RU2016121929A - Способы и композиции для устойчивой иммунотерапии - Google Patents
Способы и композиции для устойчивой иммунотерапии Download PDFInfo
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- RU2016121929A RU2016121929A RU2016121929A RU2016121929A RU2016121929A RU 2016121929 A RU2016121929 A RU 2016121929A RU 2016121929 A RU2016121929 A RU 2016121929A RU 2016121929 A RU2016121929 A RU 2016121929A RU 2016121929 A RU2016121929 A RU 2016121929A
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- Prior art keywords
- disease
- nanoparticle
- antigen
- mhcii
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- 238000000034 method Methods 0.000 title claims 11
- 238000009169 immunotherapy Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000002105 nanoparticle Substances 0.000 claims 22
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 239000011248 coating agent Substances 0.000 claims 6
- 238000000576 coating method Methods 0.000 claims 6
- 201000006417 multiple sclerosis Diseases 0.000 claims 6
- 201000004384 Alopecia Diseases 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 4
- 208000026872 Addison Disease Diseases 0.000 claims 3
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 3
- 208000003807 Graves Disease Diseases 0.000 claims 3
- 208000015023 Graves' disease Diseases 0.000 claims 3
- 208000000038 Hypoparathyroidism Diseases 0.000 claims 3
- 206010021067 Hypopituitarism Diseases 0.000 claims 3
- 208000009525 Myocarditis Diseases 0.000 claims 3
- 241000721454 Pemphigus Species 0.000 claims 3
- 208000001280 Prediabetic State Diseases 0.000 claims 3
- 206010039710 Scleroderma Diseases 0.000 claims 3
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 3
- 206010046851 Uveitis Diseases 0.000 claims 3
- 206010047642 Vitiligo Diseases 0.000 claims 3
- 231100000360 alopecia Toxicity 0.000 claims 3
- 208000037896 autoimmune cutaneous disease Diseases 0.000 claims 3
- 230000008033 biological extinction Effects 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 3
- 206010009887 colitis Diseases 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 208000003532 hypothyroidism Diseases 0.000 claims 3
- 230000002989 hypothyroidism Effects 0.000 claims 3
- 206010025135 lupus erythematosus Diseases 0.000 claims 3
- 230000002611 ovarian Effects 0.000 claims 3
- 208000005987 polymyositis Diseases 0.000 claims 3
- 201000009104 prediabetes syndrome Diseases 0.000 claims 3
- 230000002028 premature Effects 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 238000002054 transplantation Methods 0.000 claims 3
- 208000031845 Pernicious anaemia Diseases 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
- 230000003676 hair loss Effects 0.000 claims 2
- 238000007885 magnetic separation Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 210000002707 regulatory b cell Anatomy 0.000 claims 2
- 238000005979 thermal decomposition reaction Methods 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- MHDVGSVTJDSBDK-UHFFFAOYSA-N dibenzyl ether Chemical compound C=1C=CC=CC=1COCC1=CC=CC=C1 MHDVGSVTJDSBDK-UHFFFAOYSA-N 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910001922 gold oxide Inorganic materials 0.000 claims 1
- LZKLAOYSENRNKR-LNTINUHCSA-N iron;(z)-4-oxoniumylidenepent-2-en-2-olate Chemical group [Fe].C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O LZKLAOYSENRNKR-LNTINUHCSA-N 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 229940031182 nanoparticles iron oxide Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
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Claims (21)
1. Применение комплекса, включающего ядро наночастицы и комплексы причастного к заболеванию антигена с MHCII, функционально связанные с ядром наночастицы через линкерное покрытие, при экспансии и/или созревании популяций регуляторных В-клеток у субъекта, причем покрытая наночастица имеет плотность антиген-MHCII от около 0,05 рМНС/100 нм2 площади поверхности покрытой наночастицы до около 25 рМНС/100 нм2 площади поверхности покрытой наночастицы.
2. Применение комплекса, включающего ядро наночастицы и комплексы причастного к заболеванию антигена с MHCII, функционально связанные с ядром наночастицы через линкерное покрытие, при превращении когнатных В-клеток в регуляторные В-клетки у субъекта, причем покрытая наночастица имеет плотность антиген-MHCII от около 0,05 рМНС/100 нм2 площади поверхности покрытой наночастицы до около 25 рМНС/100 нм2 площади поверхности покрытой наночастицы.
3. Применение комплекса, включающего ядро наночастицы и комплексы причастного к заболеванию антигена с MHCII, функционально связанные с ядром наночастицы через линкерное покрытие, в лечении или профилактики аутоимунного растройства у субъекта, нуждающегося в этом, причем покрытая наночастица имеет плотность антиген-MHCII от около 0,05 рМНС/100 нм2 площади поверхности покрытой наночастицы до около 25 рМНС/100 нм2 площади поверхности покрытой наночастицы.
4. Применение по п. 3, где аутоиммунное расстройство выбрано из группы, включающей сахарный диабет, преддиабет, отторжение при трансплантации, рассеянный склероз, родственные рассеянному склерозу заболевания, преждевременное угасание функции яичников, склеродерма, болезнь Шегрена, волчанка, витилиго, алопеция (облысение), полигландулярная недостаточность, болезнь Грейвса, гипотиреоз, полимиозит, пузырчатка, болезнь Крона, колит, аутоиммунный гепатит, гипопитуитаризм, миокардит, болезнь Аддисона, аутоиммунные заболевания кожи, увеит, пернициозная анемия, гипопаратиреоз и/или ревматоидный артрит.
5. Применение по п. 1, при этом причастный к заболеванию антиген из комплекса антигена - MHCII происходит из аутоантигена, участвующего в аутоиммунной реакции или является его имитатором, причем необязательно аутоантиген вовлечен в аутоимунное расстройство, выбранное из сахарного диабета, преддиабета, отторжения при трансплантации, рассеянного склероза, родственного рассеянному склерозу заболевания, преждевременного угасания функции яичников, склеродермы, болезни Шегрена, волчанки, витилиго, алопеции (облысения), полигландулярной недостаточности, болезни Грейвса, гипотиреоза, полимиозита, пузырчатки, болезни Крона, колита, аутоиммунного гепатита, гипопитуитаризма, миокардита, болезни Аддисона, аутоиммунного заболевания кожи, увеита, пернициозной анемии, гипопаратиреоза и/или ревматоидного артрита.
6. Применение по п. 2, при этом причастный к заболеванию антиген из комплекса антигена - MHCII происходит из аутоантигена, участвующего в аутоиммунной реакции или является его имитатором, причем необязательно аутоантиген вовлечен в аутоимунное расстройство, выбранное из сахарного диабета, преддиабета, отторжения при трансплантации, рассеянного склероза, родственного рассеянному склерозу заболевания, преждевременного угасания функции яичников, склеродермы, болезни Шегрена, волчанки, витилиго, алопеции (облысения), полигландулярной недостаточности, болезни Грейвса, гипотиреоза, полимиозита, пузырчатки, болезни Крона, колита, аутоиммунного гепатита, гипопитуитаризма, миокардита, болезни Аддисона, аутоиммунного заболевания кожи, увеита, пернициозной анемии, гипопаратиреоза и/или ревматоидного артрита.
7. Применение по любому из пп. 1-6, при этом ядро наночастицы не является липосомой и/или является твердым ядром, предпочтительно ядром из золота или оксида железа.
8. Применение по любому из пп. 1-6, при этом линкерное покрытие содержит полиэтиленгликоль.
9. Применение по любому из пп. 1-6, при этом линкер из линкерного покрытия имеет размер менее 5 кДа.
10. Применение по любому из пп. 1-6, при этом ядро наночастицы являются биоабсорбируемыми и/или биоразлагаемыми.
11. Применение комплекса по любому из пп. 1-6, при этом диаметр ядра наночастицы составляет от примерное 1 нм до примерное 100 нм.
12. Применение по любому из пп. 1-6, при этом комплексы антиген-MHCII являются идентичными или разными.
13. Применение по п. 12, при этом линкеры из линкерного покрытия являются идентичными или разными.
14. Применение по любому из пп. 1-6, при этом субъект относится к млекопитающим.
15. Способ получения наночастиц из оксида железа, включающий термическое разложение ацетилацетоната железа в присутствии функционализированных молекул ПЭГ и/или бензилового эфира в диапазоне температур, выбранного из от примерно 80 до примерно 300°C, от примерно 80 до примерно 200°C, от примерно 80 до примерно 150°C, от примерно 100 до примерно 250°C, от примерно 100 до примерно 200°C, от примерно 150 до примерно 250°C, или от примерно 150 до примерно 250°C.
16. Способ по п. 15, при этом наночастицы из оксида железа растворимы в воде.
17. Способ по п. 15 или п. 16, при этом термическое разложение проводится в течение от 1 до 2 ч.
18. Способ по п. 15 или п. 16, при этом наночастицы являются стабильными при 4°C в PBS без заметной деградации или агрегации.
19. Способ по п. 18, при этом наночастицы стабильны в течение по крайней мере 6 месяцев.
20. Способ по п. 15 или 16, при этом способ дополнительно включает очистку наночастиц с помощью метода магнитного разделения.
21. Способ по п. 20, где метод магнитного разделения включает использование магнитной колонки.
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Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
KR20160022370A (ko) | 2013-06-24 | 2016-02-29 | 넥스이뮨 | 면역요법을 위한 조성물 및 방법 |
WO2015063616A2 (en) | 2013-11-04 | 2015-05-07 | Uti Limited Partnership | Methods and compositions for sustained immunotherapy |
GB201418433D0 (en) | 2014-10-17 | 2014-12-03 | Imcyse Sa | Novel immunogenic peptides |
SG11201705064XA (en) | 2014-12-24 | 2017-07-28 | Neximmune Inc | Nanoparticle compositions and methods for immunotherapy |
AU2016275312B2 (en) * | 2015-05-06 | 2021-12-23 | Uti Limited Partnership | Nanoparticle compositions for sustained therapy |
US20170205404A1 (en) * | 2016-01-19 | 2017-07-20 | General Electric Company | Multifunctional beads and methods of use for capturing rare cells |
BR112019009477A2 (pt) * | 2016-11-09 | 2019-07-30 | Uti Lp | moléculas de classe ii de pmhc recombinantes |
NZ755744A (en) * | 2017-03-09 | 2023-07-28 | Imcyse Sa | Peptides and methods for the treatment of diabetes |
EP3716949A4 (en) * | 2017-11-29 | 2022-05-18 | UTI Limited Partnership | METHODS OF TREATING AN AUTOIMMUNE DISEASE |
CN108753714B (zh) * | 2018-05-15 | 2019-07-30 | 夏永祥 | GSK-3β抑制剂在体外诱导人体Breg细胞的用途及分离和诱导Breg细胞的方法 |
CN109055311B (zh) * | 2018-08-21 | 2022-03-15 | 苏州沃美生物有限公司 | 基于无血清培养基的人源淋巴细胞培养方法 |
WO2021054490A1 (ko) * | 2019-09-18 | 2021-03-25 | 연세대학교 산학협력단 | 양친매성 고분자, 이를 포함하는 수분산성 금속나노입자 및 이의 제조방법 |
KR20220068802A (ko) | 2020-11-19 | 2022-05-26 | 현대제철 주식회사 | 강관용 고강도 열연강판 및 그 제조방법 |
US20230018837A1 (en) * | 2021-07-15 | 2023-01-19 | University Of Maryland, Baltimore County | Hemostatic nanocapsules for stopping bleeding, visualizing injury, and delivering drugs |
Family Cites Families (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4367110A (en) | 1979-07-02 | 1983-01-04 | Toppan Printing Co. | Decorative laminate and a manufacturing method therefor |
US4452901A (en) | 1980-03-20 | 1984-06-05 | Ciba-Geigy Corporation | Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays |
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
FR2504010B1 (fr) | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
GB2097032B (en) | 1981-04-22 | 1984-09-19 | Teron International Urban Dev | A combined ceiling air and services distribution system mechanical chasse and structural roof member |
US4478946A (en) | 1981-07-02 | 1984-10-23 | South African Inventions Development Corporation | Carrier bound immunosorbent |
US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
EP0092227B1 (en) | 1982-04-19 | 1988-07-27 | Nissan Motor Co., Ltd. | Method for controlling reduction ratio of continuously variable transmission with acceleration compensation |
US4818542A (en) | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
ATE66469T1 (de) | 1985-01-14 | 1991-09-15 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
US5171582A (en) | 1985-07-31 | 1992-12-15 | Ghent William R | Treatment of iodine deficiency diseases |
US4680338A (en) | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
US5258499A (en) | 1988-05-16 | 1993-11-02 | Vestar, Inc. | Liposome targeting using receptor specific ligands |
US6106840A (en) | 1988-06-23 | 2000-08-22 | Anergen, Inc. | MHC conjugates useful in ameliorating autoimmunity |
US5260422A (en) | 1988-06-23 | 1993-11-09 | Anergen, Inc. | MHC conjugates useful in ameliorating autoimmunity |
US4859839A (en) | 1988-07-08 | 1989-08-22 | Counter Computer Corporation | Point-of-sale terminal for laundry or dry cleaning establishments |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
EP0630255B1 (en) | 1991-04-23 | 2002-12-18 | Anergen, Inc. | Mhc conjugates useful in ameliorating autoimmunity |
US5200189A (en) | 1991-07-23 | 1993-04-06 | Ecolab Inc. | Peroxyacid antimicrobial composition |
EP0627934A4 (en) | 1992-02-27 | 1997-01-08 | Univ Leland Stanford Junior | EARLY ANTIGEN FOR AUTOIMMUNE DIABETE. |
JP2631436B2 (ja) | 1992-07-24 | 1997-07-16 | 徳厚 小島 | 排水立て管継手 |
US5972336A (en) | 1992-11-03 | 1999-10-26 | Oravax Merieux Co. | Urease-based vaccine against helicobacter infection |
CA2185810A1 (en) | 1994-03-28 | 1995-10-05 | Jo Klaveness | Liposomes |
US6103379A (en) | 1994-10-06 | 2000-08-15 | Bar-Ilan University | Process for the preparation of microspheres and microspheres made thereby |
WO1996018105A1 (en) | 1994-12-06 | 1996-06-13 | The President And Fellows Of Harvard College | Single chain t-cell receptor |
DE19508058A1 (de) | 1995-02-21 | 1996-08-22 | Schering Ag | Verfahren zur Herstellung von DTPA-Tetraestern der terminalen Carbonsäuren und deren Verwendung zur Herstellung pharmazeutischer Mittel |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
US6033864A (en) | 1996-04-12 | 2000-03-07 | The Regents Of The University Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens |
US20050003431A1 (en) | 1996-08-16 | 2005-01-06 | Wucherpfennig Kai W. | Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor |
ES2221065T3 (es) | 1996-08-16 | 2004-12-16 | The President And Fellows Of Harvard College | Proteinas de fusion de clase ii del mhc, solubles, monovalentes o polivalentes, y sus usos. |
DK1017721T3 (da) | 1997-09-16 | 2009-04-20 | Univ Oregon Health & Science | Rekombinante MHC molekyler, der kan anvendes til manipulation af antigenspecifikke T-celler |
CA2321262A1 (en) | 1998-02-19 | 1999-08-26 | President And Fellows Of Harvard College | Monovalent, multivalent, and multimeric mhc binding domain fusion proteins and conjugates, and uses therefor |
EP1094828A4 (en) | 1998-05-07 | 2005-01-26 | Univ California | USE OF TARGETED, NEGLIGATED TISSUE ANTIGENS TO MODULATE IMMUNE REACTIONS |
DE19825371A1 (de) | 1998-06-06 | 1999-12-09 | Bayer Ag | Elektrochrome Anzeigevorrichtung mit isolierten Zuleitungen |
IL125608A0 (en) | 1998-07-30 | 1999-03-12 | Yeda Res & Dev | Tumor associated antigen peptides and use of same as anti-tumor vaccines |
US7807377B2 (en) | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
US6150022A (en) | 1998-12-07 | 2000-11-21 | Flex Products, Inc. | Bright metal flake based pigments |
JP2000213425A (ja) | 1999-01-20 | 2000-08-02 | Hino Motors Ltd | Egrク―ラ |
US7090973B1 (en) | 1999-04-09 | 2006-08-15 | Oscient Pharmaceuticals Corporation | Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics |
HUP0201222A3 (en) | 1999-05-06 | 2004-07-28 | Genetics Inst Llc Delaware All | Use of soluble constimulatory molecules to enhance immune responses |
JP2003510341A (ja) | 1999-10-06 | 2003-03-18 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 細胞ターゲッティング組成物及びそれらを使用する方法 |
US6585947B1 (en) | 1999-10-22 | 2003-07-01 | The Board Of Trustess Of The University Of Illinois | Method for producing silicon nanoparticles |
US6651655B1 (en) | 2000-01-18 | 2003-11-25 | Quadrant Technologies Limited | Inhaled vaccines |
US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
KR100379250B1 (ko) | 2000-12-04 | 2003-04-08 | 한국과학기술연구원 | 나노 단위 크기의 금속 입자가 함유된 고분자 복합 소재및 그 제조 방법 |
CA2440474A1 (en) | 2001-04-05 | 2002-10-17 | Virginia Mason Research Center | Methods of mhc class ii epitope mapping, detection of autoimmune t cells and antigens, and autoimmune treatment |
DE10117858A1 (de) | 2001-04-10 | 2002-10-24 | Gsf Forschungszentrum Umwelt | MHC-Tetramere |
WO2009003492A1 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
CA2449990A1 (en) | 2001-06-22 | 2003-01-03 | The University Of British Columbia | Type 1 diabetes diagnostics and therapeutics |
US20070129307A1 (en) | 2001-06-22 | 2007-06-07 | The University Of British Columbia | Insulin epitopes for the treatment of type 1 diabetes |
US20030124149A1 (en) | 2001-07-06 | 2003-07-03 | Shalaby Shalaby W. | Bioactive absorbable microparticles as therapeutic vaccines |
ATE388691T1 (de) | 2001-07-10 | 2008-03-15 | Univ North Carolina State | Träger zur freisetzung von nanopartikeln |
DE10144252A1 (de) | 2001-08-31 | 2003-03-27 | Fraunhofer Ges Forschung | Nanopartikel mit daran immobilisiertem biologisch aktivem TNF |
ES2405405T3 (es) | 2001-12-17 | 2013-05-31 | Corixa Corporation | Composiciones y procedimientos para la terapia y el diagnóstico de enfermedad inflamatoria del intestino |
US6688494B2 (en) | 2001-12-20 | 2004-02-10 | Cima Nanotech, Inc. | Process for the manufacture of metal nanoparticle |
US7285289B2 (en) | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
AU2003256506B2 (en) | 2002-07-12 | 2009-06-04 | The Johns Hopkins University | Reagents and methods for engaging unique clonotypic lymphocyte receptors |
DE10310261A1 (de) | 2003-03-05 | 2004-09-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Identifizierung von Antigen-Epitopen |
US20040197304A1 (en) | 2003-04-01 | 2004-10-07 | The Procter & Gamble Company And Alimentary Health, Ltd. | Methods of determining efficacy of treatments of inflammatory diseases of the bowel |
US6929675B1 (en) | 2003-04-24 | 2005-08-16 | Sandia Corporation | Synthesis metal nanoparticle |
US20050118102A1 (en) | 2003-04-28 | 2005-06-02 | Intematix Corporation | Spin resonance heating and/or imaging in medical applications |
DK1623017T3 (da) | 2003-05-08 | 2011-01-10 | Life Technologies Corp | Frembringelse og isolering af antigenspecifikke T-celler |
US8758767B2 (en) | 2003-05-20 | 2014-06-24 | Albert Einstein College Of Medicine Of Yeshiva University | Antigens targeted by prevalent pathogennic T cells in type 1 diabetes and uses thereof |
US7060121B2 (en) | 2003-06-25 | 2006-06-13 | Hsing Kuang Lin | Method of producing gold nanoparticle |
US7812116B2 (en) | 2003-07-03 | 2010-10-12 | Rush University Medical Center | Immunogenic peptides |
US9149440B2 (en) | 2003-09-02 | 2015-10-06 | University Of South Florida | Nanoparticles for drug-delivery |
GB0321937D0 (en) | 2003-09-19 | 2003-10-22 | Univ Liverpool | Nanoparticle conjugates and method of production thereof |
EP1671055B1 (en) | 2003-10-09 | 2013-03-20 | Brooks Instrument LLC | Valve assembly |
DE102004023187A1 (de) | 2004-05-11 | 2005-12-01 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
CA2571899A1 (en) | 2004-07-01 | 2006-08-03 | Yale University | Targeted and high density drug loaded polymeric materials |
US9079765B2 (en) | 2004-10-01 | 2015-07-14 | Midatech Ltd. | Nanoparticles comprising antigens and adjuvants, and immunogenic structures |
WO2006054806A1 (ja) | 2004-11-22 | 2006-05-26 | Locomogene, Inc. | クローン病関連自己抗原 |
US7462446B2 (en) | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
US20070059775A1 (en) | 2005-03-29 | 2007-03-15 | The Trustees Of Columbia University In The City Of New York | Synthesis and conjugation of iron oxide nanoparticles to antibodies for targeting specific cells using fluorescence and MR imaging techniques |
US7562421B2 (en) | 2005-04-03 | 2009-07-21 | Magen Eco Energy A.C.S. Ltd. | Connecting clasp |
US7326399B2 (en) | 2005-04-15 | 2008-02-05 | Headwaters Technology Innovation, Llc | Titanium dioxide nanoparticles and nanoparticle suspensions and methods of making the same |
CN101247826A (zh) | 2005-08-25 | 2008-08-20 | 大鹏药品工业株式会社 | 固定或内包t细胞识别抗原表位肽的生物降解性纳米粒子 |
CA2631714C (en) | 2005-12-02 | 2014-09-16 | Novartis Ag | Nanoparticles for use in immunogenic compositions |
US20100061984A1 (en) | 2006-01-20 | 2010-03-11 | The Trustees Of The University Of Pennsylvania | Compositions and methods for modulation of suppressor t cell activation |
PL2059256T3 (pl) | 2006-08-11 | 2017-02-28 | Life Sciences Research Partners Vzw | Immunogenne peptydy i ich zastosowanie w zaburzeniach immunologicznych |
US7816814B1 (en) | 2006-08-18 | 2010-10-19 | Hennessy Michael J | Bi-directional power converters |
US10004703B2 (en) | 2006-10-12 | 2018-06-26 | Biogen Chesapeake Llc | Treatment of alzheimer's disease using compounds that reduce the activity of non-selective CA++ activated ATP-sensitive cation channels regulated by SUR1 channels |
US20100056444A1 (en) | 2006-10-12 | 2010-03-04 | Sven Martin Jacobson | Treatment of Alzheimer's Disease Using Compounds that Reduce the Activity of Non Selective Ca Activated ATP- Sensitive Cation Channels Regulated by SUR1 Receptors |
MX2009007101A (es) | 2006-12-29 | 2009-12-01 | Univ Washington | Superficies y materiales antibioincrustación bifuncionales. |
WO2008115641A2 (en) | 2007-02-15 | 2008-09-25 | Yale University | Modular nanoparticles for adaptable vaccines |
JP5650406B2 (ja) | 2007-03-07 | 2015-01-07 | ユーティーアイ リミテッド パートナーシップ | 自己免疫状態の予防および治療のための組成物および方法 |
US20150250871A1 (en) | 2007-03-07 | 2015-09-10 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
US20140105980A1 (en) | 2012-10-11 | 2014-04-17 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
US20100151031A1 (en) | 2007-03-23 | 2010-06-17 | Desimone Joseph M | Discrete size and shape specific organic nanoparticles designed to elicit an immune response |
WO2009013741A2 (en) | 2007-07-22 | 2009-01-29 | Camtek Ltd | Method and system for controlling a manufacturing process |
JP5085240B2 (ja) | 2007-09-03 | 2012-11-28 | 日本電波工業株式会社 | 水晶デバイス及び水晶デバイスの製造方法 |
EP2399610A3 (en) | 2007-09-24 | 2012-09-05 | Bar-Ilan University | Polymer nanoparticles coated by magnetic metal oxide and uses thereof |
WO2009064273A1 (en) | 2007-11-16 | 2009-05-22 | Paul Appelbaum | Apparatus and method for packaging articles in clear plastic packages |
US8779088B2 (en) | 2007-12-17 | 2014-07-15 | Marfl Ab | Vaccine for the treatment of Mycobacterium related disorders |
US8629098B2 (en) | 2008-01-15 | 2014-01-14 | Yale University | Compositions and methods for adoptive and active immunotherapy |
US20110165647A1 (en) | 2008-02-04 | 2011-07-07 | Fernig David G | Nanoparticle conjugates |
JP2011525477A (ja) | 2008-03-04 | 2011-09-22 | リクイディア・テクノロジーズ・インコーポレーテッド | 免疫調節剤粒子および処置方法 |
WO2009126835A2 (en) | 2008-04-09 | 2009-10-15 | University Of Washington Techtransfer Invention Licensing | Magnetic nanoparticle and method for imaging t cells |
US20090258355A1 (en) | 2008-04-11 | 2009-10-15 | Brookhaven Science Associates, Llc | Nanoscale Clusters and Methods of Making Same |
EP2324055A2 (en) | 2008-08-25 | 2011-05-25 | Amplimmune, Inc. | Pd-1 antagonists and methods of use thereof |
US8323696B2 (en) | 2008-08-29 | 2012-12-04 | Ecole Polytechnique Federale De Lausanne | Nanoparticles for immunotherapy |
EP2337795A2 (en) | 2008-10-01 | 2011-06-29 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
WO2010037397A1 (en) | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cmv immune monitoring |
US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
CA2642141A1 (en) | 2008-10-20 | 2010-04-20 | Innovative Microelectronics Inc. | Flange alignment pin |
US9267945B2 (en) | 2008-11-12 | 2016-02-23 | Yeda Research And Development Co. Ltd. | Diagnosis of multiple sclerosis |
WO2010080032A2 (en) | 2009-01-09 | 2010-07-15 | Stichting Het Nederlands Kanker Instituut | Bead-assisted viral transduction |
AU2010206854A1 (en) | 2009-01-20 | 2011-08-04 | Myelin Repair Foundation, Inc. | Compositions and methods for induction of antigen-specific tolerance |
US8383085B2 (en) | 2009-05-29 | 2013-02-26 | University Of Manitoba | Methods of making iron-containing nanoparticles |
WO2011044186A1 (en) | 2009-10-06 | 2011-04-14 | The Board Of Trustees Of The University Of Illinois | Human single-chain t cell receptors |
GB0922066D0 (en) | 2009-12-17 | 2010-02-03 | Univ Belfast | Modulator |
GB201003088D0 (en) | 2010-02-24 | 2010-04-14 | Univ Exeter | Method for the preparation of a novel nanoparticle conjugate |
SG187201A1 (en) | 2010-07-26 | 2013-02-28 | Qu Biolog Inc | Immunogenic anti-inflammatory compositions |
EP2640711B1 (en) | 2010-08-25 | 2015-10-14 | Davuluri, Ramamohan Rao | Improved process for the preparation of rufinamide |
JP6027969B2 (ja) | 2010-09-03 | 2016-11-16 | オレゴン ヘルス アンド サイエンス ユニバーシティ | 共有結合性ペプチドを有する組み換え型t細胞受容体リガンド |
AU2011310513C1 (en) | 2010-09-29 | 2016-06-02 | Uti Limited Partnership | Methods for treating autoimmune disease using biocompatible bioabsorbable nanospheres |
US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
CN103917249B (zh) | 2011-09-07 | 2016-11-09 | Mida科技有限公司 | 纳米颗粒‑肽组合物 |
WO2013043662A1 (en) | 2011-09-22 | 2013-03-28 | Marv Enterprises Llc | Method for the treatment of multiple sclerosis |
EP2591801A1 (en) | 2011-11-14 | 2013-05-15 | Universitätsklinikum Hamburg-Eppendorf | Nanoparticle compositions for generation of regulatory T cells and treatment of autoimmune diseases and other chronic inflammatory conditions |
US20130128138A1 (en) | 2011-11-18 | 2013-05-23 | Shenzhen China Star Optoelectronics Technolog Co., LTD. | Flat Panel Display Device, Stereoscopic Display Device, Plasma Display Device |
JP2015500296A (ja) | 2011-12-09 | 2015-01-05 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 定義された動的形状を有する人工抗原提示細胞 |
US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
US20150150996A1 (en) | 2012-06-06 | 2015-06-04 | Northwestern University | Compositions and methods for antigen-specific tolerance |
US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
SG11201504414UA (en) | 2012-12-21 | 2015-07-30 | Hoffmann La Roche | Disulfide-linked multivalent mhc class i comprising multi-function proteins |
RU2019108429A (ru) | 2013-04-29 | 2019-05-06 | Ф. Хоффманн-Ля Рош Аг | Модифицированные асимметричные антитела, связывающие fc-рецептор, и способы их применения |
US9335768B2 (en) | 2013-09-12 | 2016-05-10 | Lam Research Corporation | Cluster mass flow devices and multi-line mass flow devices incorporating the same |
WO2015063616A2 (en) | 2013-11-04 | 2015-05-07 | Uti Limited Partnership | Methods and compositions for sustained immunotherapy |
WO2015200728A1 (en) | 2014-06-25 | 2015-12-30 | Selecta Biosciences, Inc. | Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors |
EP3233903B1 (en) | 2014-12-19 | 2020-12-09 | ETH Zürich | Chimeric antigen receptors and methods of use |
EP3067366A1 (en) | 2015-03-13 | 2016-09-14 | Max-Delbrück-Centrum Für Molekulare Medizin | Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO-1 |
WO2016145605A1 (zh) | 2015-03-17 | 2016-09-22 | 王忠堂 | 一种便携式智能超声多普勒动态实时监测装置 |
MX2017012407A (es) | 2015-03-27 | 2018-03-07 | Harvard College | Celulas t modificadas y métodos para hacer y usar las mismas. |
AU2016275312B2 (en) | 2015-05-06 | 2021-12-23 | Uti Limited Partnership | Nanoparticle compositions for sustained therapy |
MA44907A (fr) | 2015-09-11 | 2018-07-18 | Agenus Inc | Cellules hôtes génétiquement modifiées et leurs procédés d'utilisation |
BR112019009477A2 (pt) | 2016-11-09 | 2019-07-30 | Uti Lp | moléculas de classe ii de pmhc recombinantes |
BR112019021022A2 (pt) | 2017-04-07 | 2020-06-09 | Uti Lp | ensaio para medir a potência de interações receptor-ligante em nanomedicamentos |
EP3716949A4 (en) | 2017-11-29 | 2022-05-18 | UTI Limited Partnership | METHODS OF TREATING AN AUTOIMMUNE DISEASE |
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