RU2016121929A - Способы и композиции для устойчивой иммунотерапии - Google Patents

Способы и композиции для устойчивой иммунотерапии Download PDF

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RU2016121929A
RU2016121929A RU2016121929A RU2016121929A RU2016121929A RU 2016121929 A RU2016121929 A RU 2016121929A RU 2016121929 A RU2016121929 A RU 2016121929A RU 2016121929 A RU2016121929 A RU 2016121929A RU 2016121929 A RU2016121929 A RU 2016121929A
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disease
nanoparticle
antigen
mhcii
use according
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RU2016121929A
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RU2016121929A3 (ru
RU2696876C2 (ru
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Педро САНТАМАРИЯ
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Ютиай Лимитед Партнершип
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Claims (21)

1. Применение комплекса, включающего ядро наночастицы и комплексы причастного к заболеванию антигена с MHCII, функционально связанные с ядром наночастицы через линкерное покрытие, при экспансии и/или созревании популяций регуляторных В-клеток у субъекта, причем покрытая наночастица имеет плотность антиген-MHCII от около 0,05 рМНС/100 нм2 площади поверхности покрытой наночастицы до около 25 рМНС/100 нм2 площади поверхности покрытой наночастицы.
2. Применение комплекса, включающего ядро наночастицы и комплексы причастного к заболеванию антигена с MHCII, функционально связанные с ядром наночастицы через линкерное покрытие, при превращении когнатных В-клеток в регуляторные В-клетки у субъекта, причем покрытая наночастица имеет плотность антиген-MHCII от около 0,05 рМНС/100 нм2 площади поверхности покрытой наночастицы до около 25 рМНС/100 нм2 площади поверхности покрытой наночастицы.
3. Применение комплекса, включающего ядро наночастицы и комплексы причастного к заболеванию антигена с MHCII, функционально связанные с ядром наночастицы через линкерное покрытие, в лечении или профилактики аутоимунного растройства у субъекта, нуждающегося в этом, причем покрытая наночастица имеет плотность антиген-MHCII от около 0,05 рМНС/100 нм2 площади поверхности покрытой наночастицы до около 25 рМНС/100 нм2 площади поверхности покрытой наночастицы.
4. Применение по п. 3, где аутоиммунное расстройство выбрано из группы, включающей сахарный диабет, преддиабет, отторжение при трансплантации, рассеянный склероз, родственные рассеянному склерозу заболевания, преждевременное угасание функции яичников, склеродерма, болезнь Шегрена, волчанка, витилиго, алопеция (облысение), полигландулярная недостаточность, болезнь Грейвса, гипотиреоз, полимиозит, пузырчатка, болезнь Крона, колит, аутоиммунный гепатит, гипопитуитаризм, миокардит, болезнь Аддисона, аутоиммунные заболевания кожи, увеит, пернициозная анемия, гипопаратиреоз и/или ревматоидный артрит.
5. Применение по п. 1, при этом причастный к заболеванию антиген из комплекса антигена - MHCII происходит из аутоантигена, участвующего в аутоиммунной реакции или является его имитатором, причем необязательно аутоантиген вовлечен в аутоимунное расстройство, выбранное из сахарного диабета, преддиабета, отторжения при трансплантации, рассеянного склероза, родственного рассеянному склерозу заболевания, преждевременного угасания функции яичников, склеродермы, болезни Шегрена, волчанки, витилиго, алопеции (облысения), полигландулярной недостаточности, болезни Грейвса, гипотиреоза, полимиозита, пузырчатки, болезни Крона, колита, аутоиммунного гепатита, гипопитуитаризма, миокардита, болезни Аддисона, аутоиммунного заболевания кожи, увеита, пернициозной анемии, гипопаратиреоза и/или ревматоидного артрита.
6. Применение по п. 2, при этом причастный к заболеванию антиген из комплекса антигена - MHCII происходит из аутоантигена, участвующего в аутоиммунной реакции или является его имитатором, причем необязательно аутоантиген вовлечен в аутоимунное расстройство, выбранное из сахарного диабета, преддиабета, отторжения при трансплантации, рассеянного склероза, родственного рассеянному склерозу заболевания, преждевременного угасания функции яичников, склеродермы, болезни Шегрена, волчанки, витилиго, алопеции (облысения), полигландулярной недостаточности, болезни Грейвса, гипотиреоза, полимиозита, пузырчатки, болезни Крона, колита, аутоиммунного гепатита, гипопитуитаризма, миокардита, болезни Аддисона, аутоиммунного заболевания кожи, увеита, пернициозной анемии, гипопаратиреоза и/или ревматоидного артрита.
7. Применение по любому из пп. 1-6, при этом ядро наночастицы не является липосомой и/или является твердым ядром, предпочтительно ядром из золота или оксида железа.
8. Применение по любому из пп. 1-6, при этом линкерное покрытие содержит полиэтиленгликоль.
9. Применение по любому из пп. 1-6, при этом линкер из линкерного покрытия имеет размер менее 5 кДа.
10. Применение по любому из пп. 1-6, при этом ядро наночастицы являются биоабсорбируемыми и/или биоразлагаемыми.
11. Применение комплекса по любому из пп. 1-6, при этом диаметр ядра наночастицы составляет от примерное 1 нм до примерное 100 нм.
12. Применение по любому из пп. 1-6, при этом комплексы антиген-MHCII являются идентичными или разными.
13. Применение по п. 12, при этом линкеры из линкерного покрытия являются идентичными или разными.
14. Применение по любому из пп. 1-6, при этом субъект относится к млекопитающим.
15. Способ получения наночастиц из оксида железа, включающий термическое разложение ацетилацетоната железа в присутствии функционализированных молекул ПЭГ и/или бензилового эфира в диапазоне температур, выбранного из от примерно 80 до примерно 300°C, от примерно 80 до примерно 200°C, от примерно 80 до примерно 150°C, от примерно 100 до примерно 250°C, от примерно 100 до примерно 200°C, от примерно 150 до примерно 250°C, или от примерно 150 до примерно 250°C.
16. Способ по п. 15, при этом наночастицы из оксида железа растворимы в воде.
17. Способ по п. 15 или п. 16, при этом термическое разложение проводится в течение от 1 до 2 ч.
18. Способ по п. 15 или п. 16, при этом наночастицы являются стабильными при 4°C в PBS без заметной деградации или агрегации.
19. Способ по п. 18, при этом наночастицы стабильны в течение по крайней мере 6 месяцев.
20. Способ по п. 15 или 16, при этом способ дополнительно включает очистку наночастиц с помощью метода магнитного разделения.
21. Способ по п. 20, где метод магнитного разделения включает использование магнитной колонки.
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
KR20160022370A (ko) 2013-06-24 2016-02-29 넥스이뮨 면역요법을 위한 조성물 및 방법
WO2015063616A2 (en) 2013-11-04 2015-05-07 Uti Limited Partnership Methods and compositions for sustained immunotherapy
GB201418433D0 (en) 2014-10-17 2014-12-03 Imcyse Sa Novel immunogenic peptides
SG11201705064XA (en) 2014-12-24 2017-07-28 Neximmune Inc Nanoparticle compositions and methods for immunotherapy
AU2016275312B2 (en) * 2015-05-06 2021-12-23 Uti Limited Partnership Nanoparticle compositions for sustained therapy
US20170205404A1 (en) * 2016-01-19 2017-07-20 General Electric Company Multifunctional beads and methods of use for capturing rare cells
BR112019009477A2 (pt) * 2016-11-09 2019-07-30 Uti Lp moléculas de classe ii de pmhc recombinantes
NZ755744A (en) * 2017-03-09 2023-07-28 Imcyse Sa Peptides and methods for the treatment of diabetes
EP3716949A4 (en) * 2017-11-29 2022-05-18 UTI Limited Partnership METHODS OF TREATING AN AUTOIMMUNE DISEASE
CN108753714B (zh) * 2018-05-15 2019-07-30 夏永祥 GSK-3β抑制剂在体外诱导人体Breg细胞的用途及分离和诱导Breg细胞的方法
CN109055311B (zh) * 2018-08-21 2022-03-15 苏州沃美生物有限公司 基于无血清培养基的人源淋巴细胞培养方法
WO2021054490A1 (ko) * 2019-09-18 2021-03-25 연세대학교 산학협력단 양친매성 고분자, 이를 포함하는 수분산성 금속나노입자 및 이의 제조방법
KR20220068802A (ko) 2020-11-19 2022-05-26 현대제철 주식회사 강관용 고강도 열연강판 및 그 제조방법
US20230018837A1 (en) * 2021-07-15 2023-01-19 University Of Maryland, Baltimore County Hemostatic nanocapsules for stopping bleeding, visualizing injury, and delivering drugs

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367110A (en) 1979-07-02 1983-01-04 Toppan Printing Co. Decorative laminate and a manufacturing method therefor
US4452901A (en) 1980-03-20 1984-06-05 Ciba-Geigy Corporation Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
FR2504010B1 (fr) 1981-04-15 1985-10-25 Sanofi Sa Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
GB2097032B (en) 1981-04-22 1984-09-19 Teron International Urban Dev A combined ceiling air and services distribution system mechanical chasse and structural roof member
US4478946A (en) 1981-07-02 1984-10-23 South African Inventions Development Corporation Carrier bound immunosorbent
US4671958A (en) 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
EP0092227B1 (en) 1982-04-19 1988-07-27 Nissan Motor Co., Ltd. Method for controlling reduction ratio of continuously variable transmission with acceleration compensation
US4818542A (en) 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4542225A (en) 1984-08-29 1985-09-17 Dana-Farber Cancer Institute, Inc. Acid-cleavable compound
US4659839A (en) 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
ATE66469T1 (de) 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US5171582A (en) 1985-07-31 1992-12-15 Ghent William R Treatment of iodine deficiency diseases
US4680338A (en) 1985-10-17 1987-07-14 Immunomedics, Inc. Bifunctional linker
US4699784A (en) 1986-02-25 1987-10-13 Center For Molecular Medicine & Immunology Tumoricidal methotrexate-antibody conjugate
US5258499A (en) 1988-05-16 1993-11-02 Vestar, Inc. Liposome targeting using receptor specific ligands
US6106840A (en) 1988-06-23 2000-08-22 Anergen, Inc. MHC conjugates useful in ameliorating autoimmunity
US5260422A (en) 1988-06-23 1993-11-09 Anergen, Inc. MHC conjugates useful in ameliorating autoimmunity
US4859839A (en) 1988-07-08 1989-08-22 Counter Computer Corporation Point-of-sale terminal for laundry or dry cleaning establishments
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
EP0630255B1 (en) 1991-04-23 2002-12-18 Anergen, Inc. Mhc conjugates useful in ameliorating autoimmunity
US5200189A (en) 1991-07-23 1993-04-06 Ecolab Inc. Peroxyacid antimicrobial composition
EP0627934A4 (en) 1992-02-27 1997-01-08 Univ Leland Stanford Junior EARLY ANTIGEN FOR AUTOIMMUNE DIABETE.
JP2631436B2 (ja) 1992-07-24 1997-07-16 徳厚 小島 排水立て管継手
US5972336A (en) 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
CA2185810A1 (en) 1994-03-28 1995-10-05 Jo Klaveness Liposomes
US6103379A (en) 1994-10-06 2000-08-15 Bar-Ilan University Process for the preparation of microspheres and microspheres made thereby
WO1996018105A1 (en) 1994-12-06 1996-06-13 The President And Fellows Of Harvard College Single chain t-cell receptor
DE19508058A1 (de) 1995-02-21 1996-08-22 Schering Ag Verfahren zur Herstellung von DTPA-Tetraestern der terminalen Carbonsäuren und deren Verwendung zur Herstellung pharmazeutischer Mittel
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840839A (en) 1996-02-09 1998-11-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
US6033864A (en) 1996-04-12 2000-03-07 The Regents Of The University Of California Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens
US20050003431A1 (en) 1996-08-16 2005-01-06 Wucherpfennig Kai W. Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor
ES2221065T3 (es) 1996-08-16 2004-12-16 The President And Fellows Of Harvard College Proteinas de fusion de clase ii del mhc, solubles, monovalentes o polivalentes, y sus usos.
DK1017721T3 (da) 1997-09-16 2009-04-20 Univ Oregon Health & Science Rekombinante MHC molekyler, der kan anvendes til manipulation af antigenspecifikke T-celler
CA2321262A1 (en) 1998-02-19 1999-08-26 President And Fellows Of Harvard College Monovalent, multivalent, and multimeric mhc binding domain fusion proteins and conjugates, and uses therefor
EP1094828A4 (en) 1998-05-07 2005-01-26 Univ California USE OF TARGETED, NEGLIGATED TISSUE ANTIGENS TO MODULATE IMMUNE REACTIONS
DE19825371A1 (de) 1998-06-06 1999-12-09 Bayer Ag Elektrochrome Anzeigevorrichtung mit isolierten Zuleitungen
IL125608A0 (en) 1998-07-30 1999-03-12 Yeda Res & Dev Tumor associated antigen peptides and use of same as anti-tumor vaccines
US7807377B2 (en) 1998-10-20 2010-10-05 Salvatore Albani Method of isolating antigen-specific T cells employing artificial antigen presenting cells
US6150022A (en) 1998-12-07 2000-11-21 Flex Products, Inc. Bright metal flake based pigments
JP2000213425A (ja) 1999-01-20 2000-08-02 Hino Motors Ltd Ｅｇｒク―ラ
US7090973B1 (en) 1999-04-09 2006-08-15 Oscient Pharmaceuticals Corporation Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics
HUP0201222A3 (en) 1999-05-06 2004-07-28 Genetics Inst Llc Delaware All Use of soluble constimulatory molecules to enhance immune responses
JP2003510341A (ja) 1999-10-06 2003-03-18 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 細胞ターゲッティング組成物及びそれらを使用する方法
US6585947B1 (en) 1999-10-22 2003-07-01 The Board Of Trustess Of The University Of Illinois Method for producing silicon nanoparticles
US6651655B1 (en) 2000-01-18 2003-11-25 Quadrant Technologies Limited Inhaled vaccines
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
KR100379250B1 (ko) 2000-12-04 2003-04-08 한국과학기술연구원 나노 단위 크기의 금속 입자가 함유된 고분자 복합 소재및 그 제조 방법
CA2440474A1 (en) 2001-04-05 2002-10-17 Virginia Mason Research Center Methods of mhc class ii epitope mapping, detection of autoimmune t cells and antigens, and autoimmune treatment
DE10117858A1 (de) 2001-04-10 2002-10-24 Gsf Forschungszentrum Umwelt MHC-Tetramere
WO2009003492A1 (en) 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
CA2449990A1 (en) 2001-06-22 2003-01-03 The University Of British Columbia Type 1 diabetes diagnostics and therapeutics
US20070129307A1 (en) 2001-06-22 2007-06-07 The University Of British Columbia Insulin epitopes for the treatment of type 1 diabetes
US20030124149A1 (en) 2001-07-06 2003-07-03 Shalaby Shalaby W. Bioactive absorbable microparticles as therapeutic vaccines
ATE388691T1 (de) 2001-07-10 2008-03-15 Univ North Carolina State Träger zur freisetzung von nanopartikeln
DE10144252A1 (de) 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Nanopartikel mit daran immobilisiertem biologisch aktivem TNF
ES2405405T3 (es) 2001-12-17 2013-05-31 Corixa Corporation Composiciones y procedimientos para la terapia y el diagnóstico de enfermedad inflamatoria del intestino
US6688494B2 (en) 2001-12-20 2004-02-10 Cima Nanotech, Inc. Process for the manufacture of metal nanoparticle
US7285289B2 (en) 2002-04-12 2007-10-23 Nagy Jon O Nanoparticle vaccines
AU2003256506B2 (en) 2002-07-12 2009-06-04 The Johns Hopkins University Reagents and methods for engaging unique clonotypic lymphocyte receptors
DE10310261A1 (de) 2003-03-05 2004-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Identifizierung von Antigen-Epitopen
US20040197304A1 (en) 2003-04-01 2004-10-07 The Procter & Gamble Company And Alimentary Health, Ltd. Methods of determining efficacy of treatments of inflammatory diseases of the bowel
US6929675B1 (en) 2003-04-24 2005-08-16 Sandia Corporation Synthesis metal nanoparticle
US20050118102A1 (en) 2003-04-28 2005-06-02 Intematix Corporation Spin resonance heating and/or imaging in medical applications
DK1623017T3 (da) 2003-05-08 2011-01-10 Life Technologies Corp Frembringelse og isolering af antigenspecifikke T-celler
US8758767B2 (en) 2003-05-20 2014-06-24 Albert Einstein College Of Medicine Of Yeshiva University Antigens targeted by prevalent pathogennic T cells in type 1 diabetes and uses thereof
US7060121B2 (en) 2003-06-25 2006-06-13 Hsing Kuang Lin Method of producing gold nanoparticle
US7812116B2 (en) 2003-07-03 2010-10-12 Rush University Medical Center Immunogenic peptides
US9149440B2 (en) 2003-09-02 2015-10-06 University Of South Florida Nanoparticles for drug-delivery
GB0321937D0 (en) 2003-09-19 2003-10-22 Univ Liverpool Nanoparticle conjugates and method of production thereof
EP1671055B1 (en) 2003-10-09 2013-03-20 Brooks Instrument LLC Valve assembly
DE102004023187A1 (de) 2004-05-11 2005-12-01 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
CA2571899A1 (en) 2004-07-01 2006-08-03 Yale University Targeted and high density drug loaded polymeric materials
US9079765B2 (en) 2004-10-01 2015-07-14 Midatech Ltd. Nanoparticles comprising antigens and adjuvants, and immunogenic structures
WO2006054806A1 (ja) 2004-11-22 2006-05-26 Locomogene, Inc. クローン病関連自己抗原
US7462446B2 (en) 2005-03-18 2008-12-09 University Of Washington Magnetic nanoparticle compositions and methods
US20070059775A1 (en) 2005-03-29 2007-03-15 The Trustees Of Columbia University In The City Of New York Synthesis and conjugation of iron oxide nanoparticles to antibodies for targeting specific cells using fluorescence and MR imaging techniques
US7562421B2 (en) 2005-04-03 2009-07-21 Magen Eco Energy A.C.S. Ltd. Connecting clasp
US7326399B2 (en) 2005-04-15 2008-02-05 Headwaters Technology Innovation, Llc Titanium dioxide nanoparticles and nanoparticle suspensions and methods of making the same
CN101247826A (zh) 2005-08-25 2008-08-20 大鹏药品工业株式会社 固定或内包t细胞识别抗原表位肽的生物降解性纳米粒子
CA2631714C (en) 2005-12-02 2014-09-16 Novartis Ag Nanoparticles for use in immunogenic compositions
US20100061984A1 (en) 2006-01-20 2010-03-11 The Trustees Of The University Of Pennsylvania Compositions and methods for modulation of suppressor t cell activation
PL2059256T3 (pl) 2006-08-11 2017-02-28 Life Sciences Research Partners Vzw Immunogenne peptydy i ich zastosowanie w zaburzeniach immunologicznych
US7816814B1 (en) 2006-08-18 2010-10-19 Hennessy Michael J Bi-directional power converters
US10004703B2 (en) 2006-10-12 2018-06-26 Biogen Chesapeake Llc Treatment of alzheimer's disease using compounds that reduce the activity of non-selective CA++ activated ATP-sensitive cation channels regulated by SUR1 channels
US20100056444A1 (en) 2006-10-12 2010-03-04 Sven Martin Jacobson Treatment of Alzheimer's Disease Using Compounds that Reduce the Activity of Non Selective Ca Activated ATP- Sensitive Cation Channels Regulated by SUR1 Receptors
MX2009007101A (es) 2006-12-29 2009-12-01 Univ Washington Superficies y materiales antibioincrustación bifuncionales.
WO2008115641A2 (en) 2007-02-15 2008-09-25 Yale University Modular nanoparticles for adaptable vaccines
JP5650406B2 (ja) 2007-03-07 2015-01-07 ユーティーアイ リミテッド パートナーシップ 自己免疫状態の予防および治療のための組成物および方法
US20150250871A1 (en) 2007-03-07 2015-09-10 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
US20140105980A1 (en) 2012-10-11 2014-04-17 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
US20100151031A1 (en) 2007-03-23 2010-06-17 Desimone Joseph M Discrete size and shape specific organic nanoparticles designed to elicit an immune response
WO2009013741A2 (en) 2007-07-22 2009-01-29 Camtek Ltd Method and system for controlling a manufacturing process
JP5085240B2 (ja) 2007-09-03 2012-11-28 日本電波工業株式会社 水晶デバイス及び水晶デバイスの製造方法
EP2399610A3 (en) 2007-09-24 2012-09-05 Bar-Ilan University Polymer nanoparticles coated by magnetic metal oxide and uses thereof
WO2009064273A1 (en) 2007-11-16 2009-05-22 Paul Appelbaum Apparatus and method for packaging articles in clear plastic packages
US8779088B2 (en) 2007-12-17 2014-07-15 Marfl Ab Vaccine for the treatment of Mycobacterium related disorders
US8629098B2 (en) 2008-01-15 2014-01-14 Yale University Compositions and methods for adoptive and active immunotherapy
US20110165647A1 (en) 2008-02-04 2011-07-07 Fernig David G Nanoparticle conjugates
JP2011525477A (ja) 2008-03-04 2011-09-22 リクイディア・テクノロジーズ・インコーポレーテッド 免疫調節剤粒子および処置方法
WO2009126835A2 (en) 2008-04-09 2009-10-15 University Of Washington Techtransfer Invention Licensing Magnetic nanoparticle and method for imaging t cells
US20090258355A1 (en) 2008-04-11 2009-10-15 Brookhaven Science Associates, Llc Nanoscale Clusters and Methods of Making Same
EP2324055A2 (en) 2008-08-25 2011-05-25 Amplimmune, Inc. Pd-1 antagonists and methods of use thereof
US8323696B2 (en) 2008-08-29 2012-12-04 Ecole Polytechnique Federale De Lausanne Nanoparticles for immunotherapy
EP2337795A2 (en) 2008-10-01 2011-06-29 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
WO2010037397A1 (en) 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cmv immune monitoring
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
CA2642141A1 (en) 2008-10-20 2010-04-20 Innovative Microelectronics Inc. Flange alignment pin
US9267945B2 (en) 2008-11-12 2016-02-23 Yeda Research And Development Co. Ltd. Diagnosis of multiple sclerosis
WO2010080032A2 (en) 2009-01-09 2010-07-15 Stichting Het Nederlands Kanker Instituut Bead-assisted viral transduction
AU2010206854A1 (en) 2009-01-20 2011-08-04 Myelin Repair Foundation, Inc. Compositions and methods for induction of antigen-specific tolerance
US8383085B2 (en) 2009-05-29 2013-02-26 University Of Manitoba Methods of making iron-containing nanoparticles
WO2011044186A1 (en) 2009-10-06 2011-04-14 The Board Of Trustees Of The University Of Illinois Human single-chain t cell receptors
GB0922066D0 (en) 2009-12-17 2010-02-03 Univ Belfast Modulator
GB201003088D0 (en) 2010-02-24 2010-04-14 Univ Exeter Method for the preparation of a novel nanoparticle conjugate
SG187201A1 (en) 2010-07-26 2013-02-28 Qu Biolog Inc Immunogenic anti-inflammatory compositions
EP2640711B1 (en) 2010-08-25 2015-10-14 Davuluri, Ramamohan Rao Improved process for the preparation of rufinamide
JP6027969B2 (ja) 2010-09-03 2016-11-16 オレゴン ヘルス アンド サイエンス ユニバーシティ 共有結合性ペプチドを有する組み換え型ｔ細胞受容体リガンド
AU2011310513C1 (en) 2010-09-29 2016-06-02 Uti Limited Partnership Methods for treating autoimmune disease using biocompatible bioabsorbable nanospheres
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
CN103917249B (zh) 2011-09-07 2016-11-09 Mida科技有限公司 纳米颗粒‑肽组合物
WO2013043662A1 (en) 2011-09-22 2013-03-28 Marv Enterprises Llc Method for the treatment of multiple sclerosis
EP2591801A1 (en) 2011-11-14 2013-05-15 Universitätsklinikum Hamburg-Eppendorf Nanoparticle compositions for generation of regulatory T cells and treatment of autoimmune diseases and other chronic inflammatory conditions
US20130128138A1 (en) 2011-11-18 2013-05-23 Shenzhen China Star Optoelectronics Technolog Co., LTD. Flat Panel Display Device, Stereoscopic Display Device, Plasma Display Device
JP2015500296A (ja) 2011-12-09 2015-01-05 ザ・ジョンズ・ホプキンス・ユニバーシティ 定義された動的形状を有する人工抗原提示細胞
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
US20150150996A1 (en) 2012-06-06 2015-06-04 Northwestern University Compositions and methods for antigen-specific tolerance
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
SG11201504414UA (en) 2012-12-21 2015-07-30 Hoffmann La Roche Disulfide-linked multivalent mhc class i comprising multi-function proteins
RU2019108429A (ru) 2013-04-29 2019-05-06 Ф. Хоффманн-Ля Рош Аг Модифицированные асимметричные антитела, связывающие fc-рецептор, и способы их применения
US9335768B2 (en) 2013-09-12 2016-05-10 Lam Research Corporation Cluster mass flow devices and multi-line mass flow devices incorporating the same
WO2015063616A2 (en) 2013-11-04 2015-05-07 Uti Limited Partnership Methods and compositions for sustained immunotherapy
WO2015200728A1 (en) 2014-06-25 2015-12-30 Selecta Biosciences, Inc. Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors
EP3233903B1 (en) 2014-12-19 2020-12-09 ETH Zürich Chimeric antigen receptors and methods of use
EP3067366A1 (en) 2015-03-13 2016-09-14 Max-Delbrück-Centrum Für Molekulare Medizin Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO-1
WO2016145605A1 (zh) 2015-03-17 2016-09-22 王忠堂 一种便携式智能超声多普勒动态实时监测装置
MX2017012407A (es) 2015-03-27 2018-03-07 Harvard College Celulas t modificadas y métodos para hacer y usar las mismas.
AU2016275312B2 (en) 2015-05-06 2021-12-23 Uti Limited Partnership Nanoparticle compositions for sustained therapy
MA44907A (fr) 2015-09-11 2018-07-18 Agenus Inc Cellules hôtes génétiquement modifiées et leurs procédés d'utilisation
BR112019009477A2 (pt) 2016-11-09 2019-07-30 Uti Lp moléculas de classe ii de pmhc recombinantes
BR112019021022A2 (pt) 2017-04-07 2020-06-09 Uti Lp ensaio para medir a potência de interações receptor-ligante em nanomedicamentos
EP3716949A4 (en) 2017-11-29 2022-05-18 UTI Limited Partnership METHODS OF TREATING AN AUTOIMMUNE DISEASE

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