |
| MX2020004179A (es) | 2017-10-31 | 2020-08-03 | Eisai R&D Man Co Ltd | Combinacion que comprende al menos un modulador de espliceosomas y al menos un inhibidor elegido de inhibidores de bcl2, bcl2/bclxl y bclxl, y metodos de uso. |
| TWI863903B (zh) | 2018-04-09 | 2024-12-01 | 日商衛材R&D企管股份有限公司 | 特定普拉二烯內酯化合物及其使用方法 |
| IL304988B2 (en) | 2018-04-12 | 2025-02-01 | Eisai R&D Man Co Ltd | History of Palladianolide as spliceosome-targeting agents for cancer therapy |
| JP7346466B2 (ja) | 2018-06-01 | 2023-09-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スプライシング調節薬の使用方法 |
| KR20230104204A (ko) | 2020-11-04 | 2023-07-07 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 골수이형성 증후군(mds)에 대한 바이오마커 및 이를 사용하는 방법 |
| WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
| WO2025054465A1 (en) * | 2023-09-08 | 2025-03-13 | California Institute Of Technology | Compositions for transport of therapeutic cargos using miniprotein binders targeting ca-iv |
| CN121652228A (zh) * | 2024-12-24 | 2026-03-13 | 昆明理工大学 | 榆黄菇肽及其制备和应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824513A (en) * | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
| WO1993013663A1 (en) * | 1992-01-17 | 1993-07-22 | Abbott Laboratories | Method of directing biosynthesis of specific polyketides |
| JPH07502650A (ja) | 1991-12-16 | 1995-03-23 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | ストレプトミセスにおけるＰ４５０ｓｏｙおよびフェレドキシン−ｓｏｙの構成性発現、および組み換え体生物による化学物質の生物変換 |
| US6503737B1 (en) * | 1998-10-02 | 2003-01-07 | Kosan Biosciences, Inc. | Isolated nucleic acids relating to the fkbA gene within the FK-520 polyketide synthase gene cluster |
| TWI312681B (en) | 2001-02-01 | 2009-08-01 | Novel physiologically active substance | |
| US20030068788A1 (en) | 2001-05-16 | 2003-04-10 | Buckel Thomas Gunther | Methods and compositions for making emamectin |
| ITMI20010402U1 (it) | 2001-07-18 | 2003-01-18 | Valerio Leccacorvi | Rivestimento per le superfici di una piscina |
| RU2532104C2 (ru) * | 2001-10-19 | 2014-10-27 | Сумитомо Кемикал Компани, Лимитед | Метаболизирующий гербицид белок, его ген и их применение |
| US6884608B2 (en) | 2001-12-26 | 2005-04-26 | Bristol-Myers Squibb Company | Compositions and methods for hydroxylating epothilones |
| ATE426671T1 (de) | 2002-04-12 | 2009-04-15 | Mercian Corp | Expressionssystem des aus actinomyceten stammenden cytochrom p-450 in escherichia coli |
| TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| CA2494536C (en) * | 2002-07-31 | 2011-10-04 | Mercian Corporation | A 12-membered ring macrolide active substance |
| JP4459051B2 (ja) * | 2002-07-31 | 2010-04-28 | メルシャン株式会社 | 新規生理活性物質 |
| KR20050086873A (ko) | 2002-11-29 | 2005-08-30 | 메루샹가부시키가이샤 | 매크로라이드계 화합물의 제조 방법 |
| US7416868B2 (en) * | 2003-01-21 | 2008-08-26 | Thallion Pharmaceuticals, Inc. | Polyene polyketides, processes for their production and their use as a pharmaceutical |
| EP1567484A1 (de) * | 2003-05-13 | 2005-08-31 | Ecopia Biosciences Inc. | Polyen-polyketide, deren herstellung und pharmazeutische verwendung |
| CA2546614A1 (en) * | 2003-11-27 | 2005-06-09 | Mercian Corporation | Dna participating in hydroxylation of macrolide compound |
| US8008049B2 (en) | 2004-07-20 | 2011-08-30 | Eisai R&D Management Co., Ltd. | DNA coding for polypeptide participating in biosynthesis of pladienolide |
| TW200716744A (en) * | 2005-05-26 | 2007-05-01 | Eisai R&D Man Co Ltd | Genetically modified microorganism and process for production of macrolide compound using the microorganism |
-
2005
- 2005-07-19 US US11/630,689 patent/US8008049B2/en not_active Expired - Fee Related
- 2005-07-19 CA CA2574092A patent/CA2574092C/en not_active Expired - Fee Related
- 2005-07-19 EP EP05766205A patent/EP1770165B1/de not_active Expired - Lifetime
- 2005-07-19 CN CNA2005800220462A patent/CN1977046A/zh active Pending
- 2005-07-19 WO PCT/JP2005/013541 patent/WO2006009276A1/ja not_active Ceased
- 2005-07-19 KR KR1020067024772A patent/KR100834488B1/ko not_active Expired - Fee Related
- 2005-07-19 AT AT05766205T patent/ATE538203T1/de active
- 2005-07-19 AU AU2005265443A patent/AU2005265443B2/en not_active Ceased
- 2005-07-19 JP JP2006529309A patent/JP4599357B2/ja not_active Expired - Lifetime
-
2006
- 2006-12-19 IL IL180167A patent/IL180167A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL180167A0 (en) | 2007-06-03 |
| CA2574092C (en) | 2011-08-23 |
| JPWO2006009276A1 (ja) | 2008-05-01 |
| KR100834488B1 (ko) | 2008-06-09 |
| EP1770165A1 (de) | 2007-04-04 |
| CN1977046A (zh) | 2007-06-06 |
| JP4599357B2 (ja) | 2010-12-15 |
| EP1770165B1 (de) | 2011-12-21 |
| WO2006009276A1 (ja) | 2006-01-26 |
| EP1770165A4 (de) | 2008-11-12 |
| US20090269820A1 (en) | 2009-10-29 |
| AU2005265443B2 (en) | 2008-09-04 |
| AU2005265443A1 (en) | 2006-01-26 |
| KR20070033979A (ko) | 2007-03-27 |
| CA2574092A1 (en) | 2006-01-26 |
| US8008049B2 (en) | 2011-08-30 |
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